Cellular Senescence: Pathogenic Mechanisms in Lung Fibrosis

Immune dysregulation as a driver of idiopathic pulmonary fibrosis

(2021) Kevin Shenderov et al.   JOURNAL OF CLINICAL INVESTIGATION

Hallmarks and detection techniques of cellular senescence and cellular ageing in immune cells

(2021) Dingxi Zhou et al.   AGING CELL

Molecular mapping of interstitial lung disease reveals a phenotypically distinct senescent basal epithelial cell population

(2021) Daryle J. DePianto et al.   JCI Insight

The aging lung: Physiology, disease, and immunity

(2021) Jaime L. Schneider et al.   CELL

Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis

(2021) Yue Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The twilight of the immune system: The impact of immunosenescence in aging

(2021) Jack Feehan et al.   MATURITAS

Disparate Interferon Signaling and Shared Aberrant Basaloid Cells in Single-Cell Profiling of Idiopathic Pulmonary Fibrosis and Systemic Sclerosis-Associated Interstitial Lung Disease

(2021) Eleanor Valenzi et al.   Frontiers in Immunology

Antibody-mediated depletion of CCR10+ EphA3+ cells ameliorates fibrosis in IPF

(2021) Miriam S. Hohmann et al.   JCI Insight

A CD44/Brg1 nuclear complex confers mesenchymal progenitor cells with enhanced fibrogenicity in idiopathic pulmonary fibrosis

(2021) Libang Yang et al.   JCI Insight

Chronic WNT/β-catenin signaling induces cellular senescence in lung epithelial cells

(2020) Mareike Lehmann et al.   CELLULAR SIGNALLING

SASP from lung senescent fibroblasts induces immunesenescence and fibrosis

(2020) Tamara Cruz et al.   FASEB JOURNAL

Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases

(2020) Ping Song et al.   Cells

Single Cell Reconstruction of Human Basal Cell Diversity in Normal and IPF Lung

(2020) Gianni Carraro et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis

(2020) Maximilian Strunz et al.   Nature Communications

Role of immune cells in the removal of deleterious senescent cells

(2020) Abhijit Kale et al.   Immunity & Ageing

T Cells in Fibrosis and Fibrotic Diseases

(2020) Mengjuan Zhang et al.   Frontiers in Immunology

Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis

(2020) Taylor S. Adams et al.   Science Advances

Senescence of Alveolar Type 2 Cells Drives Progressive Pulmonary Fibrosis

(2020) Changfu Yao et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Immunosenescence is both functional/adaptive and dysfunctional/maladaptive

(2020) T. Fulop et al.   Seminars in Immunopathology

Pro-fibrotic effects of IL-17A and elevated IL-17RA in IPF and RA-ILD support a direct role for IL-17A/IL-17RA in human fibrotic interstitial lung disease

(2019) Jie Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging?

(2019) Adriaan A. van Beek et al.   TRENDS IN IMMUNOLOGY

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

(2019) Jamie N. Justice et al.   EBioMedicine

Increased monocyte count as a cellular biomarker for poor outcomes in fibrotic diseases: a retrospective, multicentre cohort study

(2019) Madeleine K D Scott et al.   Lancet Respiratory Medicine

Resequencing Study Confirms Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis

(2019) Camille Moore et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The senescence-associated secretory phenotype and its regulation

(2019) Stéphane Lopes-Paciencia et al.   CYTOKINE

Beclin 1, LC3, and p62 expression in paraquat-induced pulmonary fibrosis

(2019) G Xu et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Telomerase reverse transcriptase ameliorates lung fibrosis by protecting alveolar epithelial cells against senescence

(2019) Tianju Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

(2019) Peisu Zhang et al.   NATURE NEUROSCIENCE

The Evolving Role of CD8+CD28− Immunosenescent T Cells in Cancer Immunology

(2019) Wei X. Huff et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of Telomerase and Telomeres in Interstitial Lung Diseases: From Molecules to Clinical Implications

(2019) Nissim Arish et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PGC1α repression in IPF fibroblasts drives a pathologic metabolic, secretory and fibrogenic state

(2019) Nunzia Caporarello et al.   THORAX

Mitochondrial Homeostasis and Cellular Senescence

(2019) Panagiotis V.S. Vasileiou et al.   Cells

PTEN loss regulates alveolar epithelial cell senescence in pulmonary fibrosis depending on Akt activation

(2019) Ting Qiu et al.   Aging-US

PAI-1 Regulation of TGF-β1-induced ATII Cell Senescence, SASP Secretion, and SASP-mediated Activation of Alveolar Macrophages

(2019) Tapasi Rana et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

DNA-PKcs modulates progenitor cell proliferation and fibroblast senescence in idiopathic pulmonary fibrosis

