Ikaros prevents autoimmunity by controlling anergy and Toll-like receptor signaling in B cells

A novel IKAROS haploinsufficiency kindred with unexpectedly late and variable B-cell maturation defects

(2018) Delfien J. Bogaert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A kindred with mutant IKAROS and autoimmunity

(2018) Erika Van Nieuwenhove et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate

(2018) Mark Noviski et al.   eLife

Control of autoreactive B cells by IgM and IgD B cell receptors: maintaining a fine balance

(2018) Mark Noviski et al.   CURRENT OPINION IN IMMUNOLOGY

The making of a lymphocyte: the choice among disparate cell fates and the IKAROS enigma

(2017) Katia Georgopoulos   GENES & DEVELOPMENT

Abnormal hematopoiesis and autoimmunity in human subjects with germline IKZF1 mutations

(2017) Akihiro Hoshino et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A TLR9-dependent checkpoint governs B cell responses to DNA-containing antigens

(2017) Vishal J. Sindhava et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular functions of the transcription factors E2A and E2-2 in controlling germinal center B cell and plasma cell development

(2016) Miriam Wöhner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The signaling adaptor TRAF1 negatively regulates Toll-like receptor signaling and this underlies its role in rheumatic disease

(2016) Ali A Abdul-Sater et al.   NATURE IMMUNOLOGY

New insights into the immunopathogenesis of systemic lupus erythematosus

(2016) George C. Tsokos et al.   Nature Reviews Rheumatology

Loss of B Cells in Patients with Heterozygous Mutations in IKAROS

(2016) Hye Sun Kuehn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Association of the IKZF1 5ʹ UTR variant rs1456896 with lupus nephritis in a northern Han Chinese population

(2016) Y-M Zhang et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

IgD attenuates the IgM-induced anergy response in transitional and mature B cells

(2016) Zahra Sabouri et al.   Nature Communications

Age-associated B cells: key mediators of both protective and autoreactive humoral responses

(2015) Martin S. Naradikian et al.   IMMUNOLOGICAL REVIEWS

Nucleic Acid–Sensing Receptors: Rheostats of Autoimmunity and Autoinflammation

(2015) Shruti Sharma et al.   JOURNAL OF IMMUNOLOGY

Age-Associated B Cells: A T-bet–Dependent Effector with Roles in Protective and Pathogenic Immunity

(2015) Kira Rubtsova et al.   JOURNAL OF IMMUNOLOGY

Responsiveness of B cells is regulated by the hinge region of IgD

(2015) Rudolf Übelhart et al.   NATURE IMMUNOLOGY

Ensembl 2016

(2015) Andrew Yates et al.   NUCLEIC ACIDS RESEARCH

B cell antigen receptors of the IgM and IgD classes are clustered in different protein islands that are altered during B cell activation

(2015) Palash Chandra Maity et al.   Science Signaling

B cell antigen receptors of the IgM and IgD classes are clustered in different protein islands that are altered during B cell activation

(2015) Palash Chandra Maity et al.   Science Signaling

Signaling through the Adaptor Molecule MyD88 in CD4+ T Cells Is Required to Overcome Suppression by Regulatory T Cells

(2014) Dominik Schenten et al.   IMMUNITY

Zfp318 Regulates IgD Expression by Abrogating Transcription Termination within theIghm/IghdLocus

(2014) Peter D. Pioli et al.   JOURNAL OF IMMUNOLOGY

Genetic and epigenetic fine mapping of causal autoimmune disease variants

(2014) Kyle Kai-How Farh et al.   NATURE

Stage-specific control of early B cell development by the transcription factor Ikaros

(2014) Tanja A Schwickert et al.   NATURE IMMUNOLOGY

deepTools: a flexible platform for exploring deep-sequencing data

(2014) Fidel Ramírez et al.   NUCLEIC ACIDS RESEARCH

Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes

(2014) A. Enders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

TLR9 Promotes Tolerance by Restricting Survival of Anergic Anti-DNA B Cells, Yet Is Also Required for Their Activation

(2013) K. M. Nickerson et al.   JOURNAL OF IMMUNOLOGY

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

The UCSC genome browser and associated tools

(2012) R. M. Kuhn et al.   BRIEFINGS IN BIOINFORMATICS

The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis

(2012) Roger Revilla-i-Domingo et al.   EMBO JOURNAL

The Transcription Factors Egr2 and Egr3 Are Essential for the Control of Inflammation and Antigen-Induced Proliferation of B and T Cells

(2012) Suling Li et al.   IMMUNITY

SATB1-mediated functional packaging of chromatin into loops

(2012) Terumi Kohwi-Shigematsu et al.   METHODS

Endogenous antigen tunes the responsiveness of naive B cells but not T cells

(2012) Julie Zikherman et al.   NATURE

Measurement of mRNA abundance using RNA-seq data: RPKM measure is inconsistent among samples

(2012) Günter P. Wagner et al.   THEORY IN BIOSCIENCES

Interleukin-1 receptor-associated kinase-M suppresses systemic lupus erythematosus

(2011) M. Lech et al.   ANNALS OF THE RHEUMATIC DISEASES

Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with Systemic Lupus Erythematosus

(2011) Deborah S. Cunninghame Graham et al.   PLoS Genetics

B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice

(2010) Y. Chu et al.   BLOOD

The Ubiquitin Modifying Enzyme A20 Restricts B Cell Survival and Prevents Autoimmunity

(2010) Rita M. Tavares et al.   IMMUNITY

TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1 are associated with clinical features of systemic lupus erythematosus in a Chinese Han population

(2010) C-F. He et al.   LUPUS

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Blimp-1 Transcription Factor Is Required for the Differentiation of Effector CD8+ T Cells and Memory Responses

(2009) Axel Kallies et al.   IMMUNITY

A Role for the Transcriptional Repressor Blimp-1 in CD8+ T Cell Exhaustion during Chronic Viral Infection

(2009) Haina Shin et al.   IMMUNITY

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

(2009) Vesela Gateva et al.   NATURE GENETICS

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

(2009) Jian-Wen Han et al.   NATURE GENETICS

Transcriptome analysis by strand-specific sequencing of complementary DNA

(2009) Dmitri Parkhomchuk et al.   NUCLEIC ACIDS RESEARCH

Instructive Role of the Transcription Factor E2A in Early B Lymphopoiesis and Germinal Center B Cell Development

(2008) Kyongrim Kwon et al.   IMMUNITY