Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification

The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling

(2013) Saikat Mukhopadhyay et al.   CELL

Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube

(2011) M. Tuson et al.   DEVELOPMENT

Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo

(2011) Kyu Sang Joeng et al.   DEVELOPMENTAL BIOLOGY

Heterozygous inactivation of Gnas in adipose-derived mesenchymal progenitor cells enhances osteoblast differentiation and promotes heterotopic ossification

(2011) Robert J Pignolo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Gsα enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice

(2011) Joy Y. Wu et al.   JOURNAL OF CLINICAL INVESTIGATION

Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-γ agonists

(2011) Kengo Shimono et al.   NATURE MEDICINE

Heterotopic Ossifications in a Mouse Model of Albright Hereditary Osteodystrophy

(2011) David L. Huso et al.   PLoS One

Wnt/ -catenin signaling is differentially regulated by G  proteins and contributes to fibrous dysplasia

(2011) J. B. Regard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diffusible Signals, Not Autonomous Mechanisms, Determine the Main Proximodistal Limb Subdivision

(2011) A. Rosello-Diez et al.   SCIENCE

Initiation of Proximal-Distal Patterning in the Vertebrate Limb by Signals and Growth

(2011) K. L. Cooper et al.   SCIENCE

Skeletal progenitors and the GNAS gene: fibrous dysplasia of bone read through stem cells

(2010) Mara Riminucci et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Inherited human diseases of heterotopic bone formation

(2010) Eileen M. Shore et al.   Nature Reviews Rheumatology

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

(2010) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization

(2009) K. S. Joeng et al.   DEVELOPMENT

Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase

(2009) Qing Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Establishing and Interpreting Graded Sonic Hedgehog Signaling during Vertebrate Neural Tube Patterning: The Role of Negative Feedback

(2009) V. Ribes et al.   Cold Spring Harbor Perspectives in Biology

The decoupling of Smoothened from Gαi proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning

(2008) Wee-Chuang Low et al.   DEVELOPMENTAL BIOLOGY

Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development

(2008) Yong Pan et al.   DEVELOPMENTAL BIOLOGY

Hedgehog Signaling in Development and Cancer

(2008) Jin Jiang et al.   DEVELOPMENTAL CELL

Wnt and Hedgehog Signaling Pathways in Bone Development

(2008) Timothy F. Day et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

G protein Gαi functions immediately downstream of Smoothened in Hedgehog signalling

(2008) Stacey K. Ogden et al.   NATURE