The phytochemical polydatin ameliorates non‐alcoholic steatohepatitis by restoring lysosomal function and autophagic flux

Polydatin Improves Glucose and Lipid Metabolisms in Insulin-Resistant HepG2 Cells through the AMPK Pathway

(2018) Jie Hao et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The complex relationship between TFEB transcription factor phosphorylation and subcellular localization

(2018) Rosa Puertollano et al.   EMBO JOURNAL

Defective lysosomal clearance of autophagosomes and its clinical implications in nonalcoholic steatohepatitis

(2018) Xiaojuan Wang et al.   FASEB JOURNAL

Clostridium difficile toxin B induces autophagic cell death in colonocytes

(2018) Hung Chan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Reduced lysosomal clearance of autophagosomes promotes survival and colonization of Helicobacter pylori

(2018) Lin Zhang et al.   JOURNAL OF PATHOLOGY

Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway

(2018) Xiao-Juan Zhao et al.   Redox Biology

Inflammasome and Autophagy Regulation: A Two-way Street

(2017) Qian Sun et al.   MOLECULAR MEDICINE

Polydatin alleviates alcohol-induced acute liver injury in mice: Relevance of matrix metalloproteinases (MMPs) and hepatic antioxidants

(2017) Meghana Koneru et al.   PHYTOMEDICINE

C-X-C Motif Chemokine 10 Impairs Autophagy and Autolysosome Formation in Non-alcoholic Steatohepatitis

(2017) Xiang Zhang et al.   Theranostics

Role of TFEB Mediated Autophagy, Oxidative Stress, Inflammation, and Cell Death in Endotoxin Induced Myocardial Toxicity of Young and Aged Mice

(2016) Fang Li et al.   Oxidative Medicine and Cellular Longevity

Polydatin supplementation ameliorates diet-induced development of insulin resistance and hepatic steatosis in rats

(2014) QI ZHANG et al.   Molecular Medicine Reports

Lipid Metabolism, Oxidative Stress and Cell Death Are Regulated by PKC Delta in a Dietary Model of Nonalcoholic Steatohepatitis

(2014) Michael W. Greene et al.   PLoS One

Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD

(2014) Á González-Rodríguez et al.   Cell Death & Disease

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

Polydatin: A review of pharmacology and pharmacokinetics

(2013) Qiao-Hui Du et al.   PHARMACEUTICAL BIOLOGY

Obesity, insulin resistance, NASH and hepatocellular carcinoma

(2013) Jun Yu et al.   SEMINARS IN CANCER BIOLOGY

The lysosome: from waste bag to potential therapeutic target

(2013) Hanna Appelqvist et al.   Journal of Molecular Cell Biology

Polydatin alleviates non-alcoholic fatty liver disease in rats by inhibiting the expression of TNF-α and SREBP-1c

(2012) JINGMING ZHANG et al.   Molecular Medicine Reports

Protective Effects of Polydatin from Polygonum cuspidatum against Carbon Tetrachloride-Induced Liver Injury in Mice

(2012) Hong Zhang et al.   PLoS One

Polydatin modulates inflammation by decreasing NF-κB activation and oxidative stress by increasing Gli1, Ptch1, SOD1 expression and ameliorates blood–brain barrier permeability for its neuroprotective effect in pMCAO rat brain

(2011) Hui Ji et al.   BRAIN RESEARCH BULLETIN

Dysregulation of the unfolded protein response in db/db mice with diet-induced steatohepatitis

(2011) Mary E. Rinella et al.   HEPATOLOGY

The autophagic paradox in cancer therapy

(2011) W K K Wu et al.   ONCOGENE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

The plasma lipidomic signature of nonalcoholic steatohepatitis

(2009) Puneet Puri et al.   HEPATOLOGY

Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes

(2009) Matteo Ricchi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet

(2008) Mary E. Rinella et al.   JOURNAL OF LIPID RESEARCH