Stress Responses in Down Syndrome Neurodegeneration: State of the Art and Therapeutic Molecules

Broad Kinase Inhibition Mitigates Early Neuronal Dysfunction in Tauopathy

(2021) Shon A. Koren et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Insulin resistance, oxidative stress and mitochondrial defects in Ts65dn mice brain: A harmful synergistic path in down syndrome

(2021) Chiara Lanzillotta et al.   FREE RADICAL BIOLOGY AND MEDICINE

Down syndrome and Alzheimer's disease: common molecular traits beyond the amyloid precursor protein

(2020) Wileidy Gomez et al.   Aging-US

Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome

(2020) Antonella Tramutola et al.   NEUROBIOLOGY OF DISEASE

Proteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative Stress

(2020) Annika Höhn et al.   Oxidative Medicine and Cellular Longevity

Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention

(2020) Chiara Lanzillotta et al.   PROGRESS IN NEUROBIOLOGY

Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer’s-like mouse models

(2020) Sathish Kumar et al.   Acta Neuropathologica Communications

Ultrastructural and dynamic studies of the endosomal compartment in Down syndrome

(2020) Alexandra Botté et al.   Acta Neuropathologica Communications

Mitochondrial Dysfunction, Oxidative Stress, and Neuroinflammation: Intertwined Roads to Neurodegeneration

(2020) Anna Picca et al.   Antioxidants

Antioxidants in Down Syndrome: From Preclinical Studies to Clinical Trials

(2020) Noemí Rueda Revilla et al.   Antioxidants

Apigenin as a Candidate Prenatal Treatment for Trisomy 21: Effects in Human Amniocytes and the Ts1Cje Mouse Model

(2020) Faycal Guedj et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The BACH1/Nrf2 Axis in Brain in Down Syndrome and Transition to Alzheimer Disease-Like Neuropathology and Dementia

(2020) Marzia Perluigi et al.   Antioxidants

The Dysregulation of OGT/OGA Cycle Mediates Tau and APP Neuropathology in Down Syndrome

(2020) Ilaria Zuliani et al.   Neurotherapeutics

Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome

(2019) Fabio Di Domenico et al.   Redox Biology

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

Dementia in Down syndrome: unique insights for Alzheimer disease research

(2019) Ira T. Lott et al.   Nature Reviews Neurology

The proteostasis network and its decline in ageing

(2019) Mark S. Hipp et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Trisomy 21 is a Cause of Permanent Neonatal Diabetes that is Autoimmune but not HLA Associated

(2019) Matthew B Johnson et al.   DIABETES

Lysosomal dysfunction in Down syndrome is APP-dependent and mediated by APP-βCTF (C99)

(2019) Jiang Ying et al.   JOURNAL OF NEUROSCIENCE

Insulin and Autophagy in Neurodegeneration

(2019) Natália Prudente de Mello et al.   Frontiers in Neuroscience

Long-term effects of maternal choline supplementation on CA1 pyramidal neuron gene expression in the Ts65Dn mouse model of Down syndrome and Alzheimer’s disease

(2019) Melissa J. Alldred et al.   FASEB JOURNAL

mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy

(2019) Matteo Bordi et al.   Cell Death & Disease

Neuropathological correlates of amyloid PET imaging in Down syndrome

(2019) Eric E. Abrahamson et al.   Developmental Neurobiology

Pathophysiology and Therapeutic Perspectives of Oxidative Stress and Neurodegenerative Diseases: A Narrative Review

(2019) Martina Rekatsina et al.   ADVANCES IN THERAPY

Shining a light on defective autophagy by proteomics approaches: implications for neurodegenerative illnesses

(2019) Fabio Di Domenico et al.   Expert Review of Proteomics

Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome

(2019) Ping Jun Zhu et al.   SCIENCE

Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells

(2018) Emiliano Zamponi et al.   AGING CELL

Autophagy in health and disease: A comprehensive review

(2018) Sarbari Saha et al.   BIOMEDICINE & PHARMACOTHERAPY

Mitochondria as pharmacological targets in Down syndrome

(2018) Daniela Valenti et al.   FREE RADICAL BIOLOGY AND MEDICINE

mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia

(2018) Fabio Di Domenico et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease

(2018) Daniel J. Colacurcio et al.   FREE RADICAL BIOLOGY AND MEDICINE

Early and Selective Activation and Subsequent Alterations to the Unfolded Protein Response in Down Syndrome Mouse Models

(2018) Chiara Lanzillotta et al.   JOURNAL OF ALZHEIMERS DISEASE

Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection

(2018) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

The Unfolded Protein Response and Cell Fate Control

(2018) Claudio Hetz et al.   MOLECULAR CELL

The effect of long-term treatment with coenzyme Q10 on nucleic acid modifications by oxidation in children with Down syndrome

(2018) Emil List Larsen et al.   NEUROBIOLOGY OF AGING

Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of Parkinson's disease

(2018) Gabriela Mercado et al.   NEUROBIOLOGY OF DISEASE

The age of onset and evolution of Braak tangle stage and Thal amyloid pathology of Alzheimer’s disease in individuals with Down syndrome

(2018) Yvonne S. Davidson et al.   Acta Neuropathologica Communications

Autophagy in Age-Associated Neurodegeneration

(2018) Athanasios Metaxakis et al.   Cells

HO-1/BVR-A System Analysis in Plasma from Probable Alzheimer's Disease and Mild Cognitive Impairment Subjects: A Potential Biochemical Marker for the Prediction of the Disease

(2018) Fabio Di Domenico et al.   JOURNAL OF ALZHEIMERS DISEASE

Oxidative Stress and Memory Decline in Adults with Down Syndrome: Longitudinal Study

(2018) Panagiotis Zis et al.   JOURNAL OF ALZHEIMERS DISEASE

Biliverdin Reductase-A Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease

(2018) Eugenio Barone et al.   MOLECULAR NEUROBIOLOGY

Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome

(2018) Antonella Tramutola et al.   Translational Neurodegeneration

HNE-modified proteins in Down syndrome: Involvement in development of Alzheimer disease neuropathology

(2017) Eugenio Barone et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of 4-hydroxy-2-nonenal (HNE) in the pathogenesis of alzheimer disease and other selected age-related neurodegenerative disorders

(2017) Fabio Di Domenico et al.   FREE RADICAL BIOLOGY AND MEDICINE

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury

(2017) Austin Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy

(2017) Yong Tae Kwon et al.   TRENDS IN BIOCHEMICAL SCIENCES

Enhanced exosome secretion in Down syndrome brain - a protective mechanism to alleviate neuronal endosomal abnormalities

(2017) Sébastien A. Gauthier et al.   Acta Neuropathologica Communications

The burden of trisomy 21 disrupts the proteostasis network in Down syndrome

(2017) Stefanos Aivazidis et al.   PLoS One

Aberrant protein phosphorylation in Alzheimer disease brain disturbs pro-survival and cell death pathways

(2016) M. Perluigi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Role of the mammalian ATG8/LC3 family in autophagy: differential and compensatory roles in the spatiotemporal regulation of autophagy

(2016) You-Kyung Lee et al.   BMB Reports

PERK-opathies: An Endoplasmic Reticulum Stress Mechanism Underlying Neurodegeneration

(2016) Michelle C. Bell et al.   Current Alzheimer Research

Cathepsin D as a therapeutic target in Alzheimer’s disease

(2016) Fabio Di Domenico et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Fluoxetine Inhibits NLRP3 Inflammasome Activation: Implication in Depression

(2016) Ren-Hong Du et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype

(2016) Antonella Tramutola et al.   JOURNAL OF ALZHEIMERS DISEASE

Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial

(2016) Rafael de la Torre et al.   LANCET NEUROLOGY

Dementia in Down's syndrome

(2016) Clive Ballard et al.   LANCET NEUROLOGY

Down syndrome and the complexity of genome dosage imbalance

(2016) Stylianos E. Antonarakis   NATURE REVIEWS GENETICS

Chronic Melatonin Administration Reduced Oxidative Damage and Cellular Senescence in the Hippocampus of a Mouse Model of Down Syndrome

(2016) Eduardo B. Parisotto et al.   NEUROCHEMICAL RESEARCH

Vitamin E in aging persons with Down syndrome

(2016) Mary Sano et al.   NEUROLOGY

Short- and long-term effects of neonatal pharmacotherapy with epigallocatechin-3-gallate on hippocampal development in the Ts65Dn mouse model of Down syndrome

(2016) Fiorenza Stagni et al.   NEUROSCIENCE

Nrf2–ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases

(2016) Izaskun Buendia et al.   PHARMACOLOGY & THERAPEUTICS

Translational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine

(2016) Wei Huang et al.   eLife

Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation

(2016) Ryuta Ishimura et al.   eLife

Down syndrome and Alzheimer's disease: Common pathways, common goals

(2015) Dean Hartley et al.   Alzheimers & Dementia

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight

(2015) Aashiq Hussain Bhat et al.   BIOMEDICINE & PHARMACOTHERAPY

Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology

(2015) Elizabeth Head et al.   Current Alzheimer Research

Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome

(2015) Yuniesky Andrade-Talavera et al.   NEUROBIOLOGY OF DISEASE

Pharmacological correction of excitation/inhibition imbalance in Down syndrome mouse models

(2015) Benoit Souchet et al.   Frontiers in Behavioral Neuroscience

Principal Component Analysis of the Effects of Environmental Enrichment and (-)-epigallocatechin-3-gallate on Age-Associated Learning Deficits in a Mouse Model of Down Syndrome

(2015) Silvina Catuara-Solarz et al.   Frontiers in Behavioral Neuroscience

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

(2015) Carmela Sidrauski et al.   eLife

Translational Control in Synaptic Plasticity and Cognitive Dysfunction

(2014) Shelly A. Buffington et al.   Annual Review of Neuroscience

Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain

(2014) D. Allan Butterfield et al.   BIOCHEMICAL JOURNAL

Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain

(2014) Marzia Perluigi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inactivation of brain Cofilin-1 by age, Alzheimer's disease and γ-secretase

(2014) Eugenio Barone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Endoplasmic reticulum stress associated responses in cancer

(2014) Wen-An Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Akt-mTOR Pathway in Down’s Syndrome: The Potential Use of Rapamycin/Rapalogs for Treating Cognitive Deficits

(2014) Jose Troca-Marin et al.   CNS & Neurological Disorders-Drug Targets

α-Tocopherol supplementation reduces biomarkers of oxidative stress in children with Down syndrome: a randomized controlled trial

(2014) S Mustafa Nachvak et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Strategy to reduce free radical species in Alzheimer’s disease: an update of selected antioxidants

(2014) Fabio Di Domenico et al.   Expert Review of Neurotherapeutics

Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: clues for understanding the development of Alzheimer disease

(2014) Fabio Di Domenico et al.   FREE RADICAL BIOLOGY AND MEDICINE

mTOR Hyperactivation in Down Syndrome Hippocampus Appears Early During Development

(2014) Anand M. Iyer et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The eIF2  kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression

(2014) M. A. Trinh et al.   LEARNING & MEMORY

Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α

(2014) Gonzalo Viana Di Prisco et al.   NATURE NEUROSCIENCE

The proteasome and the degradation of oxidized proteins: Part III—Redox regulation of the proteasomal system

(2014) Tobias Jung et al.   Redox Biology

Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: Redox proteomics analysis of human brain

(2013) Fabio Di Domenico et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Epigallocatechin-3-gallate prevents oxidative phosphorylation deficit and promotes mitochondrial biogenesis in human cells from subjects with Down's syndrome

(2013) Daniela Valenti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain

(2013) M. M. Ahmed et al.   HUMAN MOLECULAR GENETICS

Chronic melatonin treatment rescues electrophysiological and neuromorphological deficits in a mouse model of Down syndrome

(2013) Andrea Corrales et al.   JOURNAL OF PINEAL RESEARCH

Systemic oxidative stress in children and teenagers with Down syndrome

(2013) Thais Regina Garlet et al.   LIFE SCIENCES

Mass spectrometry and redox proteomics: Applications in disease

(2013) D. Allan Butterfield et al.   MASS SPECTROMETRY REVIEWS

Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans

(2013) Rafael De la Torre et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Usp16 contributes to somatic stem-cell defects in Down’s syndrome

(2013) Maddalena Adorno et al.   NATURE

Massively Parallel Sequencing Reveals the Complex Structure of an Irradiated Human Chromosome on a Mouse Background in the Tc1 Model of Down Syndrome

(2013) Susan M. Gribble et al.   PLoS One

Connections between SNAREs and autophagy

(2013) Kevin Moreau et al.   TRENDS IN BIOCHEMICAL SCIENCES

Autophagic/lysosomal dysfunction in Alzheimer’s disease

(2013) Miranda E Orr et al.   Alzheimers Research & Therapy

Pharmacological brake-release of mRNA translation enhances cognitive memory

(2013) Carmela Sidrauski et al.   eLife

Imaging brain amyloid in nondemented young adults with Down syndrome using Pittsburgh compound B

(2012) Benjamin L. Handen et al.   Alzheimers & Dementia

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Autophagy as a Stress-Response and Quality-Control Mechanism: Implications for Cell Injury and Human Disease

(2012) Lyndsay Murrow et al.   Annual Review of Pathology-Mechanisms of Disease

Redox Proteomics Analyses of the Influence of Co-Expression of Wild-Type or Mutated LRRK2 and Tau on C. elegans Protein Expression and Oxidative Modification: Relevance to Parkinson Disease

(2012) Fabio Di Domenico et al.   ANTIOXIDANTS & REDOX SIGNALING

Apoptosis in Down’s syndrome: lessons from studies of human and mouse models

(2012) Noemí Rueda et al.   APOPTOSIS

Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis

(2012) Kalavathi Dasuri et al.   FREE RADICAL BIOLOGY AND MEDICINE

Trisomy for Synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes

(2012) Jack-Christophe Cossec et al.   HUMAN MOLECULAR GENETICS

Long-term oral administration of melatonin improves spatial learning and memory and protects against cholinergic degeneration in middle-aged Ts65Dn mice, a model of Down syndrome

(2012) Andrea Corrales et al.   JOURNAL OF PINEAL RESEARCH

The structure of the PERK kinase domain suggests the mechanism for its activation

(2011) Wenjun Cui et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Down syndrome and dementia: A randomized, controlled trial of antioxidant supplementation

(2011) Ira T. Lott et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Deficit of complex I activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: involvement of the cAMP/PKA signalling pathway

(2011) Daniela Valenti et al.   BIOCHEMICAL JOURNAL

Antioxidants in Down syndrome

(2011) Ira T. Lott   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome

(2011) Giovanna Cenini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Dysfunction of the ubiquitin–proteasome system in the cerebellum of aging Ts65Dn mice

(2011) Daniela Necchi et al.   EXPERIMENTAL NEUROLOGY

α-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome

(2011) Mototada Shichiri et al.   FREE RADICAL BIOLOGY AND MEDICINE

IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux

(2011) Huikyong Lee et al.   HUMAN MOLECULAR GENETICS

Curcumin and Alzheimer Disease: This Marriage Is Not to Be Performed

(2011) Cesare Mancuso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of eIF2 Facilitates Ribosomal Bypass of an Inhibitory Upstream ORF to EnhanceCHOPTranslation

(2011) Lakshmi Reddy Palam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling down syndrome

(2011) Arnaud Duchon et al.   MAMMALIAN GENOME

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Prolonged coenzyme Q10 treatment in Down syndrome patients, effect on DNA oxidation

(2011) Luca Tiano et al.   NEUROBIOLOGY OF AGING

Autophagy failure in Alzheimer's disease—locating the primary defect

(2011) Ralph A. Nixon et al.   NEUROBIOLOGY OF DISEASE

Oxidative stress occurs early in Down syndrome pregnancy: A redox proteomics analysis of amniotic fluid

(2011) Marzia Perluigi et al.   Proteomics Clinical Applications

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Oxidative protein damage and the proteasome

(2010) S. Grimm et al.   AMINO ACIDS

Impairment of F1F0-ATPase, adenine nucleotide translocator and adenylate kinase causes mitochondrial energy deficit in human skin fibroblasts with chromosome 21 trisomy

(2010) Daniela Valenti et al.   BIOCHEMICAL JOURNAL

Early Pharmacotherapy Restores Neurogenesis and Cognitive Performance in the Ts65Dn Mouse Model for Down Syndrome

(2010) P. Bianchi et al.   JOURNAL OF NEUROSCIENCE

Identification of Regulators of Chaperone-Mediated Autophagy

(2010) Urmi Bandyopadhyay et al.   MOLECULAR CELL

Selective autophagy: ubiquitin-mediated recognition and beyond

(2010) Claudine Kraft et al.   NATURE CELL BIOLOGY

Autophagy and Tumorigenesis

(2010) Srirupa Roy et al.   Seminars in Immunopathology

An Upstream Open Reading Frame Regulates Translation of GADD34 during Cellular Stresses That Induce eIF2α Phosphorylation

(2009) Yun-Young Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The proteasomal system

(2009) Tobias Jung et al.   MOLECULAR ASPECTS OF MEDICINE

Down Syndrome Fibroblast Model of Alzheimer-Related Endosome Pathology

(2008) Anne M. Cataldo et al.   AMERICAN JOURNAL OF PATHOLOGY

How IRE1 Reacts to ER Stress

(2008) David Ron et al.   CELL

ATF6 Is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic Reticulum

(2008) Yusuke Adachi et al.   CELL STRUCTURE AND FUNCTION

The Stress Rheostat: An Interplay Between the Unfolded Protein Response (UPR) and Autophagy in Neurodegeneration

(2008) Soledad Matus et al.   CURRENT MOLECULAR MEDICINE

Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model

(2008) Jason Lockrow et al.   EXPERIMENTAL NEUROLOGY

Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome

(2008) Fei Liu et al.   FASEB JOURNAL

Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity

(2008) M. L. Duennwald et al.   GENES & DEVELOPMENT

The proteasome and its role in the degradation of oxidized proteins

(2008) Tobias Jung et al.   IUBMB LIFE

Phosphorylation of eIF2 DirectsATF5Translational Control in Response to Diverse Stress Conditions

(2008) Donghui Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

(2008) Julie D. Atkin et al.   NEUROBIOLOGY OF DISEASE