mTOR in Alzheimer disease and its earlier stages: Links to oxidative damage in the progression of this dementing disorder

Defective Autophagy and Mitophagy in Aging and Alzheimer’s Disease

(2021) Michael Tran et al.   Frontiers in Neuroscience

Insulin resistance, oxidative stress and mitochondrial defects in Ts65dn mice brain: A harmful synergistic path in down syndrome

(2021) Chiara Lanzillotta et al.   FREE RADICAL BIOLOGY AND MEDICINE

Stress Responses in Down Syndrome Neurodegeneration: State of the Art and Therapeutic Molecules

(2021) Chiara Lanzillotta et al.   Biomolecules

Relevance of Autophagy and Mitophagy Dynamics and Markers in Neurodegenerative Diseases

(2021) Carlotta Giorgi et al.   Biomedicines

BRAIN LIPID PEROXIDATION AND ALZHEIMER DISEASE: SYNERGY BETWEEN THE BUTTERFIELD AND MATTSON LABORATORIES

(2020) D. Allan Butterfield   AGEING RESEARCH REVIEWS

Autophagy in Neurodegenerative Diseases: A Hunter for Aggregates

(2020) Hyungsun Park et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Insulin deficiency promotes formation of toxic amyloid-β42 conformer co-aggregating with hyper-phosphorylated tau oligomer in an Alzheimer's disease model

(2020) Tomohiro Imamura et al.   NEUROBIOLOGY OF DISEASE

Proteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative Stress

(2020) Annika Höhn et al.   Oxidative Medicine and Cellular Longevity

Mechanisms of Lifespan Regulation by Calorie Restriction and Intermittent Fasting in Model Organisms

(2020) Dae-Sung Hwangbo et al.   Nutrients

Extracellular vesicle biomarkers of Alzheimer's disease associated with sub‐clinical cognitive decline in late middle age

(2020) Erden Eren et al.   Alzheimers & Dementia

Mitochondria in Alzheimer's disease and their potential role in Alzheimer's proteostasis

(2020) Ian W. Weidling et al.   EXPERIMENTAL NEUROLOGY

Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches

(2020) Derek Kellar et al.   LANCET NEUROLOGY

Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention

(2020) Chiara Lanzillotta et al.   PROGRESS IN NEUROBIOLOGY

Integrated Pathways of COX-2 and mTOR: Roles in Cell Sensing and Alzheimer’s Disease

(2020) Arti Tyagi et al.   Frontiers in Neuroscience

BVR-A Deficiency Leads to Autophagy Impairment through the Dysregulation of AMPK/mTOR Axis in the Brain—Implications for Neurodegeneration

(2020) Chiara Lanzillotta et al.   Antioxidants

Role of reactive oxygen species in the progression of Alzheimer’s disease

(2020) Shvetank Bhatt et al.   DRUG DISCOVERY TODAY

Modulatory Effects of Autophagy on APP Processing as a Potential Treatment Target for Alzheimer’s Disease

(2020) Md. Ataur Rahman et al.   Biomedicines

Disrupted ubiquitin proteasome system underlying tau accumulation in Alzheimer’s disease

(2020) Fang-lin Weng et al.   NEUROBIOLOGY OF AGING

Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis

(2019) Christopher M. Henstridge et al.   NATURE REVIEWS NEUROSCIENCE

Tau and mTOR: The Hotspots for Multifarious Diseases in Alzheimer's Development

(2019) Zeba Mueed et al.   Frontiers in Neuroscience

Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome

(2019) Fabio Di Domenico et al.   Redox Biology

The Role of NMDA Receptors in Alzheimer’s Disease

(2019) Jinping Liu et al.   Frontiers in Neuroscience

Rapamycin and Alzheimer’s disease: Time for a clinical trial?

(2019) Matt Kaeberlein et al.   Science Translational Medicine

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

Loss of biliverdin reductase-A favors Tau hyper-phosphorylation in Alzheimer's disease

(2019) Nidhi Sharma et al.   NEUROBIOLOGY OF DISEASE

Endo-lysosomal pathway and ubiquitin-proteasome system dysfunction in Alzheimer's disease pathogenesis

(2019) Jiqing Cao et al.   NEUROSCIENCE LETTERS

Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging

(2019) Dimitrios Kapogiannis et al.   JAMA Neurology

Actin(g) on mitochondria – a role for cofilin1 in neuronal cell death pathways

(2019) Lena Hoffmann et al.   BIOLOGICAL CHEMISTRY

Targeting Mitochondria in Alzheimer Disease: Rationale and Perspectives

(2019) Chiara Lanzillotta et al.   CNS DRUGS

Ketogenic Diet in Alzheimer’s Disease

(2019) Marta Rusek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Causative Links between Protein Aggregation and Oxidative Stress: A Review

