The β-cell assassin: IAPP cytotoxicity

Disaggregation of human islet amyloid polypeptide fibril formation by ruthenium polypyridyl complexes

(2017) Dengsen Zhu et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity

(2017) Pascal Krotee et al.   eLife

The Multifaceted Role of SNARE Proteins in Membrane Fusion

(2017) Jing Han et al.   Frontiers in Physiology

A Central Small Amino Acid in the VAMP2 Transmembrane Domain Regulates the Fusion Pore in Exocytosis

(2017) Benoît Hastoy et al.   Scientific Reports

Loss of prohormone convertase 2 promotes beta cell dysfunction in a rodent transplant model expressing human pro-islet amyloid polypeptide

(2016) Jaques A. Courtade et al.   DIABETOLOGIA

The S20G substitution in hIAPP is more amyloidogenic and cytotoxic than wild-type hIAPP in mouse islets

(2016) Daniel T. Meier et al.   DIABETOLOGIA

Peptide Inhibitors of the amyloidogenesis of IAPP: verification of the hairpin-binding geometry hypothesis

(2016) Kalkena Sivanesam et al.   FEBS LETTERS

Protein disulfide isomerase ameliorates β-cell dysfunction in pancreatic islets overexpressing human islet amyloid polypeptide

(2016) Joel Montane et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

CHOP Contributes to, But Is Not the Only Mediator of, IAPP Induced β-Cell Apoptosis

(2016) T. Gurlo et al.   MOLECULAR ENDOCRINOLOGY

The activities of amyloids from a structural perspective

(2016) Roland Riek et al.   NATURE

Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics

(2016) Andisheh Abedini et al.   eLife

Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology

(2016) Rehana Akter et al.   Journal of Diabetes Research

Pancreatic β-Cell Membrane Fluidity and Toxicity Induced by Human Islet Amyloid Polypeptide Species

(2016) Emily H. Pilkington et al.   Scientific Reports

Amyloid Formation in Human Islets Is Enhanced by Heparin and Inhibited by Heparinase

(2015) K. J. Potter et al.   AMERICAN JOURNAL OF TRANSPLANTATION

In Vitro Evaluation of Hypoglycemic Agents to Target Human Islet Amyloid Polypeptide: A Key Protein Involved in Amyloid Deposition and Beta-Cell Loss

(2015) Jessica S. Fortin et al.   Canadian Journal of Diabetes

Islet Amyloid-Induced Cell Death and Bilayer Integrity Loss Share a Molecular Origin Targetable with Oligopyridylamide-Based α-Helical Mimetics

(2015) Sunil Kumar et al.   CHEMISTRY & BIOLOGY

Monitoring C-Peptide Storage and Secretion in Islet β-Cells In Vitro and In Vivo

(2015) Shuaishuai Zhu et al.   DIABETES

Islet amyloid inhibitors improve glucose homeostasis in a transgenic mouse model of type 2 diabetes

(2015) N. Wijesekara et al.   DIABETES OBESITY & METABOLISM

Endoplasmic reticulum quality control and systemic amyloid disease: Impacting protein stability from the inside out

(2015) John J. Chen et al.   IUBMB LIFE

Heparan Sulfate Proteoglycans Are Important for Islet Amyloid Formation and Islet Amyloid Polypeptide-induced Apoptosis

(2015) Marie E. Oskarsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

(2015) Kyle J Gaulton et al.   NATURE GENETICS

Genetics of Type 2 Diabetes—Pitfalls and Possibilities

(2015) Rashmi Prasad et al.   Genes

Islet amyloid with macrophage migration correlates with augmented β-cell deficits in type 2 diabetic patients

(2014) Kosuke Kamata et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Rationally Designed, Nontoxic, Nonamyloidogenic Analogues of Human Islet Amyloid Polypeptide with Improved Solubility

(2014) Hui Wang et al.   BIOCHEMISTRY

Pancreatic  -Cell Failure Mediated by mTORC1 Hyperactivity and Autophagic Impairment

