Cross talk between autophagy and oncogenic signaling pathways and implications for cancer therapy
出版年份 2021 全文链接
标题
Cross talk between autophagy and oncogenic signaling pathways and implications for cancer therapy
作者
关键词
Autophagy, EMT, Cancer metastasis, Oncogenic proteins, Anticancer therapy
出版物
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Volume 1876, Issue 1, Pages 188565
出版商
Elsevier BV
发表日期
2021-05-13
DOI
10.1016/j.bbcan.2021.188565
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Targeting hypoxia in the tumor microenvironment: a potential strategy to improve cancer immunotherapy
- (2021) Bin Wang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Tumor Immunology and Tumor Evolution: Intertwined Histories
- (2020) Jérôme Galon et al. IMMUNITY
- The significance of exosomes in the development and treatment of hepatocellular carcinoma
- (2020) Xin Li et al. Molecular Cancer
- Plasma-activated medium promotes autophagic cell death along with alteration of the mTOR pathway
- (2020) Nobuhisa Yoshikawa et al. Scientific Reports
- Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation
- (2020) Leena P. Bharath et al. Cell Metabolism
- A Randomized Phase II Preoperative Study of Autophagy Inhibition with High-Dose Hydroxychloroquine and Gemcitabine/Nab-Paclitaxel in Pancreatic Cancer Patients
- (2020) Herbert J. Zeh et al. CLINICAL CANCER RESEARCH
- Autophagy promotes mammalian survival by suppressing oxidative stress and p53
- (2020) Yang Yang et al. GENES & DEVELOPMENT
- ULK1 inhibition as a targeted therapeutic strategy for FLT3-ITD-mutated acute myeloid leukemia
- (2020) Doh Yu Hwang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Relevance of immune cell and tumor microenvironment imaging in the new era of immunotherapy
- (2020) Filippo Galli et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I
- (2020) Keisuke Yamamoto et al. NATURE
- Multi-site-mediated entwining of the linear WIR-motif around WIPI β-propellers for autophagy
- (2020) Jinqi Ren et al. Nature Communications
- mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges
- (2020) Zhilin Zou et al. Cell and Bioscience
- Therapeutic Targeting of Autophagy for Renal Cell Carcinoma Therapy
- (2020) Trace M. Jones et al. Cancers
- Molecular Insights Into Therapeutic Potential of Autophagy Modulation by Natural Products for Cancer Stem Cells
- (2020) Md. Ataur Rahman et al. Frontiers in Cell and Developmental Biology
- Notch Transduction in Non-Small Cell Lung Cancer
- (2020) Amnah Sharif et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Dual targeting of NUAK1 and ULK1 using the multitargeted inhibitor MRT68921 exerts potent antitumor activities
- (2020) Yiran Chen et al. Cell Death & Disease
- mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability
- (2020) Niklas Gremke et al. Nature Communications
- Antileukemic activity of the VPS34-IN1 inhibitor in acute myeloid leukemia
- (2020) Godelieve Meunier et al. Oncogenesis
- Cep55 overexpression promotes genomic instability and tumorigenesis in mice
- (2020) Debottam Sinha et al. Communications Biology
- Biological Functions of Autophagy Genes: A Disease Perspective
- (2019) Beth Levine et al. CELL
- Autophagy inhibition to augment mTOR inhibition: A phase I/II trial of everolimus and hydroxychloroquine in patients with previously treated renal cell carcinoma
- (2019) Naomi B. Haas et al. CLINICAL CANCER RESEARCH
- Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and VEGF-C/ Bcl-2 expression
- (2019) Yunzhao Chen et al. Molecular Cancer
- Metformin prevents cell tumorigenesis through autophagy-related cell death
- (2019) Mauro De Santi et al. Scientific Reports
- Control of the Epithelial-to-Mesenchymal Transition and Cancer Metastasis by Autophagy-Dependent SNAI1 Degradation
- (2019) Sahib Zada et al. Cells
