期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 287, 期 40, 页码 33109-33115出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R112.399378
关键词
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资金
- National Institutes of Health [R21AG040589, P01AG005119]
- National Center for Research Resources [P51RR165]
- Office of Research Infrastructure Programs/Office of the Director Grant [P51OD11132]
- Coins for Alzheimer's Research Trust (CART) Foundation
- Bayer HealthCare Grants4Targets
With advancing age, the brain becomes increasingly susceptible to neurodegenerative diseases, most of which are characterized by the misfolding and errant aggregation of certain proteins. The induction of aggregation involves a crystallization-like seeding mechanism by which a specific protein is structurally corrupted by its misfolded conformer. The latest research indicates that, once formed, proteopathic seeds can spread from one locale to another via cellular uptake, transport, and release. Impeding this process could represent a unified therapeutic strategy for slowing the progression of a wide range of currently intractable disorders.
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