Review
Endocrinology & Metabolism
Chunlu Yan, Yao Shi, Lingqing Yuan, Donghui Lv, Bai Sun, Jiayu Wang, Xiyan Liu, Fangyu An
Summary: Mitochondria play a crucial role in providing cellular energy and maintaining the balance between osteogenesis and osteoclast activity. Mitochondrial dysfunction disrupts this balance and contributes to the pathogenesis of osteoporosis. Targeted therapy of mitochondria in osteoporosis can provide novel strategies for prevention and treatment of this disease.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Cell Biology
Tin Van Huynh, Lekha Rethi, Lekshmi Rethi, Chih-Hwa Chen, Yi-Jen Chen, Yu-Hsun Kao
Summary: Type 2 diabetes is a global burden with increasing numbers of affected individuals and treatment costs. Dysregulated mitochondrial dynamics play an essential role in the pathophysiology of insulin resistance, obesity, and type 2 diabetes. Mitochondrial dysfunction leads to various diseases, including cardiovascular diseases, metabolic disorders, and cancer.
Review
Biochemistry & Molecular Biology
Giovanni Fajardo, Michael Coronado, Melia Matthews, Daniel Bernstein
Summary: Alterations in mitochondrial function and morphology are critical adaptations to cardiovascular stress, working in concert in an attempt to restore organelle-level and cellular-level homeostasis. Processes that alter mitochondrial morphology include fission, fusion, mitophagy, and biogenesis, and these interact to maintain mitochondrial quality control. Both pathological stressors like ischemia and physiological stressors like aerobic exercise can induce morphologic adaptations in mitochondria, but with different outcomes for mitochondrial health. Understanding the mechanisms underlying alterations in mitochondrial quality control under diverse cardiovascular stressors can aid in developing pharmacologic interventions for restoring cellular homeostasis.
Review
Cardiac & Cardiovascular Systems
Xiaoqing Peng, Ruirui Hou, Yuanyuan Yang, Zhigang Luo, Yunxia Cao
Summary: This article discusses the role and current research status of mitochondrial quality control (mQC) in placental-originated preeclampsia (PE), and provides suggestions for future research, aiming to provide new ideas for the development of prevention and treatment strategies for PE.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Yetong Feng, Jiayi Xu, Mengjiao Shi, Rongrong Liu, Lei Zhao, Xin Chen, Miaomiao Li, Yaping Zhao, Jiahui Chen, Wenjing Du, Pengfei Liu
Summary: COX7A1 plays an important role in the metabolism and therapy of lung cancer. It increases the sensitivity of lung cancer cells to a novel form of cell death called ferroptosis by enhancing the tricarboxylic acid cycle and the activity of complex IV in the mitochondrial electron transport chain. Additionally, COX7A1 suppresses mitochondrial dynamics, biogenesis, and mitophagy through blocking autophagic flux.
CELL DEATH & DISEASE
(2022)
Review
Endocrinology & Metabolism
Shengnan Wang, Haiyang Zhao, Suxian Lin, Yang Lv, Yue Lin, Yinai Liu, Renyi Peng, Huanzhi Jin
Summary: Changes in mitochondrial dynamics play an important role in maintaining cellular metabolism homeostasis, and disturbances in mitochondrial dynamics are associated with metabolic abnormalities in diabetes. Restoring mitochondrial dynamics has potential therapeutic benefits for type II diabetes and its complications.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biology
Yaqin Yan, Jintian Tang, Qinfeng Yuan, Caiyun Liu, Xiaolin Chen, Hao Liu, Junbin Huang, Chonglai Bao, Tom Hsiang, Lu Zheng
Summary: Prohibitins play important roles in fungal virulence by regulating mitophagy, affecting the pathogenicity of Colletotrichum higginsianum.
COMMUNICATIONS BIOLOGY
(2022)
Review
Physiology
Heath G. Gasier, Hagir B. Suliman, Claude A. Piantadosi
Summary: The skeletal muscle HO-1/CO system is hypothesized to modulate components in the MQC cycle during metabolic stress.
EXERCISE AND SPORT SCIENCES REVIEWS
(2022)
Review
Medicine, Research & Experimental
Ao-ran Liu, Zhi Lv, Zi-wei Yan, Xiao-yang Wu, Li-rong Yan, Li-ping Sun, Yuan Yuan, Qian Xu
Summary: Mitochondria play a crucial role in determining the physiological status of most eukaryotes. Disrupted mitochondrial dynamics can affect cellular energy metabolism, leading to tumorigenesis. This review explores the impact of disrupted mitochondrial dynamics on the biological behaviors of gastrointestinal cancer and its association with cancer progression. By examining mitochondrial homeostasis and disorder, the aim is to provide insights into the etiology and pathogenesis of gastrointestinal cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Murali Vijayan, P. Hemachandra Reddy
Summary: The study aims to understand the protective effects of reduced VDAC1 on mitochondrial dynamics and biogenesis in transgenic TAU mice. The researchers found that a decrease in VDAC1 can significantly reduce mitochondrial fission proteins and increase mitochondrial fusion and biogenesis proteins. These findings may have significant implications for the development of reduced-VDAC1-based treatments for AD and tauopathies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Shiyi Kan, Caixia Pi, Li Zhang, Daimo Guo, Zhixing Niu, Yang Liu, Mengmeng Duan, Xiahua Pu, Mingru Bai, Chenchen Zhou, Demao Zhang, Jing Xie
Summary: This study investigates the role of FGF19 on chondrocytes, focusing on mitochondrial biogenesis and fusion. It is found that FGF19 enhances mitochondrial biogenesis and fusion through the activation of AMPKa-p38/MAPK signaling. These findings expand the understanding of FGF19 on chondrocyte metabolism.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cell Biology
Christina G. Towers, Darya K. Wodetzki, Jacqueline Thorburn, Katharine R. Smith, M. Cecilia Caino, Andrew Thorburn
Summary: This study investigated alternative forms of mitochondrial quality control beyond mitophagy to compensate for inactive autophagy. Rare surviving autophagy-deficient clones were found to adapt to maintain mitochondrial homeostasis through regulating mitochondrial dynamics and mitochondrial-derived vesicles. The research indicates unique dependencies of autophagy-dependent cells on these mechanisms to maintain mitochondrial health.
DEVELOPMENTAL CELL
(2021)
Article
Biochemistry & Molecular Biology
Yujie Zhong, Dianjun Sun, Yanpeng Yao, Qi Liu, Tianmin Guo, Xin Wang, Xiaoli Peng
Summary: This study demonstrated for the first time that DIO protected against kidney injury induced by 3-MCPD through the induction of autophagy via LKB1-AMPK-mTOR pathway and the improvement of mitochondrial fission and fusion.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Multidisciplinary Sciences
Magdalena Gorska-Ponikowska, Paulina Bastian, Agata Zauszkiewicz-Pawlak, Agata Ploska, Adrian Zubrzycki, Alicja Kuban-Jankowska, Stephan Nussberger, Leszek Kalinowski, Zbigniew Kmiec
Summary: The study shows that 2-methoxyestradiol (2-ME) inhibits osteosarcoma cell growth by increasing mitochondrial fission and inducing autophagy, activating the intrinsic apoptosis pathway through upregulation of Drp1 and BAX proteins. This finding suggests that changes in mitochondrial dynamics may represent a novel mechanism of anticancer action of 2-ME.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Zhiyong Cheng
Summary: Mitochondria play essential roles in cellular energetics, biosynthesis, and signaling transduction. Dysfunctional mitochondria have been implicated in different diseases. FoxO transcription factors are key regulators of mitochondrial homeostasis, controlling mitochondrial biogenesis, dynamics, and mitophagy. This article provides an up-to-date view of FoxOs regulating mitochondrial homeostasis and discusses the potential of targeting FoxOs for therapeutics.
BIOCHEMICAL JOURNAL
(2022)
Article
Neurosciences
Cristina Carvalho, Paula I. Moreira
Summary: Type 2 diabetes (T2D) and Alzheimer's disease (AD) are both global epidemics with shared metabolic defects and increased risk of cognitive decline and dementia. This article provides an overview of the metabolic defects that characterize and link both diseases, with a focus on mitochondria. The potential biomarkers and therapeutic drugs targeting mitochondria are also briefly discussed.
CURRENT OPINION IN NEUROBIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Judite R. M. Coimbra, Paula I. Moreira, Armanda E. Santos, Jorge A. R. Salvador
Summary: This review explores the biological functions and structures of QPCT/L enzymes, highlights their therapeutic relevance, and summarizes recent developments in the discovery of small-molecule inhibitors targeting these enzymes.
DRUG DISCOVERY TODAY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Brigida R. Pinho, Ana I. Duarte, Paula M. Canas, Paula I. Moreira, Michael P. Murphy, Jorge M. A. Oliveira
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
David F. Carrageta, Lais Freire-Brito, Barbara Guerra-Carvalho, Joao C. Ribeiro, Bruno S. Monteiro, Alberto Barros, Pedro F. Oliveira, Mariana P. Monteiro, Marco G. Alves
Summary: UCPs play a crucial role in regulating mitochondrial activity and ROS production. The expression and function of UCPs in human spermatozoa have been investigated, providing valuable insights into the mechanisms of male infertility.
Article
Biochemistry & Molecular Biology
Tiago Morais, Alexandre L. L. Seabra, Barbara G. Patricio, David F. F. Carrageta, Marta Guimaraes, Mario Nora, Pedro F. F. Oliveira, Marco G. G. Alves, Mariana P. P. Monteiro
Summary: This study found that GLP-1, GIP, and glucagon have different effects on the metabolic profile of VAT depending on BMI and glycemic status. In individuals with obesity and prediabetes, GLP-1 increased alanine and lactate production and decreased isoleucine consumption, while GIP and glucagon decreased lactate and alanine production and increased pyruvate consumption.
Review
Biology
Jose Costa, Patricia C. Braga, Irene Rebelo, Pedro F. Oliveira, Marco G. Alves
Summary: Mitochondria are crucial for cellular processes, including male reproductive health. Dysfunction in mitochondrial quality control can lead to decreased sperm quality, and understanding and managing this control could be a valuable approach to combat male infertility.
Article
Biochemistry & Molecular Biology
Joao Monteiro, Clive A. Marks, Patricia C. Braga, Raquel L. Bernardino, Marco G. Alves, Alexandre Lobo-da-Cunha, Arnaldo Videira, Filipe Pereira
Summary: Fluoroacetic acid (FAA) is a commonly used poison for controlling invasive species. Despite its long history as a pesticide, there is currently no effective treatment for accidental poisoning. Research shows that FAA affects mitochondrial function and leads to cell death.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Cell Biology
Carla Luis, Barbara Guerra-Carvalho, Patricia C. Braga, Carla Guedes, Emilia Patricio, Marco G. Alves, Ruben Fernandes, Raquel Soares
Summary: The present study aims to investigate the impact of adipose tissue on metabolic impairment in breast cancer molecular subtypes. By exposing breast cancer cell lines representing different molecular subtypes to mature adipocyte secretome, distinct metabolic patterns were observed, with HER2+ cell lines showing similar metabolism compared to luminal A and triple negative cell lines, indicating molecular subtype-specific alterations in central metabolism.
Article
Cell Biology
Joao C. Ribeiro, Raquel L. L. Bernardino, Ana Goncalves, Alberto Barros, Giuseppe Calamita, Marco G. G. Alves, Pedro F. F. Oliveira
Summary: Osmoregulation is essential for sperm function, and aquaglyceroporins play a crucial role in glycerol permeability, which is important for sperm motility. AQP7 is especially significant in glycerol transport, and its impairment may lead to reduced sperm motility in asthenozoospermic individuals.
Article
Biochemistry & Molecular Biology
Joana L. Fernandes, Fatima O. Martins, Elena Olea, Jesus Prieto-Lloret, Patricia C. Braga, Joana F. Sacramento, Catarina O. Sequeira, Ana P. Negrinho, Sofia A. Pereira, Marco G. Alves, Asuncion Rocher, Silvia V. Conde
Summary: The association between obstructive sleep apnea (OSA) and metabolic disorders is well-established, but the underlying mechanisms remain unclear. This study investigated the role of liver dysfunction in the pathogenesis of OSA-related metabolic dysfunction. The results suggest that hepatic mitochondrial dysfunction and oxidative stress, leading to inflammation, may be significant factors contributing to the development of dysmetabolism associated with OSA.
Review
Biochemistry & Molecular Biology
Ruben Moreira, Ana D. Martins, Marco G. Alves, Maria de Lourdes Pereira, Pedro F. Oliveira
Summary: Low testosterone levels are a major cause of male infertility, and endocrine-disrupting chemicals such as chromium (Cr) can affect testicular steroidogenesis and male fertility. In particular, Cr(III) picolinate (CrPic(3)) has been found to inhibit enzymes involved in steroidogenesis and impact reactive oxygen species (ROS) levels, testosterone levels, and sperm motility and count. However, further research is needed to fully understand the effects of CrPic(3) on male fertility and ensure its safety for use by men.
Review
Biochemistry & Molecular Biology
Tiago Sousa, Paula I. Moreira, Susana Cardoso
Summary: Alzheimer's disease is a prevalent neurodegenerative disorder without an effective treatment. Dysfunction of mitochondria has been found in AD, and restoring their function may be a crucial strategy for tackling the disease.
Review
Nutrition & Dietetics
Mariana Santos-Pereira, Sara C. Pereira, Irene Rebelo, Maria A. Spadella, Pedro F. Oliveira, Marco G. Alves
Summary: Obesity has become a pressing concern in public health, with a rising prevalence of metabolic disorders. Obesity affects hormone regulation, chronic inflammation, and oxidative stress, and may be associated with the development of prostate cancer.