Article
Chemistry, Multidisciplinary
Xin Chen, Santosh Pandit, Lei Shi, Vaishnavi Ravikumar, Julie Bonne Kohler, Ema Svetlicic, Zhejian Cao, Abhroop Garg, Dina Petranovic, Ivan Mijakovic
Summary: Alzheimer's disease is a common neurodegenerative disease characterized by the aggregation of misfolded amyloid-beta peptides in the brain. Graphene oxide nanoflakes have been found to effectively inhibit A beta aggregation in vitro. In this study using yeast as a model, it is shown that graphene oxide can penetrate yeast cells and reduce A beta 42 toxicity. The findings provide insights for designing graphene oxide-based therapies for attenuating cytotoxicity of A beta 42 and other misfolded proteins involved in neurodegenerative pathology.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Ratnakar Jadhav, Yogesh A. Kulkarni
Summary: Recent evidences suggest a rise in global cases of dementia, with Alzheimer's disease being the leading cause. Quercetin, a flavonoid, has shown potential therapeutic benefits including neuroprotective effects. This study evaluates the neuroprotective effect of orally administered quercetin with memantine in albino Wistar rats after induction of neurotoxicity. The results demonstrate that the treatment of quercetin with memantine improves behavioral parameters, reduces oxidative stress, inhibits amyloid-beta plaque formation, and enhances the expression of brain-derived neurotrophic factor (BDNF).
Review
Biochemistry & Molecular Biology
Elena Tamagno, Michela Guglielmotto, Valeria Vasciaveo, Massimo Tabaton
Summary: The pathogenesis of Alzheimer's disease involves the accumulation of beta amyloid and vulnerability of the brain to oxidative stress, which are linked to each other. It is difficult to determine which comes first, Aβ or oxidative stress. Evidence suggests that oxidative stress occurs early in the development of Alzheimer's disease and plays a crucial role in the manifestation of clinical and pathological symptoms.
Article
Immunology
Liu Yang, Huimin Zhou, Lei Huang, Yong Su, Liangliang Kong, Pengmin Ji, Ran Sun, Chao Wang, Weiping Li, Weizu Li
Summary: Chronic glucocorticoid exposure can accelerate neuronal damage and beta-amyloid production by activating oxidative stress and NLRP1 inflammasome, leading to the deterioration of Alzheimer's disease. Inhibition of NLRP1 inflammasome may be an important strategy in improving chronic glucocorticoid-induced neuronal injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Chia-Ling Ho, Ning-Jo Kao, Ching- Lin, Tzu-Wen L. Cross, Shyh-Hsiang Lin
Summary: Alzheimer's disease is a common neurodegenerative disorder, with oxidative stress and mitochondrial biogenesis being implicated in its progression. Quercetin has been found to increase mitochondrial biogenesis and reduce oxidative stress-induced damage, showing promise in protecting neuronal cells.
Review
Biochemistry & Molecular Biology
Vyshnavy Balendra, Sandeep Kumar Singh
Summary: Oxidative stress leads to neurotoxic protein accumulation in AD, while antioxidants like SOD and AST can prevent cognitive decline and reduce plaque burden in mice.
Article
Neurosciences
Alejandro Ruiz-Riquelme, Alison Mao, Marim M. Barghash, Heather H. C. Lau, Erica Stuart, Gabor G. Kovacs, K. Peter R. Nilsson, Paul E. Fraser, Gerold Schmitt-Ulms, Joel C. Watts
Summary: Aggregates containing longer Aβ C-terminal variants are more potent inducers of cerebral Aβ deposition. Aβ43 seeds may play a crucial role in the initial stages of Aβ pathology in AD.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Immunology
Yan Gao, Juntong Li, Qinglin Wu, Shasha Wang, Songwei Yang, Xun Li, Naihong Chen, Lin Li, Lan Zhang
Summary: TSG effectively alleviated Aβ-induced cytotoxicity in neuronal cells within APP/PS1 mice by regulating ferroptosis related proteins and enzymes, promoting activation of several antioxidative pathways, and reducing oxidative stress and inflammation levels. These findings highlight a novel mechanism of TSG in reversing Aβ-induced injury, suggesting its potential as a promising candidate in the treatment of neurodegenerative diseases, especially AD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nouf K. Alaqeel, Mona H. AlSheikh, Mohammed T. Al-Hariri
Summary: The present study evaluates the role of quercetin nanoemulsion (QCNE) in attenuating neuronal dysfunction in aluminum chloride-induced Alzheimer's disease (AD). The results show that QCNE can reduce oxidative stress and inflammation, increase neurotransmitter levels, and potentially protect against aluminum-induced neurotoxicity.
Article
Medicine, Research & Experimental
Juliet Olayinka, Anthony Eduviere, Olusegun Adeoluwa, Adedamola Fafure, Adeshina Adebanjo, Raymond Ozolua
Summary: Quercetin has significant effects against memory impairment induced by scopolamine, attenuating increases in pro-inflammatory mediators and reversing neurodegeneration to restore memory function.
Article
Biochemistry & Molecular Biology
Silvia De Caro, Giulia De Soricellis, Simone Dell'Acqua, Enrico Monzani, Stefania Nicolis
Summary: Both beta-amyloid peptides and oxidative stress are important factors in Alzheimer's disease. Hemin, which has redox properties, contributes to the disease's development and its level increases in pathological conditions and traumatic brain injuries. This study aimed to investigate the reactivity of the hemin-beta-amyloid(16) complex and found that it can catalyze oxidation and nitration reactions. The results showed that the complex binds negatively charged substrates with higher affinity and the tyrosine residue is the target of nitration. The study also found that hemin degradation is partly prevented by the coordinated peptide.
Article
Environmental Sciences
Diogo Ferreira Bicca, Cristiano Chiapinotto Spiazzi, Juliana Bernera Ramalho, Melina Bucco Soares, Francielli Weber Santos Cibin
Summary: The study revealed that subchronic low dose of GBH could affect behavior and oxidative stress in mouse hippocampus. Quercetin treatment partly or fully improved these effects, but caution is needed regarding the potential independent effects of continuous quercetin supplementation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Sanchaita Mondal, Sujata Das, Pradip Kumar Mahapatra, Krishna Das Saha
Summary: In this study, we investigated the effectiveness of morin encapsulated chitosan nanoparticles (MCNPs) against arsenic induced liver damage in mice. The results showed that MCNPs significantly reduced the liver function indicators, improved hematological and serum biochemical parameters, and decreased arsenic deposition in mice treated with arsenic. In addition, MCNPs demonstrated antioxidant, antiapoptotic, and anti-inflammatory effects.
NANOSCALE ADVANCES
(2022)
Review
Food Science & Technology
Wenli Ruan, Shuoheng Shen, Yang Xu, Na Ran, Heng Zhang
Summary: As the global population ages, more patients are diagnosed with neurodegenerative diseases, for which curative drugs or treatments are still lacking. Procyanidins, found in plants like grapes, blackberries, and hawthorn leaves, show potential protective roles in reducing oxidative stress, inhibiting neuroinflammation, and decreasing abnormal protein aggregation in Alzheimer's disease, highlighting a promising new therapeutic strategy for neurodegenerative diseases.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Review
Biochemistry & Molecular Biology
Laura Gomez-Virgilio, Alejandro Luarte, Daniela P. Ponce, Barbara A. Bruna, Maria Behrens
Summary: Among the proposed pathogenic mechanisms for Alzheimer's disease, increased oxidative stress appears to be a robust and early feature. Utilizing patient-derived peripheral cells may provide a more biologically relevant model for studying the disease. Analyzing olfactory neuronal precursors isolated non-invasively through NADH FLIM has the potential to reveal AD-related oxidative stress and accelerate the discovery of effective antioxidant therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Rodrigo G. Mira, Waldo Cerpa
Summary: Glutamate, as a major excitatory neurotransmitter in the brain, is involved in synaptic plasticity and excitotoxicity through NMDAR receptors. Mitochondria also play a crucial role in calcium homeostasis, and disruption of this homeostasis can lead to neuronal death.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Neurosciences
Claudia Jara, Waldo Cerpa, Cheril Tapia-Rojas, Rodrigo A. Quintanilla
Summary: Aging is a primary risk factor for neurodegenerative diseases, such as Alzheimer's disease, with mitochondrial dysfunction and tau protein playing crucial roles in memory decline. The absence of tau can prevent age-related cognitive impairment and improve mitochondrial function through a CypD-dependent mechanism, indicating a potential therapeutic target for aging and AD.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Sergio Linsambarth, Francisco J. Carvajal, Rodrigo Moraga-Amaro, Luis Mendez, Giovanni Tamburini, Ivanka Jimenez, Daniel Antonio Verdugo, Gonzalo Gomez, Nur Jury, Pablo Martinez, Brigitte van Zundert, Lorena Varela-Nallar, Mauricio A. Retamal, Claire Martin, Guillermo A. Altenberg, Mariana C. Fiori, Waldo Cerpa, Juan A. Orellana, Jimmy Stehberg
Summary: Astrocytes release glutamate and D-serine through Cx43 hemichannels to modulate synaptic activity, which is crucial for fear memory consolidation.
Article
Biochemistry & Molecular Biology
Sheyla Guzman-Salas, Andre Weber, Ayse Malci, Xiao Lin, Rodrigo Herrera-Molina, Waldo Cerpa, Cristina Dorador, Janetti Signorelli, Pedro Zamorano
Summary: Autism spectrum disorder (ASD) is a neurodevelopment disorder caused by various genetic and/or environmental factors. Recent studies have shown that increased levels of p-cresol, which is related to dysbiosis of the intestinal microbiota, are present in some ASD patients. This study found that p-cresol inhibits neurite outgrowth, alters dendritic morphology and synaptic density, and affects neuronal activity and calcium responses in cultured neurons, suggesting a potential role of p-cresol in the neuronal alterations seen in ASD.
JOURNAL OF NEUROCHEMISTRY
(2022)
Review
Psychology, Clinical
Constanza Caceres-Ayala, Ricardo M. Pautassi, Maria Jose Acuna, Waldo Cerpa, Daniela L. Rebolledo
Summary: Alcohol consumption has negative effects on skeletal muscle function and structure, especially in the case of binge drinking. Men are more affected than women. Alcohol can impair muscle recovery after exercise, potentially through an imbalance between anabolic and catabolic pathways, reduced regeneration, increased inflammation and fibrosis, and deficiencies in energy balance and mitochondrial function.
AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
(2022)
Article
Biochemistry & Molecular Biology
Francisca Villavicencio-Tejo, Margrethe A. Olesen, Alejandra Aranguiz, Rodrigo A. Quintanilla
Summary: Alzheimer's disease is characterized by memory and cognitive impairment, with the accumulation of amyloid beta-peptide and the presence of pathological forms of tau protein. Activation of the Nrf2 pathway has been found to protect against mitochondrial injury induced by pathological tau protein.
Review
Neurosciences
Margrethe A. Olesen, Francisca Villavicencio-Tejo, Rodrigo A. Quintanilla
Summary: Neurological disorders such as Alzheimer's disease and Parkinson's disease share common neuropathological signs, particularly mitochondrial abnormalities. Skin fibroblasts have been proposed as a useful tool to study early mitochondrial dysfunction in these diseases.
TRANSLATIONAL NEURODEGENERATION
(2022)
Review
Biochemistry & Molecular Biology
Paloma P. Maldonado, Coram Guevara, Margrethe A. Olesen, Juan Andres Orellana, Rodrigo A. Quintanilla, Fernando C. Ortiz
Summary: This article discusses the role of mitochondrial dysfunction in the progression of multiple sclerosis (MS), focusing on the potential role of Nrf2 signaling in neuroinflammation and neurodegeneration. The authors propose that Nrf2 dysfunction affects the bioenergetics, antioxidant defense, and energy supply provided by glial cells to neurons.
Review
Biochemistry & Molecular Biology
Christian Bonansco, Waldo Cerpa, Nibaldo C. C. Inestrosa
Summary: Synaptic transmission requires precise regulation, and Wnt signaling has been implicated in various forms of synaptic plasticity. Understanding the functional role of cellular signaling pathways involved in brain development is possible through the analysis of synapses from an electrophysiological perspective. The application of quantal theory can help dissect the function of structural changes associated with the birth and maturation of synapses. This article focuses on the role of the Wnt signaling pathway in regulating glutamatergic synaptic transmission and the conversion of silent synapses into functional synapses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Constanza Caceres-Ayala, Rodrigo G. Mira, Maria Jose Acuna, Enrique Brandan, Waldo Cerpa, Daniela L. Rebolledo
Summary: Binge drinking has negative effects on skeletal muscle function, leading to decreased strength, increased fatigability, muscle atrophy, fibrosis, and inflammation. These effects can persist for at least two weeks after alcohol clearance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Francisca J. Allendes, Hugo S. Diaz, Fernando C. Ortiz, Noah J. Marcus, Rodrigo Quintanilla, Nibaldo C. Inestrosa, Rodrigo Del Rio
Summary: A significant number of COVID-19 survivors experience long-lasting cardiovascular sequelae associated with autonomic nervous system dysfunction, such as fatigue, arrhythmias, and hypertension. It is crucial to develop strategies for diagnosing and managing long-term health problems (long-COVID) due to the potential burden it can impose. Cardiovascular rehabilitation programs (CRPs) have shown promise in improving patient outcomes, and their application in treating the cardiovascular sequelae of long-COVID holds potential for enhancing functional capacity and quality of life.
FRONTIERS IN MEDICINE
(2023)
Article
Neurosciences
Margrethe A. Olesen, Rodrigo A. Quintanilla
Summary: Tau protein is involved in various important functions in the central nervous system, such as maintaining cellular structure, facilitating axonal transport, and promoting synaptic communication. Studies have focused on understanding the role of tau modifications in Alzheimer's disease, particularly the cleavage of tau by caspases and its impact on neuronal function. Cleaved tau has been shown to contribute to oxidative damage, cognitive decline, and neurodegenerative manifestations in Alzheimer's disease. This review explores the significance of caspase-cleaved tau in the pathogenesis of Alzheimer's disease and its detrimental effects on neuronal function.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rodrigo G. Mira, Rodrigo A. Quintanilla, Waldo Cerpa
Summary: Traumatic brain injury (TBI) is brain damage caused by external forces. Mild TBI (mTBI) is the most common type of TBI and repeated mTBI increases the risk of neurodegenerative diseases. This study evaluated mitochondrial calcium dynamics in an mTBI mouse model using isolated hippocampal mitochondria. The findings showed that mTBI results in decreased mitochondrial membrane potential, increased basal matrix calcium levels, and increased NCLX protein levels.
Article
Biochemistry & Molecular Biology
Maria Jose Perez, Rodrigo Ibarra-Garcia-Padilla, Maoping Tang, George A. Porter Jr, Gail V. W. Johnson, Rodrigo A. Quintanilla
Summary: The cleavage of tau protein by Caspase-3 negatively affects mitochondrial bioenergetics through the activation of mitochondrial permeability transition pore (mPTP), emphasizing the importance of this channel and its regulatory protein, cyclophilin D (CypD), in neuronal damage induced by tau pathology in Alzheimer's disease.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)