Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling

Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq

(2016) Diego Adhemar Jaitin et al.   CELL

Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens

(2016) Atray Dixit et al.   CELL

TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype

(2016) Evelyn Fessler et al.   EMBO Molecular Medicine

A global genetic interaction network maps a wiring diagram of cellular function

(2016) M. Costanzo et al.   SCIENCE

A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks

(2015) Oren Parnas et al.   CELL

A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances

(2015) Marco Y. Hein et al.   CELL

The BioPlex Network: A Systematic Exploration of the Human Interactome

(2015) Edward L. Huttlin et al.   CELL

Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation

(2015) Benjamin R. Sabari et al.   MOLECULAR CELL

Gene essentiality and synthetic lethality in haploid human cells

(2015) V. A. Blomen et al.   SCIENCE

A generic strategy for CRISPR-Cas9-mediated gene tagging

(2015) Daniel H. Lackner et al.   Nature Communications

A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51

(2015) Najim Ameziane et al.   Nature Communications

Cullin 3 Recognition Is Not a Universal Property among KCTD Proteins

(2015) Giovanni Smaldone et al.   PLoS One

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

Genetics of single-cell protein abundance variation in large yeast populations

(2014) Frank W. Albert et al.   NATURE

Mutations in G protein β subunits promote transformation and kinase inhibitor resistance

(2014) Akinori Yoda et al.   NATURE MEDICINE

Auxiliary GABAB Receptor Subunits Uncouple G Protein βγ Subunits from Effector Channels to Induce Desensitization

(2014) Rostislav Turecek et al.   NEURON

Genome-wide mapping of cellular traits using yeast

(2014) Leopold Parts   YEAST

Large-scale identification of ubiquitination sites by mass spectrometry

(2013) Namrata D Udeshi et al.   Nature Protocols

Deciphering the Glycosylome of Dystroglycanopathies Using Haploid Screens for Lassa Virus Entry

(2013) L. T. Jae et al.   SCIENCE

A Census of Human Soluble Protein Complexes

(2012) Pierre C. Havugimana et al.   CELL

Regulation of the G-protein Regulatory-GαiSignaling Complex by Nonreceptor Guanine Nucleotide Exchange Factors

(2012) Sukru Sadik Oner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enabling high-throughput ligation-independent cloning and protein expression for the family of ubiquitin specific proteases

(2011) Mark P.A. Luna-Vargas et al.   JOURNAL OF STRUCTURAL BIOLOGY

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

(2011) Jan E. Carette et al.   NATURE

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

Native GABAB receptors are heteromultimers with a family of auxiliary subunits

(2010) Jochen Schwenk et al.   NATURE

Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling

(2010) Guoqiang Xu et al.   NATURE BIOTECHNOLOGY

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

Haploid Genetic Screens in Human Cells Identify Host Factors Used by Pathogens

(2009) J. E. Carette et al.   SCIENCE

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

KCTD5, a putative substrate adaptor for cullin3 ubiquitin ligases

(2008) Yolanda Bayón et al.   FEBS Journal

ConsensusPathDB—a database for integrating human functional interaction networks

(2008) Atanas Kamburov et al.   NUCLEIC ACIDS RESEARCH