Human brain organogenesis: Toward a cellular understanding of development and disease

Resolving organoid brain region identities by mapping single-cell genomic data to reference atlases

(2021) Jonas Simon Fleck et al.   Cell Stem Cell

Long-term maturation of human cortical organoids matches key early postnatal transitions

(2021) Aaron Gordon et al.   NATURE NEUROSCIENCE

Generation of hypothalamic arcuate organoids from human induced pluripotent stem cells

(2021) Wei-Kai Huang et al.   Cell Stem Cell

Primate cell fusion disentangles gene regulatory divergence in neurodevelopment

(2021) Rachel M. Agoglia et al.   NATURE

Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia

(2021) Ugomma C. Eze et al.   NATURE NEUROSCIENCE

Landmarks of human embryonic development inscribed in somatic mutations

(2021) Sara Bizzotto et al.   SCIENCE

The coding and long noncoding single-cell atlas of the developing human fetal striatum

(2021) Vittoria Dickinson Bocchi et al.   SCIENCE

Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution

(2021) Alexandro E. Trevino et al.   CELL

A map of transcriptional heterogeneity and regulatory variation in human microglia

(2021) Adam M. H. Young et al.   NATURE GENETICS

A human three-dimensional neural-perivascular ‘assembloid’ promotes astrocytic development and enables modeling of SARS-CoV-2 neuropathology

(2021) Lu Wang et al.   NATURE MEDICINE

Spatial and cell type transcriptional landscape of human cerebellar development

(2021) Kimberly A. Aldinger et al.   NATURE NEUROSCIENCE

Rewiring of human neurodevelopmental gene regulatory programs by human accelerated regions

(2021) Kelly M. Girskis et al.   NEURON

Proneural genes define ground-state rules to regulate neurogenic patterning and cortical folding

(2021) Sisu Han et al.   NEURON

Extension of retinofugal projections in an assembled model of human pluripotent stem cell-derived organoids

(2021) Clarisse M. Fligor et al.   Stem Cell Reports

Regulation of prefrontal patterning and connectivity by retinoic acid

(2021) Mikihito Shibata et al.   NATURE

Single-cell epigenomics reveals mechanisms of human cortical development

(2021) Ryan S. Ziffra et al.   NATURE

Human neocortical expansion involves glutamatergic neuron diversification

(2021) Jim Berg et al.   NATURE

Comparative cellular analysis of motor cortex in human, marmoset and mouse

(2021) Trygve E. Bakken et al.   NATURE

A human-specific modifier of cortical connectivity and circuit function

(2021) Ewoud R. E. Schmidt et al.   NATURE

Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism

(2020) F. Kyle Satterstrom et al.   CELL

Decoding the development of the human hippocampus

(2020) Suijuan Zhong et al.   NATURE

Cell stress in cortical organoids impairs molecular subtype specification

(2020) Aparna Bhaduri et al.   NATURE

Chromatin accessibility dynamics in a model of human forebrain development

(2020) Alexandro E. Trevino et al.   SCIENCE

Dendritic action potentials and computation in human layer 2/3 cortical neurons

(2020) Albert Gidon et al.   SCIENCE

Transcriptomic evidence that von Economo neurons are regionally specialized extratelencephalic-projecting excitatory neurons

(2020) Rebecca D. Hodge et al.   Nature Communications

Synthetic Analyses of Single-Cell Transcriptomes from Multiple Brain Organoids and Fetal Brain

(2020) Yoshiaki Tanaka et al.   Cell Reports

Hypothalamic Contribution to Pituitary Functions Is Recapitulated In Vitro Using 3D-Cultured Human iPS Cells

(2020) Takatoshi Kasai et al.   Cell Reports

Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation

(2020) Xuyu Qian et al.   Cell Stem Cell

Deciphering human macrophage development at single-cell resolution

(2020) Zhilei Bian et al.   NATURE

Modeling neural tube development by differentiation of human embryonic stem cells in a microfluidic WNT gradient

(2020) Pedro Rifes et al.   NATURE BIOTECHNOLOGY

Whole-Genome and RNA Sequencing Reveal Variation and Transcriptomic Coordination in the Developing Human Prefrontal Cortex

(2020) Donna M. Werling et al.   Cell Reports

Vascularized human cortical organoids (vOrganoids) model cortical development in vivo

(2020) Yingchao Shi et al.   PLOS BIOLOGY

Origins and Proliferative States of Human Oligodendrocyte Precursor Cells

(2020) Wei Huang et al.   CELL

Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes

(2020) Joel W. Blanchard et al.   NATURE MEDICINE

Huntington’s disease alters human neurodevelopment

(2020) Monia Barnat et al.   SCIENCE

Human CNS barrier-forming organoids with cerebrospinal fluid production

(2020) Laura Pellegrini et al.   SCIENCE

Human fetal microglia acquire homeostatic immune-sensing properties early in development

(2020) L. Kracht et al.   SCIENCE

Human-specific ARHGAP11B increases size and folding of primate neocortex in the fetal marmoset

(2020) Michael Heide et al.   SCIENCE

Innovations present in the primate interneuron repertoire

(2020) Fenna M. Krienen et al.   NATURE

Cell-type-specific 3D epigenomes in the developing human cortex

(2020) Michael Song et al.   NATURE

Neuronal defects in a human cellular model of 22q11.2 deletion syndrome

(2020) Themasap A. Khan et al.   NATURE MEDICINE

Electrophysiological Maturation of Cerebral Organoids Correlates with Dynamic Morphological and Cellular Development

(2020) Summer R. Fair et al.   Stem Cell Reports

Generation of Functional Human 3D Cortico-Motor Assembloids

(2020) Jimena Andersen et al.   CELL

Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells

(2020) Yuki Miura et al.   NATURE BIOTECHNOLOGY

Generation and long-term culture of advanced cerebral organoids for studying later stages of neural development

(2020) Stefano L. Giandomenico et al.   Nature Protocols

Massively parallel discovery of human-specific substitutions that alter enhancer activity

(2020) Severin Uebbing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Tradeoff in the Neural Code across Regions and Species

(2019) Raviv Pryluk et al.   CELL

Assembling human brain organoids

(2019) Sergiu P. Paşca   SCIENCE

Gliogenesis in the outer subventricular zone promotes enlargement and gyrification of the primate cerebrum

(2019) Brian G. Rash et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multimodal Single-Cell Analysis Reveals Physiological Maturation in the Developing Human Neocortex

(2019) Simone Mayer et al.   NEURON

Integrative single-cell analysis

(2019) Tim Stuart et al.   NATURE REVIEWS GENETICS

Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures

(2019) Rebecca M. Marton et al.   NATURE NEUROSCIENCE

Altered neuronal migratory trajectories in human cerebral organoids derived from individuals with neuronal heterotopia

(2019) Johannes Klaus et al.   NATURE MEDICINE

Neocortical Expansion Due to Increased Proliferation of Basal Progenitors Is Linked to Changes in Their Morphology

(2019) Nereo Kalebic et al.   Cell Stem Cell

hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids

(2019) Yangfei Xiang et al.   Cell Stem Cell

Defining the Genetic, Genomic, Cellular, and Diagnostic Architectures of Psychiatric Disorders

(2019) Patrick F. Sullivan et al.   CELL

Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution

(2019) Alex A. Pollen et al.   CELL

Specification of positional identity in forebrain organoids

(2019) Gustav Y. Cederquist et al.   NATURE BIOTECHNOLOGY

Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex

(2019) L. Telley et al.   SCIENCE

Gene expression across mammalian organ development

(2019) Margarida Cardoso-Moreira et al.   NATURE

Individual brain organoids reproducibly form cell diversity of the human cerebral cortex

(2019) Silvia Velasco et al.   NATURE

Atypical behaviour and connectivity in SHANK3-mutant macaques

(2019) Yang Zhou et al.   NATURE

A Single-Cell Transcriptomic Atlas of Human Neocortical Development during Mid-gestation

(2019) Damon Polioudakis et al.   NEURON

Modeling microcephaly with cerebral organoids reveals a WDR62–CEP170–KIF2A pathway promoting cilium disassembly in neural progenitors

(2019) Wei Zhang et al.   Nature Communications

Conserved cell types with divergent features in human versus mouse cortex

(2019) Rebecca D. Hodge et al.   NATURE

Synergistic effects of common schizophrenia risk variants

(2019) Nadine Schrode et al.   NATURE GENETICS

Development and Arealization of the Cerebral Cortex

(2019) Cathryn R. Cadwell et al.   NEURON

Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms

(2019) Rebecca L. Walker et al.   CELL

Organoid single-cell genomic atlas uncovers human-specific features of brain development

(2019) Sabina Kanton et al.   NATURE

Engineering of human brain organoids with a functional vascular-like system

(2019) Bilal Cakir et al.   NATURE METHODS

Spatiotemporal expansion of primary progenitor zones in the developing human cerebellum

(2019) Parthiv Haldipur et al.   SCIENCE

Brain cell type–specific enhancer–promoter interactome maps and disease-risk association

(2019) Alexi Nott et al.   SCIENCE

Generation of complex human organoid models including vascular networks by incorporation of mesodermal progenitor cells

(2019) Philipp Wörsdörfer et al.   Scientific Reports

Xenotransplanted Human Cortical Neurons Reveal Species-Specific Development and Functional Integration into Mouse Visual Circuits

(2019) Daniele Linaro et al.   NEURON

The Dynamic Landscape of Open Chromatin during Human Cortical Neurogenesis

(2018) Luis de la Torre-Ubieta et al.   CELL

Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation

(2018) Ikuo K. Suzuki et al.   CELL

Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis

(2018) Ian T. Fiddes et al.   CELL

A mixed model of neuronal diversity

(2018) Ludovic Telley et al.   NATURE

A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex

(2018) Suijuan Zhong et al.   NATURE

An in vivo model of functional and vascularized human brain organoids

(2018) Abed AlFatah Mansour et al.   NATURE BIOTECHNOLOGY

Deconstructing and reconstructing the mouse and human early embryo

(2018) Marta N. Shahbazi et al.   NATURE CELL BIOLOGY

De novo variants in neurodevelopmental disorders with epilepsy

(2018) Henrike O. Heyne et al.   NATURE GENETICS

Convergence of placenta biology and genetic risk for schizophrenia

(2018) Gianluca Ursini et al.   NATURE MEDICINE

Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis

(2018) Andrew E. Jaffe et al.   NATURE NEUROSCIENCE

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

Synaptic transmission from subplate neurons controls radial migration of neocortical neurons

(2018) Chiaki Ohtaka-Maruyama et al.   SCIENCE

Microglial Dynamics During Human Brain Development

(2018) David A. Menassa et al.   Frontiers in Immunology

Three-dimensional induction of dorsal, intermediate and ventral spinal cord tissues from human pluripotent stem cells

(2018) Takenori Ogura et al.   DEVELOPMENT

Induction of myelinating oligodendrocytes in human cortical spheroids

(2018) Mayur Madhavan et al.   NATURE METHODS

Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes

(2018) Kevin W. Kelley et al.   NATURE NEUROSCIENCE

Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type

(2018) Eszter Boldog et al.   NATURE NEUROSCIENCE

Enhanced Dendritic Compartmentalization in Human Cortical Neurons

(2018) Lou Beaulieu-Laroche et al.   CELL

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

(2018) Timothy R. Hammond et al.   IMMUNITY

Neurodevelopmental disease genes implicated by de novo mutation and copy number variation morbidity

(2018) Bradley P. Coe et al.   NATURE GENETICS

Reliability of human cortical organoid generation

(2018) Se-Jin Yoon et al.   NATURE METHODS

Building Models of Brain Disorders with Three-Dimensional Organoids

(2018) Neal D. Amin et al.   NEURON

h-Channels Contribute to Divergent Intrinsic Membrane Properties of Supragranular Pyramidal Neurons in Human versus Mouse Cerebral Cortex

(2018) Brian E. Kalmbach et al.   NEURON

Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing

(2018) Qingyun Li et al.   NEURON

In vivo modeling of human neuron dynamics and Down syndrome

(2018) Raquel Real et al.   SCIENCE

Microglia and early brain development: An intimate journey

(2018) Morgane S. Thion et al.   SCIENCE

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder

(2018) Michael J. Gandal et al.   SCIENCE

Integrative functional genomic analysis of human brain development and neuropsychiatric risks

(2018) Mingfeng Li et al.   SCIENCE

Comprehensive functional genomic resource and integrative model for the human brain

(2018) Daifeng Wang et al.   SCIENCE

Spatiotemporal transcriptomic divergence across human and macaque brain development

(2018) Ying Zhu et al.   SCIENCE

Transcriptome and epigenome landscape of human cortical development modeled in organoids

(2018) Anahita Amiri et al.   SCIENCE

Prevalence and architecture of de novo mutations in developmental disorders

(2017)   NATURE

Assembly of functionally integrated human forebrain spheroids

(2017) Fikri Birey et al.   NATURE

Cell diversity and network dynamics in photosensitive human brain organoids

(2017) Giorgia Quadrato et al.   NATURE

Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells

(2017) Yuchen Qi et al.   NATURE BIOTECHNOLOGY

Fused cerebral organoids model interactions between brain regions

(2017) Joshua A Bagley et al.   NATURE METHODS

Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells

(2017) Steven A. Sloan et al.   NEURON

Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex

(2017) Tomasz J. Nowakowski et al.   SCIENCE

Molecular and cellular reorganization of neural circuits in the human lineage

(2017) André M. M. Sousa et al.   SCIENCE

Dynamic behaviour of human neuroepithelial cells in the developing forebrain

(2017) Lakshmi Subramanian et al.   Nature Communications

An Organoid-Based Model of Cortical Development Identifies Non-Cell-Autonomous Defects in Wnt Signaling Contributing to Miller-Dieker Syndrome

(2017) Vira Iefremova et al.   Cell Reports

Growth of Thalamocortical Fibers to the Somatosensory Cortex in the Human Fetal Brain

(2017) Željka Krsnik et al.   Frontiers in Neuroscience

Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells

(2017) Anna S. Monzel et al.   Stem Cell Reports

Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening

(2017) Chao Wang et al.   Stem Cell Reports

The evolution and population diversity of human-specific segmental duplications

(2017) Megan Y. Dennis et al.   Nature Ecology & Evolution

Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells

(2016) Gioele La Manno et al.   CELL

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

(2016) Junghyun Jo et al.   Cell Stem Cell

A comprehensive transcriptional map of primate brain development

(2016) Trygve E. Bakken et al.   NATURE

Chromosome conformation elucidates regulatory relationships in developing human brain

(2016) Hyejung Won et al.   NATURE

The Brazilian Zika virus strain causes birth defects in experimental models

(2016) Fernanda R. Cugola et al.   NATURE

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

Gene expression elucidates functional impact of polygenic risk for schizophrenia

(2016) Menachem Fromer et al.   NATURE NEUROSCIENCE

Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience

(2016) Jerome Mertens et al.   NATURE REVIEWS NEUROSCIENCE

Transformation of the Radial Glia Scaffold Demarcates Two Stages of Human Cerebral Cortex Development

(2016) Tomasz J. Nowakowski et al.   NEURON

Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination

(2016) Jose Luis Olmos-Serrano et al.   NEURON

The Cellular and Molecular Landscapes of the Developing Human Central Nervous System

(2016) John C. Silbereis et al.   NEURON

Extensive migration of young neurons into the infant human frontal lobe

(2016) M. F. Paredes et al.   SCIENCE

Zika virus impairs growth in human neurospheres and brain organoids

(2016) P. P. Garcez et al.   SCIENCE

The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice

(2016) Xiang-Chun Ju et al.   eLife

FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

(2015) Jessica Mariani et al.   CELL

Molecular Identity of Human Outer Radial Glia during Cortical Development

(2015) Alex A. Pollen et al.   CELL

Dendritic and Axonal Architecture of Individual Pyramidal Neurons across Layers of Adult Human Neocortex

(2015) Hemanth Mohan et al.   CEREBRAL CORTEX

Human-Chimpanzee Differences in a FZD8 Enhancer Alter Cell-Cycle Dynamics in the Developing Neocortex

(2015) J. Lomax Boyd et al.   CURRENT BIOLOGY

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

Single-cell analysis reveals transcriptional heterogeneity of neural progenitors in human cortex

(2015) Matthew B Johnson et al.   NATURE NEUROSCIENCE

Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex

(2015) Andrew E Jaffe et al.   NATURE NEUROSCIENCE

Applications of CRISPR–Cas systems in neuroscience

(2015) Matthias Heidenreich et al.   NATURE REVIEWS NEUROSCIENCE

Human cerebral organoids recapitulate gene expression programs of fetal neocortex development

(2015) J. Gray Camp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolutionary changes in promoter and enhancer activity during human corticogenesis

(2015) S. K. Reilly et al.   SCIENCE

Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion

(2015) M. Florio et al.   SCIENCE

Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue

(2015) Hideya Sakaguchi et al.   Nature Communications

Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells

(2015) Keiko Muguruma et al.   Cell Reports

Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain

(2014) Maggie S.Y. Yeung et al.   CELL

Radial glia require PDGFD–PDGFRβ signalling in human but not mouse neocortex

(2014) Jan H. Lui et al.   NATURE

Connexin hemichannels contribute to spontaneous electrical activity in the human fetal cortex

(2014) Anna R. Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mammalian neocortex new pyramidal neuron: a new conception

(2014) Miguel Marín-Padilla   Frontiers in Neuroanatomy

Cerebellar granule cells are generated postnatally in humans

(2013) Maren C. Kiessling et al.   Brain Structure & Function

Coexpression Networks Implicate Human Midfetal Deep Cortical Projection Neurons in the Pathogenesis of Autism

(2013) A. Jeremy Willsey et al.   CELL

Integrative Functional Genomic Analyses Implicate Specific Molecular Pathways and Circuits in Autism

(2013) Neelroop N. Parikshak et al.   CELL

Modeling Transformations of Neurodevelopmental Sequences across Mammalian Species

(2013) A. D. Workman et al.   JOURNAL OF NEUROSCIENCE

Cytosystems dynamics in self-organization of tissue architecture

(2013) Yoshiki Sasai   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences

(2013) David V Hansen et al.   NATURE NEUROSCIENCE

Pyramidal Neurons Derived from Human Pluripotent Stem Cells Integrate Efficiently into Mouse Brain Circuits In Vivo

(2013) Ira Espuny-Camacho et al.   NEURON

Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells

(2013) Yingsha Zhang et al.   NEURON

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global Epigenomic Reconfiguration During Mammalian Brain Development

(2013) R. Lister et al.   SCIENCE

Inhibition of SRGAP2 Function by Its Human-Specific Paralogs Induces Neoteny during Spine Maturation

(2012) Cécile Charrier et al.   CELL

Evolution of Human-Specific Neural SRGAP2 Genes by Incomplete Segmental Duplication

(2012) Megan Y. Dennis et al.   CELL

The logic of gene regulatory networks in early vertebrate forebrain patterning

(2012) Leonardo Beccari et al.   MECHANISMS OF DEVELOPMENT

Interneuron dysfunction in psychiatric disorders

(2012) Oscar Marín   NATURE REVIEWS NEUROSCIENCE

Development and Evolution of the Human Neocortex

(2011) Jan H. Lui et al.   CELL

Distinctive Neurons of the Anterior Cingulate and Frontoinsular Cortex: A Historical Perspective

(2011) W. W. Seeley et al.   CEREBRAL CORTEX

Selective Frontoinsular von Economo Neuron and Fork Cell Loss in Early Behavioral Variant Frontotemporal Dementia

(2011) Eun-Joo Kim et al.   CEREBRAL CORTEX

Spontaneous Electrical Activity in the Human Fetal Cortex In Vitro

(2011) A. R. Moore et al.   JOURNAL OF NEUROSCIENCE

Human-specific loss of regulatory DNA and the evolution of human-specific traits

(2011) Cory Y. McLean et al.   NATURE

Spatio-temporal transcriptome of the human brain

(2011) Hyo Jung Kang et al.   NATURE

Temporal dynamics and genetic control of transcription in the human prefrontal cortex

(2011) Carlo Colantuoni et al.   NATURE

Transcriptomic analysis of autistic brain reveals convergent molecular pathology

(2011) Irina Voineagu et al.   NATURE

The evolution of gene expression levels in mammalian organs

(2011) David Brawand et al.   NATURE

Self-organizing optic-cup morphogenesis in three-dimensional culture

(2011) Mototsugu Eiraku et al.   NATURE

Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome

(2011) Sergiu P Paşca et al.   NATURE MEDICINE

Directed differentiation of functional astroglial subtypes from human pluripotent stem cells

(2011) Robert Krencik et al.   Nature Protocols

Developmental genetics of vertebrate glial–cell specification

(2010) David H. Rowitch et al.   NATURE

Neurogenic radial glia in the outer subventricular zone of human neocortex

(2010) David V. Hansen et al.   NATURE

Animal models of neuropsychiatric disorders

(2010) Eric J Nestler et al.   NATURE NEUROSCIENCE

OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling

(2010) Simone A Fietz et al.   NATURE NEUROSCIENCE

Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain

(2009) Frederico A.C. Azevedo et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Uniquely Hominid Features of Adult Human Astrocytes

(2009) N. A. Oberheim et al.   JOURNAL OF NEUROSCIENCE

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Oligodendrocyte development and the onset of myelination in the human fetal brain

(2009) Igor Jakovcevski   Frontiers in Neuroanatomy

Evo-Devo and an Expanding Evolutionary Synthesis: A Genetic Theory of Morphological Evolution

(2008) Sean B. Carroll   CELL

The evolution of the arcuate fasciculus revealed with comparative DTI

(2008) James K Rilling et al.   NATURE NEUROSCIENCE

Development of the human cerebral cortex: Boulder Committee revisited

(2008) Irina Bystron et al.   NATURE REVIEWS NEUROSCIENCE