Article
Geriatrics & Gerontology
Jinsu Park, Meenu Madan, Srinivasulu Chigurupati, Seung Hyun Baek, Yoonsuk Cho, Mohamed R. Mughal, Amin Yu, Sic L. Chan, Jogi Pattisapu, Mark P. Mattson, Dong-Gyu Jo
Summary: AQP1 levels are elevated in the cerebral cortex during the early stages of AD, particularly in vulnerable neurons, and increase as aging progresses in AD mouse models. AQP1 appears to reduce A beta production by inhibiting the binding between BACE1 and APP.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Neurosciences
Jonathan Aow, Tzu-Rung Huang, Gopal Thinakaran, Edward H. Koo
Summary: In this study, the researchers found that there was a significant early and aberrant Bace1-mediated APP cleavage in the presence of APP/Bace1 co-expression. This led to disturbances in the trafficking of full-length APP (fl-APP) from the secretory pathway, resulting in a substantial loss of surface fl-APP and a marked reduction in APP internalization. Therefore, caution is needed when interpreting results where APP is detected only with a C-terminal tag in the presence of Bace1 co-expression, and previous findings may need to be reinterpreted if it is unclear whether fl-APP is present in normal physiological levels.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tong Lin, Lars O. Tjernberg, Sophia Schedin-Weiss
Summary: Alzheimer's disease is a common neurodegenerative disease that primarily affects memory and cognitive abilities, with no known cure. Early diagnosis and understanding of its pathology are crucial for effective management of the disease.
Article
Chemistry, Medicinal
Panthakarn Rangsinth, Chatrawee Duangjan, Chanin Sillapachaiyaporn, Ciro Isidoro, Anchalee Prasansuklab, Tewin Tencomnao
Summary: The study demonstrated the neurite outgrowth stimulatory effect and BACE1 inhibition of Caesalpinia mimosoides extract, suggesting its potential as a source of drugs for Alzheimer's disease treatment. Further investigations are needed to fully identify bioactive constituents and confirm neuritogenesis in vivo before clinical translation.
Article
Cardiac & Cardiovascular Systems
Haoyue Zhou, Feng Gao, Xiaoli Yang, Tingting Lin, Zhenxing Li, Qiong Wang, Yang Yao, Lei Li, Xinxin Ding, Kaibin Shi, Qiang Liu, Hong Bao, Zhenyu Long, Zujun Wu, Robert Vassar, Xin Cheng, Rena Li, Yong Shen
Summary: The study reveals a direct relationship between endothelial BACE1 and cerebral small vessel damage, suggesting that abnormal elevation of endothelial BACE1 is a new mechanism for cerebral small vessel disease pathogenesis.
CIRCULATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yanna Zhao, Hongyan Zhou, Yan Zhao, Zhen Liang, Xiaokang Gong, Jing Yu, Tiantian Huang, Chaoqin Yang, Mengjuan Wu, Yifan Xiao, Youhua Yang, Wei Liu, Xiaochuan Wang, Xiji Shu, Jian Bao
Summary: BACE1 SUMOylation inhibits its phosphorylation and ubiquitination at S498, while BACE1 phosphorylation suppresses its SUMOylation. An increase in BACE1 SUMOylation and a decrease in its phosphorylation and ubiquitination are associated with AD pathology. These findings provide new insights into the regulation of BACE1 activity and A beta accumulation.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Marc R. Benoit, Mabintou Darboe, Brati Das, Yingying Ge, John Zhou, Annie Yao, Wanxia He, Riqiang Yan, Xiangyou Hu
Summary: The study reveals that neuronal BACE1 plays a critical role in the development of the central and peripheral nervous system. Deletion of BACE1 leads to impaired maturation of neural precursor cells and oligodendrocytes, as well as deficits in the trajectory of neuroblasts. Furthermore, the deficiency of BACE1 affects gene expression related to SNARE signaling, tight junction signaling, synaptogenesis, and insulin secretion pathways, resulting in deficits in synaptic functions and cognitive behaviors.
HUMAN MOLECULAR GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Jianzhong Chen, Shaolong Zhang, Wei Wang, Haibo Sun, Qinggang Zhang, Xinguo Liu
Summary: In this study, the effect of pH-dependent protonation on inhibitor binding to BACE1 was investigated using molecular simulations and analyses. Results showed that pH-dependent protonation significantly influences the binding abilities of inhibitors to BACE1, altering hydrogen bonding interactions and structural flexibility. Higher pH conditions were found to enhance the binding abilities of inhibitors to BACE1, providing valuable insights for the design of potent BACE1 inhibitors.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Xiaotong Yang, Wenqin Yang, Xue Xia, Ting Lei, Zhihang Yang, Wenfeng Jia, Yang Zhou, Guo Cheng, Huile Gao
Summary: Alzheimer's disease (AD) is a common neurodegenerative disease with no effective treatment. In this study, a multifunctional nanocarrier was developed to deliver beta-site precursor protein cleaving enzyme-1 (BACE1) siRNA and rapamycin into the brain via intranasal administration. The results showed that this nanocarrier significantly improved the cognitive ability of transgenic AD mice.
Article
Cell Biology
De-Juan Yuan, Guang Yang, Wei Wu, Qi-Fa Li, De-en Xu, Michael Ntim, Chun-Yan Jiang, Ji-Chuan Liu, Yue Zhang, Ying-Zi Wang, Dan-Dan Zhu, Supratik Kundu, Ai-Ping Li, Zhi-Cheng Xiao, Quan-Hong Ma, Shao Li
Summary: The reduction of VGSC alpha-subunit Nav1.6 in the hippocampus of APP/PS1 transgenic mice can improve cognitive impairments, attenuate synaptic deficits, reduce amyloid plaques, and lower levels of soluble A beta. Interfering with Nav1.6 suppresses BACE1 transcription, reduces intracellular calcium overload, and alleviates synaptic loss, ultimately improving learning and memory disorders in APP/PS1 mice. This study offers a potential therapeutic strategy for countering hippocampal hyperexcitability and rescuing cognitive deficits in AD by selectively targeting Nav1.6 overexpression and hyperactivity.
Review
Geriatrics & Gerontology
Jiang Chen, Jun-Sheng Chen, Song Li, Fengning Zhang, Jie Deng, Ling-Hui Zeng, Jun Tan
Summary: Decades of research have shown that amyloid-beta (Aβ) plays an undeniable role in the development of Alzheimer's disease (AD). However, the focus on the pathological effects of Aβ may overshadow the significance of its metabolic precursor, amyloid precursor protein (APP), in the occurrence and progression of AD. This review explores the various roles of APP in AD, including its structure, functions, enzymatic processing, and potential therapeutic approaches to targeting APP to ameliorate AD pathologies and halt disease progression.
Review
Biochemistry & Molecular Biology
Carmen Nanclares, Andres Mateo Baraibar, Alfonso Araque, Paulo Kofuji
Summary: Recent studies investigate the role of astrocytes in Alzheimer's disease, suggesting that their active involvement at synapses could lead to synaptic and neuronal network dysfunction, as well as cognitive impairment in AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Yaqi Wang, Yuting Cui, Jing Liu, Qiao Song, Min Cao, Yuli Hou, Xiaomin Zhang, Peichang Wang
Summary: The upregulation of KLF5 is found to positively regulate BACE1 and accelerate APP amyloidogenic cleavage in Alzheimer's disease (AD) progression. The levels of KLF5 significantly increase in AD patients and APP/PS1 mice, and are closely related to cognitive capacity. KLF5 promotes amyloidogenic metabolism and AP synthesis through BACE1.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Tatsuhiro Ayabe, Chika Takahashi, Rena Ohya, Yasuhisa Ano
Summary: Beta-lactolin improves mitochondrial functions and prevents neuronal cell death in Alzheimer's disease-related neuronal cell models, demonstrating its advantage in maintaining neuronal health.
Article
Integrative & Complementary Medicine
Zhang Wei, Bai Shan-Shan, Zhang Qi, Shi Ru-Ling, Wang He-Cheng, Liu You-Cai, Ni Tian-Jun, Wu Ying, Yao Zhao-Yang, Sun Yi, Wang Ming-Yong
Summary: Physalin B can effectively reduce BACE1 expression to decrease Aβ secretion by activating the expression of FoxO1 and inhibiting the phosphorylation of STAT3.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Oncology
Lili Chen, Ling Xi, Jie Jiang, Rutie Yin, Pengpeng Qu, Xiuqin Li, Xiaoyun Wan, Yaxia Chen, Dongxiao Hu, Yuyan Mao, Zimin Pan, Xiaodong Cheng, Xinyu Wang, Qingli Li, Danhui Weng, Xi Zhang, Hong Zhang, Quanhong Ping, Xiaomei Liu, Xing Xie, Beihua Kong, Ding Ma, Weiguo Lu
Summary: This study evaluated the efficacy and safety of single-course initial regimens in low-risk gestational trophoblastic neoplasia patients. The results showed that single-course MTX may be a new treatment option, demonstrating similar effectiveness to multi-course MTX and could be considered for low-risk GTN patients.
FRONTIERS OF MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Po-Hsun Chen, Chih-Yang Lin, Ting-Chang Chang, Jason K. Eshraghian, Yu-Ting Chao, Wei D. Lu, Simon M. Sze
Summary: Resistive random-access memory (RRAM) crossbar arrays have shown great potential for neuromorphic computing, in-memory computing, and high-density storage-class memory applications, but leakage currents through parasitic sneak paths remain a major obstacle. The use of inherent selectors native to switching, such as niobium oxide (NbOx), can help reduce sneak path currents without sacrificing structural simplicity. Experimental results demonstrate abnormal phenomena in the reset process, and the switching behaviors of NbOx devices make them attractive candidates for future memory and in-memory computing applications.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Zi Yang, Mingli Chen, Mahdieh Kazemimoghadam, Lin Ma, Strahinja Stojadinovic, Robert Timmerman, Tu Dan, Zabi Wardak, Weiguo Lu, Xuejun Gu
Summary: Stereotactic radiosurgery (SRS) is the standard of care for brain metastases (BMs) patients. However, precise target delineation can be a time bottleneck in clinical workflow for patients with multiple BMs (mBMs). To address this, an automated BMs segmentation platform was developed, but its accuracy was influenced by false-positive segmentations caused by MRI contrast injection. To improve segmentation performance, a deep-learning and radiomics ensemble classifier was developed, consisting of a Siamese network and a radiomic-based support vector machine (SVM) classifier. The proposed model achieved high accuracy and effectively reduced false positives in BMs segmentation.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Yuting Wu, Xinxin Wang, Wei D. Lu
Summary: Memristive devices have rich dynamics due to internal state variables determining conductance, which may serve as building blocks for biofaithful neuromorphic systems; these devices can be utilized in compute-in-memory architectures to process temporal data efficiently, implementing synaptic and neuronal functions effectively.
SEMICONDUCTOR SCIENCE AND TECHNOLOGY
(2022)
Article
Orthopedics
Junyuan Huang, Yingchun Zhou, Wei Xiao, Peng Deng, Qiushi Wei, Weiguo Lu
Summary: The increased level of beta-catenin may play a vital role in the progression of Osteonecrosis of the femoral head (ONFH), and the level of beta-catenin is correlated with ARCO stages. The cut-off concentration may be used as a sensitive marker to assess the disease process of ONFH.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Engineering, Environmental
Peipei Su, Haitao Zhang, Lipeng Yang, Chunxian Xing, Shanshan Pan, Wei Lu, Suojiang Zhang
Summary: This study systematically investigates the effects of conductive additives on the rheological and electrochemical properties of suspension electrodes. The results show that different additives have different percolation thresholds and inflection points. The 1.5 wt.% KB-based suspension exhibits superior cycle and rate performances.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Plant Sciences
He Wei, Yun Lian, Jinying Li, Haichao Li, Qijian Song, Yongkang Wu, Chenfang Lei, Shiwei Wang, Hui Zhang, Jinshe Wang, Weiguo Lu
Summary: This study identified three novel resistant quantitative trait loci (QTLs) for soybean cyst nematode (SCN) resistance in the soybean variety Handou 10. Candidate genes for these QTLs were predicted through functional analysis and transcriptome analysis. The study also emphasized the importance of plant-pathogen interaction in SCN resistance.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Computer Science, Information Systems
Tingting Chen, Xuechen Liu, Ruiwei Feng, Wenzhe Wang, Chunnv Yuan, Weiguo Lu, Haizhen He, Honghao Gao, Haochao Ying, Danny Z. Chen, Jian Wu
Summary: In this study, a new cervical lesion detection method for colposcopic images is proposed, which tackles the challenges posed by the specific characteristics of these images. The method utilizes novel feature enhancing mechanisms and achieves more accurate localization and diagnosis. Experimental results demonstrate the superiority of the proposed method over state-of-the-art models on four widely used metrics.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2022)
Article
Materials Science, Multidisciplinary
Minhan Fang, Ying Li, Yuanfei Han, Jianwen Le, Guangfa Huang, Xianghai Chai, Liming Lei, Weijie Lu
Summary: In this study, in-situ SEM tensile investigations were conducted to study the fracture mechanism and anisotropic behavior of selective laser melted and then heat-treated Ti6Al4V. The results showed that surface steps were formed during the plastic stage, and microcracks were mainly initiated by the separation or fracture of adjacent lamellae. Surface defects induced strain concentration and premature failure, while defects inside the specimens had little effect on ductility.
MATERIALS CHARACTERIZATION
(2022)
Article
Nanoscience & Nanotechnology
Huigang Shi, Nan Zong, Shaopeng Li, Jianwen Le, Guangfa Huang, Jiuxiao Li, Jianwei Mao, Weijie Lu
Summary: We observed an interesting phenomenon in a new polycrystalline zirconium alloy where the intensity and attenuation of yield drop behavior increase and decrease, respectively, with increasing strain. This yield discontinuity is attributed to the recombination of climb-dissociated partials introduced by previous strain, and the work hardening or softening stage with increasing or decreasing partial dislocations results in the progressive intensification or attenuation of yield drop, respectively. The anisotropic response of the strain hardening-softening transition leads to relatively higher values of yield drop and increment-decrement transition strain along the rolling direction (-5.5 MPa and -21%, respectively) compared to the transverse direction (-4.6 MPa and -10%, respectively).
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2022)
Article
Engineering, Mechanical
Weiping Lu, Wen Cui, Xiaogang Zhang, Yali Zhang, Shu Yang, Jian Pu, Junyan Li, Zhongmin Jin
Summary: The friction and wear behaviors between cartilage replacement materials and articular cartilage are crucial for the function and performance of the replacements. This study investigated the difference between cross-shear motion and reciprocal linear motion on the frictional and wear behaviors of cartilage, as well as the effect of bearing surface roughness. The results showed that there was no significant difference between the two motion types. The water contact angle of the bearing surface affected the friction and wear behaviors for low roughness implants, while the surface roughness of the material affected the behaviors for high roughness implants. PEEK was found to be a suitable material for osteochondral implants.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART J-JOURNAL OF ENGINEERING TRIBOLOGY
(2023)
Article
Computer Science, Artificial Intelligence
Zhiyun Xu, Zhaoyan Hu, Xiaoyao Zheng, Haiyan Zhang, Yonglong Luo
Summary: This paper proposes a matrix factorization tourism point of interest recommendation model based on interest offset and differential privacy, which improves the recommendation performance by analyzing user interest preferences. It also designs a privacy neighbor selection algorithm and uses the Laplace mechanism to implement differential privacy protection. Experimental results show that the proposed model has advantages in recommendation accuracy and privacy protection.
JOURNAL OF INTELLIGENT & FUZZY SYSTEMS
(2023)
Article
Automation & Control Systems
Xiaoyao Zheng, Baoting Han, Zhen Ni
Summary: In this study, a two-stage Pareto layering-based multi-objective evolutionary algorithm (MOTRR) is proposed for tourism route recommendation. The method decomposes the multi-objective problem into subproblems and improves solution distribution through a two-stage approach. The algorithm combines the two-stage method with Pareto layering to maintain distribution and diversity, while avoiding duplicate solutions. Experimental results demonstrate competitive advantages and better solution distribution compared to benchmark algorithms, using both simulated test functions and real scenic spot datasets.
IEEE-CAA JOURNAL OF AUTOMATICA SINICA
(2023)
Article
Computer Science, Cybernetics
Xiaoyao Zheng, Manping Guan, Xianmin Jia, Liangmin Guo, Yonglong Luo
Summary: This article proposes a novel matrix factorization algorithm and a recommendation system for preserving user privacy. The experimental results show that the proposed algorithm achieves better recommendation performance at the same privacy-preserving level.
IEEE TRANSACTIONS ON COMPUTATIONAL SOCIAL SYSTEMS
(2023)
Article
Automation & Control Systems
Qiwen Wang, Yongmo Park, Wei D. Lu
Summary: This article investigates the performance of neural network models in analog in-memory computing systems based on nonvolatile memories, with a focus on the deviation issue during weight programming. The study considers realistic system limitations and evaluates approaches to mitigate device and circuit nonidealities through architecture-aware training.
ADVANCED INTELLIGENT SYSTEMS
(2022)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
