Sirtuin1 Protects against Systemic Sclerosis–related Pulmonary Fibrosis by Decreasing Proinflammatory and Profibrotic Processes

SIRT1 activation attenuates diastolic dysfunction by reducing cardiac fibrosis in a model of anthracycline cardiomyopathy

(2016) Donato Cappetta et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Resveratrol and acetyl-resveratrol modulate activity of VEGF and IL-8 in ovarian cancer cell aggregates via attenuation of the NF-κB protein

(2016) Alexandria B. Tino et al.   Journal of Ovarian Research

Resveratrol ameliorates fibrosis and inflammation in a mouse model of nonalcoholic steatohepatitis

(2016) Takaomi Kessoku et al.   Scientific Reports

Salvianolic Acid B Attenuates Experimental Pulmonary Fibrosis through Inhibition of the TGF-β Signaling Pathway

(2016) Qingmei Liu et al.   Scientific Reports

Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake

(2015) Adam P. Sharples et al.   AGING CELL

The role of sirtuins in cardiac disease

(2015) Shouji Matsushima et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The chemical biology of sirtuins

(2015) Bing Chen et al.   CHEMICAL SOCIETY REVIEWS

Loss of sirtuin 1 (SIRT1) disrupts skin barrier integrity and sensitizes mice to epicutaneous allergen challenge

(2015) Mei Ming et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dual mTOR Inhibition Is Required to Prevent TGF-β-Mediated Fibrosis: Implications for Scleroderma

(2015) Anupam Mitra et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A proteomics approach to identifying key protein targets involved in VEGF inhibitor mediated attenuation of bleomycin-induced pulmonary fibrosis

(2015) Yogesh M. Kulkarni et al.   PROTEOMICS

Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion

(2015) Yuting Wu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Histone Deacetylase Sirtuin 1 Is Reduced in Systemic Sclerosis and Abrogates Fibrotic Responses by Targeting Transforming Growth Factor β Signaling

(2015) Jun Wei et al.   Arthritis & Rheumatology

mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis

(2015) Yao-Song Gui et al.   PLoS One

Sirt1 regulates canonical TGF-β signalling to control fibroblast activation and tissue fibrosis

(2014) Pawel Zerr et al.   ANNALS OF THE RHEUMATIC DISEASES

Dissection of the mechanism of traditional Chinese medical prescription-Yiqihuoxue formula as an effective anti-fibrotic treatment for systemic sclerosis

(2014) Ting Wu et al.   BMC Complementary and Alternative Medicine

Effects of the immunosuppressant rapamycin on the expression of human α2(I) collagen and matrix metalloproteinase 1 genes in scleroderma dermal fibroblasts

(2014) Zenshiro Tamaki et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

The Suppressive Effect of Resveratrol on HIF-1α and VEGF Expression after Warm Ischemia and Reperfusion in Rat Liver

(2014) Mei Zhang et al.   PLoS One

SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling

(2014) Xiao-Ling Zhou et al.   Journal of Ovarian Research

Clinical significance of mTOR, ZEB1, ROCK1 expression in lung tissues of pulmonary fibrosis patients

(2014) Jong Sun Park et al.   BMC Pulmonary Medicine

Review: Interstitial Lung Disease Associated With Systemic Sclerosis and Idiopathic Pulmonary Fibrosis: How Similar and Distinct?

(2014) Erica L. Herzog et al.   Arthritis & Rheumatology

Mesenchymal Stem Cells and Idiopathic Pulmonary Fibrosis. Potential for Clinical Testing

(2013) Rebecca L. Toonkel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pathogenesis of Idiopathic Pulmonary Fibrosis

(2013) Paul J. Wolters et al.   Annual Review of Pathology-Mechanisms of Disease

Sirt1 Activation Ameliorates Renal Fibrosis by Inhibiting the TGF-β/Smad3 Pathway

(2013) Xin-Zhong Huang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Resveratrol as a therapeutic agent for renal fibrosis induced by unilateral ureteral obstruction

(2013) Jin Liang et al.   RENAL FAILURE

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Clinical and serological features of systemic sclerosis in a Chinese cohort

(2012) Jiucun Wang et al.   CLINICAL RHEUMATOLOGY

Pulmonary fibrosis: patterns and perpetrators

(2012) Paul W. Noble et al.   JOURNAL OF CLINICAL INVESTIGATION

SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes

(2012) M.-H. Moon et al.   OSTEOARTHRITIS AND CARTILAGE

Negative regulation of inflammation by SIRT1

(2012) Jun Xie et al.   PHARMACOLOGICAL RESEARCH

SirT1 Regulates Adipose Tissue Inflammation

(2011) M. P. Gillum et al.   DIABETES

Integrating mechanisms of pulmonary fibrosis

(2011) Thomas A. Wynn   JOURNAL OF EXPERIMENTAL MEDICINE

Activation of Sirt1 by Resveratrol Inhibits TNF-α Induced Inflammation in Fibroblasts

(2011) Xiaoxia Zhu et al.   PLoS One

The protective effect of resveratrol on dimethylnitrosamine-induced liver fibrosis in rats

(2010) Sang-Won Hong et al.   ARCHIVES OF PHARMACAL RESEARCH

Resveratrol Inhibits Angiogenic Response of Cultured Endothelial F-2 Cells to Vascular Endothelial Growth Factor, but Not to Basic Fibroblast Growth Factor

(2010) Tomomi Uchiyama et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Recent advances in pulmonary fibrosis: implications for scleroderma

(2010) Robert J Homer et al.   CURRENT OPINION IN RHEUMATOLOGY

Pathogenesis of Pulmonary Fibrosis in Systemic Sclerosis: Lessons from Interstitial Lung Disease

(2010) Kristen L. Veraldi et al.   Current Rheumatology Reports

Efficacy of Rapamycin in Scleroderma: A Case Study

(2008) Levi Fried et al.   Lymphatic Research and Biology

The bleomycin animal model: A useful tool to investigate treatment options for idiopathic pulmonary fibrosis?

(2007) Antje Moeller et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY