NF-κB: At the Borders of Autoimmunity and Inflammation

Attenuation of canonical NF‐κB signaling maintains function and stability of human Treg

(2020) Liesa S. Ziegler et al.   FEBS Journal

Bortezomib in antibody-mediated autoimmune diseases (TAVAB): study protocol for a unicentric, non-randomised, non-placebo controlled trial

(2019) Siegfried Kohler et al.   BMJ Open

SHARPIN at the nexus of integrin, immune, and inflammatory signaling in human platelets

(2019) Ana Kasirer-Friede et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional and epigenetic regulation of immune tolerance: roles of the NF-κB family members

(2019) Lei Zhang et al.   Cellular & Molecular Immunology

Trace levels of peptidoglycan in serum underlie the NOD-dependent cytokine response to endoplasmic reticulum stress

(2019) Raphael Molinaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Effectiveness and Safety of Total Glucosides of Paeony in Primary Sjögren's Syndrome: A Systematic Review and Meta-Analysis

(2019) Zhe Feng et al.   Frontiers in Pharmacology

A PD-1-specific toxin suppresses autoimmunity

(2019) Zhirui Wang et al.   Nature Biomedical Engineering

BANK1 interacts with TRAF6 and MyD88 in innate immune signaling in B cells

(2019) Ina Georg et al.   Cellular & Molecular Immunology

The E3 ligase HOIL-1 catalyses ester bond formation between ubiquitin and components of the Myddosome in mammalian cells

(2019) Ian R. Kelsall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNGR1-mediated deletion of A20/Tnfaip3 in dendritic cells alters T and B-cell homeostasis and promotes autoimmune liver pathology

(2019) Tridib Das et al.   JOURNAL OF AUTOIMMUNITY

Medullary thymic epithelial NF–kB-inducing kinase (NIK)/IKKα pathway shapes autoimmunity and liver and lung homeostasis in mice

(2019) Hong Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-programmed cell death protein 1 (anti-PD1) immunotherapy induced autoimmune polyendocrine syndrome type II (APS-2): a case report and review of the literature

(2019) Ashray Gunjur et al.   Journal for ImmunoTherapy of Cancer

Tumor angiogenesis: causes, consequences, challenges and opportunities

(2019) Roberta Lugano et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ikaros prevents autoimmunity by controlling anergy and Toll-like receptor signaling in B cells

(2019) Tanja A. Schwickert et al.   NATURE IMMUNOLOGY

A20 deficiency in hematopoietic stem cells causes lymphopenia and myeloproliferation due to elevated Interferon-γ signals

(2019) Masahiro Marshall Nakagawa et al.   Scientific Reports

A20 haploinsufficiency (HA20): clinical phenotypes and disease course of patients with a newly recognised NF-kB-mediated autoinflammatory disease

(2018) Florence A Aeschlimann et al.   ANNALS OF THE RHEUMATIC DISEASES

Modeling the therapeutic efficacy of NFκB synthetic decoy oligodeoxynucleotides (ODNs)

(2018) Zhipeng Wang et al.   BMC Systems Biology

RELA haploinsufficiency in CD4 lymphoproliferative disease with autoimmune cytopenias

(2018) William A. Comrie et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

(2018) Sofie Voet et al.   Nature Communications

Cooperative Domain Formation by Homologous Motifs in HOIL-1L and SHARPIN Plays A Crucial Role in LUBAC Stabilization

(2018) Hiroaki Fujita et al.   Cell Reports

Nuclear Factor-kappaB in Autoimmunity: Man and Mouse

(2018) Bahar Miraghazadeh et al.   Frontiers in Immunology

OTULIN limits cell death and inflammation by deubiquitinating LUBAC

(2018) Klaus Heger et al.   NATURE

LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis

(2018) Nieves Peltzer et al.   NATURE

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L

(2018) Lucia Taraborrelli et al.   Nature Communications

Targeting IKKβ in Cancer: Challenges and Opportunities for the Therapeutic Utilisation of IKKβ Inhibitors

(2018) Jack Prescott et al.   Cells

Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency

(2018) Anna S. Lehle et al.   GASTROENTEROLOGY

Roles of the immune system in cancer: from tumor initiation to metastatic progression

(2018) Hugo Gonzalez et al.   GENES & DEVELOPMENT

Autoimmunity and Cancer, the Paradox Comorbidities Challenging Therapy in the Context of Preexisting Autoimmunity

(2018) Julio C. Valencia et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases

(2018) Yue Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical and Genetic Heterogeneity of CARD14 Mutations in Psoriatic Skin Disease

(2018) Laura Israel et al.   Frontiers in Immunology

Reactive Oxygen Species as Regulators of MDSC-Mediated Immune Suppression

(2018) Kim Ohl et al.   Frontiers in Immunology

The family of the interleukin-1 receptors

(2017) Diana Boraschi et al.   IMMUNOLOGICAL REVIEWS

Dextran sulphate sodium colitis in C57BL/6J mice is alleviated by Lactococcus lactis and worsened by the neutralization of Tumor necrosis Factor α

(2017) Aleš Berlec et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes

(2017) Meri Kaustio et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Haploinsufficiency of TNFAIP3 ( A20 ) by germline mutation is involved in autoimmune lymphoproliferative syndrome

(2017) Masatoshi Takagi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Central immune tolerance depends on crosstalk between the classical and alternative NF-κB pathways in medullary thymic epithelial cells

(2017) Marc Riemann et al.   JOURNAL OF AUTOIMMUNITY

HumanRELAhaploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration

(2017) Yousef R. Badran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hypomorphic A20 expression confers susceptibility to psoriasis

(2017) Anri Aki et al.   PLoS One

NLRP3mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy

(2017) Hiroshi Nakanishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NOD1 and NOD2: Beyond Peptidoglycan Sensing

(2017) A. Marijke Keestra-Gounder et al.   TRENDS IN IMMUNOLOGY

TLR7/TLR9- and B Cell Receptor-Signaling Crosstalk: Promotion of Potentially Dangerous B Cells

(2017) Amy N. Suthers et al.   Frontiers in Immunology

PD-1/PD-L and autoimmunity: A growing relationship

(2016) Mohammad Reza Zamani et al.   CELLULAR IMMUNOLOGY

Immunoproteasome-Selective Inhibitors: A Promising Strategy to Treat Hematologic Malignancies, Autoimmune and Inflammatory Diseases

(2016) Roberta Ettari et al.   CURRENT MEDICINAL CHEMISTRY

Variants in TRIM22 That Affect NOD2 Signaling Are Associated With Very-Early-Onset Inflammatory Bowel Disease

(2016) Qi Li et al.   GASTROENTEROLOGY

T-cell selection in the thymus: a spatial and temporal perspective

(2016) Nadia Kurd et al.   IMMUNOLOGICAL REVIEWS

NF-κB1 Haploinsufficiency Causing Immunodeficiency and EBV-Driven Lymphoproliferation

(2016) Heidrun Boztug et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT

(2016) Baerbel Keller et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type I interferon–mediated monogenic autoinflammation: The type I interferonopathies, a conceptual overview

(2016) Mathieu P. Rodero et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Loss of B Cells in Patients with Heterozygous Mutations in IKAROS

(2016) Hye Sun Kuehn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recruitment of A20 by the C-terminal domain of NEMO suppresses NF-κB activation and autoinflammatory disease

(2016) Jevgenia Zilberman-Rudenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease

(2016) Qing Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood

(2016) Katrin Klocke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Negative regulation of NF-κB p65 activity by serine 536 phosphorylation

(2016) Jean-Philippe Pradère et al.   Science Signaling

NOD2 up-regulates TLR2-mediated IL-23p19 expression via NF-κB subunit c-Rel in Paneth cell-like cells

(2016) Gao Tan et al.   Oncotarget

Negative regulation of NF-κB p65 activity by serine 536 phosphorylation

(2016) Jean-Philippe Pradère et al.   Science Signaling

The Regulation of NF-κB Subunits by Phosphorylation

(2016) Frank Christian et al.   Cells

Haploinsufficiency of the NF-κB1 Subunit p50 in Common Variable Immunodeficiency

(2015) Manfred Fliegauf et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Significant lethality following liver resection in A20 heterozygous knockout mice uncovers a key role for A20 in liver regeneration

(2015) P Studer et al.   CELL DEATH AND DIFFERENTIATION

Homeostatic NF-κB Signaling in Steady-State Migratory Dendritic Cells Regulates Immune Homeostasis and Tolerance

(2015) Myriam Baratin et al.   IMMUNITY

Linear ubiquitination in immunity

(2015) Yutaka Shimizu et al.   IMMUNOLOGICAL REVIEWS

The deubiquitinating enzyme CYLD regulates the differentiation and maturation of thymic medullary epithelial cells

