CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB

(2011) William Mair et al.   NATURE

Phosphorylation of the CREB-specific coactivator TORC2 at Ser307 regulates its intracellular localization in COS-7 cells and in the mouse liver

(2010) Tatsuya Uebi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Regulation of Hepatic Gluconeogenesis by an ER-Bound Transcription Factor, CREBH

(2010) Min-Woo Lee et al.   Cell Metabolism

Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle

(2010) Carles Cantó et al.   Cell Metabolism

CBP/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivation

(2010) Lawryn H Kasper et al.   EMBO JOURNAL

DrosophilaSalt-inducible Kinase (SIK) Regulates Starvation Resistance through cAMP-response Element-binding Protein (CREB)-regulated Transcription Coactivator (CRTC)

(2010) Sekyu Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FoxOs Function Synergistically to Promote Glucose Production

(2010) Rebecca A. Haeusler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

CRTC3 links catecholamine signalling to energy balance

(2010) Youngsup Song et al.   NATURE

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis

(2010) Eric E Zhang et al.   NATURE MEDICINE

Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic subunit (PP4C) is a key regulator of hepatic gluconeogenesis

(2010) Young-Sil Yoon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity

(2010) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases

(2010) Shin-ichiro Imai et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes

(2009) Maziyar Saberi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Unifying Model for the Selective Regulation of Inducible Transcription by CpG Islands and Nucleosome Remodeling

(2009) Vladimir R. Ramirez-Carrozzi et al.   CELL

Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein

(2009) Ling He et al.   CELL

Prevention of Hepatic Steatosis and Hepatic Insulin Resistance by Knockdown of cAMP Response Element-Binding Protein

(2009) Derek M. Erion et al.   Cell Metabolism

CRTC2 (TORC2) Contributes to the Transcriptional Response to Fasting in the Liver but Is Not Required for the Maintenance of Glucose Homeostasis

(2009) John Le Lay et al.   Cell Metabolism

Adipocyte CREB Promotes Insulin Resistance in Obesity

(2009) Ling Qi et al.   Cell Metabolism

Bipartite functions of the CREB co-activators selectively direct alternative splicing or transcriptional activation

(2009) Antonio L Amelio et al.   EMBO JOURNAL

A role for the CREB co-activator CRTC2 in the hypothalamic mechanisms linking glucose sensing with gene regulation

(2009) Robin G Lerner et al.   EMBO REPORTS

Hepatic energy state is regulated by glucagon receptor signaling in mice

(2009) Eric D. Berglund et al.   JOURNAL OF CLINICAL INVESTIGATION

The coactivator CRTC1 promotes cell proliferation and transformation via AP-1

(2009) G. Canettieri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Meter of Metabolism

(2008) Carla B. Green et al.   CELL

The Insulin-Regulated CREB Coactivator TORC Promotes Stress Resistance in Drosophila

(2008) Biao Wang et al.   Cell Metabolism

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

(2008) Yi Liu et al.   NATURE

The Creb1 coactivator Crtc1 is required for energy balance and fertility

(2008) Judith Y Altarejos et al.   NATURE MEDICINE

Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2

(2008) D. Jansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatic Glucose Sensing via the CREB Coactivator CRTC2

(2008) R. Dentin et al.   SCIENCE