标题
Targeting adipose tissue in the treatment of obesity-associated diabetes
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume 15, Issue 9, Pages 639-660
出版商
Springer Nature
发表日期
2016-06-03
DOI
10.1038/nrd.2016.75
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Leptin dose-dependently decreases atherosclerosis by attenuation of hypercholesterolemia and induction of adiponectin
- (2016) Annett Hoffmann et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- FGF21 Regulates Sweet and Alcohol Preference
- (2016) Saswata Talukdar et al. Cell Metabolism
- Pdgfrβ+ Mural Preadipocytes Contribute to Adipocyte Hyperplasia Induced by High-Fat-Diet Feeding and Prolonged Cold Exposure in Adult Mice
- (2016) Lavanya Vishvanath et al. Cell Metabolism
- A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects
- (2016) Saswata Talukdar et al. Cell Metabolism
- Inhibition of Myocardin-Related Transcription Factor/Serum Response Factor Signaling Decreases Lung Fibrosis and Promotes Mesenchymal Cell Apoptosis
- (2015) Thomas H. Sisson et al. AMERICAN JOURNAL OF PATHOLOGY
- Repurposing metformin: an old drug with new tricks in its binding pockets
- (2015) R. Pryor et al. BIOCHEMICAL JOURNAL
- Pharmacokinetics and pharmacodynamics of PF-05231023, a novel long-acting FGF21 mimetic, in a first-in-human study
- (2015) Jennifer Q. Dong et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Myocardin-Related Transcription Factor A Regulates Conversion of Progenitors to Beige Adipocytes
- (2015) Meghan E. McDonald et al. CELL
- A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat
- (2015) Lawrence Kazak et al. CELL
- Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat
- (2015) Garron T. Dodd et al. CELL
- A New Biology of Diabetes Revealed by Leptin
- (2015) Roger H. Unger et al. Cell Metabolism
- Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation
- (2015) Xiaoyan Hui et al. Cell Metabolism
- Transplanted Bone Marrow-Derived Cells Contribute to Human Adipogenesis
- (2015) Mikael Rydén et al. Cell Metabolism
- Pharmacologic Effects of FGF21 Are Independent of the “Browning” of White Adipose Tissue
- (2015) Murielle M. Véniant et al. Cell Metabolism
- Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist
- (2015) Aaron M. Cypess et al. Cell Metabolism
- Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis
- (2015) Jonathan Y. Xia et al. Cell Metabolism
- Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry
- (2015) Mark P. Jedrychowski et al. Cell Metabolism
- Leptin Beyond the Lipostat: Key Component of Blood Pressure Regulation
- (2015) C. M. Kusminski et al. CIRCULATION RESEARCH
- One week treatment with the IL-1 receptor antagonist anakinra leads to a sustained improvement in insulin sensitivity in insulin resistant patients with type 1 diabetes mellitus
- (2015) Edwin J.P. van Asseldonk et al. CLINICAL IMMUNOLOGY
- A Novel Role for Subcutaneous Adipose Tissue in Exercise-Induced Improvements in Glucose Homeostasis
- (2015) Kristin I. Stanford et al. DIABETES
- Impaired Mitochondrial Biogenesis in Adipose Tissue in Acquired Obesity
- (2015) Sini Heinonen et al. DIABETES
- 6. Obesity Management for the Treatment of Type 2 Diabetes
- (2015) DIABETES CARE
- Introduction: Table 1
- (2015) DIABETES CARE
- Salsalate has no effect on insulin secretion but decreases insulin clearance: a randomized, placebo-controlled trial in subjects without diabetes
- (2015) A. Penesova et al. DIABETES OBESITY & METABOLISM
- Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: A randomized controlled trial
- (2015) Shihui Chen et al. DIGESTIVE AND LIVER DISEASE
- Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice
- (2015) Nicholas Douris et al. ENDOCRINOLOGY
- Positive Feedback Regulation Between Adiponectin and T-Cadherin Impacts Adiponectin Levels in Tissue and Plasma of Male Mice
- (2015) Keisuke Matsuda et al. ENDOCRINOLOGY
- PDGFRα signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity
- (2015) Tomoaki Iwayama et al. GENES & DEVELOPMENT
- The cell biology of fat expansion
- (2015) Joseph M. Rutkowski et al. JOURNAL OF CELL BIOLOGY
- Contrast-Enhanced Ultrasound: A Novel Noninvasive, Nonionizing Method for the Detection of Brown Adipose Tissue in Humans
- (2015) Aidan Flynn et al. JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
- Crystal structures of the human adiponectin receptors
- (2015) Hiroaki Tanabe et al. NATURE
- Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation
- (2015) Qiong A. Wang et al. NATURE CELL BIOLOGY
- Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
- (2015) Sungsoon Fang et al. NATURE MEDICINE
- Regulation of metabolism by the innate immune system
- (2015) Denise E. Lackey et al. Nature Reviews Endocrinology
- Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes
- (2015) Bernard Zinman et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management
- (2015) Xavier Pi-Sunyer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Células madre mesenquimales derivadas de tejido adiposo y su potencial reparador en la enfermedad isquémica coronaria
- (2015) Lina Badimon et al. REVISTA ESPANOLA DE CARDIOLOGIA
- Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats
- (2015) R. J. Perry et al. SCIENCE
- Delivery of Adipose-Derived Stem Cells Attenuates Adipose Tissue Inflammation and Insulin Resistance in Obese Mice Through Remodeling Macrophage Phenotypes
- (2015) Qianwen Shang et al. STEM CELLS AND DEVELOPMENT
- Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21
- (2015) Bryn M. Owen et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Adipokines in health and disease
- (2015) Mathias Fasshauer et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- A subcutaneous adipose tissue–liver signalling axis controls hepatic gluconeogenesis
- (2015) Shannon M. Reilly et al. Nature Communications
- Liraglutide reduces lipogenetic signals in visceral adipose of db/db mice with AMPK activation and Akt suppression
- (2015) Yimin Shao et al. Drug Design Development and Therapy
- Irisin – a myth rather than an exercise-inducible myokine
- (2015) Elke Albrecht et al. Scientific Reports
- Adipose-derived mesenchymal stem cells improve glucose homeostasis in high-fat diet-induced obese mice
- (2015) Mingjun Cao et al. Stem Cell Research & Therapy
- Intralesional injection of adipose-derived stem cells reduces hypertrophic scarring in a rabbit ear model
- (2015) Qi Zhang et al. Stem Cell Research & Therapy
- Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1
- (2015) Ricardo J. Samms et al. Cell Reports
- The effect of CCR2 inhibitor CCX140-B on residual albuminuria in patients with type 2 diabetes and nephropathy: a randomised trial
- (2015) Dick de Zeeuw et al. Lancet Diabetes & Endocrinology
- Leukotriene B4 as a Potential Therapeutic Target for the Treatment of Metabolic Disorders
- (2015) Luciano Ribeiro Filgueiras et al. Frontiers in Immunology
- Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity
- (2015) Rafael Mayoral et al. Molecular Metabolism
- A major role of insulin in promoting obesity-associated adipose tissue inflammation
- (2015) David J. Pedersen et al. Molecular Metabolism
- Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex
- (2015) Ganesh Kolumam et al. EBioMedicine
- Is interleukin-1β a culprit in macrophage-adipocyte crosstalk in obesity?
- (2015) Chen Bing Adipocyte
- Pharmacokinetics (PK), Pharmacodynamics (PD) and Integrated PK/PD Modeling of a Novel Long Acting FGF21 Clinical Candidate PF-05231023 in Diet-Induced Obese and Leptin-Deficient Obese Mice
- (2015) Yan Weng et al. PLoS One
- Targeting hypoxia-inducible factor-1α (HIF-1α) in combination with antiangiogenic therapy: A phase I trial of bortezomib plus bevacizumab
- (2015) Gerald S. Falchook et al. Oncotarget
- Interleukin-1β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes
- (2014) Dan Gao et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Hypoxia and Adipocyte Physiology: Implications for Adipose Tissue Dysfunction in Obesity
- (2014) Paul Trayhurn Annual Review of Nutrition
- IRF4 Is a Key Thermogenic Transcriptional Partner of PGC-1α
- (2014) Xingxing Kong et al. CELL
- Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat
- (2014) Yifu Qiu et al. CELL
- Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis
- (2014) Rajesh R. Rao et al. CELL
- Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects
- (2014) Mark M. Yore et al. CELL
- What We Talk About When We Talk About Fat
- (2014) Evan D. Rosen et al. CELL
- Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch
- (2014) Paul Cohen et al. CELL
- FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure, and Weight Loss
- (2014) Bryn M. Owen et al. Cell Metabolism
- Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans
- (2014) Paul Lee et al. Cell Metabolism
- Adipocyte Inflammation Is Essential for Healthy Adipose Tissue Expansion and Remodeling
- (2014) Ingrid Wernstedt Asterholm et al. Cell Metabolism
- Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans
- (2014) M. Chondronikola et al. DIABETES
- Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding
- (2014) K. R. Markan et al. DIABETES
- CCR2 antagonism in patients with type 2 diabetes mellitus: a randomized, placebo-controlled study
- (2014) N. A. Di Prospero et al. DIABETES OBESITY & METABOLISM
- Fibroblast growth factor 21 analogue LY2405319 lowers blood glucose in streptozotocin-induced insulin-deficient diabetic mice by restoring brown adipose tissue function
- (2014) J.-H. Kim et al. DIABETES OBESITY & METABOLISM
- Combinational therapy with metformin and sodium-glucose cotransporter inhibitors in management of type 2 diabetes: Systematic review and meta-analyses
- (2014) Qian Zhang et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Benefit-Risk Assessment of Orlistat in the Treatment of Obesity
- (2014) Priya Sumithran et al. DRUG SAFETY
- Pharmacology, Physiology, and Mechanisms of Action of Dipeptidyl Peptidase-4 Inhibitors
- (2014) Erin E. Mulvihill et al. ENDOCRINE REVIEWS
- Fibroblast Growth Factor 21 Limits Lipotoxicity by Promoting Hepatic Fatty Acid Activation in Mice on Methionine and Choline-Deficient Diets
- (2014) Ffolliott M. Fisher et al. GASTROENTEROLOGY
- Increased Brown Adipose Tissue Oxidative Capacity in Cold-Acclimated Humans
- (2014) Denis P. Blondin et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- 20 YEARS OF LEPTIN: Leptin at 20: an overview
- (2014) Jeffrey Friedman JOURNAL OF ENDOCRINOLOGY
- 20 YEARS OF LEPTIN: Role of leptin in energy homeostasis in humans
- (2014) Michael Rosenbaum et al. JOURNAL OF ENDOCRINOLOGY
- Enhanced ROS production and oxidative damage in subcutaneous white adipose tissue mitochondria in obese and type 2 diabetes subjects
- (2014) Mrittika Chattopadhyay et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- The different shades of fat
- (2014) Vivian Peirce et al. NATURE
- An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ
- (2014) Alexander S. Banks et al. NATURE
- A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice
- (2014) Da Young Oh et al. NATURE MEDICINE
- A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
- (2014) Brian Finan et al. NATURE MEDICINE
- FGF21-based pharmacotherapy – potential utility for metabolic disorders
- (2014) Ruth E. Gimeno et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- MitoNEET-mediated effects on browning of white adipose tissue
- (2014) Christine M. Kusminski et al. Nature Communications
- Immune Cell Toll-like Receptor 4 Mediates the Development of Obesity- and Endotoxemia-Associated Adipose Tissue Fibrosis
- (2014) Isabelle K. Vila et al. Cell Reports
- ROCK1 isoform-specific deletion reveals a role for diet-induced insulin resistance
