The mitochondrial uncoupler DNP triggers brain cell mTOR signaling network reprogramming and CREB pathway up-regulation
出版年份 2015 全文链接
标题
The mitochondrial uncoupler DNP triggers brain cell mTOR signaling network reprogramming and CREB pathway up-regulation
作者
关键词
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出版物
JOURNAL OF NEUROCHEMISTRY
Volume 134, Issue 4, Pages 677-692
出版商
Wiley
发表日期
2015-05-23
DOI
10.1111/jnc.13176
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- (2014) Margalit Goldgof et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2013) Evi M. Mercken et al. AGING CELL
- Higher activation of autophagy in skeletal muscle of mice during endurance exercise in the fasted state
- (2013) Cécile Jamart et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Reversal of Hypertriglyceridemia, Fatty Liver Disease, and Insulin Resistance by a Liver-Targeted Mitochondrial Uncoupler
- (2013) Rachel J. Perry et al. Cell Metabolism
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- (2013) Kenta Masui et al. Cell Metabolism
- Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies
- (2013) Claudia Manzoni et al. FASEB JOURNAL
- The control of brain mitochondrial energization by cytosolic calcium: The mitochondrial gas pedal
- (2013) Frank Norbert Gellerich et al. IUBMB LIFE
- mTOR is a key modulator of ageing and age-related disease
- (2013) Simon C. Johnson et al. NATURE
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- (2013) Jenq-Lin Yang et al. NEUROMOLECULAR MEDICINE
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- (2013) P. Sahin et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
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- (2013) Krisztina Marosi et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
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- (2013) Robert Meller et al. Translational Stroke Research
- Energy Intake and Exercise as Determinants of Brain Health and Vulnerability to Injury and Disease
- (2012) Mark P. Mattson Cell Metabolism
- Glucocorticoid receptors recruit the CaMKIIα-BDNF-CREB pathways to mediate memory consolidation
- (2012) Dillon Y Chen et al. NATURE NEUROSCIENCE
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- (2012) Kathleen J. Griffioen et al. NEUROBIOLOGY OF AGING
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- (2012) Aiwu Cheng et al. Nature Communications
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- (2012) Thomas D. Baird et al. Advances in Nutrition
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- (2011) Youngil Lee et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets
- (2011) Ken Inoki et al. Annual Review of Pharmacology and Toxicology
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- (2011) Rajat Singh et al. Cell Metabolism
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- (2011) Ryan C. Russell et al. DEVELOPMENT
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- (2011) Sei Yoshida et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2011) A. Suzuki et al. JOURNAL OF NEUROSCIENCE
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- (2011) I. Ramirez-Rangel et al. MOLECULAR AND CELLULAR BIOLOGY
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- (2011) Judith Y. Altarejos et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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- (2011) Ralph A. Nixon et al. NEUROBIOLOGY OF DISEASE
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- (2011) F. Zhang et al. NEUROSCIENCE
- Preventing NAD+ Depletion Protects Neurons against Excitotoxicity
- (2010) Dong Liu et al. Annals of the New York Academy of Sciences
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- (2010) Silvia Carloni et al. Autophagy
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- (2010) Chang Hwa Jung et al. FEBS LETTERS
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- (2010) C. Malagelada et al. JOURNAL OF NEUROSCIENCE
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- (2010) Marianne H. Larsen et al. JOURNAL OF PSYCHIATRIC RESEARCH
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- (2010) Shona A. Mookerjee et al. MECHANISMS OF AGEING AND DEVELOPMENT
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- (2010) Li Yu et al. NATURE
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- (2010) Yu-Hua Tseng et al. NATURE REVIEWS DRUG DISCOVERY
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- (2010) Richard J. Youle et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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- (2010) Patricia Spilman et al. PLoS One
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- (2010) Zhiyong Cheng et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
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- (2009) Thiruma V. Arumugam et al. ANNALS OF NEUROLOGY
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- (2009) Congcong He et al. Annual Review of Genetics
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- (2009) Jingxiang Huang et al. BIOCHEMICAL SOCIETY TRANSACTIONS
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- (2009) Suresh L Mehta et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
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