期刊
NEURON
卷 104, 期 5, 页码 972-+出版社
CELL PRESS
DOI: 10.1016/j.neuron.2019.10.002
关键词
-
资金
- Hercules [AKUL/15/37_GOH1816N]
- FWO [G.0929.15]
- Vlaams Instituut voor Biotechnologie (VIB)
- Neuro-Electronics Research Flanders
- European Research Council (ERC Adv Grant GENDEVOCORTEX)
- Fondation ROGER DE SPOELBERCH
- EOS Program SYNET
- Fonds de la Recherche Scientifique/Fonds National de la Recherche Scientifique (FRS/FNRS)
- Welbio Program of the Walloon Region
- Biowin iCONE program of the Walloon Region
- AXA Research Fund
- Fondation ULB
- Fondation JED
- KU Leuven Research Council [C14/19/111, C14/16/048]
- FWO Research Grant [1237220N]
- FRS/FNRS
- FWO
How neural circuits develop in the human brain has remained almost impossible to study at the neuronal level. Here, we investigate human cortical neuron development, plasticity, and function using a mouse/human chimera model in which xenotransplanted human cortical pyramidal neurons integrate as single cells into the mouse cortex. Combined neuronal tracing, electrophysiology, and in vivo structural and functional imaging of the transplanted cells reveal a coordinated developmental roadmap recapitulating key milestones of human cortical neuron development. The human neurons display a prolonged developmental timeline, indicating the neuron-intrinsic retention of juvenile properties as an important component of human brain neoteny. Following maturation, human neurons in the visual cortex display tuned, decorrelated responses to visual stimuli, like mouse neurons, demonstrating their capacity for physiological synaptic integration in host cortical circuits. These findings provide new insights into human neuronal development and open novel avenues for the study of human neuronal function and disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据