(2019) Elise Lévy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species

(2019) Xu-Qiao Chen et al.   Frontiers in Neuroscience

Brain Insulin Resistance and Hippocampal Plasticity: Mechanisms and Biomarkers of Cognitive Decline

(2019) Matteo Spinelli et al.   Frontiers in Neuroscience

Shining a light on defective autophagy by proteomics approaches: implications for neurodegenerative illnesses

(2019) Fabio Di Domenico et al.   Expert Review of Proteomics

Dietary Neuroketotherapeutics for Alzheimer’s Disease: An Evidence Update and the Potential Role for Diet Quality

(2019) Matthew K. Taylor et al.   Nutrients

The emerging roles of protein homeostasis-governing pathways in Alzheimer's disease

(2018) Ji Cheng et al.   AGING CELL

Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: Implications for Alzheimer disease

(2018) Francesca Triani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Proteomic identification of altered protein O-GlcNAcylation in a triple transgenic mouse model of Alzheimer's disease

(2018) Antonella Tramutola et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Oxidative Stress and Decreased Mitochondrial Superoxide Dismutase 2 and Peroxiredoxins 1 and 4 Based Mechanism of Concurrent Activation of AMPK and mTOR in Alzheimer’s Disease

(2018) Shohreh Majd et al.   Current Alzheimer Research

A Futile Battle? Protein Quality Control and the Stress of Aging

(2018) Ryo Higuchi-Sanabria et al.   DEVELOPMENTAL CELL

Regulation of mitophagy by the ubiquitin pathway in neurodegenerative diseases

(2018) Shyamal Desai et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia

(2018) Fabio Di Domenico et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Perfect sTORm: The Role of the Mammalian Target of Rapamycin (mTOR) in Cerebrovascular Dysfunction of Alzheimer's Disease: A Mini-Review

(2018) Candice E. Van Skike et al.   GERONTOLOGY

Oxidative Stress, Amyloid-β Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer’s Disease

(2018) D. Allan Butterfield et al.   JOURNAL OF ALZHEIMERS DISEASE

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Genetically reducing mTOR signaling rescues central insulin dysregulation in a mouse model of Alzheimer's disease

(2018) Antonella Caccamo et al.   NEUROBIOLOGY OF AGING

Poly-ubiquitin profile in Alzheimer disease brain

(2018) Antonella Tramutola et al.   NEUROBIOLOGY OF DISEASE

Alzheimer’s disease and the autophagic-lysosomal system

(2018) Kyung Min Chung et al.   NEUROSCIENCE LETTERS

A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers

(2018) Tiffany A. Thibaudeau et al.   Nature Communications

Autophagy and Alzheimer’s Disease: From Molecular Mechanisms to Therapeutic Implications

(2018) Md. Sahab Uddin et al.   Frontiers in Aging Neuroscience

Long-lived rodents reveal signatures of positive selection in genes associated with lifespan

(2018) Arne Sahm et al.   PLoS Genetics

Redox Proteomics Analysis of Brains from Subjects with Amnestic Mild Cognitive Impairment Compared to Brains from Subjects with Preclinical Alzheimer's Disease: Insights into Memory Loss in MCI

(2018) Christopher D. Aluise et al.   JOURNAL OF ALZHEIMERS DISEASE

Redox Proteomics and Amyloid β-Peptide: Insights into Alzheimer Disease

(2018) D Allan Butterfield et al.   JOURNAL OF NEUROCHEMISTRY

Biliverdin Reductase-A Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease

(2018) Eugenio Barone et al.   MOLECULAR NEUROBIOLOGY

mTOR-dependent phosphorylation controls TFEB nuclear export

(2018) Gennaro Napolitano et al.   Nature Communications

A novel lysosome‐to‐mitochondria signaling pathway disrupted by amyloid‐β oligomers

(2018) Andrés Norambuena et al.   EMBO JOURNAL

Early intrathecal infusion of everolimus restores cognitive function and mood in a murine model of Alzheimer's disease

(2018) Tommaso Cassano et al.   EXPERIMENTAL NEUROLOGY

Autophagic dysfunction in Alzheimer’s disease: Cellular and molecular mechanistic approaches to halt Alzheimer’s pathogenesis

(2018) Md. Sahab Uddin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome

(2018) Antonella Tramutola et al.   Translational Neurodegeneration

Using comparative biology to understand how aging affects mitochondrial metabolism

(2017) Rashpal S. Dhillon et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Molecular neurobiology of mTOR

(2017) Katarzyna Switon et al.   NEUROSCIENCE

The role of ubiquitin proteasomal system and autophagy-lysosome pathway in Alzheimer’s disease

(2017) Yuan Zhang et al.   REVIEWS IN THE NEUROSCIENCES

Biphasic Modeling of Mitochondrial Metabolism Dysregulation during Aging

(2017) Darren J. Baker et al.   TRENDS IN BIOCHEMICAL SCIENCES

p70 S6 Kinase and Tau in Alzheimer's Disease

(2017) Jin-Jing Pei et al.   JOURNAL OF ALZHEIMERS DISEASE

Oxidative stress affects processing of amyloid precursor protein in vascular endothelial cells

(2017) Abebe Muche et al.   PLoS One

The Proteasome and Oxidative Stress in Alzheimer's Disease

(2016) Vicent Bonet-Costa et al.   ANTIOXIDANTS & REDOX SIGNALING

Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders

(2016) Yu Cai et al.   Autophagy

Aberrant protein phosphorylation in Alzheimer disease brain disturbs pro-survival and cell death pathways

(2016) M. Perluigi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Aβ-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis

(2016) Dah Ihm Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The fine-tuning of proteolytic pathways in Alzheimer’s disease

(2016) Valentina Cecarini et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Autophagy and Alzheimer’s Disease

(2016) Qian Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Mitochondria are required for pro‐ageing features of the senescent phenotype

(2016) Clara Correia‐Melo et al.   EMBO JOURNAL

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice

(2016) V. Martínez-Cisuelo et al.   EXPERIMENTAL GERONTOLOGY

Cathepsin D as a therapeutic target in Alzheimer’s disease

(2016) Fabio Di Domenico et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies

(2016) Antonella Tramutola et al.   Expert Review of Neurotherapeutics

Oxidative signature of cerebrospinal fluid from mild cognitive impairment and Alzheimer disease patients

(2016) Fabio Di Domenico et al.   FREE RADICAL BIOLOGY AND MEDICINE

Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm

(2016) Eugenio Barone et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neuroprotection Through Rapamycin-Induced Activation of Autophagy and PI3K/Akt1/mTOR/CREB Signaling Against Amyloid-β-Induced Oxidative Stress, Synaptic/Neurotransmission Dysfunction, and Neurodegeneration in Adult Rats

(2016) Abhishek Kumar Singh et al.   MOLECULAR NEUROBIOLOGY

It Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease

(2016) Antonella Tramutola et al.   Oxidative Medicine and Cellular Longevity

Role of Carbonyl Modifications on Aging-Associated Protein Aggregation

(2016) Maya Tanase et al.   Scientific Reports

Therapies for Prevention and Treatment of Alzheimer’s Disease

(2016) J. Mendiola-Precoma et al.   Biomed Research International

Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies

(2016) Antonella Tramutola et al.   Expert Review of Neurotherapeutics

Interventions to Slow Aging in Humans: Are We Ready?

(2015) Valter D. Longo et al.   AGING CELL

The mitochondrial uncoupler DNP triggers brain cell mTOR signaling network reprogramming and CREB pathway up-regulation

(2015) Dong Liu et al.   JOURNAL OF NEUROCHEMISTRY

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD

(2015) Antonella Tramutola et al.   JOURNAL OF NEUROCHEMISTRY

Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

(2015) A. Caccamo et al.   JOURNAL OF NEUROSCIENCE

mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy

(2015) Marzia Perluigi et al.   NEUROBIOLOGY OF DISEASE

Increased Mammalian Target of Rapamycin Signaling Contributes to the Accumulation of Protein Oxidative Damage in a Mouse Model of Down's Syndrome

(2015) Antonella Tramutola et al.   Neurodegenerative Diseases

Early Shifts of Brain Metabolism by Caloric Restriction Preserve White Matter Integrity and Long-Term Memory in Aging Mice

(2015) Janet Guo et al.   Frontiers in Aging Neuroscience

Redox control of protein degradation

(2015) Marta Pajares et al.   Redox Biology

Dietary restriction involves NAD+-dependent mechanisms and a shift toward oxidative metabolism

(2014) Natalie Moroz et al.   AGING CELL

Regulation of autophagy by amino acids and MTOR-dependent signal transduction

(2014) Alfred J. Meijer et al.   AMINO ACIDS

Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain

(2014) D. Allan Butterfield et al.   BIOCHEMICAL JOURNAL

Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain

(2014) Marzia Perluigi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Elevated risk of type 2 diabetes for development of Alzheimer disease: A key role for oxidative stress in brain

(2014) D. Allan Butterfield et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inactivation of brain Cofilin-1 by age, Alzheimer's disease and γ-secretase

