Review
Cell Biology
Tanyalak Parimon, Peter Chen, Barry R. Stripp, Jiurong Liang, Dianhua Jiang, Paul W. Noble, William C. Parks, Changfu Yao
Summary: Pulmonary fibrosis refers to a group of chronic lung diseases that impose a significant burden on patients and public health. Idiopathic pulmonary fibrosis (IPF) is the most common and severe form of these diseases and is mainly treated by lung transplantation. Research has shown that repeated injury and cellular senescence of alveolar epithelial cells contribute to the development and progression of fibrosis.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Immunology
Jian-Bing Xiong, Jia-Xi Duan, Nan Jiang, Chen-Yu Zhang, Wen-Jing Zhong, Jin-Tong Yang, Yu-Biao Liu, Feng Su, Yong Zhou, Dai Li, Hui-Hui Yang, Cha-Xiang Guan
Summary: TREM-1 plays a pro-fibrotic role in pulmonary fibrosis by inducing senescence in alveolar epithelial cells. Blocking TREM-1 can protect against Bleomycin-induced pulmonary fibrosis and reduce the expression of senescence-related proteins in lung tissue.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Environmental Sciences
Joseph H. Lucas, Qixin Wang, Thivanka Muthumalage, Irfan Rahman
Summary: The study found that exposure to MWCNTs can lead to cellular senescence in human bronchial epithelial cells, with increased production of reactive oxygen species and inhibition of cell proliferation. Co-exposure with the cytokine TGF-beta further exacerbated cellular senescence, as indicated by increased levels of related proteins and significantly elevated production of fibronectin and plasminogen activator inhibitor.
Article
Respiratory System
Zaira Aversa, Elizabeth J. Atkinson, Eva M. Carmona, Thomas A. White, Amanda A. Heeren, Sarah K. Jachim, Xu Zhang, Steven R. Cummings, Sergio E. Chiarella, Andrew H. Limper, Nathan K. LeBrasseur
Summary: This study assessed the circulating levels of candidate senescence biomarkers in IPF patients and controls, and evaluated their ability to predict disease outcomes. The results suggest that these biomarkers are associated with disease status, pulmonary and physical function, and health-related quality of life. Further studies are needed to validate the combinatorial biomarker signatures.
RESPIRATORY RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Thi Hang Giang Phan, Panagiotis Paliogiannis, Gheyath K. Nasrallah, Roberta Giordo, Ali Hussein Eid, Alessandro Giuseppe Fois, Angelo Zinellu, Arduino Aleksander Mangoni, Gianfranco Pintus
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible, and typically lethal lung disease with poorly understood mechanisms, involving various cellular processes and molecular pathways. Apoptosis, senescence, epithelial-mesenchymal transition, and other processes have been identified as key factors in tissue remodeling associated with IPF.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Critical Care Medicine
Huachun Cui, Na Xie, Sami Banerjee, Tapan Dey, Rui-Ming Liu, Veena B. Antony, Yan Y. Sanders, Taylor S. Adams, Jose L. Gomez, Victor J. Thannickal, Naftali Kaminski, Gang Liu
Summary: This study identifies CD38 as a key player in alveolar epithelial aging and lung fibrosis, with increased CD38 expression in IPF lungs correlating negatively with lung function. Targeting alveolar CD38 appears to be a novel and effective therapeutic strategy for this pathology.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Cell Biology
Shenghui Zhou, Jiaojiao Zhu, Ping-Kun Zhou, Yongqing Gu
Summary: This review summarizes the mechanism and functions of type 2 alveolar epithelial cell senescence in radiation-induced pulmonary fibrosis (RIPF) and discusses the prospects of clinical treatment by targeting senescent AT2 cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Respiratory System
Mingjin Tu, Ting Wei, Yufang Jia, Yajun Wang, Jun Wu
Summary: This article summarizes the recent advances in understanding the molecular mechanisms of alveolar epithelial cell senescence and its role in the development of pulmonary fibrosis. It highlights the potential of targeting senescent cells as a promising therapeutic strategy for the treatment of idiopathic pulmonary fibrosis.
JOURNAL OF THORACIC DISEASE
(2023)
Review
Endocrinology & Metabolism
Jun-Qing Zhang, Ying-Ying Li, Xue-Yan Zhang, Zeng-Hui Tian, Cheng Liu, Shi-Tao Wang, Fa-Rong Zhang
Summary: Renal fibrosis is a common pathological manifestation of chronic kidney diseases and a major cause of end-stage renal disease, but its pathogenesis remains unclear. Renal tubular epithelial cell senescence has been found to accelerate the progression of renal fibrosis. Oxidative stress, telomere attrition, and DNA damage are the major causes of renal tubular epithelial cell senescence. Interventions and therapeutic strategies targeting cellular senescence, such as calorie restriction, exercise, Klotho, senolytics, and senostatics, show potential for the treatment of renal fibrosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Minxue Jia, Khaled Sayed, Maria G. Kapetanaki, William Dion, Lorena Rosas, Saad Irfan, Eleanor Valenzi, Ana L. Mora, Robert A. Lafyatis, Mauricio Rojas, Bokai Zhu, Panayiotis V. Benos
Summary: The study of aging and its mechanisms, such as cellular senescence, has provided valuable insights into age-related pathologies. Through the analysis of transcriptional profiles, the lymphoid enhancer binding factor 1 (LEF1) has been identified as an important regulator of gene expression in lung cells, which is associated with aging and cellular senescence.
Article
Biotechnology & Applied Microbiology
Xiang Zhang, Xinxin Hu, Yuqing Zhang, Bin Liu, Haihong Pan, Zikai Liu, Zhuomeng Yao, Qixing Zhu, Changhao Wu, Tong Shen
Summary: The study found that increased production and application of carbon nanotubes (CNTs) have raised concerns about their potential risks to human health. Single-walled CNTs (SWCNTs) have been shown to induce pulmonary fibrosis in animal models, but the underlying mechanisms are uncertain. The research revealed that SWCNTs exposure accelerates senescence of alveolar type II epithelial cells (AECIIs), leading to pulmonary fibrosis. Additionally, restoring autophagy flux can alleviate SWCNTs-induced senescence and fibroblast-myofibroblast transdifferentiation.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Medicine, Research & Experimental
Hassan Hayek, Beata Kosmider, Karim Bahmed
Summary: COPD is a major cause of mortality and morbidity globally, with exposure to harmful particles like cigarette smoke being a significant risk factor. Pulmonary emphysema, a part of COPD, is characterized by alveolar destruction and enlargement. MiRNAs play an important role in regulating COPD development, acting as potential biomarkers and therapeutics.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Medicine, Research & Experimental
Shan Han, Qiangwei Lu, Xiaoqiu Liu
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible and fatal interstitial lung disease of unknown cause, with a median survival of 2-3 years. Aging may be linked to the development of IPF, but the mechanism remains unclear. Senescence of alveolar epithelial cells and lung fibroblasts (LFs) and their senescence-associated secretion phenotype (SASP) may play a role in IPF. This review focuses on the senescence of LFs and epithelial and stem cells, SASP, profibrotic signaling pathway activation, and potential treatments for IPF pathogenesis.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Cell Biology
Yu Jiang, Zhongzhen Wang, Jinying Hu, Wei Wang, Na Zhang, Lili Gao
Summary: This study reveals that the modification of core fucosylation (CF) is associated with alveolar epithelial cells (AECs) senescence in pulmonary fibrosis. Inhibition of CF modification can attenuate AECs senescence and reduce pulmonary fibrosis.
Article
Respiratory System
Sabha Asghar, Susan Monkley, David J. F. Smith, Richard J. Hewitt, Ken Grime, Lynne A. Murray, Catherine L. Overed-Sayer, Philip L. Molyneaux
Summary: This study found that small extracellular vesicles (sEVs) released by bronchial epithelial cells in IPF patients can transfer senescence to neighboring healthy cells, promoting the development of IPF. The researchers also identified several differentially expressed miRNAs in the sEVs released by IPF-diseased bronchial epithelial cells. These findings contribute to a better understanding of the pathogenesis of IPF.
RESPIRATORY RESEARCH
(2023)