Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β′-site increases Aβ generation

Novel Research Horizons for Presenilins and γ-Secretases in Cell Biology and Disease

(2010) Bart De Strooper et al.   Annual Review of Cell and Developmental Biology

Effects of the English (H6R) and Tottori (D7N) Familial Alzheimer Disease Mutations on Amyloid β-Protein Assembly and Toxicity

(2010) Kenjiro Ono et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An APP inhibitory domain containing the Flemish mutation residue modulates γ-secretase activity for Aβ production

(2010) Yuan Tian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Towards a complete resolution of the genetic architecture of disease

(2010) Andrew B. Singleton et al.   TRENDS IN GENETICS

Synaptic NMDA Receptor Activation Stimulates  -Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid-  Production

(2009) S. E. Hoey et al.   JOURNAL OF NEUROSCIENCE

 -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of  -Carboxyl Terminal Fragment

(2009) M. Takami et al.   JOURNAL OF NEUROSCIENCE

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

A Recessive Mutation in the APP Gene with Dominant-Negative Effect on Amyloidogenesis

(2009) G. Di Fede et al.   SCIENCE

Molecular genetics of Alzheimer's disease: An update

(2008) Nathalie Brouwers et al.   ANNALS OF MEDICINE

A new amyloid β variant favoring oligomerization in Alzheimer's-type dementia

(2008) Takami Tomiyama et al.   ANNALS OF NEUROLOGY

Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP

(2008) Rita Joao Guerreiro et al.   NEUROBIOLOGY OF AGING

Aggregation and catabolism of disease-associated intra-Aβ mutations: reduced proteolysis of AβA21G by neprilysin

(2008) Vicki Betts et al.   NEUROBIOLOGY OF DISEASE