(2014) Eugenio Barone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Oxidative stress and autophagy: the clash between damage and metabolic needs

(2014) G Filomeni et al.   CELL DEATH AND DIFFERENTIATION

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

(2014) David Heras-Sandoval et al.   CELLULAR SIGNALLING

Brain PET in the Diagnosis of Alzheimer’s Disease

(2014) Charles Marcus et al.   CLINICAL NUCLEAR MEDICINE

Defects in GABA metabolism affect selective autophagy pathways and are alleviated by mTOR inhibition

(2014) R. Lakhani et al.   EMBO Molecular Medicine

Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: clues for understanding the development of Alzheimer disease

(2014) Fabio Di Domenico et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Diagnosis and Management of Mild Cognitive Impairment

(2014) Kenneth M. Langa et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Where is mTOR and what is it doing there?

(2014) Charles Betz et al.   JOURNAL OF CELL BIOLOGY

ER-associated degradation: Protein quality control and beyond

(2014) Annamaria Ruggiano et al.   JOURNAL OF CELL BIOLOGY

Genetic Reduction of Mammalian Target of Rapamycin Ameliorates Alzheimer's Disease-Like Cognitive and Pathological Deficits by Restoring Hippocampal Gene Expression Signature

(2014) A. Caccamo et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial quality control systems sustain brain mitochondrial bioenergetics in early stages of type 2 diabetes

(2014) R. X. Santos et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Mechanism of Oxidative Stress and Synapse Dysfunction in the Pathogenesis of Alzheimer’s Disease: Understanding the Therapeutics Strategies

(2014) Pradip K. Kamat et al.   MOLECULAR NEUROBIOLOGY

Effects of Oxidative Stress on the Solubility of HRD1, a Ubiquitin Ligase Implicated in Alzheimer’s Disease

(2014) Ryo Saito et al.   PLoS One

Akt and mTOR mediate programmed necrosis in neurons

(2014) Q Liu et al.   Cell Death & Disease

The role of protein clearance mechanisms in organismal ageing and age-related diseases

(2014) David Vilchez et al.   Nature Communications

Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: Redox proteomics analysis of human brain

(2013) Fabio Di Domenico et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease

(2013) Cora O' Neill   EXPERIMENTAL GERONTOLOGY

Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines

(2013) D. F. Silva et al.   HUMAN MOLECULAR GENETICS

Mass spectrometry and redox proteomics: Applications in disease

(2013) D. Allan Butterfield et al.   MASS SPECTROMETRY REVIEWS

Nutrient Sensing, Metabolism, and Cell Growth Control

(2013) Hai-Xin Yuan et al.   MOLECULAR CELL

Protein Quality Control System in Neurodegeneration: A Healing Company Hard to Beat but Failure is Fatal

(2013) Deepak Chhangani et al.   MOLECULAR NEUROBIOLOGY

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS

(2013) Jiangwei Zhang et al.   NATURE CELL BIOLOGY

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

(2013) Yan Zhao et al.   Oxidative Medicine and Cellular Longevity

Phosphorylation of Tau Protein as the Link between Oxidative Stress, Mitochondrial Dysfunction, and Connectivity Failure: Implications for Alzheimer’s Disease

(2013) Siddhartha Mondragón-Rodríguez et al.   Oxidative Medicine and Cellular Longevity

Amyloid β-protein oligomers and Alzheimer’s disease

(2013) Eric Y Hayden et al.   Alzheimers Research & Therapy

Oxidative modification of lipoic acid by HNE in Alzheimer disease brain

(2013) Sarita S. Hardas et al.   Redox Biology

Redox-Dependent Protein Quality Control in the Endoplasmic Reticulum: Folding to Degradation

(2012) Masatoshi Hagiwara et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Proteomics Analyses of the Influence of Co-Expression of Wild-Type or Mutated LRRK2 and Tau on C. elegans Protein Expression and Oxidative Modification: Relevance to Parkinson Disease

(2012) Fabio Di Domenico et al.   ANTIOXIDANTS & REDOX SIGNALING

Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease

(2012) Cora O'Neill et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Crosstalk between the ubiquitin–proteasome system and autophagy in a human cellular model of Alzheimer's disease

(2012) Valentina Cecarini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Insulin signaling, glucose metabolism and mitochondria: Major players in Alzheimer's disease and diabetes interrelation

(2012) Sónia C. Correia et al.   BRAIN RESEARCH

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

Lipid peroxidation triggers neurodegeneration: A redox proteomics view into the Alzheimer disease brain

