Amyloid-type Protein Aggregation and Prion-like Properties of Amyloids

In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics

(2021) Hong Xu et al.   ACTA NEUROPATHOLOGICA

Proteostasis of Islet Amyloid Polypeptide: A Molecular Perspective of Risk Factors and Protective Strategies for Type II Diabetes

(2021) Danilo Milardi et al.   CHEMICAL REVIEWS

Molecular structure of a prevalent amyloid-β fibril polymorph from Alzheimer's disease brain tissue

(2021) Ujjayini Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Breakdown of supersaturation barrier links protein folding to amyloid formation

(2021) Masahiro Noji et al.   Communications Biology

Accumulation of cellular prion protein within β‐amyloid oligomer plaques in aged human brains

(2021) Reisuke H. Takahashi et al.   BRAIN PATHOLOGY

A Review: Molecular Chaperone-mediated Folding, Unfolding and Disaggregation of Expressed Recombinant Proteins

(2021) Komal Fatima et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Structural details of amyloid β oligomers in complex with human prion protein as revealed by solid-state MAS NMR spectroscopy

(2021) Anna S. König et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Huntington’s disease: lessons from prion disorders

(2021) Melanie Alpaugh et al.   JOURNAL OF NEUROLOGY

Expanding the role of proteasome homeostasis in Parkinson’s disease: beyond protein breakdown

(2021) Mingxia Bi et al.   Cell Death & Disease

Cryo-EM reveals structural breaks in a patient-derived amyloid fibril from systemic AL amyloidosis

(2021) Lynn Radamaker et al.   Nature Communications

AA amyloid fibrils from diseased tissue are structurally different from in vitro formed SAA fibrils

(2021) Akanksha Bansal et al.   Nature Communications

Impact of Chaperone-Mediated Autophagy in Brain Aging: Neurodegenerative Diseases and Glioblastoma

(2021) Jaione Auzmendi-Iriarte et al.   Frontiers in Aging Neuroscience

Seeded assembly in vitro does not replicate the structures of α‐synuclein filaments from multiple system atrophy

(2021) Sofia Lövestam et al.   FEBS Open Bio

Accumulation of alpha-synuclein within the liver, potential role in the clearance of brain pathology associated with Parkinson’s disease

(2021) Juan F. Reyes et al.   Acta Neuropathologica Communications

Aβ receptors specifically recognize molecular features displayed by fibril ends and neurotoxic oligomers

(2021) Ladan Amin et al.   Nature Communications

Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains

(2020) Tamta Arakhamia et al.   CELL

Autophagy and disease: unanswered questions

(2020) Ying Yang et al.   CELL DEATH AND DIFFERENTIATION

Novel tau filament fold in corticobasal degeneration

(2020) Wenjuan Zhang et al.   NATURE

The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure

(2020) David R. Boyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Aggrephagy for the Treatment of Alzheimer’s Disease

(2020) Sandeep Malampati et al.   Cells

Autophagy, Cellular Aging and Age-related Human Diseases

(2020) So Yeong Cheon et al.   Experimental Neurobiology

Cryo-EM structure of full-length α-synuclein amyloid fibril with Parkinson’s disease familial A53T mutation

(2020) Yunpeng Sun et al.   CELL RESEARCH

The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation

(2020) Georg Meisl et al.   CURRENT OPINION IN NEUROBIOLOGY

Lysosomal Exocytosis, Exosome Release and Secretory Autophagy: The Autophagic- and Endo-Lysosomal Systems Go Extracellular

(2020) Sandra Buratta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Out-of-register parallel β-sheets and antiparallel β-sheets coexist in 150 kDa oligomers formed by Amyloid-β(1-42)

(2020) Yuan Gao et al.   JOURNAL OF MOLECULAR BIOLOGY

Transgenic Overexpression of the Disordered Prion Protein N1 Fragment in Mice Does Not Protect Against Neurodegenerative Diseases Due to Impaired ER Translocation

(2020) Behnam Mohammadi et al.   MOLECULAR NEUROBIOLOGY

Structures of α-synuclein filaments from multiple system atrophy

(2020) Manuel Schweighauser et al.   NATURE

Do infections have a role in the pathogenesis of Alzheimer disease?

(2020) Ruth F. Itzhaki et al.   Nature Reviews Neurology

Protein transmission in neurodegenerative disease

(2020) Chao Peng et al.   Nature Reviews Neurology

Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core

(2020) Calina Glynn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Braak hypothesis in prion disease with a focus on Creutzfeldt–Jakob disease

(2020) Yasushi Iwasaki   NEUROPATHOLOGY

Cryo-EM structure of a neuronal functional amyloid implicated in memory persistence in Drosophila

(2020) Ruben Hervas et al.   SCIENCE

Activation and targeting of ATG8 protein lipidation

(2020) Sascha Martens et al.   Cell Discovery

The existence of Aβ strains and their potential for driving phenotypic heterogeneity in Alzheimer’s disease

(2020) Heather H. C. Lau et al.   ACTA NEUROPATHOLOGICA

Nonenzymatic Metabolic Reactions and Life’s Origins

(2020) Kamila B. Muchowska et al.   CHEMICAL REVIEWS

Comparative study of the stabilities of synthetic in vitro and natural ex vivo transthyretin amyloid fibrils

(2020) Sara Raimondi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryo-EM structure of an amyloid fibril formed by full-length human prion protein

(2020) Li-Qiang Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils

(2020) Qin Cao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-β fibrils

(2020) Christine Röder et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The age-related microglial transformation in Alzheimer's disease pathogenesis

(2020) Chunxu Yuan et al.   NEUROBIOLOGY OF AGING

Parkinson’s disease-related phosphorylation at Tyr39 rearranges α-synuclein amyloid fibril structure revealed by cryo-EM

(2020) Kun Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage

(2020) Sonia Ciudad et al.   Nature Communications

Functional insights from biophysical study of TREM2 interactions with apoE and Aβ 1‐42

(2020) Daniel L. Kober et al.   Alzheimers & Dementia

Developing Therapies for Neurodegenerative Disorders: Insights from Protein Aggregation and Cellular Stress Responses

(2020) Giovanna R. Mallucci et al.   Annual Review of Cell and Developmental Biology

Phase Separation and Neurodegenerative Diseases: A Disturbance in the Force

(2020) Aurélie Zbinden et al.   DEVELOPMENTAL CELL

Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns

(2020) David M Asher et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Prion biology: implications for Alzheimer's disease therapeutics

(2020) Carlo Condello et al.   LANCET NEUROLOGY

The three-dimensional structure of human β-endorphin amyloid fibrils

(2020) Carolin Seuring et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Fibril structures of diabetes-related amylin variants reveal a basis for surface-templated assembly

(2020) Rodrigo Gallardo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer’s Disease

(2020) Joseph W. Lewcock et al.   NEURON

Shifts and drifts in prion science

(2020) Adriano Aguzzi et al.   SCIENCE

Beyond aggregation: Pathological phase transitions in neurodegenerative disease

(2020) Cécile Mathieu et al.   SCIENCE

CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid

(2020) Jiahui Lu et al.   Nature Communications

Assessment of the Effects of Altered Amyloid-Beta Clearance on Behavior following Repeat Closed-Head Brain Injury in Amyloid-Beta Precursor Protein Humanized Mice

(2020) Kathleen C. Maigler et al.   JOURNAL OF NEUROTRAUMA

APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches

(2020) Alberto Serrano-Pozo et al.   LANCET NEUROLOGY

Structural and molecular basis of cross-seeding barriers in amyloids

(2020) Asen Daskalov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein condensates as aging Maxwell fluids

(2020) Louise Jawerth et al.   SCIENCE

The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure

(2020) Yunpeng Sun et al.   Nature Communications

Induction of amyloid-β deposits from serially transmitted, histologically silent, Aβ seeds issued from human brains

(2020) Anne-Sophie Hérard et al.   Acta Neuropathologica Communications

Cryo-EM structure of a light chain-derived amyloid fibril from a patient with systemic AL amyloidosis

(2019) Lynn Radamaker et al.   Nature Communications

Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain AL amyloidosis patient

(2019) Paolo Swuec et al.   Nature Communications

Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids

(2019) Falk Liberta et al.   Nature Communications

Prion and Prion-Like Protein Strains: Deciphering the Molecular Basis of Heterogeneity in Neurodegeneration

(2019) Carlo Scialò et al.   Viruses-Basel

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

(2019) Benjamin Falcon et al.   NATURE

Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity

(2019) Stefano Thellung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines

(2019) Amanda L. Woerman et al.   ACTA NEUROPATHOLOGICA

Mechanistic approaches to understand the prion-like propagation of aggregates of the human tau protein

(2019) Harish Kumar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The prion-like propagation hypothesis in Alzheimerʼs and Parkinsonʼs disease

(2019) Charles Duyckaerts et al.   CURRENT OPINION IN NEUROLOGY

Molecular structure of an N-terminal phosphorylated β-amyloid fibril

(2019) Zhi-Wen Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aβ and tau prion-like activities decline with longevity in the Alzheimer’s disease human brain

(2019) Atsushi Aoyagi et al.   Science Translational Medicine

Dual Role of Autophagy in Diseases of the Central Nervous System

(2019) Tamara Bar-Yosef et al.   Frontiers in Cellular Neuroscience

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

(2019) Wenjuan Zhang et al.   eLife

Morphological and primary structural consistency of fibrils from different AA patients (common variant)

(2019) Falk Liberta et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Prion disease is accelerated in mice lacking stress-induced heat shock protein 70 (HSP70)

(2019) Charles E. Mays et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two decades of progress in structural and dynamic studies of amyloids by solid-state NMR

(2019) Christopher P. Jaroniec   JOURNAL OF MAGNETIC RESONANCE

Phase Separation in Regulation of Aggrephagy

(2019) Daxiao Sun et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Insights into α-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations

(2019) Xiaodan Ni et al.   JOURNAL OF MOLECULAR BIOLOGY

Selective Autophagy: ATG8 Family Proteins, LIR Motifs and Cargo Receptors

(2019) Terje Johansen et al.   JOURNAL OF MOLECULAR BIOLOGY

Do We Need Anti-Prion Compounds to Treat Alzheimer’s Disease?

(2019) Dieter Willbold et al.   MOLECULES

Cryo-EM structures of four polymorphic TDP-43 amyloid cores

(2019) Qin Cao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The peptide hormone glucagon forms amyloid fibrils with two coexisting β-strand conformations

(2019) Martin D. Gelenter et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Optimal control strategies for inhibition of protein aggregation

(2019) Thomas C. T. Michaels et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy Modulation as a Treatment of Amyloid Diseases

(2019) Zoe Mputhia et al.   MOLECULES

Encephalopathy induced by Alzheimer brain inoculation in a non-human primate

(2019) Charlotte Gary et al.   Acta Neuropathologica Communications

Mechanisms of secretion and spreading of pathological tau protein

(2019) Cecilia A. Brunello et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs

(2019) David R. Boyer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy

(2019) Christine Röder et al.   Nature Communications

Cryo-EM structure of a transthyretin-derived amyloid fibril from a patient with hereditary ATTR amyloidosis

(2019) Matthias Schmidt et al.   Nature Communications

Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue

(2019) Marius Kollmer et al.   Nature Communications

Autophagic and endo-lysosomal dysfunction in neurodegenerative disease

(2019) Bilal R. Malik et al.   Molecular Brain

Aβ Seeding as a Tool to Study Cerebral Amyloidosis and Associated Pathology

(2019) Marina Friesen et al.   Frontiers in Molecular Neuroscience

PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins

(2019) Grant T. Corbett et al.   ACTA NEUROPATHOLOGICA

Amyloid structures: much more than just a cross-β fold

(2019) Rodrigo Gallardo et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A Turning Point in Alzheimer’s Disease: Microbes Matter

(2019) Ruth F. Itzhaki   JOURNAL OF ALZHEIMERS DISEASE

Autophagy Induction as a Therapeutic Strategy for Neurodegenerative Diseases

(2019) Alvin Djajadikerta et al.   JOURNAL OF MOLECULAR BIOLOGY

α-Synuclein strains target distinct brain regions and cell types

(2019) Angus Lau et al.   NATURE NEUROSCIENCE

Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

(2019) Ricardo Guerrero-Ferreira et al.   eLife

Tau-Cofactor Complexes as Building Blocks of Tau Fibrils

(2019) Yann Fichou et al.   Frontiers in Neuroscience

Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation

(2018) Thomas C.T. Michaels et al.   Annual Review of Physical Chemistry

The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex

(2018) Miguel Mompeán et al.   CELL

Mechanisms of protein toxicity in neurodegenerative diseases

(2018) Chang Geon Chung et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

3D structure determination of amyloid fibrils using solid-state NMR spectroscopy

(2018) Antoine Loquet et al.   METHODS

A brief history of autophagy from cell biology to physiology and disease

(2018) Noboru Mizushima   NATURE CELL BIOLOGY

Exogenous α-synuclein hinders synaptic communication in cultured cortical primary rat neurons

(2018) G. C. Hassink et al.   PLoS One

Molecular basis for diversification of yeast prion strain conformation

(2018) Yumiko Ohhashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physical basis of amyloid fibril polymorphism

(2018) William Close et al.   Nature Communications

Critical aggregation concentration for the formation of early Amyloid-β (1–42) oligomers

(2018) Mercedes Novo et al.   Scientific Reports

Cryo-EM structure of alpha-synuclein fibrils

(2018) Ricardo Guerrero-Ferreira et al.   eLife

Association Between Autophagy and Neurodegenerative Diseases

(2018) Nobuhiro Fujikake et al.   Frontiers in Neuroscience

Intercellular Spread of Protein Aggregates in Neurodegenerative Disease

(2018) Albert A. Davis et al.   Annual Review of Cell and Developmental Biology

Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy

(2018) Yaowang Li et al.   CELL RESEARCH

Selective autophagy as a potential therapeutic target for neurodegenerative disorders

(2018) Aurora Scrivo et al.   LANCET NEUROLOGY

Structures of filaments from Pick’s disease reveal a novel tau protein fold

(2018) Benjamin Falcon et al.   NATURE

Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases

(2018) Mathias Jucker et al.   NATURE NEUROSCIENCE

A new era for understanding amyloid structures and disease

(2018) Matthew G. Iadanza et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel

(2018) Binsen Li et al.   Nature Communications

Pathological Changes of Tau Related to Alzheimer’s Disease

(2018) Dandan Chu et al.   ACS Chemical Neuroscience

Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold

(2018) Benjamin Falcon et al.   ACTA NEUROPATHOLOGICA

Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau In Vivo

(2018) Tomas Ondrejcak et al.   JOURNAL OF NEUROSCIENCE

Liquid and Hydrogel Phases of PrPC Linked to Conformation Shifts and Triggered by Alzheimer’s Amyloid-β Oligomers

(2018) Mikhail A. Kostylev et al.   MOLECULAR CELL

Cofactors are essential constituents of stable and seeding-active tau fibrils

(2018) Yann Fichou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of a β2-microglobulin fibril suggests a molecular basis for its amyloid polymorphism

(2018) Matthew G. Iadanza et al.   Nature Communications

Corroboration of a Major Role for Herpes Simplex Virus Type 1 in Alzheimer’s Disease

(2018) Ruth F. Itzhaki   Frontiers in Aging Neuroscience

Cellular prion protein targets amyloid-β fibril ends via its C-terminal domain to prevent elongation

(2017) Erin Bove-Fenderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The β-cell assassin: IAPP cytotoxicity

(2017) Daniel Raleigh et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Amyloid Fibril Polymorphism: Almost Identical on the Atomic Level, Mesoscopically Very Different

(2017) Carolin Seuring et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes

(2017) Wei Qiang et al.   NATURE

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B

(2017) Diana G Ferreira et al.   NATURE NEUROSCIENCE

Combining DNP NMR with segmental and specific labeling to study a yeast prion protein strain that is not parallel in-register

(2017) Kendra K. Frederick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zinc-binding structure of a catalytic amyloid from solid-state NMR

(2017) Myungwoon Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibril structure of amyloid-β(1–42) by cryo–electron microscopy

(2017) Lothar Gremer et al.   SCIENCE

Insights into protein misfolding and aggregation enabled by solid-state NMR spectroscopy

(2017) Patrick C.A. van der Wel   SOLID STATE NUCLEAR MAGNETIC RESONANCE

Emerging Structural Understanding of Amyloid Fibrils by Solid-State NMR

(2017) Beat H. Meier et al.   TRENDS IN BIOCHEMICAL SCIENCES

β-Amyloid Prions and the Pathobiology of Alzheimer’s Disease

(2017) Joel C. Watts et al.   Cold Spring Harbor Perspectives in Medicine

Aβ42 pentamers/hexamers are the smallest detectable oligomers in solution

(2017) Martin Wolff et al.   Scientific Reports

Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils

(2016) Michael T. Colvin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Electron tomography reveals the fibril structure and lipid interactions in amyloid deposits

(2016) Marius Kollmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a novel cell death-inducing domain reveals that fungal amyloid-controlled programmed cell death is related to necroptosis

(2016) Asen Daskalov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Huntingtin exon 1 fibrils feature an interdigitated β-hairpin–based polyglutamine core

(2016) Cody L. Hoop et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic-resolution structure of a disease-relevant Aβ(1–42) amyloid fibril

(2016) Marielle Aulikki Wälti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular Structure of Aggregated Amyloid-β: Insights from Solid-State Nuclear Magnetic Resonance

(2016) Robert Tycko   Cold Spring Harbor Perspectives in Medicine

The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy

(2016) Ester Vázquez-Fernández et al.   PLoS Pathogens

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

(2016) Daniel L Kober et al.   eLife

Untangling a Repetitive Amyloid Sequence: Correlating Biofilm-Derived and Segmentally Labeled Curli Fimbriae by Solid-State NMR Spectroscopy

(2015) Tobias Schubeis et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Age and amyloid effects on human central nervous system amyloid-beta kinetics

(2015) Bruce W. Patterson et al.   ANNALS OF NEUROLOGY

Neurodegenerative Diseases: Expanding the Prion Concept

(2015) Lary C. Walker et al.   Annual Review of Neuroscience

Solid-State Nuclear Magnetic Resonance on the Static and Dynamic Domains of Huntingtin Exon-1 Fibrils

(2015) J. Mario Isas et al.   BIOCHEMISTRY

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

The revolution will not be crystallized: a new method sweeps through structural biology

(2015) Ewen Callaway   NATURE

Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy

(2015) Zane Jaunmuktane et al.   NATURE

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

(2015) Yiling Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

On the lag phase in amyloid fibril formation

(2015) Paolo Arosio et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Molecular structure of monomorphic peptide fibrils within a kinetically trapped hydrogel network

(2015) Katelyn Nagy-Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling an In-Register, Parallel “Iowa” Aβ Fibril Structure Using Solid-State NMR Data from Labeled Samples with Rosetta

(2015) Nikolaos G. Sgourakis et al.   STRUCTURE

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

(2015) Yiling Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Amyloid β Oligomeric Species Present in the Lag Phase of Amyloid Formation

(2015) Martin Wolff et al.   PLoS One

Atomic-Resolution Three-Dimensional Structure of Amyloid β Fibrils Bearing the Osaka Mutation

(2014) Anne K. Schütz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Polyglutamine Amyloid Core Boundaries and Flanking Domain Dynamics in Huntingtin Fragment Fibrils Determined by Solid-State Nuclear Magnetic Resonance

(2014) Cody L. Hoop et al.   BIOCHEMISTRY

Serial propagation of distinct strains of A  prions from Alzheimer's disease patients

(2014) J. C. Watts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physical and structural basis for polymorphism in amyloid fibrils

(2014) Robert Tycko   PROTEIN SCIENCE

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

(2013) Jun-Xia Lu et al.   CELL

Selective autophagy

(2013) Steingrim Svenning et al.   Essays in Biochemistry

Amyloid-β induced signaling by cellular prion protein and Fyn kinase in Alzheimer disease

(2013) Ji Won Um et al.   Prion

Atomic structure and hierarchical assembly of a cross-  amyloid fibril

(2013) A. W. P. Fitzpatrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity

(2013) Andrew J. Nicoll et al.   Nature Communications

Structural and functional characterization of two alpha-synuclein strains

(2013) Luc Bousset et al.   Nature Communications

An Asymmetric Dimer as the Basic Subunit in Alzheimer’s Disease Amyloid β Fibrils

(2012) Juan Miguel Lopez del Amo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Corruption and Spread of Pathogenic Proteins in Neurodegenerative Diseases

(2012) Lary C. Walker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Soluble Prion Protein Inhibits Amyloid-β (Aβ) Fibrillization and Toxicity

(2012) Krzysztof Nieznanski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

(2012) Ji Won Um et al.   NATURE NEUROSCIENCE

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antiparallel  -sheet architecture in Iowa-mutant  -amyloid fibrils

(2012) W. Qiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Protein Seeding in Neurodegenerative Diseases

(2012) Lary C. Walker et al.   JAMA Neurology

The Amyloid-Congo Red Interface at Atomic Resolution

(2011) Anne K. Schütz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Solid-State NMR Studies of Amyloid Fibril Structure

(2011) Robert Tycko   Annual Review of Physical Chemistry

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

(2011) Ulrike K Resenberger et al.   EMBO JOURNAL

α-Secretase-derived Fragment of Cellular Prion, N1, Protects against Monomeric and Oligomeric Amyloid β (Aβ)-associated Cell Death

(2011) Marie-Victoire Guillot-Sestier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β-induced Synapse Damage Is Mediated via Cross-linkage of Cellular Prion Proteins

(2011) Clive Bate et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β42 Interacts Mainly with Insoluble Prion Protein in the Alzheimer Brain

(2011) Wen-Quan Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Characterization of Polyglutamine Fibrils by Solid-State NMR Spectroscopy

(2011) Robert Schneider et al.   JOURNAL OF MOLECULAR BIOLOGY

Alzheimer's Disease Brain-Derived Amyloid- -Mediated Inhibition of LTP In Vivo Is Prevented by Immunotargeting Cellular Prion Protein

(2011) A. E. Barry et al.   JOURNAL OF NEUROSCIENCE

Ablation of Cellular Prion Protein Does Not Ameliorate Abnormal Neural Network Activity or Cognitive Dysfunction in the J20 Line of Human Amyloid Precursor Protein Transgenic Mice

(2011) M. Cisse et al.   JOURNAL OF NEUROSCIENCE

α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study

(2011) Brit Mollenhauer et al.   LANCET NEUROLOGY

Amyloid-β forms fibrils by nucleated conformational conversion of oligomers

(2011) Jiyong Lee et al.   Nature Chemical Biology

Structural dependence of HET-s amyloid fibril infectivity assessed by cryoelectron microscopy

(2011) N. Mizuno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Characterization of GNNQQNY Amyloid Fibrils by Magic Angle Spinning NMR

(2010) Patrick C. A. van der Wel et al.   BIOCHEMISTRY

LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis

(2010) Hilla Weidberg et al.   EMBO JOURNAL

Prion protein and Aβ-related synaptic toxicity impairment

(2010) Anna Maria Calella et al.   EMBO Molecular Medicine

Atomic-Resolution Three-Dimensional Structure of HET-s(218−289) Amyloid Fibrils by Solid-State NMR Spectroscopy

(2010) Hélène Van Melckebeke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The prion protein as a receptor for amyloid-β

(2010) Helmut W. Kessels et al.   NATURE

The elimination of accumulated and aggregated proteins: A role for aggrephagy in neurodegeneration

(2010) Ai Yamamoto et al.   NEUROBIOLOGY OF DISEASE

Accumulation of cellular prion protein within dystrophic neurites of amyloid plaques in the Alzheimer's disease brain

(2010) Reisuke H. Takahashi et al.   NEUROPATHOLOGY

Synthetic amyloid-  oligomers impair long-term memory independently of cellular prion protein

(2010) C. Balducci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unique Identification of Supramolecular Structures in Amyloid Fibrils by Solid-State NMR Spectroscopy

(2009) Jakob T. Nielsen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Two Prion Variants of Sup35p Have In-Register Parallel β-Sheet Structures, Independent of Hydration

(2009) Frank Shewmaker et al.   BIOCHEMISTRY

Structural Characterization of a Soluble Amyloid β-Peptide Oligomer

(2009) Liping Yu et al.   BIOCHEMISTRY

The Functional Curli Amyloid Is Not Based on In-register Parallel β-Sheet Structure

(2009) Frank Shewmaker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

(2009) Summer L. Bernstein et al.   Nature Chemistry

Comparison of Alzheimer A (1-40) and A (1-42) amyloid fibrils reveals similar protofilament structures

(2009) M. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-neurotoxicity relationships of amyloid  -protein oligomers

(2009) K. Ono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloidogenesis in its biological environment: challenging a fundamental issue in protein misfolding diseases

(2008) Vittorio Bellotti et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural Insights into the Polymorphism of Amyloid-Like Fibrils Formed by Region 20−29 of Amylin Revealed by Solid-State NMR and X-ray Fiber Diffraction

(2008) Jillian Madine et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Paired  -sheet structure of an A (1-40) amyloid fibril revealed by electron microscopy

(2008) C. Sachse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular structural basis for polymorphism in Alzheimer's  -amyloid fibrils

(2008) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-  Dynamics Correlate with Neurological Status in the Injured Human Brain

(2008) D. L. Brody et al.   SCIENCE

Amyloid Fibrils of the HET-s(218-289) Prion Form a   Solenoid with a Triangular Hydrophobic Core

(2008) C. Wasmer et al.   SCIENCE