Journal
CELL
Volume 185, Issue 1, Pages 42-61Publisher
CELL PRESS
DOI: 10.1016/j.cell.2021.10.003
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Funding
- Stanford Wu Tsai Neurosciences Institute's Big Idea Grant on Human Brain Organ-ogenesis, Stanford Bio-X, NIH [R01 MH115012]
- Chan Zuckerberg Ben Barres Investigator Award
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The construction of the human nervous system is a complex and regulated process. Recent advancements in genomics and stem cell-based tissue modeling have allowed for a better understanding of human neural development and dysfunction in neuropsychiatric disease.
The construction of the human nervous system is a distinctly complex although highly regulated process. Human tissue inaccessibility has impeded a molecular understanding of the developmental specializations from which our unique cognitive capacities arise. A confluence of recent technological advances in genomics and stem cell-based tissue modeling is laying the foundation for a new understanding of human neural development and dysfunction in neuropsychiatric disease. Here, we review recent progress on uncovering the cellular and molecular principles of human brain organogenesis in vivo as well as using organoids and assembloids in vitro to model features of human evolution and disease.
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