Ceramides are necessary and sufficient for diet-induced impairment of thermogenic adipocytes

The role of ceramides in metabolic disorders: when size and localization matters

(2020) Sarah M. Turpin-Nolan et al.   Nature Reviews Endocrinology

CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance

(2019) Sarah M. Turpin-Nolan et al.   Cell Reports

CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity

(2019) Philipp Hammerschmidt et al.   CELL

Targeting a ceramide double bond improves insulin resistance and hepatic steatosis

(2019) Bhagirath Chaurasia et al.   SCIENCE

The lipidome of primary murine white, brite, and brown adipocytes—Impact of beta-adrenergic stimulation

(2019) Sabine Schweizer et al.   PLOS BIOLOGY

Identification of functional lipid metabolism biomarkers of brown adipose tissue aging

(2019) Sabrina Gohlke et al.   Molecular Metabolism

Human brown adipose tissue: Underestimated target in metabolic disease?

(2018) Michiel P.B. Moonen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars

(2018) Panu K. Luukkonen et al.   DIABETES CARE

New Advances in Adaptive Thermogenesis: UCP1 and Beyond

(2018) Edward T. Chouchani et al.   Cell Metabolism

De NovoSphingolipid Biosynthesis Is Required for Adipocyte Survival and Metabolic Homeostasis

(2017) Aikaterini Alexaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cold-Induced Brown Adipose Tissue Activity Alters Plasma Fatty Acids and Improves Glucose Metabolism in Men

(2017) K Alexander Iwen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism

(2016) Bhagirath Chaurasia et al.   Cell Metabolism

Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans

(2016) Maria Chondronikola et al.   Cell Metabolism

A Role for Ceramides, but Not Sphingomyelins, as Antagonists of Insulin Signaling and Mitochondrial Metabolism in C2C12 Myotubes

(2016) Min Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease

(2016) Panu K. Luukkonen et al.   JOURNAL OF HEPATOLOGY

Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis

(2015) Jonathan Y. Xia et al.   Cell Metabolism

Brown and Beige Fat: Physiological Roles beyond Heat Generation

(2015) Shingo Kajimura et al.   Cell Metabolism

Brown and Beige Fat: Molecular Parts of a Thermogenic Machine

(2015) Paul Cohen et al.   DIABETES

Ceramides – Lipotoxic Inducers of Metabolic Disorders

(2015) Bhagirath Chaurasia et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

IRF4 Is a Key Thermogenic Transcriptional Partner of PGC-1α

(2014) Xingxing Kong et al.   CELL

Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance

(2014) Sarah M. Turpin et al.   Cell Metabolism

C16:0-Ceramide Signals Insulin Resistance

(2014) Timothy Hla et al.   Cell Metabolism

CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance

(2014) Suryaprakash Raichur et al.   Cell Metabolism

Reduced skeletal muscle oxidative capacity and elevated ceramide but not diacylglycerol content in severe obesity

(2013) P.M. Coen et al.   Obesity

Construction of Conditional Acid Ceramidase Knockout Mice andin vivoEffects on Oocyte Development and Fertility

(2012) Efrat Eliyahu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Ceramide Mediates Vascular Dysfunction in Diet-Induced Obesity by PP2A-Mediated Dephosphorylation of the eNOS-Akt Complex

(2012) Q.-J. Zhang et al.   DIABETES

Fenretinide Prevents Lipid-induced Insulin Resistance by Blocking Ceramide Biosynthesis

(2012) Benjamin T. Bikman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans

(2012) Véronique Ouellet et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression of ceramide-metabolising enzymes in subcutaneous and intra-abdominal human adipose tissue

(2012) Maria Kolak et al.   Lipids in Health and Disease

Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin

(2011) Janne Orava et al.   Cell Metabolism

Brown Adipose Tissue in Humans Is Activated by Elevated Plasma Catecholamines Levels and Is Inversely Related to Central Obesity

(2011) Qidi Wang et al.   PLoS One

The Changed Metabolic World with Human Brown Adipose Tissue: Therapeutic Visions

(2010) Jan Nedergaard et al.   Cell Metabolism

Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

(2010) J. R. Ussher et al.   DIABETES

Impact of Age on the Relationships of Brown Adipose Tissue With Sex and Adiposity in Humans

(2010) C. Pfannenberg et al.   DIABETES

Transplantation of adipose tissue and stem cells: role in metabolism and disease

(2010) Thien T. Tran et al.   Nature Reviews Endocrinology

Plasma Membrane Subdomain Compartmentalization Contributes to Distinct Mechanisms of Ceramide Action on Insulin Signaling

(2009) C. M. Blouin et al.   DIABETES

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Serine palmitoyltransferase inhibitor myriocin induces the regression of atherosclerotic plaques in hyperlipidemic ApoE-deficient mice

(2008) T PARK et al.   PHARMACOLOGICAL RESEARCH