Review
Cell Biology
Shengnan Yang, Peipei Liu, Yale Jiang, Zai Wang, Huaping Dai, Chen Wang
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with unknown causes, and currently the only medications that can slow down the progression of the disease and improve survival rate are pirfenidone and nintedanib. The use of mesenchymal stem cells (MSCs) provides a new hope for treating interstitial lung disease, but optimal treatment protocols are still lacking.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Linli Shi, Qian Han, Yimei Hong, Weifeng Li, Gencheng Gong, Jiangyu Cui, Mengmeng Mao, Xiaoting Liang, Bei Hu, Xin Li, Qun Luo, Yuelin Zhang
Summary: IPF-MSCs exhibit increased cellular senescence and decreased proliferative capacity compared to control-MSCs. The expression of miR-199a-5p is significantly enhanced in IPF patients and IPF-MSCs. miR-199a-5p regulates MSC senescence by modulating the Sirt1/AMPK signaling pathway, and its inhibition can ameliorate IPF-MSC senescence and enhance therapeutic efficacy.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell & Tissue Engineering
Seiko Harada, Yo Mabuchi, Jun Kohyama, Daisuke Shimojo, Sadafumi Suzuki, Yoshimi Kawamura, Daisuke Araki, Takashi Suyama, Masunori Kajikawa, Chihiro Akazawa, Hideyuki Okano, Yumi Matsuzaki
Summary: The study compared gene expression profiles of immature hMSCs and less potent MSCs to explore the molecular mechanisms regulating senescence in hMSCs. It was found that FZD5, a transcription factor expressed specifically in immature hMSCs, plays a crucial role in regulating senescence by promoting proliferation and delaying cell cycle arrest. Controlling FZD5 signaling may offer potential to improve hMSC quality for cell-replacement therapies.
Review
Biochemistry & Molecular Biology
Sevindzh Kletukhina, Guzel Mutallapova, Angelina Titova, Marina Gomzikova
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive disease caused by the aberrant regeneration of pulmonary epithelium. Mesenchymal stem cells (MSCs) and extracellular vesicles (EVs) are promising therapies for pulmonary fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Respiratory System
Zaira Aversa, Elizabeth J. Atkinson, Eva M. Carmona, Thomas A. White, Amanda A. Heeren, Sarah K. Jachim, Xu Zhang, Steven R. Cummings, Sergio E. Chiarella, Andrew H. Limper, Nathan K. LeBrasseur
Summary: This study assessed the circulating levels of candidate senescence biomarkers in IPF patients and controls, and evaluated their ability to predict disease outcomes. The results suggest that these biomarkers are associated with disease status, pulmonary and physical function, and health-related quality of life. Further studies are needed to validate the combinatorial biomarker signatures.
RESPIRATORY RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Thi Hang Giang Phan, Panagiotis Paliogiannis, Gheyath K. Nasrallah, Roberta Giordo, Ali Hussein Eid, Alessandro Giuseppe Fois, Angelo Zinellu, Arduino Aleksander Mangoni, Gianfranco Pintus
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible, and typically lethal lung disease with poorly understood mechanisms, involving various cellular processes and molecular pathways. Apoptosis, senescence, epithelial-mesenchymal transition, and other processes have been identified as key factors in tissue remodeling associated with IPF.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Rocio Mato-Basalo, Miriam Morente-Lopez, Onno J. Arntz, Fons A. J. van de Loo, Juan Fafian-Labora, Maria C. Arufe
Summary: Mesenchymal stem cells have potential in treating age-related diseases, and small extracellular vesicles derived from these cells have been proposed as therapies. The activation of p65 is found to be important in cellular senescence and inflammatory activation in mesenchymal stem cells. Inhibiting p65 can prevent cellular senescence and the activation of proinflammatory molecules, highlighting its role in restoring functionality and preventing inflamm-aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Mustafa Burak Acar, Serife Ayaz-Guner, Zeynep Gunaydin, Musa Karakukcu, Gianfranco Peluso, Giovanni Di Bernardo, Servet Ozcan, Umberto Galderisi
Summary: Senotherapeutics, including senolytics and senomorphics, can delay replicative senescence and cell death, improving cell function through specific pathways. Metformin, a potential senomorphic agent, may exert its effects by scavenging ROS and regulating key transcription factors involved in blocking oxidative stress.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Anna Valeria Samarelli, Roberto Tonelli, Irene Heijink, Aina Martin Medina, Alessandro Marchioni, Giulia Bruzzi, Ivana Castaniere, Dario Andrisani, Filippo Gozzi, Linda Manicardi, Antonio Moretti, Stefania Cerri, Riccardo Fantini, Luca Tabbi, Chiara Nani, Ilenia Mastrolia, Daniel J. Weiss, Massimo Dominici, Enrico Clini
Summary: Idiopathic pulmonary fibrosis (IPF) is a aggressive form of idiopathic interstitial pneumonias characterized by chronic and progressive fibrosis, resulting in lung functional decline, respiratory failure, and high mortality. The role of endogenous MSCs in the lungs and the potential therapeutic role of administered MSCs from other sources for IPF are still under debate.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Josep Mercader-Barcelo, Aina Martin-Medina, Joan Truyols-Vives, Gabriel Escarrer-Garau, Linda Elowsson, Ana Montes-Worboys, Carlos Rio-Bocos, Josep Muncunill-Farreny, Julio Velasco-Roca, Anna Cederberg, Mans Kadefors, Maria Molina-Molina, Gunilla Westergren-Thorsson, Ernest Sala-Llinas
Summary: Idiopathic pulmonary fibrosis (IPF) is characterized by abnormal repair response and uncontrolled turnover of extracellular matrix. Lung resident mesenchymal stem cells (LRMSC) are believed to play an important role in IPF, but their contribution is not fully understood. This study analyzed LRMSC isolated from IPF patients and control patients, and found that oxidative phosphorylation was dysregulated in IPF LRMSC. Additionally, mitochondrial dysfunction and impaired autophagy response were observed in IPF LRMSC, which might contribute to the development of IPF.
Article
Biochemistry & Molecular Biology
Gabriella Teti, Eleonora Mazzotti, Valentina Gatta, Francesca Chiarini, Maria Laura Alfieri, Mirella Falconi
Summary: Osteoarthritis (OA) is a chronic degenerative disease characterized by the loss of articular cartilage. Senescent cells in mesenchymal stem/stromal cells (MSCs) isolated from OA joints have been shown to inhibit cartilage regeneration. However, the connection between cellular senescence in MSCs and OA progression is still debated. This study aimed to characterize and compare synovial fluid MSCs (sf-MSCs) from OA joints with healthy sf-MSCs, and investigate the influence of senescence on cartilage repair. The findings demonstrated the presence of senescent sf-MSCs in OA joints, impairing chondrogenic differentiation abilities and potentially impacting OA progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Chiel van Geffen, Astrid Deissler, Markus Quante, Harald Renz, Dominik Hartl, Saeed Kolahian
Summary: The immune system plays a crucial role in interstitial lung diseases, especially in the development and treatment response of pulmonary fibrosis. Understanding immune regulation is essential for the development of new therapeutic approaches for idiopathic pulmonary fibrosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Wei Sun, Xiaoshu Liu, Xiaoyu Yang, Xiaoyan Jing, Chunyan Duan, Ganghao Yang, Chi Wu, Hui Huang, Qun Luo, Shu Xia, Qian Zhang, Yang Yang, Zuojun Xu
Summary: The differentiation of lung resident mesenchymal stem cells into myofibroblasts is accompanied by enhanced SENP1-mediated deSUMOylation. The activation of WNT/beta-Catenin and Hedgehog/GLI signaling pathways depends on SENP1-mediated deSUMOylation. SENP1 might be a potential target to restore the repair function of LR-MSCs and treat pulmonary fibrosis.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Biochemistry & Molecular Biology
Fernanda Hernandez-Gonzalez, Rosa Faner, Mauricio Rojas, Alvar Agusti, Manuel Serrano, Jacobo Sellares
Summary: Fibrosing interstitial lung diseases are chronic and fatal lung diseases characterized by the irreversible accumulation of scar tissue in the lung tissue. Cellular senescence, defined as a cell fate decision caused by unrepairable cellular damage, plays an important role in the initiation and progression of pulmonary fibrosis, likely by promoting molecular and cellular changes in chronic fibrosing processes. Targeting cellular senescence may be a potential therapeutic approach for treating fibrosing ILDs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Matthias Mietsch, Rabea Hinkel
Summary: With the prevalence of cardiovascular diseases, there is an urgent need for new treatment strategies. While stem cell based approaches have shown promise in improving cardiac functions, recent research has highlighted the potential importance of mitochondria in these treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Respiratory System
Michael Emmet O'Brien, Richard H. Zou, Nathan Hyre, Joseph K. Leader, Carl R. Fuhrman, Frank C. Sciurba, Mehdi Nouraie, Jessica Bon
Summary: PMA, quantifiable by CT, is strongly associated with DXA measures and serves as a useful clinical surrogate for assessing skeletal muscle loss in smokers. Decreased PMA is correlated with emphysema progression, but not with lung function decline.
Article
Immunology
Richard J. Wang, Mehdi Nouraie, Ken M. Kunisaki, Laurence Huang, Phyllis C. Tien, Kathryn Anastos, Neha Bhandari, Surya P. Bhatt, Hector Bolivar, Sushma K. Cribbs, Robert Foronjy, Stephen J. Gange, Deepa Lazarous, Alison Morris, M. Bradley Drummond
Summary: This study investigated the association between HIV infection and differences in lung function in women. The results showed that HIV infection was associated with impaired respiratory gas exchange in women, and among women with HIV, lower nadir CD4+ cell counts and hepatitis C infection were associated with decreased respiratory gas exchange.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Respiratory System
Amanda L. Stapleton, Adam J. Kimple, Jennifer L. Goralski, S. Mehdi Nouraie, Barton F. Branstetter, Amber Shaffer, Joseph M. Pilewski, Brent A. Senior, Stella E. Lee, Anna C. Zemke
Summary: ELX/TEZ/IVA therapy rapidly and durably improves sinonasal disease in individuals with cystic fibrosis, as evidenced by objective measures such as endoscopy and CT findings.
JOURNAL OF CYSTIC FIBROSIS
(2022)
Article
Respiratory System
Yandong Lai, Xiuying Li, Tiao Li, Xiaoyun Li, Toru Nyunoya, Kong Chen, Georgios Kitsios, Mehdi Nouraie, Yingze Zhang, Bryan J. McVerry, Janet S. Lee, Rama K. Mallmapalli, Chunbin Zou
Summary: This study found that PRMT4 is elevated in septic patients and experimental sepsis. Enhanced PRMT4 plays a key role in lymphocyte apoptosis, while it has no effect on monocytes. Inhibition of PRMT4 can attenuate lymphocyte death.
Article
Hematology
Angelo D'Alessandro, S. Mehdi Nouraie, Yingze Zhang, Francesca Cendali, Fabia Gamboni, Julie A. Reisz, Xu Zhang, Kyle W. Bartsch, Matthew D. Galbraith, Victor R. Gordeuk, Mark T. Gladwin
Summary: This study evaluates the red blood cell metabolism of 587 sickle cell disease patients and finds significant metabolic alterations in RBC acylcarnitines, pyruvate, sphingosine 1-phosphate, creatinine, kynurenine, and urate in Hb SS genotype compared to AA and SC RBCs. Surprisingly, the metabolism of SC RBCs is dramatically different from SS RBCs, with all glycolytic intermediates significantly elevated. These findings provide insights into the metabolic signatures and potential underlying mechanisms in sickle cell disease.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Letter
Critical Care Medicine
Franziska J. Rosser, Yueh-Ying Han, Erick Forno, Theresa W. Guilbert, Leonard B. Bacharier, Wanda Phipatanakul, Gillian C. Goobie, S. Mehdi Nouraie, Mary Martinez, Juan C. Celedon
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Respiratory System
Eleanor Valenzi, Harinath Bahudhanapati, Jiangning Tan, Tracy Tabib, Daniel I. Sullivan, Mehdi Nouraie, John Sembrat, Li Fan, Kong Chen, Silvia Liu, Mauricio Rojas, Audrey Lafargue, Dean W. Felsher, Phuoc T. Tran, Daniel J. Kass, Robert Lafyatis
Summary: The study finds that TWIST1 and other E-box transcription factor motifs play a critical role in the activity of IPF myofibroblasts, and understanding their regulation may lead to new therapeutic interventions for fibrotic pulmonary diseases.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Medicine, Research & Experimental
Marta Bueno, Jazmin Calyeca, Timur Khaliullin, Megan P. . Miller, Diana Alvarez, Lorena Rosas, Judith Brands, Christian Baker, Amro Nasser, Stephanie Shulkowski, August Mathien, Nneoma Uzoukwu, John Sembrat, Brenton G. . Mays, Kaitlin Fiedler, Scott A. . Hahn, Sonia R. . Salvatore, Francisco J. . Schopfer, Mauricio Rojas, Peter Sandner, Adam C. Straub, Ana L. Mora
Summary: The deficiency of CYB5R3 in type II alveolar epithelial cells (AECII) contributes to the activation of fibrosis. Treatment with sGC agonists can reduce the fibrotic outcomes caused by CYB5R3 deficiency in AECII. CYB5R3 plays a critical role in maintaining resilience after lung injury and fibrosis, and sGC can be used as a therapeutic target for fibrotic conditions in the lung and beyond.
