The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice

Regulators of Cholangiocyte Proliferation

(2017) Chad Hall et al.   GENE EXPRESSION

Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives

(2016) Juan P. Arab et al.   HEPATOLOGY

The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases

(2016) Masayuki Nagahashi et al.   JOURNAL OF LIPID RESEARCH

Murine model of long-term obstructive jaundice

(2016) Hiroaki Aoki et al.   JOURNAL OF SURGICAL RESEARCH

TGR5 activation suppressed S1P/S1P2 signaling and resisted high glucose-induced fibrosis in glomerular mesangial cells

(2016) Zhiying Yang et al.   PHARMACOLOGICAL RESEARCH

Bile acids evoke placental inflammation by activating Gpbar1/NF-κB pathway in intrahepatic cholestasis of pregnancy

(2016) YouHua Zhang et al.   Journal of Molecular Cell Biology

Increased sphingosine 1-phosphate mediates inflammation and fibrosis in tubular injury in diabetic nephropathy

(2015) Dania Yaghobian et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

TGR5 in the Cholangiociliopathies

(2015) Tatyana V. Masyuk et al.   DIGESTIVE DISEASES

Transforming growth factor-β-sphingosine kinase 1/S1P signaling upregulates microRNA-21 to promote fibrosis in renal tubular epithelial cells

(2015) Xiujuan Liu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro

(2015) Maria Reich et al.   GUT

Conjugated bile acid-activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression

(2015) Masayuki Nagahashi et al.   HEPATOLOGY

Taurocholate Induces Cyclooxygenase-2 Expression via the Sphingosine 1-phosphate Receptor 2 in a Human Cholangiocarcinoma Cell Line

(2015) Runping Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity

(2015) Firhan A. Malik et al.   PLoS One

Sphingosine 1-Phosphate Receptor 2 and 3 Mediate Bone Marrow-Derived Monocyte/Macrophage Motility in Cholestatic Liver Injury in Mice

(2015) Le Yang et al.   Scientific Reports

TGR5: Pathogenetic Role and/or Therapeutic Target in Fibrosing Cholangitis?

(2014) Verena Keitel et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Conjugated bile acids promote cholangiocarcinoma cell invasive growth through activation of sphingosine 1-phosphate receptor 2

(2014) Runping Liu et al.   HEPATOLOGY

Export of sphingosine-1-phosphate and cancer progression

(2014) Kazuaki Takabe et al.   JOURNAL OF LIPID RESEARCH

Bile acids are nutrient signaling hormones

(2014) Huiping Zhou et al.   STEROIDS

IL-17A Synergistically Enhances Bile Acid–Induced Inflammation during Obstructive Cholestasis

(2013) Kate M. O'Brien et al.   AMERICAN JOURNAL OF PATHOLOGY

Sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptor axis is involved in liver fibrosis-associated angiogenesis

(2013) Le Yang et al.   JOURNAL OF HEPATOLOGY

Evaluation of Serum Bile Acid Profiles as Biomarkers of Liver Injury in Rodents

(2013) Lina Luo et al.   TOXICOLOGICAL SCIENCES

Perturbation of bile acid homeostasis is an early pathogenesis event of drug induced liver injury in rats

(2013) Makoto Yamazaki et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Bile acids and liver carcinogenesis: TGR5 as a novel piece in the puzzle?

(2013) Noémie Péan et al.   Clinics and Research in Hepatology and Gastroenterology

Antagonism of sphingosine 1-phosphate receptor 2 causes a selective reduction of portal vein pressure in bile duct-ligated rodents

(2012) Yuko Kageyama et al.   HEPATOLOGY

Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes

(2011) Elaine Studer et al.   HEPATOLOGY

Effect of bile duct ligation on bile acid composition in mouse serum and liver

(2011) Youcai Zhang et al.   LIVER INTERNATIONAL

Taurocholic acid prevents biliary damage induced by hepatic artery ligation in cholestatic rats

(2010) Shannon Glaser et al.   DIGESTIVE AND LIVER DISEASE

Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility

(2010) Changyong Li et al.   JOURNAL OF HEPATOLOGY

The Role of Inflammation in Cholestasis: Clinical and Basic Aspects

(2010) Astrid Kosters et al.   SEMINARS IN LIVER DISEASE

Involvement of Sphingosine 1-Phosphate (SIP)/S1P 3 Signaling in Cholestasis-Induced Liver Fibrosis

(2009) Changyong Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Cholestasis and cholestatic syndromes

(2009) Gideon M Hirschfield et al.   CURRENT OPINION IN GASTROENTEROLOGY

Cholangiocyte proliferation and liver fibrosis

(2009) Shannon S. Glaser et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis

(2009) Changyong Li et al.   JOURNAL OF HEPATOLOGY

Bile acids as regulatory molecules

(2009) Phillip B. Hylemon et al.   JOURNAL OF LIPID RESEARCH

Morphological and functional heterogeneity of the mouse intrahepatic biliary epithelium

(2009) Shannon S Glaser et al.   LABORATORY INVESTIGATION

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2

(2008) Hitoshi Ikeda et al.   JOURNAL OF LIPID RESEARCH

"Inside-Out" Signaling of Sphingosine-1-Phosphate: Therapeutic Targets

(2008) K. Takabe et al.   PHARMACOLOGICAL REVIEWS

An integrated metabonomic method for profiling of metabolic changes in carbon tetrachloride induced rat urine

(2008) Yanping Lin et al.   TOXICOLOGY