(2019) David M. Habiel et al.   BMC Pulmonary Medicine

Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention

(2019) Anna Aiello et al.   Frontiers in Immunology

Grp78 Loss in Epithelial Progenitors Reveals an Age-Linked Role for ER Stress in Pulmonary Fibrosis

(2019) Zea Borok et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis

(2019) Richard J Allen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Caveolin-1–derived peptide limits development of pulmonary fibrosis

(2019) Amarnath Satheesh Marudamuthu et al.   Science Translational Medicine

Telomere shortening activates TGF-β/Smads signaling in lungs and enhances both lipopolysaccharide and bleomycin-induced pulmonary fibrosis

(2018) Ying-ying Liu et al.   ACTA PHARMACOLOGICA SINICA

ATF3 represses PINK1 gene transcription in lung epithelial cells to control mitochondrial homeostasis

(2018) Marta Bueno et al.   AGING CELL

IL-8 mediates idiopathic pulmonary fibrosis mesenchymal progenitor cell fibrogenicity

(2018) Libang Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

PD-1/PD-L1 Pathway Mediates the Alleviation of Pulmonary Fibrosis by Human Mesenchymal Stem Cells in Humanized Mice

(2018) Ke Ni et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Sirtuin1 Protects against Systemic Sclerosis–related Pulmonary Fibrosis by Decreasing Proinflammatory and Profibrotic Processes

(2018) Haiyan Chu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Risk factors for interstitial lung disease: a 9-year Nationwide population-based study

(2018) Won-Il Choi et al.   BMC Pulmonary Medicine

Diagnosis of Idiopathic Pulmonary Fibrosis. An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline

(2018) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Quercetin Enhances Ligand-induced Apoptosis in Senescent IPF Fibroblasts and Reduces Lung Fibrosis In Vivo

(2018) Miriam S Hohmann et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Expression of mutant Sftpc in murine alveolar epithelia drives spontaneous lung fibrosis

(2018) Shin-Ichi Nureki et al.   JOURNAL OF CLINICAL INVESTIGATION

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Senescence of bone marrow-derived mesenchymal stem cells from patients with idiopathic pulmonary fibrosis

(2018) Nayra Cárdenes et al.   Stem Cell Research & Therapy

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

(2018) Paul A Reyfman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Characterization of CD28null T cells in idiopathic pulmonary fibrosis

(2018) David M. Habiel et al.   Mucosal Immunology

Impaired immune surveillance accelerates accumulation of senescent cells and aging

(2018) Yossi Ovadya et al.   Nature Communications

Targeted migration of bone marrow mesenchymal stem cells inhibits silica-induced pulmonary fibrosis in rats

(2018) Xiaoli Li et al.   Stem Cell Research & Therapy

Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosisex vivo

(2017) Mareike Lehmann et al.   EUROPEAN RESPIRATORY JOURNAL

Markers of T Cell Senescence in Humans

(2017) Weili Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of Bcl-2/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice

(2017) Jin Pan et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

NADPH Oxidase 4 (Nox4) Suppresses Mitochondrial Biogenesis and Bioenergetics in Lung Fibroblasts via a Nuclear Factor Erythroid-derived 2-like 2 (Nrf2)-dependent Pathway

(2017) Karen Bernard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Senescence and aging: Causes, consequences, and therapeutic avenues

(2017) Domhnall McHugh et al.   JOURNAL OF CELL BIOLOGY

Mitochondria in the spotlight of aging and idiopathic pulmonary fibrosis

(2017) Ana L. Mora et al.   JOURNAL OF CLINICAL INVESTIGATION

Calcium-binding protein S100A4 confers mesenchymal progenitor cell fibrogenicity in idiopathic pulmonary fibrosis

(2017) Hong Xia et al.   JOURNAL OF CLINICAL INVESTIGATION

Corrigendum: Targeting cellular senescence prevents age-related bone loss in mice

(2017) Joshua N Farr et al.   NATURE MEDICINE

Targeting cellular senescence prevents age-related bone loss in mice

(2017) Joshua N Farr et al.   NATURE MEDICINE

Homeostatic nuclear RAGE–ATM interaction is essential for efficient DNA repair

(2017) Varun Kumar et al.   NUCLEIC ACIDS RESEARCH

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Divergent roles for Clusterin in Lung Injury and Repair

(2017) David M. Habiel et al.   Scientific Reports

Regulation of TERRA on telomeric and mitochondrial functions in IPF pathogenesis

(2017) Yulin Gao et al.   BMC Pulmonary Medicine

Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence

(2017) Annika Höhn et al.   Redox Biology

Idiopathic pulmonary fibrosis

(2017) Fernando J. Martinez et al.   Nature Reviews Disease Primers

mTORC1 activation decreases autophagy in aging and idiopathic pulmonary fibrosis and contributes to apoptosis resistance in IPF fibroblasts

(2016) Yair Romero et al.   AGING CELL

Cellular senescence impact on immune cell fate and function

(2016) Rita Vicente et al.   AGING CELL

Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells

(2016) Brandon M. Hall et al.   Aging-US

Influences of innate immunity, autophagy, and fibroblast activation in the pathogenesis of lung fibrosis

(2016) David N. O'Dwyer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Age-Dependent Susceptibility to Pulmonary Fibrosis Is Associated with NLRP3 Inflammasome Activation

(2016) Heather W. Stout-Delgado et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Cellular senescence and tumor promotion: Is aging the key?

(2016) Natalia Loaiza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis

(2016) Jennifer L. Larson-Casey et al.   IMMUNITY

Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis

(2016) Kenji Kobayashi et al.   JOURNAL OF IMMUNOLOGY

Idiopathic pulmonary fibrosis fibroblasts become resistant to Fas ligand-dependent apoptosis via the alteration of decoy receptor 3

(2016) Jintaek Im et al.   JOURNAL OF PATHOLOGY

Essential Role for Premature Senescence of Myofibroblasts in Myocardial Fibrosis

(2016) Kathleen Meyer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Hyaluronan synthase 2 regulates fibroblast senescence in pulmonary fibrosis

(2016) Yuejuan Li et al.   MATRIX BIOLOGY

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

Type 2 Diabetes and the Aging Pancreatic Beta Cell

(2016) Uma Gunasekaran et al.   Aging-US

miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis

(2016) Supparerk Disayabutr et al.   PLoS One

Deregulation of selective autophagy during aging and pulmonary fibrosis: the role of TGFβ1

(2015) Meredith L. Sosulski et al.   AGING CELL

Cellular senescence-like features of lung fibroblasts derived from idiopathic pulmonary fibrosis patients

(2015) Hagai Yanai et al.   Aging-US

Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis

(2015) Na Xie et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Usual interstitial pneumonia end-stage features from explants with radiologic and pathological correlations

(2015) Maud Rabeyrin et al.   Annals of Diagnostic Pathology

The genetic basis of idiopathic pulmonary fibrosis

(2015) Jonathan A. Kropski et al.   EUROPEAN RESPIRATORY JOURNAL

Plasminogen activator inhibitor 1, fibroblast apoptosis resistance, and aging-related susceptibility to lung fibrosis

(2015) Wen-Tan Huang et al.   EXPERIMENTAL GERONTOLOGY

Innate immunity alterations in idiopathic interstitial pneumonias and rheumatoid arthritis-associated interstitial lung diseases

(2015) Ilias C. Papanikolaou et al.   IMMUNOLOGY LETTERS

The Impact of Immunosenescence on Pulmonary Disease

(2015) Michelle A. Murray et al.   MEDIATORS OF INFLAMMATION

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Telomere dysfunction causes alveolar stem cell failure

(2015) Jonathan K. Alder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mice with Pulmonary Fibrosis Driven by Telomere Dysfunction

(2015) Juan M. Povedano et al.   Cell Reports

Identification of a Cell-of-Origin for Fibroblasts Comprising the Fibrotic Reticulum in Idiopathic Pulmonary Fibrosis

(2014) Hong Xia et al.   AMERICAN JOURNAL OF PATHOLOGY

Revealing the Pathogenic and Aging-related Mechanisms of the Enigmatic Idiopathic Pulmonary Fibrosis. An Integral Model

(2014) Moisés Selman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Peripheral depletion of NK cells and imbalance of the Treg/Th17 axis in idiopathic pulmonary fibrosis patients

(2014) Domenico Galati et al.   CYTOKINE

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Cellular senescence and its effector programs

(2014) R. Salama et al.   GENES & DEVELOPMENT

Immunosenescence in monocytes, macrophages, and dendritic cells: Lessons learned from the lung and heart

(2014) Phyllis-Jean Linton et al.   IMMUNOLOGY LETTERS

PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis

(2014) Marta Bueno et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

IPF Fibroblasts Are Desensitized to Type I Collagen Matrix-Induced Cell Death by Suppressing Low Autophagy via Aberrant Akt/mTOR Kinases

(2014) Richard Seonghun Nho et al.   PLoS One

Telomeric transcripts stimulate telomere recombination to suppress senescence in cells lacking telomerase