- (2013) Seung-Hwan Lee et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Salicylate (Salsalate) in Patients With Type 2 Diabetes
- (2013) Allison B. Goldfine ANNALS OF INTERNAL MEDICINE
- High-Dose Resveratrol Treatment for 2 Weeks Inhibits Intestinal and Hepatic Lipoprotein Production in Overweight/Obese Men
- (2013) Satya Dash et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Adiponectin Mediates the Metabolic Effects of FGF21 on Glucose Homeostasis and Insulin Sensitivity in Mice
- (2013) Zhuofeng Lin et al. Cell Metabolism
- Mechanisms and Metabolic Implications of Regional Differences among Fat Depots
- (2013) Tamara Tchkonia et al. Cell Metabolism
- Reversal of Hypertriglyceridemia, Fatty Liver Disease, and Insulin Resistance by a Liver-Targeted Mitochondrial Uncoupler
- (2013) Rachel J. Perry et al. Cell Metabolism
- Fibrosis and Adipose Tissue Dysfunction
- (2013) Kai Sun et al. Cell Metabolism
- An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice
- (2013) William L. Holland et al. Cell Metabolism
- The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes
- (2013) Gregory Gaich et al. Cell Metabolism
- Metformin Lowers Plasma Triglycerides by Promoting VLDL-Triglyceride Clearance by Brown Adipose Tissue in Mice
- (2013) J. J. Geerling et al. DIABETES
- The Impact of Salsalate Treatment on Serum Levels of Advanced Glycation End Products in Type 2 Diabetes
- (2013) Joshua I. Barzilay et al. DIABETES CARE
- Thirty days of resveratrol supplementation does not affect postprandial incretin hormone responses, but suppresses postprandial glucagon in obese subjects
- (2013) F. K. Knop et al. DIABETIC MEDICINE
- Aspirin in type 2 diabetes, a randomised controlled study: effect of different doses on inflammation, oxidative stress, insulin resistance and endothelial function
- (2013) R. P. Raghavan et al. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
- Impact of brown adipose tissue on body fatness and glucose metabolism in healthy humans
- (2013) M Matsushita et al. INTERNATIONAL JOURNAL OF OBESITY
- Brown Fat Activation Mediates Cold-Induced Thermogenesis in Adult Humans in Response to a Mild Decrease in Ambient Temperature
- (2013) Kong Y. Chen et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Recruited brown adipose tissue as an antiobesity agent in humans
- (2013) Takeshi Yoneshiro et al. JOURNAL OF CLINICAL INVESTIGATION
- Experimental evidence for the use of CCR2 antagonists in the treatment of type 2 diabetes
- (2013) Timothy J. Sullivan et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity
- (2013) Miki Okada-Iwabu et al. NATURE
- FGF21 contributes to neuroendocrine control of female reproduction
- (2013) Bryn M Owen et al. NATURE MEDICINE
- Tracking adipogenesis during white adipose tissue development, expansion and regeneration
- (2013) Qiong A Wang et al. NATURE MEDICINE
- An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice
- (2013) Shannon M Reilly et al. NATURE MEDICINE
- FGF21 regulates metabolism and circadian behavior by acting on the nervous system
- (2013) Angie L Bookout et al. NATURE MEDICINE
- Lifestyle intervention in childhood obesity: changes and challenges
- (2013) Thomas Reinehr Nature Reviews Endocrinology
- Blunted metabolic responses to cold and insulin stimulation in brown adipose tissue of obese humans
- (2013) Janne Orava et al. Obesity
- XOMA 052, an anti-IL-1β monoclonal antibody, prevents IL-1β-mediated insulin resistance in 3T3-L1 adipocytes
- (2013) Masahisa Handa et al. Obesity
- Fibroblast growth factor 21 (FGF21) and bone: is there a relationship in humans?
- (2013) P. Lee et al. OSTEOPOROSIS INTERNATIONAL
- Rational Design of a Fibroblast Growth Factor 21-Based Clinical Candidate, LY2405319
- (2013) Alexei Kharitonenkov et al. PLoS One
- LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys
- (2013) Andrew C. Adams et al. PLoS One
- Evidence against a Beneficial Effect of Irisin in Humans
- (2013) Silja Raschke et al. PLoS One
- Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans
- (2013) B. Finan et al. Science Translational Medicine
- Pharmacological strategies for targeting BAT thermogenesis
- (2013) Andrew Whittle et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Regulation of glucose homoeostasis by brown adipose tissue
- (2013) Vivian Peirce et al. Lancet Diabetes & Endocrinology
- Adiponectin, driver or passenger on the road to insulin sensitivity?
- (2013) Risheng Ye et al. Molecular Metabolism
- Leptin reverses declines in satiation in weight-reduced obese humans
- (2012) Harry R Kissileff et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- The HIF-pathway inhibitor NSC-134754 induces metabolic changes and anti-tumour activity while maintaining vascular function
- (2012) L C J Baker et al. BRITISH JOURNAL OF CANCER
- Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ
- (2012) Li Qiang et al. CELL
- Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones
- (2012) Paul A. Dutchak et al. CELL
- BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions
- (2012) Andrew J. Whittle et al. CELL
- Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
- (2012) Jun Wu et al. CELL
- Challenges and Opportunities of Defining Clinical Leptin Resistance
- (2012) Martin G. Myers et al. Cell Metabolism
- Adipose-Specific Deletion of TFAM Increases Mitochondrial Oxidation and Protects Mice against Obesity and Insulin Resistance
- (2012) Cecile Vernochet et al. Cell Metabolism
- βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism
- (2012) Xunshan Ding et al. Cell Metabolism
- Systemic -Adrenergic Stimulation of Thermogenesis Is Not Accompanied by Brown Adipose Tissue Activity in Humans
- (2012) M. J. Vosselman et al. DIABETES
- Effect of anti-IL-1β antibody (canakinumab) on insulin secretion rates in impaired glucose tolerance or type 2 diabetes: results of a randomized, placebo-controlled trial
- (2012) A. Rissanen et al. DIABETES OBESITY & METABOLISM
- Ephedrine activates brown adipose tissue in lean but not obese humans
- (2012) A. L. Carey et al. DIABETOLOGIA
- Adiponectin: mechanistic insights and clinical implications
- (2012) A. T. Turer et al. DIABETOLOGIA
- Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors
- (2012) Yan Xia et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway
- (2012) Kristy L. Townsend et al. FASEB JOURNAL
- Dietary obesity-associated Hif1 activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system
- (2012) J. Krishnan et al. GENES & DEVELOPMENT
- FGF21 regulates PGC-1 and browning of white adipose tissues in adaptive thermogenesis
- (2012) f. M. Fisher et al. GENES & DEVELOPMENT
- Fibroblast Growth Factor 21 (FGF21) Inhibits Chondrocyte Function and Growth Hormone Action Directly at the Growth Plate
- (2012) Shufang Wu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Adipocyte-derived endotrophin promotes malignant tumor progression
- (2012) Jiyoung Park et al. JOURNAL OF CLINICAL INVESTIGATION
- Selective Inhibition of Hypoxia-Inducible Factor 1 Ameliorates Adipose Tissue Dysfunction
- (2012) K. Sun et al. MOLECULAR AND CELLULAR BIOLOGY
- ‘Metabolically healthy obesity’: Origins and implications
- (2012) Gerald V. Denis et al. MOLECULAR ASPECTS OF MEDICINE
- Adipose tissue heterogeneity: Implication of depot differences in adipose tissue for obesity complications
- (2012) Mi-Jeong Lee et al. MOLECULAR ASPECTS OF MEDICINE
- A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
- (2012) Pontus Boström et al. NATURE
- MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity
- (2012) Christine M Kusminski et al. NATURE MEDICINE
- From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior
- (2012) Kevin W Williams et al. NATURE NEUROSCIENCE
- Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations
- (2012) Keith T. Flaherty et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cold but not sympathomimetics activates human brown adipose tissue in vivo
- (2012) A. M. Cypess et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor
- (2012) W. Wei et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dichotomous effects of VEGF-A on adipose tissue dysfunction
- (2012) K. Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondrial dysfunction in white adipose tissue
- (2012) Christine M. Kusminski et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- PPARs at the crossroads of lipid signaling and inflammation
- (2012) Walter Wahli et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Functional annotation of the human fat cell secretome
- (2012) Ingrid Dahlman et al. ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
- The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue
- (2012) Andrew C. Adams et al. Molecular Metabolism
- Three years with adult human brown adipose tissue
- (2011) Jan Nedergaard et al. Annals of the New York Academy of Sciences
- Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients
- (2011) Pál Brasnyó et al. BRITISH JOURNAL OF NUTRITION
- Recombinant Human Leptin Treatment Does Not Improve Insulin Action in Obese Subjects With Type 2 Diabetes
- (2011) B. Mittendorfer et al. DIABETES
- The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia
- (2011) R. A. DeFronzo et al. DIABETES OBESITY & METABOLISM
- Serum bone morphogenetic protein 7, insulin resistance, and insulin secretion in non-diabetic individuals
- (2011) Jun Zeng et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Adipose tissue mass and location affect circulating adiponectin levels
- (2011) A. T. Turer et al. DIABETOLOGIA
- Topiramate-induced weight loss: A review
- (2011) Alberto Verrotti et al. EPILEPSY RESEARCH
- Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide
- (2011) A Astrup et al. INTERNATIONAL JOURNAL OF OBESITY
- Association Between Disease-Modifying Antirheumatic Drugs and Diabetes Risk in Patients With Rheumatoid Arthritis and Psoriasis
- (2011) Daniel H. Solomon JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Regulation of Adipocyte Formation by GLP-1/GLP-1R Signaling
- (2011) Tenagne Delessa Challa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Preferential Fat Deposition in SubcutaneousVersusVisceral Depots Is Associated with Insulin Sensitivity
- (2011) Tracey McLaughlin et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Adipose tissue remodeling and obesity
- (2011) Kai Sun et al. JOURNAL OF CLINICAL INVESTIGATION
- Adipose tissue stem cells meet preadipocyte commitment: going back to the future
- (2011) William P. Cawthorn et al. JOURNAL OF LIPID RESEARCH
- Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis
- (2011) Khoa D. Nguyen et al. NATURE
- Brown adipose tissue activity controls triglyceride clearance
- (2011) Alexander Bartelt et al. NATURE MEDICINE
- Adipokines: A treasure trove for the discovery of biomarkers for metabolic disorders
- (2011) Stefan Lehr et al. Proteomics Clinical Applications
- Discovery of INCB8761/PF-4136309, a Potent, Selective, and Orally Bioavailable CCR2 Antagonist
- (2011) Chu-Biao Xue et al. ACS Medicinal Chemistry Letters
- Adiponectin resistance and vascular dysfunction in the hyperlipidemic state
- (2010) Rong Li et al. ACTA PHARMACOLOGICA SINICA
- Enhanced Metabolic Flexibility Associated with Elevated Adiponectin Levels
- (2010) Ingrid Wernstedt Asterholm et al. AMERICAN JOURNAL OF PATHOLOGY
- Mitiglinide: A Novel Agent for the Treatment of Type 2 Diabetes Mellitus
- (2010) Haley M Phillippe et al. ANNALS OF PHARMACOTHERAPY
- GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects
- (2010) Da Young Oh et al. CELL
- Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption
- (2010) J. R. Ussher et al. DIABETES
- Exercise and Type 2 Diabetes: The American College of Sports Medicine and the American Diabetes Association: joint position statement
- (2010) S. R. Colberg et al. DIABETES CARE
- Development and Characterization of High Affinity Leptins and Leptin Antagonists
- (2010) Michal Shpilman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TNF-α Antagonism with Etanercept Decreases Glucose and Increases the Proportion of High Molecular Weight Adiponectin in Obese Subjects with Features of the Metabolic Syndrome
- (2010) Takara L. Stanley et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- T-cadherin is critical for adiponectin-mediated cardioprotection in mice
- (2010) Martin S. Denzel et al. JOURNAL OF CLINICAL INVESTIGATION
- Rimonabant for prevention of cardiovascular events (CRESCENDO): a randomised, multicentre, placebo-controlled trial
- (2010) Eric J Topol et al. LANCET
- Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial
- (2010) Frank L Greenway et al. LANCET
- Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial
- (2010) Faramarz Ismail-Beigi et al. LANCET
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- (2007) Alexander R. Vaccaro et al. Spine Journal
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