Cholesterol crystallization within hepatocyte lipid droplets and its role in murine NASH

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

The Role of Cholesterol in the Pathogenesis of NASH

(2016) George N. Ioannou   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Formation of 3D Cholesterol Crystals from 2D Nucleation Sites in Lipid Bilayer Membranes: Implications for Atherosclerosis

(2015) Neta Varsano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Cholesterol-lowering drugs cause dissolution of cholesterol crystals and disperse Kupffer cell crown-like structures during resolution of NASH

(2014) George N. Ioannou et al.   JOURNAL OF LIPID RESEARCH

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

Pharmacological cholesterol lowering reverses fibrotic NASH in obese, diabetic mice with metabolic syndrome

(2013) Derrick M. Van Rooyen et al.   JOURNAL OF HEPATOLOGY

Hepatic cholesterol crystals and crown-like structures distinguish NASH from simple steatosis

(2013) George N. Ioannou et al.   JOURNAL OF LIPID RESEARCH

IL-1β Production through the NLRP3 Inflammasome by Hepatic Macrophages Links Hepatitis C Virus Infection with Liver Inflammation and Disease

(2013) Amina A. Negash et al.   PLoS Pathogens

Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease

(2012) Hae-Ki Min et al.   Cell Metabolism

Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis

(2012) Christopher Savard et al.   HEPATOLOGY

LDL Receptor Knock-Out Mice Are a Physiological Model Particularly Vulnerable to Study the Onset of Inflammation in Non-Alcoholic Fatty Liver Disease

(2012) Veerle Bieghs et al.   PLoS One

Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis

(2012) Giovanni Musso et al.   PROGRESS IN LIPID RESEARCH

Hepatic Free Cholesterol Accumulates in Obese, Diabetic Mice and Causes Nonalcoholic Steatohepatitis

(2011) Derrick M. Van Rooyen et al.   GASTROENTEROLOGY

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice

(2011) Savitha Subramanian et al.   JOURNAL OF LIPID RESEARCH

Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus

(2011) S. M. Horner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipopolysaccharide induces and activates the Nalp3 inflammasome in the liver

(2011) Michal Ganz   WORLD JOURNAL OF GASTROENTEROLOGY

Atorvastatin and Antioxidants for the Treatment of Nonalcoholic Fatty Liver Disease: The St Francis Heart Study Randomized Clinical Trial

(2010) Temitope Foster et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Effect of Ezetimibe on Hepatic Fat, Inflammatory Markers, and Apolipoprotein B-100 Kinetics in Insulin-Resistant Obese Subjects on a Weight Loss Diet

(2010) D. C. Chan et al.   DIABETES CARE

Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice

(2010) Kristiaan Wouters et al.   FEBS LETTERS

Efficacy of ezetimibe for the treatment of non-alcoholic steatohepatitis: An open-label, pilot study

(2010) Masato Yoneda et al.   HEPATOLOGY RESEARCH

Efficacy of long-term ezetimibe therapy in patients with nonalcoholic fatty liver disease

(2010) Hyohun Park et al.   JOURNAL OF GASTROENTEROLOGY

Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis

(2010) Vasilios G Athyros et al.   LANCET

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

(2010) Kristiina Rajamäki et al.   PLoS One

Association between dietary nutrient composition and the incidence of cirrhosis or liver cancer in the united states population

(2009) George N. Ioannou et al.   HEPATOLOGY

A Pilot Study Using Simvastatin in the Treatment of Nonalcoholic Steatohepatitis

(2009) Austin Nelson et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Esterified Cholesterol Is Highly Localized to Bruch's Membrane, as Revealed by Lipid Histochemistry in Wholemounts of Human Choroid

(2009) Martin Rudolf et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Macrophages Create an Acidic Extracellular Hydrolytic Compartment to Digest Aggregated Lipoproteins

(2009) Abigail S. Haka et al.   MOLECULAR BIOLOGY OF THE CELL

Ezetimibe improves high fat and cholesterol diet-induced non-alcoholic fatty liver disease in mice

(2008) Shuqin Zheng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis

(2008) Kristiaan Wouters et al.   HEPATOLOGY

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The Nalp3 inflammasome is essential for the development of silicosis

(2008) Suzanne L. Cassel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE