PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis

PTENα, a PTEN Isoform Translated through Alternative Initiation, Regulates Mitochondrial Function and Energy Metabolism

(2014) Hui Liang et al.   Cell Metabolism

Receptor-mediated mitophagy in yeast and mammalian systems

(2014) Lei Liu et al.   CELL RESEARCH

Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD

(2014) Kenji Mizumura et al.   JOURNAL OF CLINICAL INVESTIGATION

Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance

(2014) L. Hecker et al.   Science Translational Medicine

Enhanced parkin levels favor ER-mitochondria crosstalk and guarantee Ca2+ transfer to sustain cell bioenergetics

(2013) Tito Calì et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Functional and morphological impact of ER stress on mitochondria

(2013) Kayleen Vannuvel et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The role of mitochondria in aging

(2013) Ana Bratic et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial DNA Damage and Dysfunction, and Oxidative Stress Are Associated with Endoplasmic Reticulum Stress, Protein Degradation and Apoptosis in High Fat Diet-Induced Insulin Resistance Mice

(2013) Larysa V. Yuzefovych et al.   PLoS One

PINK1 Deficiency Enhances Inflammatory Cytokine Release from Acutely Prepared Brain Slices

(2013) Jun Kim et al.   Experimental Neurobiology

Insufficient autophagy in idiopathic pulmonary fibrosis

(2012) Jun Araya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Epithelial Pten Controls Acute Lung Injury and Fibrosis by Regulating Alveolar Epithelial Cell Integrity

(2012) Kahori Miyoshi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Role of Endoplasmic Reticulum Stress in Age-Related Susceptibility to Lung Fibrosis

(2012) Edilson Torres-González et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Angiogenesis in Pulmonary Fibrosis

(2012) Chandru Hanumegowda et al.   CHEST

Contribution of Impaired Mitochondrial Autophagy to Cardiac Aging

(2012) Debapriya Dutta et al.   CIRCULATION RESEARCH

Nitrite activates AMP kinase to stimulate mitochondrial biogenesis independent of soluble guanylate cyclase

(2012) Li Mo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Loss of Mitofusin 2 Promotes Endoplasmic Reticulum Stress

(2012) Gladys A. Ngoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pulmonary fibrosis: patterns and perpetrators

(2012) Paul W. Noble et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

Mitochondria: master regulators of danger signalling

(2012) Lorenzo Galluzzi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy in Idiopathic Pulmonary Fibrosis

(2012) Avignat S. Patel et al.   PLoS One

Mitochondrial Quality Control Mediated by PINK1 and Parkin: Links to Parkinsonism

(2012) D. Narendra et al.   Cold Spring Harbor Perspectives in Biology

PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons

(2011) Hung-Li Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrially localized PKA reverses mitochondrial pathology and dysfunction in a cellular model of Parkinson's disease

(2011) R K Dagda et al.   CELL DEATH AND DIFFERENTIATION

Bioenergetic Consequences of PINK1 Mutations in Parkinson Disease

(2011) Andrey Yurevich Abramov et al.   PLoS One

Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs

(2011) W. E. Lawson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function

(2011) F. Billia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission

(2011) W. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of NF-κB Signaling Reduces Virus Load and Gammaherpesvirus-Induced Pulmonary Fibrosis

(2010) Laurie T. Krug et al.   AMERICAN JOURNAL OF PATHOLOGY

Pathologic Caveolin-1 Regulation of PTEN in Idiopathic Pulmonary Fibrosis

(2010) Hong Xia et al.   AMERICAN JOURNAL OF PATHOLOGY

Clinical Course and Prediction of Survival in Idiopathic Pulmonary Fibrosis

(2010) Brett Ley et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Workshop on Idiopathic Pulmonary Fibrosis in Older Adults

(2010) Richard J. Castriotta et al.   CHEST

Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients

(2010) A. Rakovic et al.   HUMAN MOLECULAR GENETICS

A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease

(2010) C. T. Chu   HUMAN MOLECULAR GENETICS

PINK1 displays tissue-specific subcellular location and regulates apoptosis and cell growth in breast cancer cells☆

(2010) Arnaud Berthier et al.   HUMAN PATHOLOGY

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial autophagy in neural function, neurodegenerative disease, neuron cell death, and aging

(2010) Yakup Batlevi et al.   NEUROBIOLOGY OF DISEASE

Aging and Interstitial Lung Diseases: Unraveling an Old Forgotten Player in the Pathogenesis of Lung Fibrosis

(2010) Moisés Selman et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

(2009) Vanessa A. Morais et al.   EMBO Molecular Medicine

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Silencing of PINK1 Expression Affects Mitochondrial DNA and Oxidative Phosphorylation in DOPAMINERGIC Cells

(2009) Matthew E. Gegg et al.   PLoS One

Twist: A Regulator of Epithelial-Mesenchymal Transition in Lung Fibrosis

(2009) Veronika Pozharskaya et al.   PLoS One

Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection

(2008) William E. Lawson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Epithelial Endoplasmic Reticulum Stress and Apoptosis in Sporadic Idiopathic Pulmonary Fibrosis

(2008) Martina Korfei et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis

(2008) Hong Xia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Loss of PINK1 Function Affects Development and Results in Neurodegeneration in Zebrafish

(2008) O. Anichtchik et al.   JOURNAL OF NEUROSCIENCE