(2014) A. Bartolome et al.   DIABETES

Islet amyloid formation is an important determinant for inducing islet inflammation in high-fat-fed human IAPP transgenic mice

(2014) Daniel T. Meier et al.   DIABETOLOGIA

The pathogenic mechanism of diabetes varies with the degree of overexpression and oligomerization of human amylin in the pancreatic islet β cells

(2014) Shaoping Zhang et al.   FASEB JOURNAL

Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity

(2014) Jacqueline F. Rivera et al.   JOURNAL OF CLINICAL INVESTIGATION

Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry–mass spectrometry

(2014) Lydia M. Young et al.   Nature Chemistry

pH Dependence of Amylin Fibrillization

(2013) Suman Jha et al.   BIOCHEMISTRY

A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide

(2013) Sunil Kumar et al.   CHEMICAL COMMUNICATIONS

The Role of Proinsulin and Insulin in the Diagnosis of Insulinoma: A Critical Evaluation of the Endocrine Society Clinical Practice Guideline

(2013) Jean-Marc Guettier et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Ion Mobility Spectrometry–Mass Spectrometry Defines the Oligomeric Intermediates in Amylin Amyloid Formation and the Mode of Action of Inhibitors

(2013) Lydia M. Young et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Islet amyloid polypeptide toxicity and membrane interactions

(2013) P. Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extensive amyloid formation in transplanted microencapsulated mouse and human islets

(2012) Sara Bohman et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

How Type II Diabetes-Related Islet Amyloid Polypeptide Damages Lipid Bilayers

(2012) Chang-Chun Lee et al.   BIOPHYSICAL JOURNAL

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

Aggregation of islet amyloid polypeptide: from physical chemistry to cell biology

(2012) Ping Cao et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The Polyphenol EGCG Inhibits Amyloid Formation Less Efficiently at Phospholipid Interfaces than in Bulk Solution

(2012) Maarten F. M. Engel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Cell Loss and β-Cell Apoptosis in Human Type 2 Diabetes Are Related to Islet Amyloid Deposition

(2011) Catherine A. Jurgens et al.   AMERICAN JOURNAL OF PATHOLOGY

Biphasic Effects of Insulin on Islet Amyloid Polypeptide Membrane Disruption

(2011) Jeffrey R. Brender et al.   BIOPHYSICAL JOURNAL

Clustering and Internalization of Toxic Amylin Oligomers in Pancreatic Cells Require Plasma Membrane Cholesterol

(2011) Saurabh Trikha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-1 Blockade Attenuates Islet Amyloid Polypeptide-Induced Proinflammatory Cytokine Release and Pancreatic Islet Graft Dysfunction

(2011) C. Westwell-Roper et al.   JOURNAL OF IMMUNOLOGY

Sensitivity of Amyloid Formation by Human Islet Amyloid Polypeptide to Mutations at Residue 20

(2011) Ping Cao et al.   JOURNAL OF MOLECULAR BIOLOGY

Resolving controversies on the path to Alzheimer's therapeutics

(2011) Dennis J Selkoe   NATURE MEDICINE

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Further Evidence for Amyloid Deposition in Clinical Pancreatic Islet Grafts

(2011) Gunilla T. Westermark et al.   TRANSPLANTATION

The Flavanol (−)-Epigallocatechin 3-Gallate Inhibits Amyloid Formation by Islet Amyloid Polypeptide, Disaggregates Amyloid Fibrils, and Protects Cultured Cells against IAPP-Induced Toxicity

(2010) Fanling Meng et al.   BIOCHEMISTRY

 -Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide-Induced UCH-L1 Deficiency

(2010) S. Costes et al.   DIABETES

Differences between amyloid toxicity in alpha and beta cells in human and mouse islets and the role of caspase-3

(2010) E. Law et al.   DIABETOLOGIA

Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?

(2010) S. Zraika et al.   DIABETOLOGIA

Human pro-islet amyloid polypeptide (ProIAPP1–48) forms amyloid fibrils and amyloid spherulites in vitro

(2010) Christopher Exley et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Inhibition of Glycosaminoglycan-Mediated Amyloid Formation by Islet Amyloid Polypeptide and proIAPP Processing Intermediates

(2010) Fanling Meng et al.   JOURNAL OF MOLECULAR BIOLOGY

Role of Zinc in Human Islet Amyloid Polypeptide Aggregation

(2010) Jeffrey R. Brender et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts

(2010) K. J. Potter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Recapture of Secretory Granule Components After Full Collapse Exocytosis in Neuroendocrine Chromaffin Cells

(2010) Mara Ceridono et al.   TRAFFIC

Evidence for Proteotoxicity in β Cells in Type 2 Diabetes

(2009) Tatyana Gurlo et al.   AMERICAN JOURNAL OF PATHOLOGY

Amyloid inhibitors enhance survival of cultured human islets

(2009) Kathryn J. Potter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Inhibiting Islet Amyloid Polypeptide Fibril Formation by the Red Wine Compound Resveratrol

(2009) Rajesh Mishra et al.   CHEMBIOCHEM

Membrane permeabilization by Islet Amyloid Polypeptide

(2009) Maarten F.M. Engel   CHEMISTRY AND PHYSICS OF LIPIDS

The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation

(2009) M. Cnop et al.   DIABETOLOGIA

Islet-associated macrophages in type 2 diabetes

(2009) S. J. Richardson et al.   DIABETOLOGIA

Helix Stabilization Precedes Aqueous and Bilayer-Catalyzed Fiber Formation in Islet Amyloid Polypeptide

(2009) Jessica A. Williamson et al.   JOURNAL OF MOLECULAR BIOLOGY

Elucidating the Mechanism of Lipid Membrane-Induced IAPP Fibrillogenesis and Its Inhibition by the Red Wine Compound Resveratrol: A Synchrotron X-ray Reflectivity Study

(2009) Florian Evers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pancreatic islet amyloidosis,  -cell apoptosis, and  -cell proliferation are determinants of islet remodeling in type-2 diabetic baboons

(2009) R. Guardado-Mendoza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process

(2009) Jed J. W. Wiltzius et al.   PROTEIN SCIENCE

Amyloid formation results in recurrence of hyperglycaemia following transplantation of human IAPP transgenic mouse islets

(2008) J. Udayasankar et al.   DIABETOLOGIA

Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4

(2008) S. Casas et al.   DIABETOLOGIA

Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis

(2008) Leena Haataja et al.   ENDOCRINE REVIEWS

The Role of the 14–20 Domain of the Islet Amyloid Polypeptide in Amyloid Formation

(2008) Sharon Gilead et al.   Experimental Diabetes Research

Structure of α-Helical Membrane-bound Human Islet Amyloid Polypeptide and Its Implications for Membrane-mediated Misfolding

(2008) Melania Apostolidou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Classification of Toxic Amyloid Oligomers

(2008) Charles G. Glabe   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Interleukin (IL)-1β Messenger Ribonucleic Acid Expression in β-Cells of Individuals with Type 2 Diabetes and Regulation of IL-1β in Human Islets by Glucose and Autostimulation

(2008) Marianne Böni-Schnetzler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane

(2008) M. F. M. Engel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amide inequivalence in the fibrillar assembly of islet amyloid polypeptide

(2008) Bon W. Koo et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Atomic structure of the cross-β spine of islet amyloid polypeptide (amylin)

(2008) Jed J.W. Wiltzius et al.   PROTEIN SCIENCE

Interaction of membrane-bound islet amyloid polypeptide with soluble and crystalline insulin

(2008) Jefferson D. Knight et al.   PROTEIN SCIENCE

Amyloid oligomers in diabetic and nondiabetic human pancreas

(2008) Hai-Lu Zhao et al.   Translational Research

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY