α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B

Synucleinopathies: common features and hippocampal manifestations

(2016) Weiwei Yang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulation of Amyloid β Oligomer Binding to Neurons and Neurotoxicity by the Prion Protein-mGluR5 Complex

(2016) Flavio H. Beraldo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Common molecular mechanism of amyloid pore formation by Alzheimer’s β-amyloid peptide and α-synuclein

(2016) Coralie Di Scala et al.   Scientific Reports

The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function

(2016) Vânia L. Batalha et al.   Scientific Reports

Adenosine A2Areceptors permit mGluR5-evoked tyrosine phosphorylation of NR2B (Tyr1472) in rat hippocampus: a possible key mechanism in NMDA receptor modulation

(2015) Konstantinos Sarantis et al.   JOURNAL OF NEUROCHEMISTRY

The prion protein constitutively controls neuronal store-operated Ca2+ entry through Fyn kinase

(2015) Agnese De Mario et al.   Frontiers in Cellular Neuroscience

Increased α-synuclein levels in the cerebrospinal fluid of patients with Creutzfeldt–Jakob disease

(2014) Takashi Kasai et al.   JOURNAL OF NEUROLOGY

Loss of Prion Protein Leads to Age-Dependent Behavioral Abnormalities and Changes in Cytoskeletal Protein Expression

(2014) Matthias Schmitz et al.   MOLECULAR NEUROBIOLOGY

A2A adenosine receptor deletion is protective in a mouse model of Tauopathy

(2014) C Laurent et al.   MOLECULAR PSYCHIATRY

The spectrum of cognitive impairment in Lewy body diseases

(2014) Jennifer G. Goldman et al.   MOVEMENT DISORDERS

Extracellular α-synuclein—a novel and crucial factor in Lewy body diseases

(2014) He-Jin Lee et al.   Nature Reviews Neurology

Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locomotion, and Anxiety

(2014) Joana E. Coelho et al.   Frontiers in Psychiatry

Istradefylline: First Global Approval

(2013) Rosselle Dungo et al.   DRUGS

Heat-mediated enrichment of α-synuclein from cells and tissue for assessing post-translational modifications

(2013) Hugo Vicente Miranda et al.   JOURNAL OF NEUROCHEMISTRY

Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

(2013) Ji Won Um et al.   NEURON

Amyloid-β induced signaling by cellular prion protein and Fyn kinase in Alzheimer disease

(2013) Ji Won Um et al.   Prion

Cognitive deficits in a mouse model of pre-manifest Parkinson’s disease

(2012) Iddo Magen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neuroprotection afforded by adenosine A2Areceptor blockade is modulated by corticotrophin-releasing factor (CRF) in glutamate injured cortical neurons

(2012) Jorge S. Valadas et al.   JOURNAL OF NEUROCHEMISTRY

Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

(2012) M. J. Diogenes et al.   JOURNAL OF NEUROSCIENCE

The Complex PrPc-Fyn Couples Human Oligomeric A  with Pathological Tau Changes in Alzheimer's Disease

(2012) M. Larson et al.   JOURNAL OF NEUROSCIENCE

Adenosine A2A receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation

(2012) V L Batalha et al.   MOLECULAR PSYCHIATRY

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

(2012) Ji Won Um et al.   NATURE NEUROSCIENCE

A Progressive Mouse Model of Parkinson’s Disease: The Thy1-aSyn (“Line 61”) Mice

(2012) Marie-Francoise Chesselet et al.   Neurotherapeutics

Alpha-synuclein: from secretion to dysfunction and death

(2012) O Marques et al.   Cell Death & Disease

Adenosine A2A receptor gene disruption protects in an α-synuclein model of Parkinson's disease

(2011) Anil Kachroo et al.   ANNALS OF NEUROLOGY

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

(2011) Ulrike K Resenberger et al.   EMBO JOURNAL

Amyloid-beta oligomers increase the localization of prion protein at the cell surface

(2011) Fabiana A. Caetano et al.   JOURNAL OF NEUROCHEMISTRY

α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases

(2011) Zane S. Martin et al.   JOURNAL OF NEUROCHEMISTRY

The synaptic pathology of α-synuclein aggregation in dementia with Lewy bodies, Parkinson’s disease and Parkinson’s disease dementia

(2010) Walter J. Schulz-Schaeffer   ACTA NEUROPATHOLOGICA

Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein

(2010) D. A. Gimbel et al.   JOURNAL OF NEUROSCIENCE

Histology of the Central Nervous System

(2010) Robert H. Garman   TOXICOLOGIC PATHOLOGY

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Image analysis of Ca2+ signals as a basis for neurotoxicity assays: Promises and challenges

(2009) Rola Barhoumi et al.   NEUROTOXICOLOGY AND TERATOLOGY

From cell protection to death: May Ca2+ signals explain the chameleonic attributes of the mammalian prion protein?

(2008) M. Catia Sorgato et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prion protein attenuates excitotoxicity by inhibiting NMDA receptors

(2008) Houman Khosravani et al.   JOURNAL OF CELL BIOLOGY

Evolutionary expansion and anatomical specialization of synapse proteome complexity

(2008) Richard D Emes et al.   NATURE NEUROSCIENCE

Physiology of the Prion Protein

(2008) Rafael Linden et al.   PHYSIOLOGICAL REVIEWS

Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

(2008) Tiago Fleming Outeiro et al.   PLoS One

Membrane-bound β-amyloid oligomers are recruited into lipid rafts by a fyn-dependent mechanism

(2007) Ritchie Williamson et al.   FASEB JOURNAL