Sphingolipids in metabolic disease: The good, the bad, and the unknown

Dairy consumption, plasma metabolites, and risk of type 2 diabetes

(2021) Jean-Philippe Drouin-Chartier et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Hepatic lipidomic remodeling in severe obesity manifests with steatosis and does not evolve with non-alcoholic steatohepatitis

(2021) Geraldine J. Ooi et al.   JOURNAL OF HEPATOLOGY

Altering Sphingolipid Metabolism Attenuates Cell Death and Inflammatory Response after Myocardial Infarction

(2020) Yoav Hadas et al.   CIRCULATION

Protection Against Insulin Resistance by Apolipoprotein M/Sphingosine 1-Phosphate

(2020) Makoto Kurano et al.   DIABETES

Targeting alkaline ceramidase 3 alleviates the severity of nonalcoholic steatohepatitis by reducing oxidative stress

(2020) Kai Wang et al.   Cell Death & Disease

Alterations in plasma triglycerides and ceramides: links with cardiac function in humans with type 2 diabetes

(2020) Linda R. Peterson et al.   JOURNAL OF LIPID RESEARCH

Circulating Ceramide 16:0 in Heart Failure With Preserved Ejection Fraction

(2020) Ali Javaheri et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels

(2020) Elizabeth L. Johnson et al.   Nature Communications

Depletion of adipocyte sphingosine kinase 1 causes cell hypertrophy, impaired lipolysis, and NAFLD

(2020) Andrea K Anderson et al.   JOURNAL OF LIPID RESEARCH

An adiponectin-S1P autocrine axis protects skeletal muscle cells from palmitate-induced cell death

(2020) Amy Botta et al.   Lipids in Health and Disease

A G protein–biased S1P1 agonist, SAR247799, protects endothelial cells without affecting lymphocyte numbers

(2020) Bruno Poirier et al.   Science Signaling

Association of 1-deoxy-sphingolipids with steatosis but not steatohepatitis nor fibrosis in non-alcoholic fatty liver disease

(2020) J. Weyler et al.   ACTA DIABETOLOGICA

Nervonic acid limits weight gain in a mouse model of diet‐induced obesity

(2020) Laura J. W. Keppley et al.   FASEB JOURNAL

Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2

(2020) Gulibositan Aji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sphingolipids in the Heart: From Cradle to Grave

(2020) Anna Kovilakath et al.   Frontiers in Endocrinology

Human adiponectin receptor AdipoR1 assumes closed and open structures

(2020) Hiroaki Tanabe et al.   Communications Biology

Endothelial‐protective effects of a G‐protein‐biased sphingosine‐1 phosphate receptor‐1 agonist, SAR247799, in type‐2 diabetes rats and a randomized placebo‐controlled patient trial

(2020) Luc Bergougnan et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Ceramides in Metabolism: Key Lipotoxic Players

(2020) Bhagirath Chaurasia et al.   Annual Review of Physiology

Ceramides are necessary and sufficient for diet-induced impairment of thermogenic adipocytes

(2020) Bhagirath Chaurasia et al.   Molecular Metabolism

Identification of a Metabolic, Transcriptomic, and Molecular Signature of Patatin‐Like Phospholipase Domain Containing 3–Mediated Acceleration of Steatohepatitis

(2020) Bubu A. Banini et al.   HEPATOLOGY

Inhibition of S1P Receptor 2 Attenuates Endothelial Dysfunction and Inhibits Atherogenesis in Apolipoprotein E-Deficient Mice

(2020) Byambasuren Ganbaatar et al.   Journal of Atherosclerosis and Thrombosis

1-Deoxy-sphingolipids

(2019) M.A. Lone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Regulation of ABCA1-mediated cholesterol efflux by sphingosine-1-phosphate signalling in macrophages

(2019) Mithila Vaidya et al.   JOURNAL OF LIPID RESEARCH

CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance

(2019) Sarah M. Turpin-Nolan et al.   Cell Reports

FTY720/Fingolimod Decreases Hepatic Steatosis and Expression of Fatty Acid Synthase in Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice

(2019) Timothy D. Rohrbach et al.   JOURNAL OF LIPID RESEARCH

Plasma Apolipoprotein M and Sphingosine-1-Phosphate Levels are Inversely Associated with Mortality in African Americans with Type 2 Diabetes Mellitus

(2019) Mingxia Liu et al.   JOURNAL OF LIPID RESEARCH

Ceramides bind VDAC2 to trigger mitochondrial apoptosis

(2019) Shashank Dadsena et al.   Nature Communications

CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity

(2019) Philipp Hammerschmidt et al.   CELL

Targeting a ceramide double bond improves insulin resistance and hepatic steatosis

(2019) Bhagirath Chaurasia et al.   SCIENCE

Genetic architecture of human plasma lipidome and its link to cardiovascular disease

(2019) Rubina Tabassum et al.   Nature Communications

Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation

(2019) Kazuhiro Ishimaru et al.   Scientific Reports

Could Ceramides Become the New Cholesterol?

