期刊
BIOCHEMISTRY-MOSCOW
卷 85, 期 6, 页码 643-650出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S0006297920060012
关键词
liquid-liquid phase separation; chromatin; cell nucleus; transcription; nuclear compartment; spatial genome organization
资金
- Russian Science Foundation [18~14~00011]
- Russian Science Foundation [18-14-00011] Funding Source: Russian Science Foundation
Functional compartmentalization of the cell nucleus plays an important role in the regulation of genome activity by providing accumulation of enzymes and auxiliary factors in the reaction centers, such as transcription factories, Cajal bodies, speckles, etc. The mechanisms behind the nucleus functional compartmentalization are still poorly understood. There are reasons to believe that the key role in the nucleus compartmentalization belongs to the process of liquid-liquid phase separation. In this brief review, we analyze results of experimental studies demonstrating that liquid-liquid phase separation not only governs functional compartmentalization of the cell nucleus but also contributes to the formation of the 3D genomic architecture.
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