Letter
Respiratory System
Georgios D. Kitsios, Seyed Mehdi Nouraie, Shulin Qin, Yingze Zhang, Prabir Ray, Anuradha Ray, Janet S. Lee, Alison Morris, Bryan J. McVerry, William Bain
Article
Toxicology
Jason J. J. Rose, Michael S. S. Zhang, Jerry Pan, Marc C. C. Gauthier, Anthony F. F. Pizon, Melissa I. I. Saul, Seyed M. M. Nouraie
Summary: A clinical risk score was developed to identify carbon monoxide-poisoned patients at risk for acute and long-term mortality. This score takes into account age, altered mental status, and cardiac complications. It has shown good predictive ability in both derivation and validation cohorts.
CLINICAL TOXICOLOGY
(2023)
Article
Respiratory System
Sanjay R. Patel, Jessie P. Bakker, Christy J. Stitt, William Hardy, Mark S. Aloia, S. Mehdi Nouraie
Summary: A 3-month behavioral support program can increase CPAP use in the short term, but does not lead to sustained improvement. In contrast, a 12-month program can lead to sustained improvement, but results diminish once coaching ceases. Implementation of longer-term telemonitoring and coaching programs may be vital to obtaining long-term benefits from CPAP therapy.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Respiratory System
Ioannis Konstantinidis, Shulin Qin, Meghan Fitzpatrick, Cathy Kessinger, Heather Gentry, Deborah McMahon, R. Dawn Weinman, Phyllis Tien, Laurence Huang, Meredith McCormack, Igor Barjaktarevic, Divya Reddy, Robert Foronjy, Deepa Lazarous, Mardge H. Cohen, Heather McKay, Adaora A. Adimora, Caitlin Moran, Margaret A. Fischl, Jodie Dionne-Odom, Valentina Stosor, M. Bradley Drummond, Sushma K. Cribbs, Ken Kunisaki, Charles Rinaldo, Alison Morris, S. Mehdi Nouraie
Summary: This study identified distinct longitudinal pulmonary function phenotypes in HIV patients and investigated their determinants and outcomes. The findings showed significant differences in characteristics and outcomes among different pulmonary function phenotypes, highlighting the importance of monitoring lung dysfunction over time in people with HIV.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Meeting Abstract
Critical Care Medicine
A. S. Labar, W. Bain, F. A. Shah, J. Evankovich, C. Schaefer, C. M. Drohan, B. A. Kaufman, K. M. Redding, M. Finkelman, S. Qin, X. Wang, Y. Zhang, S. Nouraie, J. Lee, A. Morris, B. J. Mcverry, G. Kitsios
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
T. Khaliullin, M. Bueno, J. Calyeca, T. Tabib, A. C. Straub, R. A. Lafyatis, M. Rojas, A. L. Mora
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
M. Bueno, N. Smirnova, K. Riemondy, P. Suresh, X. Wang, M. Brown, S. Collins, J. Sembrat, M. Koenigshoff, M. E. Snyder, J. F. McDyer, O. Eickelberg
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)