(2014) Tai-Yuan Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance

(2014) L. Hecker et al.   Science Translational Medicine

Fibroblasts in fibrosis: novel roles and mediators

(2014) Ryan T. Kendall et al.   Frontiers in Pharmacology

Idiopathic pulmonary fibrosis in US Medicare beneficiaries aged 65 years and older: incidence, prevalence, and survival, 2001–11

(2014) Ganesh Raghu et al.   Lancet Respiratory Medicine

Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts

(2013) Chad Lerner et al.   AGING CELL

Aging is associated with increased regulatory T-cell function

(2013) Sanjay K. Garg et al.   AGING CELL

T Cell Replicative Senescence in Human Aging

(2013) Jennifer P. Chou et al.   CURRENT PHARMACEUTICAL DESIGN

Type 2 alveolar cells are stem cells in adult lung

(2013) Christina E. Barkauskas et al.   JOURNAL OF CLINICAL INVESTIGATION

The architecture of Tetrahymena telomerase holoenzyme

(2013) Jiansen Jiang et al.   NATURE

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis

(2013) Tasha E Fingerlin et al.   NATURE GENETICS

FoxO3a (Forkhead Box O3a) Deficiency Protects Idiopathic Pulmonary Fibrosis (IPF) Fibroblasts from Type I Polymerized Collagen Matrix-Induced Apoptosis via Caveolin-1 (cav-1) and Fas

(2013) Richard Seonghun Nho et al.   PLoS One

Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema

(2013) Marco Chilosi et al.   Translational Research

Insufficient autophagy in idiopathic pulmonary fibrosis

(2012) Jun Araya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Abnormal Lung Aging in Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis

(2012) Rosa Faner et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Intersection Between Aging and Cardiovascular Disease

(2012) Brian J. North et al.   CIRCULATION RESEARCH

Ageing as a Risk Factor for Disease

(2012) Teresa Niccoli et al.   CURRENT BIOLOGY

Telomerase deficiency does not alter bleomycin-induced fibrosis in mice

(2012) Amber L. Degryse et al.   EXPERIMENTAL LUNG RESEARCH

Mitochondrial Reactive Oxygen Species Regulate Transforming Growth Factor-β Signaling

(2012) Manu Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decreased expression of autophagic beclin 1 protein in idiopathic pulmonary fibrosis fibroblasts

(2012) Alberto Ricci et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Tregs Promote the Differentiation of Th17 Cells in Silica-Induced Lung Fibrosis in Mice

(2012) Laiyu Song et al.   PLoS One

Autophagy in Idiopathic Pulmonary Fibrosis

(2012) Avignat S. Patel et al.   PLoS One

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)

(2011) Antero Salminen et al.   CELLULAR SIGNALLING

Dendritic cells and aging: consequences for autoimmunity

(2011) Anshu Agrawal et al.   Expert Review of Clinical Immunology

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs

(2011) W. E. Lawson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathologic Caveolin-1 Regulation of PTEN in Idiopathic Pulmonary Fibrosis

(2010) Hong Xia et al.   AMERICAN JOURNAL OF PATHOLOGY

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Connecting autophagy to senescence in pathophysiology

(2010) Andrew RJ Young et al.   CURRENT OPINION IN CELL BIOLOGY

Alzheimer Disease

(2010) Rudy J. Castellani et al.   DM DISEASE-A-MONTH

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

(2010) Joon-Il Jun et al.   NATURE CELL BIOLOGY

CD28 Down-Regulation on Circulating CD4 T-Cells Is Associated with Poor Prognoses of Patients with Idiopathic Pulmonary Fibrosis

(2010) Syed R. Gilani et al.   PLoS One

TLR9 Differentiates Rapidly from Slowly Progressing Forms of Idiopathic Pulmonary Fibrosis

(2010) G. Trujillo et al.   Science Translational Medicine

NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGF 1-induced fibroblast differentiation into myofibroblasts

(2010) N. Amara et al.   THORAX

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

Aging: Central role for autophagy and the lysosomal degradative system

(2009) Yogendra S. Rajawat et al.   AGEING RESEARCH REVIEWS

Compartmentalized Expression of c-FLIP in Lung Tissues of Patients with Idiopathic Pulmonary Fibrosis

(2009) Seung-Ick Cha et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Increased Bronchoalveolar Lavage Fluid CD1c Expressing Dendritic Cells in Idiopathic Pulmonary Fibrosis

(2009) M. Tsoumakidou et al.   RESPIRATION

Human innate immunosenescence: causes and consequences for immunity in old age

(2009) Alexander Panda et al.   TRENDS IN IMMUNOLOGY

Telomere Shortening in Familial and Sporadic Pulmonary Fibrosis

(2008) Jennifer T. Cronkhite et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL