Formaldehyde‐Crosslinked Nontoxic Aβ Monomers to Form Toxic Aβ Dimers and Aggregates: Pathogenicity and Therapeutic Perspectives
出版年份 2021 全文链接
标题
Formaldehyde‐Crosslinked Nontoxic Aβ Monomers to Form Toxic Aβ Dimers and Aggregates: Pathogenicity and Therapeutic Perspectives
作者
关键词
-
出版物
ChemMedChem
Volume -, Issue -, Pages -
出版商
Wiley
发表日期
2021-08-16
DOI
10.1002/cmdc.202100428
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis
- (2021) Phuong H. Nguyen et al. CHEMICAL REVIEWS
- Drug Repositioning for Alzheimer’s Disease: Finding Hidden Clues in Old Drugs
- (2020) Masafumi Ihara et al. JOURNAL OF ALZHEIMERS DISEASE
- An RNA aptamer with potent affinity for a toxic dimer of amyloid β42 has potential utility for histochemical studies of Alzheimer’s disease
- (2020) Kazuma Murakami et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Impact of the Astaxanthin, Betanin and EGCG Compounds on Small Oligomers of the Amyloid Aβ40 Peptide
- (2020) Huynh Minh Hung et al. Journal of Chemical Information and Modeling
- Learning and memory impairment of mice caused by gaseous formaldehyde
- (2020) Fuhong Li et al. ENVIRONMENTAL RESEARCH
- Alzheimer’s Disease-Like Neurodegeneration in Porphyromonas gingivalis Infected Neurons with Persistent Expression of Active Gingipains
- (2020) Ursula Haditsch et al. JOURNAL OF ALZHEIMERS DISEASE
- X-ray Crystallography Reveals Parallel and Antiparallel β-Sheet Dimers of a β-Hairpin Derived from Aβ16–36 that Assemble to Form Different Tetramers
- (2020) Adam G. Kreutzer et al. ACS Chemical Neuroscience
- Brain‐targeted co‐delivery of β‐amyloid converting enzyme 1 shRNA and epigallocatechin‐3‐gallate by multifunctional nanocarriers for Alzheimer's disease treatment
- (2020) Lijie Lv et al. IUBMB LIFE
- Annexin A5 prevents amyloid-β-induced toxicity in choroid plexus: implication for Alzheimer’s disease
- (2020) Fernando Bartolome et al. Scientific Reports
- Structures of the intrinsically disordered Aβ, tau and α-synuclein proteins in aqueous solution from computer simulations
- (2020) Phuong H. Nguyen et al. BIOPHYSICAL CHEMISTRY
- Structural rearrangement of amyloid-β upon inhibitor binding suppresses formation of Alzheimer disease related oligomers
- (2020) Tobias Lieblein et al. eLife
- Late-onset vs nonmendelian early-onset Alzheimer disease
- (2020) Christiane Reitz et al. Neurology-Genetics
- The interaction of insoluble Amyloid‐β with soluble Amyloid‐β dimers decreases Amyloid‐β plaque numbers
- (2020) Else F. Gerresheim et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Formaldehyde induces ferroptosis in hippocampal neuronal cells by upregulation of the Warburg effect
- (2020) Xiao-Na Li et al. TOXICOLOGY
- Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors
- (2019) Stephen S. Dominy et al. Science Advances
- The anti‐prion RNA aptamer R12 disrupts the Alzheimer's disease‐related complex between prion and amyloid β
- (2019) Mamiko Iida et al. FEBS Journal
- Dual-drug loaded nanoparticles of Epigallocatechin-3-gallate (EGCG)/Ascorbic acid enhance therapeutic efficacy of EGCG in a APPswe/PS1dE9 Alzheimer's disease mice model
- (2019) Amanda Cano et al. JOURNAL OF CONTROLLED RELEASE
- Assessment of diets containing curcumin, epigallocatechin-3-gallate, docosahexaenoic acid and α-lipoic acid on amyloid load and inflammation in a male transgenic mouse model of Alzheimer's disease: Are combinations more effective?
- (2019) Matthew J. Sharman et al. NEUROBIOLOGY OF DISEASE
- Amyloid Beta and MicroRNAs in Alzheimer’s Disease
- (2019) Nnana Amakiri et al. Frontiers in Neuroscience
- Inhibition of the Self-Assembly of Aβ and of Tau by Polyphenols: Mechanistic Studies
- (2019) Qiuchen Zheng et al. MOLECULES
- An ultrasensitive electrochemical aptasensor for early diagnosis of Alzheimer’s disease, using a fern leaves-like gold nanostructure
- (2019) M. Negahdary et al. TALANTA
- A vicious cycle of β amyloid–dependent neuronal hyperactivation
- (2019) Benedikt Zott et al. SCIENCE
- Crossing the Blood-Brain Barrier: A Review on Drug Delivery Strategies for Treatment of the Central Nervous System Diseases
- (2019) Nur Izzati Mansor et al. Current Drug Delivery
- Copper, dityrosine cross-links and amyloid-β aggregation
- (2019) Guillem Vázquez et al. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- Super-Resolution Imaging of the Extracellular Space in Living Brain Tissue
- (2018) Jan Tønnesen et al. CELL
- Natural Polyphenols in the Treatment of Alzheimer’s Disease
- (2018) Syed-Badrul Syarifah-Noratiqah et al. CURRENT DRUG TARGETS
- Formaldehyde induces diabetes-associated cognitive impairments
- (2018) Tao Tan et al. FASEB JOURNAL
- Amyloid β fibrils assembled on ganglioside-enriched membranes contain both parallel β-sheets and turns
- (2018) Teruhiko Matsubara et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Systemic delivery of BACE1 siRNA through neuron-targeted nanocomplexes for treatment of Alzheimer's disease
- (2018) Pengzhen Wang et al. JOURNAL OF CONTROLLED RELEASE
- Protective roles of melatonin against the amyloid-dependent development of Alzheimer’s disease: A critical review
- (2018) Bruno Vincent PHARMACOLOGICAL RESEARCH
- On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations
- (2018) Xiaoting Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Association of Tea Consumption with Risk of Alzheimer’s Disease and Anti-Beta-Amyloid Effects of Tea
- (2018) Curt Polito et al. Nutrients
- Age-Dependent and Tissue-Related Glutathione Redox Status in a Mouse Model of Alzheimer's Disease
- (2018) Cheng Zhang et al. JOURNAL OF ALZHEIMERS DISEASE
- A Novel Mechanism for Endogenous Formaldehyde Elevation in SAMP8 Mouse
- (2018) Min Qiang et al. JOURNAL OF ALZHEIMERS DISEASE
- Copper Redox Cycling Inhibits Aβ Fibre Formation and Promotes Fibre Fragmentation, while Generating a Dityrosine Aβ Dimer
- (2018) Miao Gu et al. Scientific Reports
- EGCG Nanoparticles Attenuate Aluminum Chloride Induced Neurobehavioral Deficits, Beta Amyloid and Tau Pathology in a Rat Model of Alzheimer’s Disease
- (2018) Neha Atulkumar Singh et al. Frontiers in Aging Neuroscience
- Roles of reactive oxygen species and antioxidant enzymes on formaldehyde removal from air by plants
- (2018) Hanxiao Liang et al. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING
- Inhibitory Effect of Naphthoquinone-Tryptophan Hybrid towards Aggregation of PAP f39 Semen Amyloid
- (2018) Guru Viswanathan et al. MOLECULES
- Energy Fluctuations in Slowly Sheared Granular Materials
- (2018) Jie Zheng et al. PHYSICAL REVIEW LETTERS
- Identification of Circulating miR-125b as a Potential Biomarker of Alzheimer’s Disease in APP/PS1 Transgenic Mouse
- (2017) Honghai Hong et al. JOURNAL OF ALZHEIMERS DISEASE
- Ubisol-Q10 (a Nanomicellar Water-Soluble Formulation of CoQ10) Treatment Inhibits Alzheimer-Type Behavioral and Pathological Symptoms in a Double Transgenic Mouse (TgAPEswe, PSEN1dE9) Model of Alzheimer’s Disease
- (2017) Krithika Muthukumaran et al. JOURNAL OF ALZHEIMERS DISEASE
- Conformational Ensembles of the Wild-Type and S8C Aβ1–42 Dimers
- (2017) Viet Hoang Man et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Stabilization, Assembly, and Toxicity of Trimers Derived from Aβ
- (2017) Adam G. Kreutzer et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Alzheimer's disease and other dementias: update on research
- (2017) Lon Schneider LANCET NEUROLOGY
- Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism
- (2017) Guillermo Burgos-Barragan et al. NATURE
- The brain interstitial system: Anatomy, modeling, in vivo measurement, and applications
- (2017) Yiming Lei et al. PROGRESS IN NEUROBIOLOGY
- Structural Characterization of Amyloid β17-42 Dimer by Potential of Mean Force Analysis: Insights from Molecular Dynamics Simulations
- (2017) Mary Dutta et al. PROTEIN AND PEPTIDE LETTERS
- Acute formaldehyde exposure induced early Alzheimer-like changes in mouse brain
- (2017) Xudong Liu et al. TOXICOLOGY MECHANISMS AND METHODS
- Brain grants permission of access to Zika virus but denies entry to drugs: a molecular modeling perspective to infiltrate the boundary
- (2017) Nikita Devnarain et al. RSC Advances
- Acute formaldehyde exposure induced early Alzheimer-like changes in mouse brain
- (2017) Xudong Liu et al. TOXICOLOGY MECHANISMS AND METHODS
- APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases
- (2017) Hélène-Marie Lanoiselée et al. PLOS MEDICINE
- The efficacy of Epigallocatechin-3-gallate (green tea) in the treatment of Alzheimer’s disease: an overview of pre-clinical studies and translational perspectives in clinical practice
- (2017) Marco Cascella et al. Infectious Agents and Cancer
- Diabetes Mellitus and Alzheimer’s Disease: The Protection of Epigallocatechin-3-gallate in Streptozotocin Injection-Induced Models
- (2017) Jin-Jing Jia et al. Frontiers in Pharmacology
- Anti-Amyloid-β Immunotherapy in Alzheimer's Disease: Relevance of Transgenic Mouse Studies to Clinical Trials
- (2017) Donna M. Wilcock et al. JOURNAL OF ALZHEIMERS DISEASE
- Impact of the A2V Mutation on the Heterozygous and Homozygous Aβ1–40 Dimer Structures from Atomistic Simulations
- (2016) Phuong H. Nguyen et al. ACS Chemical Neuroscience
- Alzheimer’s Protective Cross-Interaction between Wild-Type and A2T Variants Alters Aβ42 Dimer Structure
- (2016) Payel Das et al. ACS Chemical Neuroscience
- Development of a Two-Photon Fluorescent Probe for Imaging of Endogenous Formaldehyde in Living Tissues
- (2016) Yonghe Tang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Histidine-Rich Oligopeptides To Lessen Copper-Mediated Amyloid-β Toxicity
- (2016) Ana B. Caballero et al. CHEMISTRY-A EUROPEAN JOURNAL
- Metal chelation, radical scavenging and inhibition of Aβ42 fibrillation by food constituents in relation to Alzheimer’s disease
- (2016) Stephen Chan et al. FOOD CHEMISTRY
- Urine Formaldehyde Predicts Cognitive Impairment in Post-Stroke Dementia and Alzheimer’s Disease
- (2016) Zhiqian Tong et al. JOURNAL OF ALZHEIMERS DISEASE
- Dimerization Mechanism of Alzheimer Aβ40 Peptides: The High Content of Intrapeptide-Stabilized Conformations in A2V and A2T Heterozygous Dimers Retards Amyloid Fibril Formation
- (2016) Phuong H. Nguyen et al. JOURNAL OF PHYSICAL CHEMISTRY B
- X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an Aβ17–36 β-Hairpin
- (2016) Adam G. Kreutzer et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils
- (2016) Michael T. Colvin et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Demethylation of methylmercury and the enhanced production of formaldehyde in mouse liver
- (2016) Takuya Uchikawa et al. JOURNAL OF TOXICOLOGICAL SCIENCES
- Quercetin Exerts Differential Neuroprotective Effects Against H2O2 and Aβ Aggregates in Hippocampal Neurons: the Role of Mitochondria
- (2016) Juan A. Godoy et al. MOLECULAR NEUROBIOLOGY
- The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction
- (2016) Nazanin Hoshyar et al. Nanomedicine
- Single-nanotube tracking reveals the nanoscale organization of the extracellular space in the live brain
- (2016) Antoine G. Godin et al. Nature Nanotechnology
- Reduction of Endogenous Melatonin Accelerates Cognitive Decline in Mice in a Simulated Occupational Formaldehyde Exposure Environment
- (2016) Yufei Mei et al. International Journal of Environmental Research and Public Health
- Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer’s disease
- (2015) Yang Xiang et al. ACTA NEUROPATHOLOGICA
- Aging-associated formaldehyde-induced norepinephrine deficiency contributes to age-related memory decline
- (2015) Yufei Mei et al. AGING CELL
- Role of monomer arrangement in the amyloid self-assembly
- (2015) Alexander Portillo et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity
- (2015) Andreas Müller-Schiffmann et al. BRAIN
- Emerging drug targets for Aβand tau in Alzheimer's disease: a systematic review
- (2015) Sophie West et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Effects of formaldehyde on mitochondrial dysfunction and apoptosis in SK-N-SH neuroblastoma cells
- (2015) Tamanna Zerin et al. CELL BIOLOGY AND TOXICOLOGY
- Combined Experimental and Simulation Studies Suggest a Revised Mode of Action of the Anti-Alzheimer Disease Drug NQ-Trp
- (2015) Olivia Berthoumieu et al. CHEMISTRY-A EUROPEAN JOURNAL
- (−)-Epigallocatechin-3-gallate attenuates cognitive deterioration in Alzheimer׳s disease model mice by upregulating neprilysin expression
- (2015) Xiang Chang et al. EXPERIMENTAL CELL RESEARCH
- Formaldehyde exposure alters miRNA expression profiles in the olfactory bulb
- (2015) Guifa Li et al. INHALATION TOXICOLOGY
- Development of an Anti-Vascular Cell Adhesion Protein-1 Aptamer for Molecular Imaging and Inflammation Detection in Transgenic
- (2015) Teresa Simao et al. Journal of Biomedical Nanotechnology
- Antiparallel β-Sheet Structure within the C-Terminal Region of 42-Residue Alzheimer's Amyloid-β Peptides When They Form 150-kDa Oligomers
- (2015) Danting Huang et al. JOURNAL OF MOLECULAR BIOLOGY
- Job-related formaldehyde exposure and ALS mortality in the USA: Table 1
- (2015) Andrea L Roberts et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Therapeutic role of curcumin in oxidative DNA damage caused by formaldehyde
- (2015) Gulay Ciftci et al. MICROSCOPY RESEARCH AND TECHNIQUE
- Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen
- (2015) Lucas B. Pontel et al. MOLECULAR CELL
- Age-related hearing impairment—a risk factor and frailty marker for dementia and AD
- (2015) Francesco Panza et al. Nature Reviews Neurology
- Inhibition of BACE1 Activity by a DNA Aptamer in an Alzheimer’s Disease Cell Model
- (2015) Huiyu Liang et al. PLoS One
- Peptide dimer structure in an Aβ(1–42) fibril visualized with cryo-EM
- (2015) Matthias Schmidt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Fluorogenic Resveratrol-Confined Graphene Oxide For Economic and Rapid Detection Of Alzheimer’s Disease
- (2014) Xiao-Peng He et al. ACS Applied Materials & Interfaces
- Early-Onset Familial Alzheimer's Disease (EOFAD)
- (2014) Liyong Wu et al. CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
- Differences between amyloid-β aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease
- (2014) Samuel A. Kotler et al. CHEMICAL SOCIETY REVIEWS
- The Peculiar Role of the A2V Mutation in Amyloid-β (Aβ) 1–42 Molecular Assembly
- (2014) Massimo Messa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Alzheimer Disease Protective Mutation A2T Modulates Kinetic and Thermodynamic Properties of Amyloid-β (Aβ) Aggregation
- (2014) Iryna Benilova et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Self-assembled nanocomplexes of anionic pullulan and polyallylamine for DNA and pH-sensitive intracellular drug delivery
- (2014) Lalit Vora et al. JOURNAL OF NANOPARTICLE RESEARCH
- Phosphorylation of Ser8 promotes zinc-induced dimerization of the amyloid-β metal-binding domain
- (2014) Alexandra A. Kulikova et al. Molecular BioSystems
- Gold nanoparticles for photothermally controlled drug release
- (2014) Ariel R Guerrero et al. Nanomedicine
- Soluble Aβ Oligomers Are Rapidly Sequestered from Brain ISF In Vivo and Bind GM1 Ganglioside on Cellular Membranes
- (2014) Soyon Hong et al. NEURON
- Uric formaldehyde levels are negatively correlated with cognitive abilities in healthy older adults
- (2014) Jing Yu et al. Neuroscience Bulletin
- Amyloid-β and Tau
- (2014) George S. Bloom JAMA Neurology
- Stem Cells on Biomaterials for Synthetic Grafts to Promote Vascular Healing
- (2014) Patrick Babczyk et al. Journal of Clinical Medicine
- Atomic and Dynamic Insights into the Beneficial Effect of the 1,4-Naphthoquinon-2-yl-l-tryptophan Inhibitor on Alzheimer’s Aβ1–42 Dimer in Terms of Aggregation and Toxicity
- (2013) Tong Zhang et al. ACS Chemical Neuroscience
- Oligomers, fact or artefact? SDS-PAGE induces dimerization of β-amyloid in human brain samples
- (2013) Andrew D. Watt et al. ACTA NEUROPATHOLOGICA
- Formaldehyde induces hyperphosphorylation and polymerization of Tau protein both in vitro and in vivo
- (2013) Jing Lu et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Brain amyloid-β oligomers in ageing and Alzheimer’s disease
- (2013) Sylvain E. Lesné et al. BRAIN
- Nucleic Acid Aptamers as Novel Class of Therapeutics to Mitigate Alzheimer’s Disease Pathology
- (2013) Rudi K. Tannenberg et al. Current Alzheimer Research
- Formaldehyde and Epigenetic Alterations: MicroRNA Changes in the Nasal Epithelium of Nonhuman Primates
- (2013) Julia E. Rager et al. ENVIRONMENTAL HEALTH PERSPECTIVES
- Aggravation of atopic dermatitis-like symptoms by consecutive low concentration of formaldehyde exposure in NC/Nga mice
- (2013) Ji-Yun Kim et al. EXPERIMENTAL DERMATOLOGY
- Formaldehyde metabolism and formaldehyde-induced stimulation of lactate production and glutathione export in cultured neurons
- (2013) Ketki Tulpule et al. JOURNAL OF NEUROCHEMISTRY
- Molecular Mechanism of the Inhibition of EGCG on the Alzheimer Aβ1–42 Dimer
- (2013) Tong Zhang et al. JOURNAL OF PHYSICAL CHEMISTRY B
- A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease
- (2013) Rachelle S. Doody et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Novel Retro-Inverso Peptide Inhibitor Reduces Amyloid Deposition, Oxidation and Inflammation and Stimulates Neurogenesis in the APPswe/PS1ΔE9 Mouse Model of Alzheimer’s Disease
- (2013) Vadivel Parthsarathy et al. PLoS One
- Lysine-Specific Demethylase 1 in Breast Cancer Cells Contributes to the Production of Endogenous Formaldehyde in the Metastatic Bone Cancer Pain Model of Rats
- (2013) Jia Liu et al. PLoS One
- Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid- species
- (2013) S.-J. Hyung et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sleep Drives Metabolite Clearance from the Adult Brain
- (2013) L. Xie et al. SCIENCE
- Aging-associated excess formaldehyde leads to spatial memory deficits
- (2013) Zhiqian Tong et al. Scientific Reports
- Correlation of Specific Amyloid-β Oligomers With Tau in Cerebrospinal Fluid From Cognitively Normal Older Adults
- (2013) Maureen Handoko et al. JAMA Neurology
- Comparison of Three Amyloid Assembly Inhibitors: The Sugar scyllo-Inositol, the Polyphenol Epigallocatechin Gallate, and the Molecular Tweezer CLR01
- (2012) Sharmistha Sinha et al. ACS Chemical Neuroscience
- Accumulated hippocampal formaldehyde induces age-dependent memory decline
- (2012) Zhiqian Tong et al. AGE
- The Elevated Copper Binding Strength of Amyloid-β Aggregates Allows the Sequestration of Copper from Albumin: A Pathway to Accumulation of Copper in Senile Plaques
- (2012) Dianlu Jiang et al. BIOCHEMISTRY
- Distinct Dimerization for Various Alloforms of the Amyloid-Beta Protein: Aβ1–40, Aβ1–42, and Aβ1–40(D23N)
- (2012) Sébastien Côté et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Aggregation, impaired degradation and immunization targeting of amyloid-beta dimers in Alzheimer’s disease: a stochastic modelling approach
- (2012) Carole J Proctor et al. Molecular Neurodegeneration
- Formation of Aldehyde and Ketone Compounds during Production and Storage of Milk Powder
- (2012) Yanhua Li et al. MOLECULES
- Drug repositioning for Alzheimer's disease
- (2012) Anne Corbett et al. NATURE REVIEWS DRUG DISCOVERY
- Naphthoquinone-tyrptophan reduces neurotoxic Aβ*56 levels and improves cognition in Alzheimer's disease animal model
- (2012) R. Scherzer-Attali et al. NEUROBIOLOGY OF DISEASE
- Postoperative Cognitive Dysfunction is Correlated with Urine Formaldehyde in Elderly Noncardiac Surgical Patients
- (2012) Jiawan Wang et al. NEUROCHEMICAL RESEARCH
- Amyloid-β Peptide Binds to Cytochrome C Oxidase Subunit 1
- (2012) Luis Fernando Hernandez-Zimbron et al. PLoS One
- Human Anti-Aβ IgGs Target Conformational Epitopes on Synthetic Dimer Assemblies and the AD Brain-Derived Peptide
- (2012) Alfred T. Welzel et al. PLoS One
- Molecular Engineering of a Secreted, Highly Homogeneous, and Neurotoxic Aβ Dimer
- (2011) Andreas Müller-Schiffmann et al. ACS Chemical Neuroscience
- The presence of Aβ seeds, and not age per se, is critical to the initiation of Aβ deposition in the brain
- (2011) Tsuyoshi Hamaguchi et al. ACTA NEUROPATHOLOGICA
- Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β′-site increases Aβ generation
- (2011) Lujia Zhou et al. EMBO Molecular Medicine
- Amyloid-β Annular Protofibrils Evade Fibrillar Fate in Alzheimer Disease Brain
- (2011) Cristian A. Lasagna-Reeves et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Functions of Aβ, sAPPα and sAPPβ : similarities and differences
- (2011) Stéphanie Chasseigneaux et al. JOURNAL OF NEUROCHEMISTRY
- Soluble Aβ oligomer production and toxicity
- (2011) Megan E. Larson et al. JOURNAL OF NEUROCHEMISTRY
- A monoclonal antibody against synthetic Aβ dimer assemblies neutralizes brain-derived synaptic plasticity-disrupting Aβ
- (2011) Brian O’Nuallain et al. JOURNAL OF NEUROCHEMISTRY
- Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins
- (2011) Sharmistha Sinha et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Long-term oral intake of aluminium or zinc does not accelerate Alzheimer pathology in AβPP and AβPP/tau transgenic mice
- (2011) Haruhiko Akiyama et al. NEUROPATHOLOGY
- Novel demonstration of amyloid-β oligomers in sporadic inclusion-body myositis muscle fibers
- (2010) Anna Nogalska et al. ACTA NEUROPATHOLOGICA
- Development of a Proteolytically Stable Retro-Inverso Peptide Inhibitor of β-Amyloid Oligomerization as a Potential Novel Treatment for Alzheimer’s Disease
- (2010) Mark Taylor et al. BIOCHEMISTRY
- Aβ(1–40) Forms Five Distinct Amyloid Structures whose β-Sheet Contents and Fibril Stabilities Are Correlated
- (2010) Ravindra Kodali et al. JOURNAL OF MOLECULAR BIOLOGY
- Alzheimer's disease: clinical trials and drug development
- (2010) Francesca Mangialasche et al. LANCET NEUROLOGY
- Alzheimer's disease: strategies for disease modification
- (2010) Martin Citron NATURE REVIEWS DRUG DISCOVERY
- Structural conversion of neurotoxic amyloid-β1–42 oligomers to fibrils
- (2010) Mahiuddin Ahmed et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Tumor Tissue-Derived Formaldehyde and Acidic Microenvironment Synergistically Induce Bone Cancer Pain
- (2010) Zhiqian Tong et al. PLoS One
- Complete Phenotypic Recovery of an Alzheimer's Disease Model by a Quinone-Tryptophan Hybrid Aggregation Inhibitor
- (2010) Roni Scherzer-Attali et al. PLoS One
- Structural Characterization of a Soluble Amyloid β-Peptide Oligomer
- (2009) Liping Yu et al. BIOCHEMISTRY
- A liposome-based nanostructure for aptamer directed delivery
- (2009) Huaizhi Kang et al. CHEMICAL COMMUNICATIONS
- The Cu(II)/Aβ/Human Serum Albumin Model of Control Mechanism for Copper-Related Amyloid Neurotoxicity
- (2009) Małgorzata Rózga et al. CHEMICAL RESEARCH IN TOXICOLOGY
- The chemistry of Alzheimer’s disease
- (2009) Arvi Rauk CHEMICAL SOCIETY REVIEWS
- Cellular pathways for DNA repair and damage tolerance of formaldehyde-induced DNA-protein crosslinks
- (2009) Bendert de Graaf et al. DNA REPAIR
- Tau-directed drug discovery for Alzheimer's disease and related tauopathies: A focus on tau assembly inhibitors
- (2009) Kurt R. Brunden et al. EXPERIMENTAL NEUROLOGY
- Development of semagacestat (LY450139), a functional γ-secretase inhibitor, for the treatment of Alzheimer's disease
- (2009) David B Henley et al. EXPERT OPINION ON PHARMACOTHERAPY
- Synaptic Activity Reduces Intraneuronal A , Promotes APP Transport to Synapses, and Protects against A -Related Synaptic Alterations
- (2009) D. Tampellini et al. JOURNAL OF NEUROSCIENCE
- Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease
- (2009) Summer L. Bernstein et al. Nature Chemistry
- Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies
- (2009) Kurt R. Brunden et al. NATURE REVIEWS DRUG DISCOVERY
- Urine formaldehyde level is inversely correlated to mini mental state examination scores in senile dementia
- (2009) Zhiqian Tong et al. NEUROBIOLOGY OF AGING
- Small molecule blockers of the Alzheimer A calcium channel potently protect neurons from A cytotoxicity
- (2009) J. C. Diaz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations
- (2009) Marc Fisher et al. STROKE
- P2-375: Efficacy of the novel γ-secretase inhibitor, PF-3084014, in reducing Aβ in brain, CSF, and plasma in guinea pigs and Tg2576 mice
- (2008) Kathleen M. Wood et al. Alzheimers & Dementia
- 2008 Alzheimer’s disease facts and figures
- (2008) Alzheimers & Dementia
- Mass spectrometric identification of formaldehyde-induced peptide modifications under in vivo protein cross-linking conditions
- (2008) Judy Toews et al. ANALYTICA CHIMICA ACTA
- Designing Peptide Inhibitors for Oligomerization and Toxicity of Alzheimer's β-Amyloid Peptide†
- (2008) Brian M. Austen et al. BIOCHEMISTRY
- SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Aβ-Degrading Enzymes in Alzheimer's Disease
- (2008) James Scott Miners et al. BRAIN PATHOLOGY
- Effect of inhaled formaldehyde on learning and memory of mice
- (2008) Z. Lu et al. INDOOR AIR
- Effects of Familial Alzheimer’s Disease Mutations on the Folding Nucleation of the Amyloid β-Protein
- (2008) Mary Griffin Krone et al. JOURNAL OF MOLECULAR BIOLOGY
- Amyloid- Peptide (A ) Neurotoxicity Is Modulated by the Rate of Peptide Aggregation: A Dimers and Trimers Correlate with Neurotoxicity
- (2008) L. W. Hung et al. JOURNAL OF NEUROSCIENCE
- Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
- (2008) Ganesh M Shankar et al. NATURE MEDICINE
- Oxidation of proteins: Basic principles and perspectives for blood proteomics
- (2008) Stefano Barelli et al. Proteomics Clinical Applications
- Amyloid- Dynamics Correlate with Neurological Status in the Injured Human Brain
- (2008) D. L. Brody et al. SCIENCE
- Characterization of Copper Interactions with Alzheimer Amyloid β Peptides
- (2003) Craig S. Atwood et al. JOURNAL OF NEUROCHEMISTRY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started