(2012) Rukhsana Sultana et al.   FREE RADICAL BIOLOGY AND MEDICINE

Endoplasmic reticulum: The unfolded protein response is tangled in neurodegeneration

(2012) Jeroen J.M. Hoozemans et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The impact of the unfolded protein response on human disease

(2012) Shiyu Wang et al.   JOURNAL OF CELL BIOLOGY

Endoplasmic reticulum dysfunction in neurological disease

(2012) Benoit D Roussel et al.   LANCET NEUROLOGY

Protein damage, repair and proteolysis

(2012) Niki Chondrogianni et al.   MOLECULAR ASPECTS OF MEDICINE

Chaperone-mediated autophagy: a unique way to enter the lysosome world

(2012) Susmita Kaushik et al.   TRENDS IN CELL BIOLOGY

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

The unfolded protein response and proteostasis in Alzheimer disease

(2011) Wiep Scheper et al.   Autophagy

Macroautophagy-generated increase of lysosomal amyloid β-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells

(2011) Lin Zheng et al.   Autophagy

A review of the mammalian unfolded protein response

(2011) Anirikh Chakrabarti et al.   BIOTECHNOLOGY AND BIOENGINEERING

Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions

(2011) Heidi Olzscha et al.   CELL

Nuclear and mitochondrial DNA oxidation in Alzheimer's disease

(2011) Renato X. Santos et al.   FREE RADICAL RESEARCH

Curcumin and Alzheimer Disease: This Marriage Is Not to Be Performed

(2011) Cesare Mancuso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy failure in Alzheimer's disease—locating the primary defect

(2011) Ralph A. Nixon et al.   NEUROBIOLOGY OF DISEASE

ATP13A2 regulates mitochondrial bioenergetics through macroautophagy

(2011) Aaron M. Gusdon et al.   NEUROBIOLOGY OF DISEASE

Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits

(2011) Smita Majumder et al.   PLoS One

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

The Role of Tau in Alzheimer's Disease and Related Disorders

(2010) Rodrigo Medeiros et al.   CNS Neuroscience & Therapeutics

Tau in Alzheimer Disease and Related Tauopathies

(2010) K. Iqbal et al.   Current Alzheimer Research

TOR on the brain

(2010) Michael G. Garelick et al.   EXPERIMENTAL GERONTOLOGY

Increased protein hydrophobicity in response to aging and Alzheimer disease

(2010) Kalavathi Dasuri et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Mitochondrial uncoupling and lifespan

(2010) Shona A. Mookerjee et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

Preclinical Alzheimer disease: Brain oxidative stress, Aβ peptide and proteomics

(2010) Christopher D. Aluise et al.   NEUROBIOLOGY OF DISEASE

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Autophagy, a guardian against neurodegeneration

(2010) Moisés García-Arencibia et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Biomarkers of oxidative and nitrosative damage in Alzheimer's disease and mild cognitive impairment

(2009) Francesca Mangialasche et al.   AGEING RESEARCH REVIEWS

Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways inC. elegans

(2009) Eric L. Greer et al.   AGING CELL

The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus

(2009) Jeroen J.M. Hoozemans et al.   AMERICAN JOURNAL OF PATHOLOGY

Redox Proteomic Analysis of Carbonylated Brain Proteins in Mild Cognitive Impairment and Early Alzheimer's Disease

(2009) Rukhsana Sultana et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence

(2009) O. Moiseeva et al.   MOLECULAR AND CELLULAR BIOLOGY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

The Stress Rheostat: An Interplay Between the Unfolded Protein Response (UPR) and Autophagy in Neurodegeneration

(2008) Soledad Matus et al.   CURRENT MOLECULAR MEDICINE

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

(2008) R. I. Morimoto   GENES & DEVELOPMENT

Mitophagy in Yeast Occurs through a Selective Mechanism

(2008) Tomotake Kanki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR-dependent signalling in Alzheimer's disease

(2008) Jin-Jing Pei et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Expression of mutant SOD1G93Ain astrocytes induces functional deficits in motoneuron mitochondria

(2008) Lynsey G. Bilsland et al.   JOURNAL OF NEUROCHEMISTRY

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease

(2008) Claudine Kraft et al.   NATURE CELL BIOLOGY

Redox proteomic identification of 4-Hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: Insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease

(2008) Tanea Reed et al.   NEUROBIOLOGY OF DISEASE

Oxidative Damage and Cognitive Dysfunction: Antioxidant Treatments to Promote Healthy Brain Aging

(2008) Elizabeth Head   NEUROCHEMICAL RESEARCH

Oxidative Stress and Neurotoxicity

(2007) Lawrence M. Sayre et al.   CHEMICAL RESEARCH IN TOXICOLOGY