(2018) Scott A. Summers   Cell Metabolism

Ceramide Transporter CERT Is Involved in Muscle Insulin Signaling Defects Under Lipotoxic Conditions

(2018) Cécile L. Bandet et al.   DIABETES

Circulating Sphingolipids, Insulin, HOMA-IR, and HOMA-B: The Strong Heart Family Study

(2018) Rozenn N. Lemaitre et al.   DIABETES

Lipotoxic very-long-chain ceramides cause mitochondrial dysfunction, oxidative stress, and cell death in cardiomyocytes

(2018) Brittany A. Law et al.   FASEB JOURNAL

Plasma concentrations of molecular lipid species predict long-term clinical outcome in coronary artery disease patients

(2018) Sharda S. Anroedh et al.   JOURNAL OF LIPID RESEARCH

Type 2 diabetes is associated with loss of HDL endothelium protective functions

(2018) Tomáš Vaisar et al.   PLoS One

The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity

(2018) Christina Christoffersen et al.   Cell Reports

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

(2018) Nigel Turner et al.   Nature Communications

Sphingosine kinase 2 promotes lipotoxicity in pancreatic β-cells and the progression of diabetes

(2018) Ziyu Song et al.   FASEB JOURNAL

Sphk2−/− mice are protected from obesity and insulin resistance

(2018) Shwetha Ravichandran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells

(2017) Francesca Virginia Bruschi et al.   HEPATOLOGY

The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice

(2017) Yongqing Wang et al.   HEPATOLOGY

De NovoSphingolipid Biosynthesis Is Required for Adipocyte Survival and Metabolic Homeostasis

(2017) Aikaterini Alexaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis

(2017) Clair Crewe et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural insights into adiponectin receptors suggest ceramidase activity

(2017) Ieva Vasiliauskaité-Brooks et al.   NATURE

Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis

(2017) Cen Xie et al.   NATURE MEDICINE

Sphingolipids and their metabolism in physiology and disease

(2017) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance

(2017) Max C. Petersen et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans

(2017) Leonore Wigger et al.   Cell Reports

Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis

(2017) William L. Holland et al.   Molecular Metabolism

Acid sphingomyelinase deficiency in Western diet-fed mice protects against adipocyte hypertrophy and diet-induced liver steatosis

(2017) Svenja Sydor et al.   Molecular Metabolism

High-Density Lipoprotein–Associated Apolipoprotein M Limits Endothelial Inflammation by Delivering Sphingosine-1-Phosphate to the Sphingosine-1-Phosphate Receptor 1Highlights

(2016) Mario Ruiz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Circulating Ceramides Predict Cardiovascular Outcomes in the Population-Based FINRISK 2002 CohortHighlights

(2016) Aki S. Havulinna et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ

(2016) Jinbiao Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism

(2016) Bhagirath Chaurasia et al.   Cell Metabolism

Involvement of Sphingosine 1-Phosphate in Palmitate-Induced Non-Alcoholic Fatty Liver Disease

(2016) Frdoos Al Fadel et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Tumor Necrosis Factor/Sphingosine-1-Phosphate Signaling Augments Resistance Artery Myogenic Tone in Diabetes

(2016) Meghan Sauvé et al.   DIABETES

Muscle sphingolipids during rest and exercise: a C18:0 signature for insulin resistance in humans

(2016) Bryan C. Bergman et al.   DIABETOLOGIA

Blockade of Sphingosine 1-Phosphate Receptor 2 Signaling Attenuates High-Fat Diet-Induced Adipocyte Hypertrophy and Systemic Glucose Intolerance in Mice

(2016) Yoshihiko Kitada et al.   ENDOCRINOLOGY

Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease

(2016) Panu K. Luukkonen et al.   JOURNAL OF HEPATOLOGY

CrossTalk opposing view: Intramyocellular ceramide accumulation does not modulate insulin resistance

(2016) Max C. Petersen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Targeting adipose tissue in the treatment of obesity-associated diabetes

(2016) Christine M. Kusminski et al.   NATURE REVIEWS DRUG DISCOVERY

Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis

(2015) Jonathan Y. Xia et al.   Cell Metabolism

Activation of sphingosine kinase 2 by endoplasmic reticulum stress ameliorates hepatic steatosis and insulin resistance in mice

(2015) Su-Yeon Lee et al.   HEPATOLOGY

Conjugated bile acid-activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression

(2015) Masayuki Nagahashi et al.   HEPATOLOGY

SphK1 mediates hepatic inflammation in a mouse model of NASH induced by high saturated fat feeding and initiates proinflammatory signaling in hepatocytes

(2015) Tuoyu Geng et al.   JOURNAL OF LIPID RESEARCH

HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1to limit vascular inflammation

(2015) Sylvain Galvani et al.   Science Signaling

Ceramides – Lipotoxic Inducers of Metabolic Disorders

(2015) Bhagirath Chaurasia et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

(2015) Changtao Jiang et al.   Nature Communications

HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1to limit vascular inflammation

(2015) Sylvain Galvani et al.   Science Signaling

Sphingosine kinase 1 regulates adipose proinflammatory responses and insulin resistance

(2014) Jing Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Sphingolipids from a Symbiotic Microbe Regulate Homeostasis of Host Intestinal Natural Killer T Cells

(2014) Dingding An et al.   CELL

Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance

(2014) Sarah M. Turpin et al.   Cell Metabolism

CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance

(2014) Suryaprakash Raichur et al.   Cell Metabolism

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

(2014) Changtao Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic β-cell death in diet-induced obese mice

(2013) Yanfei Qi et al.   FASEB JOURNAL

Ablation of Ceramide Synthase 2 Causes Chronic Oxidative Stress Due to Disruption of the Mitochondrial Respiratory Chain

(2013) Hila Zigdon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine Kinase 1 Is Regulated by Peroxisome Proliferator-activated Receptor α in Response to Free Fatty Acids and Is Essential for Skeletal Muscle Interleukin-6 Production and Signaling in Diet-induced Obesity

(2013) Jessica S. Ross et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myristate-derived d16:0 Sphingolipids Constitute a Cardiac Sphingolipid Pool with Distinct Synthetic Routes and Functional Properties

(2013) Sarah Brice Russo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma Sphingosine-1-Phosphate Is Elevated in Obesity

(2013) Greg M. Kowalski et al.   PLoS One

Ventricular Assist Device Implantation Corrects Myocardial Lipotoxicity, Reverses Insulin Resistance, and Normalizes Cardiac Metabolism in Patients With Advanced Heart Failure

(2012) Aalap Chokshi et al.   CIRCULATION

Overexpression of Sphingosine Kinase 1 Prevents Ceramide Accumulation and Ameliorates Muscle Insulin Resistance in High-Fat Diet-Fed Mice

(2012) C. R. Bruce et al.   DIABETES

The Sphingosine-1-Phosphate Analog FTY720 Reduces Muscle Ceramide Content and Improves Glucose Tolerance in High Fat-Fed Male Mice

(2012) Clinton R. Bruce et al.   ENDOCRINOLOGY

Fenretinide Prevents Lipid-induced Insulin Resistance by Blocking Ceramide Biosynthesis

(2012) Benjamin T. Bikman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine 1-Phosphate (S1P) Carrier-dependent Regulation of Endothelial Barrier

(2012) Brent A. Wilkerson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes

(2012) Sarah Brice Russo et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression of ceramide-metabolising enzymes in subcutaneous and intra-abdominal human adipose tissue

(2012) Maria Kolak et al.   Lipids in Health and Disease

Differential Regulation of Dihydroceramide Desaturase by PalmitateversusMonounsaturated Fatty Acids

(2011) Wei Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

(2011) William L. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

Sphingosine-1-Phosphate Receptor-2 Function in Myeloid Cells Regulates Vascular Inflammation and Atherosclerosis

(2010) Athanasia Skoura et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Saturated- and n-6 Polyunsaturated-Fat Diets Each Induce Ceramide Accumulation in Mouse Skeletal Muscle: Reversal and Improvement of Glucose Tolerance by Lipid Metabolism Inhibitors

(2010) G. Frangioudakis et al.   ENDOCRINOLOGY

Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility

(2010) Changyong Li et al.   JOURNAL OF HEPATOLOGY

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

(2010) William L Holland et al.   NATURE MEDICINE

Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome

(2009) Guang Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity

(2009) Wei Hu et al.   JOURNAL OF LIPID RESEARCH

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity

(2008) M. Skovbro et al.   DIABETOLOGIA

Ceramide is a cardiotoxin in lipotoxic cardiomyopathy

(2008) Tae-Sik Park et al.   JOURNAL OF LIPID RESEARCH

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY