Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction
出版年份 2015 全文链接
标题
Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction
作者
关键词
-
出版物
Nature Communications
Volume 6, Issue 1, Pages -
出版商
Springer Nature
发表日期
2015-12-16
DOI
10.1038/ncomms10166
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Bile acid signaling in lipid metabolism: Metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice
- (2015) Yunpeng Qi et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis
- (2015) Min-Woo Lee et al. CELL
- The future of brown adipose tissues in the treatment of type 2 diabetes
- (2015) Patrick Schrauwen et al. DIABETOLOGIA
- Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis
- (2015) Labros Sidossis et al. JOURNAL OF CLINICAL INVESTIGATION
- Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity
- (2015) Michaela Mueller et al. JOURNAL OF HEPATOLOGY
- Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
- (2015) Sungsoon Fang et al. NATURE MEDICINE
- Genetic and functional characterization of clonally derived adult human brown adipocytes
- (2015) Kosaku Shinoda et al. NATURE MEDICINE
- Novel therapeutic targets in primary biliary cirrhosis
- (2015) Jessica K. Dyson et al. Nature Reviews Gastroenterology & Hepatology
- Brite/beige fat and UCP1 — is it thermogenesis?
- (2014) Susanne Keipert et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat
- (2014) Yifu Qiu et al. CELL
- Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis
- (2014) Rajesh R. Rao et al. CELL
- Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch
- (2014) Paul Cohen et al. CELL
- Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance
- (2014) Sarah M. Turpin et al. Cell Metabolism
- CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance
- (2014) Suryaprakash Raichur et al. Cell Metabolism
- Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
- (2014) Changtao Jiang et al. JOURNAL OF CLINICAL INVESTIGATION
- The structure, function, and importance of ceramides in skin and their use as therapeutic agents in skin-care products
- (2014) Matthew H. Meckfessel et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity
- (2014) Jonathan R. Brestoff et al. NATURE
- Obesity
- (2014) Tony Scully NATURE
- FXR is a molecular target for the effects of vertical sleeve gastrectomy
- (2014) Karen K. Ryan et al. NATURE
- FXR: the key to benefits in bariatric surgery?
- (2014) Folkert Kuipers et al. NATURE MEDICINE
- Glucose-lowering effects of intestinal bile acid sequestration through enhancement of splanchnic glucose utilization
- (2014) Janne Prawitt et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Systematic review with meta-analysis: non-alcoholic steatohepatitis - a case for personalised treatment based on pathogenic targets
- (2013) Z. M. Younossi et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Pleiotropic Roles of Bile Acids in Metabolism
- (2013) Thomas Q. de Aguiar Vallim et al. Cell Metabolism
- Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist
- (2013) Sama I. Sayin et al. Cell Metabolism
- An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice
- (2013) William L. Holland et al. Cell Metabolism
- Long-term Drug Treatment for Obesity
- (2013) Susan Z. Yanovski et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Recruited brown adipose tissue as an antiobesity agent in humans
- (2013) Takeshi Yoneshiro et al. JOURNAL OF CLINICAL INVESTIGATION
- Cold acclimation recruits human brown fat and increases nonshivering thermogenesis
- (2013) Anouk A.J.J. van der Lans et al. JOURNAL OF CLINICAL INVESTIGATION
- Brown and beige fat: development, function and therapeutic potential
- (2013) Matthew Harms et al. NATURE MEDICINE
- Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice
- (2012) Matthew J. Potthoff et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
- (2012) Jun Wu et al. CELL
- Estimating energy expenditure in mice using an energy balance technique
- (2012) Y Ravussin et al. INTERNATIONAL JOURNAL OF OBESITY
- FXR signaling in the enterohepatic system
- (2012) Tsutomu Matsubara et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Fecal Lipocalin 2, a Sensitive and Broadly Dynamic Non-Invasive Biomarker for Intestinal Inflammation
- (2012) Benoit Chassaing et al. PLoS One
- A less stressful alternative to oral gavage for pharmacological and toxicological studies in mice
- (2012) Mary K. Walker et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- TGR5 potentiates GLP-1 secretion in response to anionic exchange resins
- (2012) Taoufiq Harach et al. Scientific Reports
- Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity
- (2011) J. Prawitt et al. DIABETES
- Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor (FXR) Agonist Induces Obesity and Diabetes through Reduced Energy Expenditure
- (2011) Mitsuhiro Watanabe et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women
- (2010) Marleen Kars et al. DIABETES
- Transgenic expression of cholesterol 7α-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice
- (2010) Tiangang Li et al. HEPATOLOGY
- A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis
- (2010) Vlad Ratziu et al. JOURNAL OF HEPATOLOGY
- Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine
- (2009) Ann M. Thomas et al. HEPATOLOGY
- Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes
- (2009) Natasa Petrovic et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats
- (2009) Sabrina Cipriani et al. JOURNAL OF LIPID RESEARCH
- Bile acids: regulation of synthesis
- (2009) John Y. L. Chiang JOURNAL OF LIPID RESEARCH
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started