(2015) Sonja Reissig et al.   IMMUNOLOGY AND CELL BIOLOGY

Inhibition of RANKL- and LPS-induced osteoclast differentiations by novel NF-κB inhibitor DTCM-glutarimide

(2015) Naoki Koide et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Phenotypic and genotypic association of epithelial IL1RL1 to human TH2-like asthma

(2015) Russell S. Traister et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mild B-cell lymphocytosis in patients with a CARD11 C49Y mutation

(2015) David Buchbinder et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The effects of RelB deficiency on lymphocyte development and function

(2015) Nigel Sharfe et al.   JOURNAL OF AUTOIMMUNITY

The immunogenetics of Psoriasis: A comprehensive review

(2015) Jamie L. Harden et al.   JOURNAL OF AUTOIMMUNITY

Symptomatic Males and Female Carriers in a Large Caucasian Kindred with XIAP Deficiency

(2015) Magdalena Dziadzio et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia

(2015) Bertrand Boisson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NF-κB Regulates PD-1 Expression in Macrophages

(2015) Alexander P. R. Bally et al.   JOURNAL OF IMMUNOLOGY

The novel S59P mutation in the TNFRSF1A gene identified in an adult onset TNF receptor associated periodic syndrome (TRAPS) constitutively activates NF-κB pathway

(2015) Eliana Greco et al.   ARTHRITIS RESEARCH & THERAPY

OX40/OX40L axis: not a friend in autoimmunity

(2015) Hideki Ueno et al.   Oncotarget

Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection

(2015) Donna A MacDuff et al.   eLife

Discovery of thienopyrimidine-based FLT3 inhibitors from the structural modification of known IKKβ inhibitors

(2014) Chun-Ho Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Autosomal-dominant B-cell deficiency with alopecia due to a mutation in NFKB2 that results in nonprocessable p100

(2014) C. E. Lee et al.   BLOOD

Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN

(2014) Tsuyoshi Takiuchi et al.   GENES TO CELLS

The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency

(2014) Stuart E. Turvey et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Germline CARD11 Mutation in a Patient with Severe Congenital B Cell Lymphocytosis

(2014) Andrew S. Brohl et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations

(2014) Nadia Jeremiah et al.   JOURNAL OF CLINICAL INVESTIGATION

The genetic background of generalized pustular psoriasis: IL36RN mutations and CARD14 gain-of-function variants

(2014) Kazumitsu Sugiura   JOURNAL OF DERMATOLOGICAL SCIENCE

A20 deficiency causes spontaneous neuroinflammation in mice

(2014) Renata Guedes et al.   Journal of Neuroinflammation

TPCA-1 Is a Direct Dual Inhibitor of STAT3 and NF- B and Regresses Mutant EGFR-Associated Human Non-Small Cell Lung Cancers

(2014) J. Nan et al.   MOLECULAR CANCER THERAPEUTICS

TGFβ Activated Kinase 1 (TAK1) at the Crossroad of B Cell Receptor and Toll-Like Receptor 9 Signaling Pathways in Human B Cells

(2014) Dániel Szili et al.   PLoS One

A20 controls intestinal homeostasis through cell-specific activities

(2014) Lars Vereecke et al.   Nature Communications

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice

(2014) James A Rickard et al.   eLife

Brief Report: Involvement ofTNFRSF11AMolecular Defects in Autoinflammatory Disorders

(2014) Isabelle Jéru et al.   Arthritis & Rheumatology

Astrocytic A20 ameliorates experimental autoimmune encephalomyelitis by inhibiting NF-κB- and STAT1-dependent chemokine production in astrocytes

(2013) Xu Wang et al.   ACTA NEUROPATHOLOGICA

Germline Mutations in NFKB2 Implicate the Noncanonical NF-κB Pathway in the Pathogenesis of Common Variable Immunodeficiency

(2013) Karin Chen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

CTLA-4 and autoimmunity: New insights into the dual regulator of tolerance

(2013) Jorge Romo-Tena et al.   AUTOIMMUNITY REVIEWS

OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin

(2013) Kirstin Keusekotten et al.   CELL

Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells

(2013) Yoshiteru Sasaki et al.   EMBO JOURNAL

Autosomal Dominant Anhidrotic Ectodermal Dysplasia with Immunodeficiency Caused by a Novel NFKBIA Mutation, p.Ser36Tyr, Presents with Mild Ectodermal Dysplasia and Non-Infectious Systemic Inflammation

(2013) Takakazu Yoshioka et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The Role of TL1A and DR3 in Autoimmune and Inflammatory Diseases

(2013) Yoshihiro Aiba et al.   MEDIATORS OF INFLAMMATION

The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis

(2013) Elena Rivkin et al.   NATURE

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

(2013) C. H. Emmerich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A20 in inflammation and autoimmunity

(2013) Leen Catrysse et al.   TRENDS IN IMMUNOLOGY

Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccination

(2013) Nao Jounai et al.   Frontiers in Cellular and Infection Microbiology

NF-κB regulation: lessons from structures

(2012) Gourisankar Ghosh et al.   IMMUNOLOGICAL REVIEWS

Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome is linked to dysregulated monocyte IL-1β production

(2012) Laeticia Kolly et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Analysis of Nuclear Factor-κB (NF-κB) Essential Modulator (NEMO) Binding to Linear and Lysine-linked Ubiquitin Chains and Its Role in the Activation of NF-κB

(2012) Tobias Kensche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells

(2012) Anne Brüstle et al.   JOURNAL OF CLINICAL INVESTIGATION

Congenital B cell lymphocytosis explained by novel germlineCARD11mutations

(2012) Andrew L. Snow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A20 and CYLD Do Not Share Significant Overlapping Functions during B Cell Development and Activation

(2012) Yuanyuan Chu et al.   JOURNAL OF IMMUNOLOGY

Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells

(2012) Jae-Hoon Chang et al.   NATURE IMMUNOLOGY

Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency

(2012) Bertrand Boisson et al.   NATURE IMMUNOLOGY

Interleukin-1 Inhibition and Fatigue in Primary Sjögren's Syndrome – A Double Blind, Randomised Clinical Trial

(2012) Katrine Brække Norheim et al.   PLoS One

Dual signaling by innate and adaptive immune receptors is required for TLR7-induced B-cell-mediated autoimmunity

(2012) E. R. Walsh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell receptor/CARMA1/NF- B signaling controls T-helper (Th) 17 differentiation

(2012) L. L. Molinero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-Cell Tolerance: Central and Peripheral

(2012) Y. Xing et al.   Cold Spring Harbor Perspectives in Biology

CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt

(2012) Jae Hyang Lim et al.   Nature Communications

Proteins derived from neutrophil extracellular traps may serve as self-antigens and mediate organ damage in autoimmune diseases

(2012) Jason S. Knight et al.   Frontiers in Immunology

Mutations in IL36RN/IL1F5 Are Associated with the Severe Episodic Inflammatory Skin Disease Known as Generalized Pustular Psoriasis

(2011) Alexandros Onoufriadis et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Inhibitory kappa B kinases as targets for pharmacological regulation

(2011) Carly Gamble et al.   BRITISH JOURNAL OF PHARMACOLOGY

CYLD Inhibits Tumorigenesis and Metastasis by Blocking JNK/AP1 Signaling at Multiple Levels

(2011) P. M. de Marval et al.   Cancer Prevention Research

The role of TNF and Fas dependent signaling in animal models of inflammatory liver injury and liver cancer

(2011) Christian Liedtke et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Proinflammatory Cytokines in the Pathogenesis of Inflammatory Bowel Diseases

(2011) Warren Strober et al.   GASTROENTEROLOGY

Transcriptional regulation by STAT6

(2011) Shreevrat Goenka et al.   IMMUNOLOGIC RESEARCH

Type 2 innate immune responses and the natural helper cell

(2011) Shigeo Koyasu et al.   IMMUNOLOGY

Proteasome Inhibition with Bortezomib Depletes Plasma Cells and Autoantibodies in Experimental Autoimmune Myasthenia Gravis

(2011) A. M. Gomez et al.   JOURNAL OF IMMUNOLOGY

IL-1F5, -F6, -F8, and -F9: A Novel IL-1 Family Signaling System That Is Active in Psoriasis and Promotes Keratinocyte Antimicrobial Peptide Expression

(2011) A. Johnston et al.   JOURNAL OF IMMUNOLOGY

The Role of Nuclear Factor κB in the Interferon Response

(2011) Lawrence M. Pfeffer   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

(2011) Fuminori Tokunaga et al.   NATURE

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

(2011) Fumiyo Ikeda et al.   NATURE

Linear ubiquitination prevents inflammation and regulates immune signalling

(2011) Björn Gerlach et al.   NATURE

Interleukin-36–Receptor Antagonist Deficiency and Generalized Pustular Psoriasis

(2011) Slaheddine Marrakchi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Overexpression of a Minimal Domain of Calpastatin Suppresses IL-6 Production and Th17 Development via Reduced NF-κB and Increased STAT5 Signals

(2011) Mikiko Iguchi-Hashimoto et al.   PLoS One

Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF B signalling pathways

(2010) C. Potter et al.   ANNALS OF THE RHEUMATIC DISEASES

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

The association of a non-synonymous SNP in theTNFAIP3gene with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population

(2010) Kenichi Shimane et al.   ARTHRITIS AND RHEUMATISM

A single NFκB system for both canonical and non-canonical signaling

(2010) Vincent Feng-Sheng Shih et al.   CELL RESEARCH

The complicated role of NF-κB in T-cell selection

(2010) Mingzhao Zhu et al.   Cellular & Molecular Immunology

B-cell tolerance: mechanisms and implications

(2010) Antony Basten et al.   CURRENT OPINION IN IMMUNOLOGY

Regulation of natural killer T-cell development by deubiquitinase CYLD

(2010) Andrew J Lee et al.   EMBO JOURNAL

Inflammation and Colon Cancer

(2010) Janoš Terzić et al.   GASTROENTEROLOGY

Ubiquitin Makes Its Mark on Immune Regulation

(2010) Barbara A. Malynn et al.   IMMUNITY

The Ubiquitin Modifying Enzyme A20 Restricts B Cell Survival and Prevents Autoimmunity

(2010) Rita M. Tavares et al.   IMMUNITY

Regulation of the Ifng locus in the context of T-lineage specification and plasticity

(2010) Anand Balasubramani et al.   IMMUNOLOGICAL REVIEWS

Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor–induced toxicity and experimental colitis

(2010) Lars Vereecke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Decision checkpoints in the thymus

(2010) Andrea C Carpenter et al.   NATURE IMMUNOLOGY

The role of defective clearance of apoptotic cells in systemic autoimmunity

(2010) Luis E. Muñoz et al.   Nature Reviews Rheumatology

Gene profiling predicts rheumatoid arthritis responsiveness to IL-1Ra (anakinra)

(2010) C. Bansard et al.   RHEUMATOLOGY

Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation

(2009) Simin Rahighi et al.   CELL

NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain

(2009) E Laplantine et al.   EMBO JOURNAL

The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-κB signalling

(2009) Noula Shembade et al.   EMBO JOURNAL

Development of Foxp3+ Regulatory T Cells Is Driven by the c-Rel Enhanceosome

(2009) Qingguo Ruan et al.   IMMUNITY

Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8

(2009) Dipyaman Ganguly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

c-Rel is required for the development of thymic Foxp3+CD4 regulatory T cells

(2009) Iwao Isomura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cell-Autonomous Role for NF- B in Immature Bone Marrow B Cells

(2009) E. Claudio et al.   JOURNAL OF IMMUNOLOGY

The Nfkb1 and Nfkb2 Proteins p105 and p100 Function as the Core of High-Molecular-Weight Heterogeneous Complexes

(2009) Olga V. Savinova et al.   MOLECULAR CELL

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

(2009) Jian-Wen Han et al.   NATURE GENETICS

Development of immunoglobulin λ-chain–positive B cells, but not editing of immunoglobulin κ-chain, depends on NF-κB signals

(2009) Emmanuel Derudder et al.   NATURE IMMUNOLOGY

Mechanisms maintaining peripheral tolerance

(2009) Daniel L Mueller   NATURE IMMUNOLOGY

Crucial Role for BAFF-BAFF-R Signaling in the Survival and Maintenance of Mature B Cells

(2009) Melanie Rauch et al.   PLoS One

The NF- B Family of Transcription Factors and Its Regulation

(2009) A. Oeckinghaus et al.   Cold Spring Harbor Perspectives in Biology

CD1d-restricted iNKT cells, the ‘Swiss-Army knife’ of the immune system

(2008) Jennifer L Matsuda et al.   CURRENT OPINION IN IMMUNOLOGY

Adult-Onset Still???s Disease

(2008) Apostolos Kontzias et al.   DRUGS

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus

(2008) Robert R Graham et al.   NATURE GENETICS