期刊
EXPERIMENTAL NEUROBIOLOGY
卷 28, 期 6, 页码 643-657出版社
KOREAN SOC BRAIN & NEURAL SCIENCE, KOREAN SOC NEURODEGENERATIVE DISEASE
DOI: 10.5607/en.2019.28.6.643
关键词
Autophagy; Aging; DNA damage; Oxidative stress; Telomere shortening; SASP
资金
- UK Dementia Research Institute (MRC)
- UK Dementia Research Institute (Alzheimer's Research UK)
- UK Dementia Research Institute (Alzheimer's Society)
- Roger de Spoelberch Foundation
- Alzheimer's Research UK
- Tau Consortium
- Cambridge Centre for Parkinson-Plus
- National Institute for Health Research Cambridge Biomedical Research Centre
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute - Ministry of Health & Welfare, Republic of Korea [HI14C2173]
- MRC [UKDRI-2002] Funding Source: UKRI
Macroautophagy/autophagy is a conserved degradation system that engulfs intracytoplasmic contents, including aggregated proteins and organelles, which is crucial for cellular homeostasis. During aging, cellular factors suggested as the cause of aging have been reported to be associated with progressively compromised autophagy. Dysfunctional autophagy may contribute to age-related diseases, such as neurodegenerative disease, cancer, and metabolic syndrome, in the elderly. Therefore, restoration of impaired autophagy to normal may help to prevent age-related disease and extend lifespan and longevity. Therefore, this review aims to provide an overview of the mechanisms of autophagy underlying cellular aging and the consequent disease. Understanding the mechanisms of autophagy may provide potential information to aid therapeutic interventions in age-related diseases.
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