Liquid-Liquid Phase Separation of Tau Driven by Hydrophobic Interaction Facilitates Fibrillization of Tau

Electrostatically Driven Complex Coacervation and Amyloid Aggregation of Tau Are Independent Processes with Overlapping Conditions

(2020) Yanxian Lin et al.   ACS Chemical Neuroscience

Zinc promotes liquid–liquid phase separation of tau protein

(2020) Virender Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Just Took a DNA Test, Turns Out 100% Not That Phase

(2020) Aaron D. Gitler et al.   MOLECULAR CELL

Liquid-liquid phase separation induces pathogenic tau conformations in vitro

(2020) Nicholas M. Kanaan et al.   Nature Communications

Dehydration entropy drives liquid-liquid phase separation by molecular crowding

(2020) Sohee Park et al.   Communications Chemistry

Cryo-EM structures of tau filaments

(2020) Sjors HW Scheres et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Aggregation of the nucleic acid–binding protein TDP-43 occurs via distinct routes that are coordinated with stress granule formation

(2019) Youjun Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liquid-liquid phase separation of tau protein: The crucial role of electrostatic interactions

(2019) Solomiia Boyko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions

(2019) Yanxian Lin et al.   eLife

Liquid–Liquid Phase Separation Is Driven by Large-Scale Conformational Unwinding and Fluctuations of Intrinsically Disordered Protein Molecules

(2019) Anupa Majumdar et al.   Journal of Physical Chemistry Letters

Cation−π Interactions and Their Contribution to Mussel Underwater Adhesion Studied Using a Surface Forces Apparatus: A Mini-Review

(2019) Sohee Park et al.   LANGMUIR

Hydrogen bond guidance and aromatic stacking drive liquid-liquid phase separation of intrinsically disordered histidine-rich peptides

(2019) Bartosz Gabryelczyk et al.   Nature Communications

Tau-Cofactor Complexes as Building Blocks of Tau Fibrils

(2019) Yann Fichou et al.   Frontiers in Neuroscience

An Optical Technique for Mapping Microviscosity Dynamics in Cellular Organelles

(2018) Joseph E. Chambers et al.   ACS Nano

Fluorescent Molecular Rotors for Viscosity Sensors

(2018) Seung-Chul Lee et al.   CHEMISTRY-A EUROPEAN JOURNAL

Tau protein liquid–liquid phase separation can initiate tau aggregation

(2018) Susanne Wegmann et al.   EMBO JOURNAL

Acetylation Disfavors Tau Phase Separation

(2018) Josephine Ferreon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Quality Control of Membraneless Organelles

(2018) Simon Alberti et al.   JOURNAL OF MOLECULAR BIOLOGY

Reentrant Phase Behavior in Protein Solutions Induced by Multivalent Salts: Strong Effect of Anions Cl– Versus NO3–

(2018) Michal K. Braun et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau

(2017) Susmitha Ambadipudi et al.   Nature Communications

Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase

(2017) Amayra Hernández-Vega et al.   Cell Reports

RNA stores tau reversibly in complex coacervates

(2017) Xuemei Zhang et al.   PLOS BIOLOGY

Tau and tauopathies

(2016) Thomas Arendt et al.   BRAIN RESEARCH BULLETIN

Water accessibility in a membrane-inserting peptide comparing Overhauser DNP and pulse EPR methods

(2016) Takuya F. Segawa et al.   JOURNAL OF CHEMICAL PHYSICS

Complexation and coacervation of like-charged polyelectrolytes inspired by mussels

(2016) Sangsik Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

Anomalously Rapid Hydration Water Diffusion Dynamics Near DNA Surfaces

(2015) John M. Franck et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

(2015) Yuan Lin et al.   MOLECULAR CELL

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

(2015) Timothy J. Nott et al.   MOLECULAR CELL

Polymer physics of intracellular phase transitions

(2015) Clifford P. Brangwynne et al.   Nature Physics

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

(2015) Tetsuro Murakami et al.   NEURON

Protein structural and surface water rearrangement constitute major events in the earliest aggregation stages of tau

(2015) Anna Pavlova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics

(2015) Shana Elbaum-Garfinkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

Assemblages: Functional units formed by cellular phase separation

(2014) Jeffrey A. Toretsky et al.   JOURNAL OF CELL BIOLOGY

Probing Water Density and Dynamics in the Chaperonin GroEL Cavity

(2014) John M. Franck et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stress granules as crucibles of ALS pathogenesis

(2013) Yun R. Li et al.   JOURNAL OF CELL BIOLOGY

Rapid Global Fitting of Large Fluorescence Lifetime Imaging Microscopy Datasets

(2013) Sean C. Warren et al.   PLoS One

Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation

(2013) S. L. Crick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

Pulsed EPR Determination of Water Accessibility to Spin-Labeled Amino Acid Residues in LHCIIb

(2009) A. Volkov et al.   BIOPHYSICAL JOURNAL

Overhauser Dynamic Nuclear Polarization To Study Local Water Dynamics

(2009) Brandon D. Armstrong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-specific dynamic nuclear polarization of hydration water as a generally applicable approach to monitor protein aggregation

(2009) Anna Pavlova et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

The inverse and direct Hofmeister series for lysozyme

(2009) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Soluble Oligomer of Tau Associated with Fiber Formation Analyzed by NMR

(2008) Dylan W. Peterson et al.   BIOCHEMISTRY

Molecular Rotor Measures Viscosity of Live Cells via Fluorescence Lifetime Imaging

(2008) Marina K. Kuimova et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY