Sphingosine kinase 1 regulates adipose proinflammatory responses and insulin resistance

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

(2013) N. Turner et al.   DIABETOLOGIA

Overexpression of Sphingosine Kinase 1 Prevents Ceramide Accumulation and Ameliorates Muscle Insulin Resistance in High-Fat Diet-Fed Mice

(2012) C. R. Bruce et al.   DIABETES

Ceramides Contained in LDL Are Elevated in Type 2 Diabetes and Promote Inflammation and Skeletal Muscle Insulin Resistance

(2012) J. Boon et al.   DIABETES

The Sphingosine-1-Phosphate Analog FTY720 Reduces Muscle Ceramide Content and Improves Glucose Tolerance in High Fat-Fed Male Mice

(2012) Clinton R. Bruce et al.   ENDOCRINOLOGY

Antiobesity activity of a sphingosine 1-phosphate analogue FTY720 observed in adipocytes and obese mouse model

(2012) Myung-Hee Moon et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell–dependent murine model of allergic asthma

(2012) Megan M. Price et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Expression of ceramide-metabolising enzymes in subcutaneous and intra-abdominal human adipose tissue

(2012) Maria Kolak et al.   Lipids in Health and Disease

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

Sphingolipid Content of Human Adipose Tissue: Relationship to Adiponectin and Insulin Resistance

(2012) Agnieszka U. Blachnio-Zabielska et al.   Obesity

Adipocyte NCoR Knockout Decreases PPARγ Phosphorylation and Enhances PPARγ Activity and Insulin Sensitivity

(2011) Pingping Li et al.   CELL

Preadipocytes of type 2 diabetes subjects display an intrinsic gene expression profile of decreased differentiation capacity

(2011) F H J van Tienen et al.   INTERNATIONAL JOURNAL OF OBESITY

Tissue factor–protease-activated receptor 2 signaling promotes diet-induced obesity and adipose inflammation

(2011) Leylla Badeanlou et al.   NATURE MEDICINE

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

The involvement of sphingosine kinase 1 in LPS-induced Toll-like receptor 4-mediated accumulation of HIF-1α protein, activation of ASK1 and production of the pro-inflammatory cytokine IL-6

(2010) Dmitri Pchejetski et al.   IMMUNOLOGY AND CELL BIOLOGY

Sphingosine 1-Phosphate Lyase Deficiency Disrupts Lipid Homeostasis in Liver

(2010) Meryem Bektas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular models for understanding adipogenesis, adipose dysfunction, and obesity

(2010) Andrea Armani et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Genetic Sphingosine Kinase 1 Deficiency Significantly Decreases Synovial Inflammation and Joint Erosions in Murine TNF- -Induced Arthritis

(2010) D. A. Baker et al.   JOURNAL OF IMMUNOLOGY

SphK1 Regulates Proinflammatory Responses Associated with Endotoxin and Polymicrobial Sepsis

(2010) P. Puneet et al.   SCIENCE

Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity

(2010) Roger H. Unger et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome

(2009) Guang Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4himonocytes in obesity

(2009) Daniel J. Westcott et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Posttranslational Modifications of PPAR-γ: Fine-tuning the Metabolic Master Regulator

(2009) Olivier van Beekum et al.   Obesity

A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia

(2008) S. W. Paugh et al.   BLOOD

Plasma Ceramides Are Elevated in Obese Subjects With Type 2 Diabetes and Correlate With the Severity of Insulin Resistance

(2008) J. M. Haus et al.   DIABETES

Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a “come-and-get-me” signal

(2008) David R. Gude et al.   FASEB JOURNAL

Protection from High Fat Diet-induced Increase in Ceramide in Mice Lacking Plasminogen Activator Inhibitor 1

(2008) Charmi Shah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine kinase is induced in mouse 3T3-L1 cells and promotes adipogenesis

(2008) Takeshi Hashimoto et al.   JOURNAL OF LIPID RESEARCH

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

(2008) Adilson Guilherme et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome

(2008) M.-Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA