Article
Clinical Neurology
Juraj Secnik, Hong Xu, Emilia Schwertner, Niklas Hammar, Michael Alvarsson, Bengt Winblad, Maria Eriksdotter, Sara Garcia-Ptacek, Dorota Religa
Summary: The study found that the use of metformin and DPP-4i in patients with diabetes and dementia was associated with a slower decline in MMSE scores, while insulin and sulfonylureas were associated with larger decrements in MMSE scores. Further research on the cognitive effects of metformin and incretin-based medications is needed.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Psychology, Multidisciplinary
Alma M. Bueno-Cayo, Minerva del Rio Carmona, Rosa Castell-Enguix, Isabel Iborra-Marmolejo, Mike Murphy, Tatiana Quarti Irigaray, Jose Francisco Cervera, Carmen Moret-Tatay
Summary: The study examines the relationship between language components and MMSE scores, finding that participants with higher MMSE scores have higher lexical density, longer speeches, and more tokens related to Time, Space and Action. These findings have potential significance in the screening of MCI.
BEHAVIORAL SCIENCES
(2022)
Article
Health Care Sciences & Services
Jie Wang, Zhuo Wang, Ning Liu, Caiyan Liu, Chenhui Mao, Liling Dong, Jie Li, Xinying Huang, Dan Lei, Shanshan Chu, Jianyong Wang, Jing Gao
Summary: This study optimized a cognitive assessment model through machine learning, which can be used for the diagnosis of MCI and dementia in patients with normal MMSE. It not only optimizes the content of cognitive evaluation, but also improves diagnosis accuracy and reduces missed diagnosis.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Akhilesh Vyas, Fotis Aisopos, Maria-Esther Vidal, Peter Garrard, George Paliouras
Summary: The study examines various clinical attributes of dementia patients, using machine learning models to calibrate MMSE scores accurately determining cognitive status and provides an effective classification mechanism to identify inaccurate MMSE values.
APPLIED SCIENCES-BASEL
(2021)
Article
Neurosciences
Knut Engedal, Jurate Saltyte Benth, Linda Gjora, Havard Kjesbu Skjellegrind, Marit Navik, Geir Selbaek
Summary: This study examined normative scores for the third Norwegian version of the MMSE and found that age and years of education influenced MMSE scores, with education being the strongest predictor.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Mandy Roheger, Hong Xu, Minh Tuan Hoang, Maria Eriksdotter, Sara Garcia-Ptacek
Summary: This study presents a reliable and simple method for converting MMSE scores to MoCA scores (and vice versa) in patients with different types of dementia. By establishing a conversion table, the scores of the two assessment tools can be easily compared, facilitating research and clinical practice.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Clinical Neurology
Jakub P. Hlavka, Jeffrey C. Yu, Darius N. Lakdawalla
Summary: This study presents a crosswalk between MMSE and TICS, providing a comparable cognitive measurement tool for adults aged 65 and older.
ALZHEIMERS & DEMENTIA
(2022)
Article
Computer Science, Interdisciplinary Applications
Hezhe Qiao, Lin Chen, Fan Zhu
Summary: The study introduces a ranking convolutional neural network (rankCNN) method to predict MMSE through multi-classification, which outperforms other state-of-the-art methods on both ADNI-1 and ADNI-2 datasets. The proposed model achieved RMSE of 2.238 and 2.434 at baseline on the two datasets, demonstrating high prediction accuracy.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Neurosciences
Tom Ala, Danah Bakir, Srishti Goel, Nida Feller, Albert Botchway, Cindy Womack
Summary: This study aims to improve the ability to differentiate between AD and DLB by studying MMSE scores and including other dementia patients for perspective. The results suggest that the equation P minus M can effectively distinguish between AD and DLB, and it can also differentiate AD from Parkinson's disease dementia.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Geriatrics & Gerontology
Jael S. Fasnacht, Alexandra S. Wueest, Manfred Berres, Alessandra E. Thomann, Sabine Krumm, Klemens Gutbrod, Luzius A. Steiner, Nicolai Goettel, Andreas U. Monsch
Summary: This study aimed to define corresponding scores for the Mini-Mental Status Examination (MMSE) and the Montreal Cognitive Assessment (MoCA). The results showed that MoCA scores were consistently lower than MMSE scores. A conversion table was provided to convert MoCA scores into MMSE scores and vice versa. This allows for direct comparison of cognitive test scores and observation of changes over the course of disease in patients with neurocognitive disorders.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Neurosciences
Jordi A. Matias-Guiu, Vanesa Pytel, Laura Hernandez-Lorenzo, Nikil Patel, Katie A. Peterson, Jorge Matias-Guiu, Peter Garrard, Fernando Cuetos
Summary: The study adapted and validated the Spanish version of MLSE for PPA diagnosis, showing excellent internal consistency and discriminative properties. MLSE performed well in distinguishing PPA patients from healthy controls and differentiating between clinical variants.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Psychology, Multidisciplinary
Maria Nieves Cabrera-Martin, Pedro Nespral, Maria Valles-Salgado, Pablo Bascunana, Cristina Delgado-Alonso, Alfonso Delgado-Alvarez, Lucia Fernandez-Romero, Juan Ignacio Lopez-Carbonero, Maria Diez-Cirarda, Maria Jose Gil-Moreno, Jorge Matias-Guiu, Jordi A. Matias-Guiu
Summary: This study investigated the metabolic correlates associated with the performance of ACE-III in Alzheimer's disease (AD) and frontotemporal dementia (FTD). The results showed distinct neural correlates for ACE-III in bvFTD and AD, with lower scores associated with more advanced stages in both disorders. ACE-III exhibited high discrimination between bvFTD vs. HC and AD vs. HC. It was also sensitive to detect hypometabolism in brain regions associated with bvFTD and AD.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ying Xue, Xiangqun Xie
Summary: This study explores the potential impact of metformin on the development of severe dementia in individuals with AD and T2DM. The findings suggest that metformin usage is not significantly associated with a decreased risk of severe dementia, regardless of APOE epsilon 4 carrier status.
Article
Geriatrics & Gerontology
Ya-Chen Lee, Shu-Chun Lee, En-Chi Chiu
Summary: The study demonstrated that the practice effect could be minimized when alternate forms of the MMSE-2 were used. The MMSE-2 had good to excellent test-retest reliability, except for three subtests: visual-constructional ability, registration, and recall.
Article
Neurosciences
Xiaoli Pan, Xiaoqin Cheng, Jie Zhang, Yingfeng Xia, Chunjiu Zhong, Guoqiang Fei
Summary: The five-minute cognitive test (FCT) is a novel and reliable method for detecting cognitive impairment at an early stage. This study analyzed the impact of sociodemographic and health-related factors on FCT performance and investigated its consistency. The results showed that FCT scores were influenced by age, education attainment, dwelling condition, and Body Mass Index. Additionally, FCT scores correlated significantly with specific neuropsychological tests.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Qing-Ying Liu, Wen Chen, Shuang Cui, Fei-Fei Liao, Ming Yi, Feng-Yu Liu, You Wan
NEUROSCIENCE RESEARCH
(2019)
Article
Multidisciplinary Sciences
Lupeng Yue, Fengrui Zhang, Xuejing Lu, You Wan, Li Hu
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Article
Infectious Diseases
Yan Zhua, Irene Galani, Ilias Karaiskos, Jing Lu, Su Mon Aye, Jiayuan Huang, Heidi H. Yu, Tony Velkov, Helen Giamarellou, Jian Li
JOURNAL OF INFECTION
(2019)
Article
Neurosciences
Longyu Ma, Yuqi Zhang, Lupeng Yue, Xueying Zhang, Shuang Cui, Feng-Yu Liu, You Wan, Ming Yi
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Neurosciences
Zhao-Huan Huang, Rong-Jun Ni, Peng-Hao Luo, Jiang-Ning Zhou
JOURNAL OF COMPARATIVE NEUROLOGY
(2020)
Article
Neurosciences
Cheng Wang, Yu Zhang, Shan Shao, Shuang Cui, You Wan, Ming Yi
Article
Cell Biology
Longyu Ma, Lupeng Yue, Yuqi Zhang, Yue Wang, Bingxuan Han, Shuang Cui, Feng-Yu Liu, You Wan, Ming Yi
Article
Cell & Tissue Engineering
Jie Zheng, Hong-Lian Li, Na Tian, Fei Liu, Lu Wang, Yaling Yin, Lupeng Yue, Longyu Ma, You Wan, Jian-Zhi Wang
Article
Oncology
Jiheng Chen, Yunxiao Zhang, Xiaoxi Li, You Wan, Xinqiang Ji, Wei Wang, Xiaozheng Kang, Wanpu Yan, Zhiyi Fan
Article
Neurosciences
Jun Ma, Zifang Zhao, Shuang Cui, Feng-Yu Liu, Ming Yi, You Wan
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Haojie Sun, Su Fu, Shuang Cui, Xiangsha Yin, Xiaoyan Sun, Xuetao Qi, Kun Cui, Jiaxin Wang, Longyu Ma, Feng-Yu Liu, Fei-Fei Liao, Xin-Hong Wang, Ming Yi, You Wan
Editorial Material
Neurosciences
Haojie Sun, Jie Zheng, Ming Yi, You Wan
NEUROSCIENCE BULLETIN
(2021)
Article
Neurosciences
Yin Lv, Peng Chen, Qing-Hong Shan, Xin-Ya Qin, Xiu-Hong Qi, Jiang-Ning Zhou
Summary: The study reveals a critical role of AMv CRF neurons in the regulation of conditioned fear memory, with chemogenetic activation enhancing cued fear expression and inhibition reducing the fear response, while not affecting fear acquisition or contextual fear expression. Anterograde tracing shows that AMv CRF neurons project to wide areas of the cerebral cortex and the limbic system.
NEUROSCIENCE BULLETIN
(2021)
Article
Multidisciplinary Sciences
Sara Oberrauch, Jing Lu, Linda Cornthwaite-Duncan, Maytham Hussein, Jian Li, Gauri Rao, Tony Velkov
Summary: This article introduces a unique method of treating brain infections through intraventricular delivery of antibiotics. Researchers have developed a simple surgical procedure to implant a guide cannula reaching into the lateral ventricle, allowing for drug injection and flow control.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Neurosciences
Yue Wang, Naizheng Liu, Longyu Ma, Lupeng Yue, Shuang Cui, Feng-Yu Liu, Ming Yi, You Wan
Summary: As a major component of the limbic system, the hippocampus, specifically the ventral hippocampal CA1 (vCA1) region, is involved in the processing of pain perception and chronicity. This study used in vivo electrophysiological recording to characterize vCA1 pyramidal neurons and their encoding of nociceptive information. It was found that these neurons exhibited inhibitory or excitatory responses to plantar stimuli, with functional heterogeneity observed in neuropathic pain conditions. Increased theta power and theta-spike coupling in vCA1 were correlated with nociceptive behaviors. Optogenetic and chemogenetic manipulations of vCA1 activity further confirmed its role in pain modulation.
NEUROSCIENCE BULLETIN
(2023)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)