NADPH Oxidase 4 (Nox4) Suppresses Mitochondrial Biogenesis and Bioenergetics in Lung Fibroblasts via a Nuclear Factor Erythroid-derived 2-like 2 (Nrf2)-dependent Pathway

Impaired Nrf2 regulation of mitochondrial biogenesis in rostral ventrolateral medulla on hypertension induced by systemic inflammation

(2016) Kay L.H. Wu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nuclear factor erythroid-derived 2-like 2 (NFE2L2, Nrf2) mediates exercise-induced mitochondrial biogenesis and the anti-oxidant response in mice

(2016) Troy L. Merry et al.   JOURNAL OF PHYSIOLOGY-LONDON

NOX4 in Mitochondria: Yeast Two-Hybrid-Based Interaction with Complex I Without Relevance for Basal Reactive Oxygen Species?

(2015) Christine Hirschhäuser et al.   ANTIOXIDANTS & REDOX SIGNALING

The regulation of mitochondrial transcription factor A (Tfam) expression during skeletal muscle cell differentiation

(2015) Melania Collu-Marchese et al.   BIOSCIENCE REPORTS

The emerging role of Nrf2 in mitochondrial function

(2015) Albena T. Dinkova-Kostova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Transcriptional Regulation of Cystathionine-γ-Lyase in Endothelial Cells by NADPH Oxidase 4-Dependent Signaling

(2015) Rajesh K. Mistry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic Reprogramming Is Required for Myofibroblast Contractility and Differentiation

(2015) Karen Bernard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease

(2015) Y.-H. You et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Redox mechanisms of cardiomyocyte mitochondrial protection

(2015) Raquel R. Bartz et al.   Frontiers in Physiology

Nox4: A Hydrogen Peroxide-Generating Oxygen Sensor

(2014) Yukio Nisimoto et al.   BIOCHEMISTRY

NADPH Oxidase NOX4 Supports Renal Tumorigenesis by Promoting the Expression and Nuclear Accumulation of HIF2 

(2014) J. L. Gregg et al.   CANCER RESEARCH

The thyroid hormone receptor β induces DNA damage and premature senescence

(2014) Alberto Zambrano et al.   JOURNAL OF CELL BIOLOGY

Comprehensive measurement of respiratory activity in permeabilized cells using extracellular flux analysis

(2014) Joshua K Salabei et al.   Nature Protocols

Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance

(2014) L. Hecker et al.   Science Translational Medicine

MYC and Mitochondrial Biogenesis

(2014) F. Morrish et al.   Cold Spring Harbor Perspectives in Medicine

Mitochondrial respiratory chain complex I is inactivated by NADPH oxidase Nox4

(2013) Rafał Kozieł et al.   BIOCHEMICAL JOURNAL

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

(2013) K. M. Holmstrom et al.   Biology Open

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

(2013) Emilia Kansanen et al.   Redox Biology

Recent Developments in Myofibroblast Biology

(2012) Boris Hinz et al.   AMERICAN JOURNAL OF PATHOLOGY

ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy

(2012) Yuqing Wang et al.   Autophagy

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo

(2012) Joy X. Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects

(2012) Steen Larsen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

(2011) Pablo J Fernandez-Marcos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Nrf2 regulates hyperoxia-induced Nox4 expression in human lung endothelium: Identification of functional antioxidant response elements on the Nox4 promoter

(2011) Srikanth Pendyala et al.   FREE RADICAL BIOLOGY AND MEDICINE

Assessing bioenergetic function in response to oxidative stress by metabolic profiling

(2011) Brian P. Dranka et al.   FREE RADICAL BIOLOGY AND MEDICINE

A role for focal adhesion kinase in cardiac mitochondrial biogenesis induced by mechanical stress

(2010) Thais F. Tornatore et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

NADPH oxidase 4 is an oncoprotein localized to mitochondria

(2010) Kelly A. Graham et al.   CANCER BIOLOGY & THERAPY

Poldip2, a Novel Regulator of Nox4 and Cytoskeletal Integrity in Vascular Smooth Muscle Cells

(2009) Alicia N. Lyle et al.   CIRCULATION RESEARCH

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury

(2009) Louise Hecker et al.   NATURE MEDICINE

Subcellular localization of Nox4 and regulation in diabetes

(2009) K. Block et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1

(2008) Claude A. Piantadosi et al.   CIRCULATION RESEARCH

Reactive Oxygen Species Regulate Hypoxia-Inducible Factor 1  Differentially in Cancer and Ischemia

(2008) A. A. Qutub et al.   MOLECULAR AND CELLULAR BIOLOGY