Linear ubiquitination in immunity

A20 Restricts Ubiquitination of Pro-Interleukin-1β Protein Complexes and Suppresses NLRP3 Inflammasome Activity

(2015) Bao H. Duong et al.   IMMUNITY

Cutting Edge: SHARPIN Is Required for Optimal NLRP3 Inflammasome Activation

(2015) Prajwal Gurung et al.   JOURNAL OF IMMUNOLOGY

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Deubiquitinase-based analysis of ubiquitin chain architecture using Ubiquitin Chain Restriction (UbiCRest)

(2015) Manuela K Hospenthal et al.   Nature Protocols

Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity

(2015) Yusuke Sato et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity

(2015) Yusuke Sato et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A catalytic-independent role for the LUBAC in NF- B activation upon antigen receptor engagement and in lymphoma cells

(2014) S. M. Dubois et al.   BLOOD

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

A20: attractive without showing cleavage

(2014) K. Verhelst et al.   EMBO REPORTS

The deubiquitinase activity of A20 is dispensable for NF- B signaling

(2014) A. De et al.   EMBO REPORTS

Met1-linked ubiquitination in immune signalling

(2014) Berthe K. Fiil et al.   FEBS Journal

Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN

(2014) Tsuyoshi Takiuchi et al.   GENES TO CELLS

The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation

(2014) Mary A. Rodgers et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: K63-Linked Polyubiquitination of NEMO Modulates TLR Signaling and Inflammation In Vivo

(2014) C.-Y. Ni et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice

(2014) S. B. Berger et al.   JOURNAL OF IMMUNOLOGY

Binding of OTULIN to the PUB Domain of HOIP Controls NF-κB Signaling

(2014) Veronique Schaeffer et al.   MOLECULAR CELL

Molecular Basis and Regulation of OTULIN-LUBAC Interaction

(2014) Paul R. Elliott et al.   MOLECULAR CELL

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

(2014) Nozomi Takahashi et al.   NATURE

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

(2014) Marius Dannappel et al.   NATURE

Linear ubiquitin chains: NF-κB signalling, cell death and beyond

(2014) Kazuhiro Iwai et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chronic Proliferative Dermatitis in Sharpin Null Mice: Development of an Autoinflammatory Disease in the Absence of B and T Lymphocytes and IL4/IL13 Signaling

(2014) Christopher S. Potter et al.   PLoS One

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

(2014) Maria Stella Ritorto et al.   Nature Communications

Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms

(2014) Y. Yang et al.   Cancer Discovery

HOIP Deficiency Causes Embryonic Lethality by Aberrant TNFR1-Mediated Endothelial Cell Death

(2014) Nieves Peltzer et al.   Cell Reports

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice

(2014) James A Rickard et al.   eLife

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis

(2014) Snehlata Kumari et al.   eLife

CYLD controls c-MYC expression through the JNK-dependent signaling pathway in hepatocellular carcinoma

(2013) Rajeswara Rao Pannem et al.   CARCINOGENESIS

OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis

(2013) Tycho E.T. Mevissen et al.   CELL

OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin

(2013) Kirstin Keusekotten et al.   CELL

Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells

(2013) Yoshiteru Sasaki et al.   EMBO JOURNAL

Ubiquitin in the immune system

(2013) Julia Zinngrebe et al.   EMBO REPORTS

Dimerization and Ubiquitin Mediated Recruitment of A20, a Complex Deubiquitinating Enzyme

(2013) Timothy T. Lu et al.   IMMUNITY

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

Cutting Edge: ABIN-1 Protects against Psoriasis by Restricting MyD88 Signals in Dendritic Cells

(2013) J. A. Callahan et al.   JOURNAL OF IMMUNOLOGY

Fas/CD95-Induced Chemokines Can Serve as “Find-Me” Signals for Apoptotic Cells

(2013) Sean P. Cullen et al.   MOLECULAR CELL

OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling

(2013) Berthe Katrine Fiil et al.   MOLECULAR CELL

The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis

(2013) Elena Rivkin et al.   NATURE

Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP

(2013) Benjamin Stieglitz et al.   NATURE

Molecular control of the NEMO family of ubiquitin-binding proteins

(2013) Kristopher Clark et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

(2013) C. H. Emmerich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genome-Wide siRNA Screen Reveals Positive and Negative Regulators of the NOD2 and NF- B Signaling Pathways

(2013) N. Warner et al.   Science Signaling

Death Receptor-Ligand Systems in Cancer, Cell Death, and Inflammation

(2013) H. Walczak   Cold Spring Harbor Perspectives in Biology

Innate Immune-Directed NF-κB Signaling Requires Site-Specific NEMO Ubiquitination

(2013) Janice C. Jun et al.   Cell Reports

RIP3 Inhibits Inflammatory Hepatocarcinogenesis but Promotes Cholestasis by Controlling Caspase-8- and JNK-Dependent Compensatory Cell Proliferation

(2013) Mihael Vucur et al.   Cell Reports

MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades

(2013) Siqi Liu et al.   eLife

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

Inactivation of the Deubiquitinase CYLD in Hepatocytes Causes Apoptosis, Inflammation, Fibrosis, and Cancer

(2012) Kostas Nikolaou et al.   CANCER CELL

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Linear Ubiquitination of NEMO Negatively Regulates the Interferon Antiviral Response through Disruption of the MAVS-TRAF3 Complex

(2012) S. Mehdi Belgnaoui et al.   Cell Host & Microbe

A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7

(2012) Kelly Verhelst et al.   EMBO JOURNAL

Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation

(2012) Fuminori Tokunaga et al.   EMBO JOURNAL

IAPs limit activation of RIP kinases by TNF receptor 1 during development

(2012) Maryline Moulin et al.   EMBO JOURNAL

LUBAC synthesizes linear ubiquitin chains via a thioester intermediate

(2012) Benjamin Stieglitz et al.   EMBO REPORTS

Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation

(2012) James E. Vince et al.   IMMUNITY

Ubiquitin-Induced Oligomerization of the RNA Sensors RIG-I and MDA5 Activates Antiviral Innate Immune Response

(2012) Xiaomo Jiang et al.   IMMUNITY

No one can whistle a symphony alone - how different ubiquitin linkages cooperate to orchestrate NF- B activity

(2012) A. C. Schmukle et al.   JOURNAL OF CELL SCIENCE

Emerging Role of Ubiquitination in Antiviral RIG-I Signaling

(2012) J. Maelfait et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

(2012) Rune Busk Damgaard et al.   MOLECULAR CELL

Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

(2012) Bénédicte F. Py et al.   MOLECULAR CELL

Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency

(2012) Bertrand Boisson et al.   NATURE IMMUNOLOGY

Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages

(2012) Yogesh Kulathu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Survival Function of the FADD-CASPASE-8-cFLIPL Complex

(2012) Christopher P. Dillon et al.   Cell Reports

Proteolytic Processing of Nlrp1b Is Required for Inflammasome Activity

(2012) Bradley C. Frew et al.   PLoS Pathogens

New mechanism of X-linked anhidrotic ectodermal dysplasia with immunodeficiency: impairment of ubiquitin binding despite normal folding of NEMO protein

(2011) M. Hubeau et al.   BLOOD

Sequencing of TNFAIP3 and association of variants with multiple autoimmune diseases

(2011) S L Musone et al.   GENES AND IMMUNITY

Cellular Inhibitors of Apoptosis Proteins cIAP1 and cIAP2 Are Required for Efficient Caspase-1 Activation by the Inflammasome

(2011) Katherine Labbé et al.   IMMUNITY

The Ubiquitin-Editing Protein A20 Prevents Dendritic Cell Activation, Recognition of Apoptotic Cells, and Systemic Autoimmunity

(2011) Mirjam Kool et al.   IMMUNITY

TNF and ubiquitin at the crossroads of gene activation, cell death, inflammation, and cancer

(2011) Henning Walczak   IMMUNOLOGICAL REVIEWS

The PYHIN protein family as mediators of host defenses

(2011) Stefan A. Schattgen et al.   IMMUNOLOGICAL REVIEWS

Ubiquitin-mediated modulation of the cytoplasmic viral RNA sensor RIG-I

(2011) H. Oshiumi et al.   JOURNAL OF BIOCHEMISTRY

SHARPIN regulates mitochondria-dependent apoptosis in keratinocytes

(2011) Yanhua Liang et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Polyubiquitin binding to ABIN1 is required to prevent autoimmunity

(2011) Sambit K. Nanda et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Direct, Noncatalytic Mechanism of IKK Inhibition by A20

(2011) Brian Skaug et al.   MOLECULAR CELL

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction

(2011) Kyung-Soo Inn et al.   MOLECULAR CELL

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

(2011) Fuminori Tokunaga et al.   NATURE

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

(2011) Fumiyo Ikeda et al.   NATURE

Linear ubiquitination prevents inflammation and regulates immune signalling

(2011) Björn Gerlach et al.   NATURE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Caspase 8 inhibits programmed necrosis by processing CYLD

(2011) Marie Anne O’Donnell et al.   NATURE CELL BIOLOGY

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

(2011) Mourad Matmati et al.   NATURE GENETICS

Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis

(2011) Gianna Elena Hammer et al.   NATURE IMMUNOLOGY

HOIL-1L Interacting Protein (HOIP) Is Essential for CD40 Signaling

(2011) Bruce S. Hostager et al.   PLoS One

Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses

(2011) D. E. Zak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice

(2010) Y. Chu et al.   BLOOD

What Determines the Specificity and Outcomes of Ubiquitin Signaling?

(2010) Fumiyo Ikeda et al.   CELL

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Differential Requirement for Caspase-1 Autoproteolysis in Pathogen-Induced Cell Death and Cytokine Processing

(2010) Petr Broz et al.   Cell Host & Microbe

c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling

(2010) Jasmin N Dynek et al.   EMBO JOURNAL

The Ubiquitin Modifying Enzyme A20 Restricts B Cell Survival and Prevents Autoimmunity

(2010) Rita M. Tavares et al.   IMMUNITY

Loss of the Tumor Suppressor CYLD Enhances Wnt/β-Catenin Signaling through K63-Linked Ubiquitination of Dvl

(2010) Daniele V.F. Tauriello et al.   MOLECULAR CELL

Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling

(2010) Guoqiang Xu et al.   NATURE BIOTECHNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study

(2010) Aya Kawasaki et al.   ARTHRITIS RESEARCH & THERAPY

Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation

(2009) Simin Rahighi et al.   CELL

CYLD: a tumor suppressor deubiquitinase regulating NF-κB activation and diverse biological processes

(2009) S-C Sun   CELL DEATH AND DIFFERENTIATION

Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by NZF domains of TAB2 and TAB3

(2009) Yusuke Sato et al.   EMBO JOURNAL

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

(2009) David Komander et al.   EMBO REPORTS

Efficient protection and isolation of ubiquitylated proteins using tandem ubiquitin-binding entities

(2009) Roland Hjerpe et al.   EMBO REPORTS

Anti-IL5 decreases the number of eosinophils but not the severity of dermatitis in Sharpin-deficient mice

(2009) Matthew L. Renninger et al.   EXPERIMENTAL DERMATOLOGY

Crystal structure of the NEMO ubiquitin-binding domain in complex with Lys 63-linked di-ubiquitin

(2009) Azusa Yoshikawa et al.   FEBS LETTERS

Cellular Inhibitors of Apoptosis cIAP1 and cIAP2 Are Required for Innate Immunity Signaling by the Pattern Recognition Receptors NOD1 and NOD2

(2009) Mathieu J.M. Bertrand et al.   IMMUNITY

Molecular mechanism and function of CD40/CD40L engagement in the immune system

(2009) Raul Elgueta et al.   IMMUNOLOGICAL REVIEWS

Structural Basis for Recognition of Diubiquitins by NEMO

(2009) Yu-Chih Lo et al.   MOLECULAR CELL

Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

(2009) Tobias L. Haas et al.   MOLECULAR CELL

Ubiquitylation in innate and adaptive immunity

(2009) Vijay G. Bhoj et al.   NATURE

Involvement of linear polyubiquitylation of NEMO in NF-κB activation

(2009) Fuminori Tokunaga et al.   NATURE CELL BIOLOGY

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

(2009) Jian-Wen Han et al.   NATURE GENETICS

Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production

(2009) Mikyoung Chang et al.   NATURE IMMUNOLOGY

Building ubiquitin chains: E2 enzymes at work

(2009) Yihong Ye et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways

(2009) Brenda A. Schulman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain

(2009) Yogesh Kulathu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

NOD-Like Receptors: Role in Innate Immunity and Inflammatory Disease

(2008) Grace Chen et al.   Annual Review of Pathology-Mechanisms of Disease

Ubiquitin Chain Editing Revealed by Polyubiquitin Linkage-Specific Antibodies

(2008) Kim Newton et al.   CELL

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

(2008) Lai Wang et al.   CELL

The Ubiquitin-Editing Enzyme A20 Restricts Nucleotide-Binding Oligomerization Domain Containing 2-Triggered Signals

(2008) Osamu Hitotsumatsu et al.   IMMUNITY

TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral Pathway

(2008) Marie-Cécile Michallet et al.   IMMUNITY

c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation

(2008) Eugene Varfolomeev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20

(2008) Emre E. Turer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

(2008) Mathieu J.M. Bertrand et al.   MOLECULAR CELL

The Structure of the CYLD USP Domain Explains Its Specificity for Lys63-Linked Polyubiquitin and Reveals a B Box Module

(2008) David Komander et al.   MOLECULAR CELL

ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development

(2008) Shigeru Oshima et al.   NATURE

Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus

(2008) Stacy L Musone et al.   NATURE GENETICS

Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses

(2008) Maria A Ermolaeva et al.   NATURE IMMUNOLOGY

Genome-Wide and Functional Annotation of Human E3 Ubiquitin Ligases Identifies MULAN, a Mitochondrial E3 that Regulates the Organelle's Dynamics and Signaling

(2008) Wei Li et al.   PLoS One

Molecular Basis for the Unique Deubiquitinating Activity of the NF-κB Inhibitor A20

(2007) Su-Chang Lin et al.   JOURNAL OF MOLECULAR BIOLOGY