- Cathelicidin Suppresses Colon Cancer Metastasis via a P2RX7-Dependent Mechanism
- (2019) Jiani Wang et al. Molecular Therapy-Oncolytics
- Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers
- (2019) Conan G. Kinsey et al. NATURE MEDICINE
- Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer
- (2019) Kirsten L. Bryant et al. NATURE MEDICINE
- The relationship between autophagy and the immune system and its applications for tumor immunotherapy
- (2019) Guan-Min Jiang et al. Molecular Cancer
- Autophagy and cancer stem cells: molecular mechanisms and therapeutic applications
- (2019) Francesca Nazio et al. CELL DEATH AND DIFFERENTIATION
- Autophagy protein ATG5 regulates CD36 expression and anti-tumor MHC class II antigen presentation in dendritic cells
- (2019) Dong Sun Oh et al. Autophagy
- Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells
- (2019) Yihua Wang et al. Autophagy
- FOXO3 directly regulates an autophagy network to functionally regulate proteostasis in adult neural stem cells
- (2019) Amanda J. Audesse et al. PLoS Genetics
- In Situ Manipulation of Dendritic Cells by an Autophagy-Regulative Nanoactivator Enables Effective Cancer Immunotherapy
- (2019) Yi Wang et al. ACS Nano
- Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences
- (2019) Mara Cirone et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Targeting Autophagy in Cancer: Recent Advances and Future Directions
- (2019) Ravi K. Amaravadi et al. Cancer Discovery
- Hydroxychloroquine potentiates the anti-cancer effect of bevacizumab on glioblastoma via the inhibition of autophagy
- (2019) Lin-qing Liu et al. BIOMEDICINE & PHARMACOTHERAPY
- A Potent Autophagy Inhibitor (Lys05) Enhances the Impact of Ionizing Radiation on Human Lung Cancer Cells H1299
- (2019) Lucie Cechakova et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Resveratrol As A Natural Regulator Of Autophagy For Prevention And Treatment Of Cancer
- (2019) Yuanyuan Tian et al. OncoTargets and Therapy
- Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients
- (2019) Jean M. Mulcahy Levy et al. CELL DEATH AND DIFFERENTIATION
- Neferine induces autophagy-dependent cell death in apoptosis-resistant cancers via ryanodine receptor and Ca2+-dependent mechanism
- (2019) Betty Yuen Kwan Law et al. Scientific Reports
- Targeting autophagy blocks melanoma growth by bringing natural killer cells to the tumor battlefield
- (2018) Muhammad Zaeem Noman et al. Autophagy
- Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion
- (2018) Mario Mauthe et al. Autophagy
- Pro-survival autophagy and cancer cell resistance to therapy
- (2018) Chandan Kanta Das et al. CANCER AND METASTASIS REVIEWS
- Docetaxel-mediated autophagy promotes chemoresistance in castration-resistant prostate cancer cells by inhibiting STAT3
- (2018) Fei Hu et al. CANCER LETTERS
- Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
- (2018) Lorenzo Galluzzi et al. CELL DEATH AND DIFFERENTIATION
- Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover
- (2018) Brent E. Fitzwalter et al. DEVELOPMENTAL CELL
- Uncoupling effects of estrogen receptor α on LKB1/AMPK interaction upon adiponectin exposure in breast cancer
- (2018) Loredana Mauro et al. FASEB JOURNAL
- Matrine inhibiting pancreatic cells epithelial-mesenchymal transition and invasion through ROS/NF-κB/MMPs pathway
- (2018) Minna Huang et al. LIFE SCIENCES
- The mTOR–S6K pathway links growth signalling to DNA damage response by targeting RNF168
- (2018) Xiaoduo Xie et al. NATURE CELL BIOLOGY
- The coming of age of chaperone-mediated autophagy
- (2018) Susmita Kaushik et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Mechanism and medical implications of mammalian autophagy
- (2018) Ivan Dikic et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Ovatodiolide suppresses nasopharyngeal cancer by targeting stem cell-like population, inducing apoptosis, inhibiting EMT and dysregulating JAK/STAT signaling pathway
- (2018) Shao-Cheng Liu et al. PHYTOMEDICINE
- MDA-9/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells
- (2018) Sarmistha Talukdar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autophagy Sustains Pancreatic Cancer Growth through Both Cell-Autonomous and Nonautonomous Mechanisms
- (2018) Annan Yang et al. Cancer Discovery
- Resveratrol ameliorates autophagic flux to promote functional recovery in rats after spinal cord injury
- (2018) Peng Wang et al. Oncotarget
- Targeting Autophagy in the Tumor Microenvironment: New Challenges and Opportunities for Regulating Tumor Immunity
- (2018) Bassam Janji et al. Frontiers in Immunology
- Yap promotes hepatocellular carcinoma metastasis and mobilization via governing cofilin/F-actin/lamellipodium axis by regulation of JNK/Bnip3/SERCA/CaMKII pathways
- (2018) Chen Shi et al. Redox Biology
- Migration inhibition of water stress proteins from Nostoc commune Vauch. via activation of autophagy in DLD-1 cells
- (2018) Songjia Guo et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Macroautophagy Regulates Nuclear NOTCH1 Activity Through Multiple p62 Binding Sites
- (2018) Ting Zhang et al. IUBMB LIFE
- Autophagy induces transforming growth factor-β-dependent epithelial-mesenchymal transition in hepatocarcinoma cells through cAMP response element binding signalling
- (2018) Shaobo Hu et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells
- (2018) Themis Alissafi et al. JOURNAL OF CLINICAL INVESTIGATION
- Targeted inhibition of ULK1 promotes apoptosis and suppresses tumor growth and metastasis in neuroblastoma
- (2018) Christopher M Dower et al. MOLECULAR CANCER THERAPEUTICS
- Hyperphosphatemia Promotes Senescence of Myoblasts by Impairing Autophagy Through Ilk Overexpression, A Possible Mechanism Involved in Sarcopenia
- (2018) Patricia Sosa et al. Aging and Disease
- Overexpression of ULK1 Represents a Potential Diagnostic Marker for Clear Cell Renal Carcinoma and the Antitumor Effects of SBI-0206965
- (2018) Jun Lu et al. EBioMedicine
- Autophagosome maturation: An epic journey from the ER to lysosomes
- (2018) Yan G. Zhao et al. JOURNAL OF CELL BIOLOGY
- Autophagy, Cancer Stem Cells & Drug Resistance
- (2018) Alexandra G. Smith et al. JOURNAL OF PATHOLOGY
- Autophagy maintains tumour growth through circulating arginine
- (2018) Laura Poillet-Perez et al. NATURE
- Targeting surface nucleolin induces autophagy-dependent cell death in pancreatic cancer via AMPK activation
- (2018) Cheng Xu et al. ONCOGENE
- PPT1 promotes tumor growth and is the molecular target of chloroquine derivatives in cancer.
- (2018) Vito W Rebecca et al. Cancer Discovery
- Integrin signaling potentiates transforming growth factor-beta 1 (TGF-β1) dependent down-regulation of E-Cadherin expression – Important implications for epithelial to mesenchymal transition (EMT) in renal cell carcinoma
- (2017) B. Feldkoren et al. EXPERIMENTAL CELL RESEARCH
- Inhibiting ROS-NF-κB-dependent autophagy enhanced brazilin-induced apoptosis in head and neck squamous cell carcinoma
- (2017) Zhi-Jing He et al. FOOD AND CHEMICAL TOXICOLOGY
- Regulation of Mitochondrial Structure and Dynamics by the Cytoskeleton and Mechanical Factors
- (2017) Erzsébet Bartolák-Suki et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Regulation of autophagy and EMT by the interplay between p53 and RAS during cancer progression (Review)
- (2017) Xiaofei Zhang et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- TGF-β2 initiates autophagy via Smad and non-Smad pathway to promote glioma cells’ invasion
- (2017) Chao Zhang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways
- (2017) Marisa Granato et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Melatonin reverses H2 O2 -induced senescence in SH-SY5Y cells by enhancing autophagy via sirtuin 1 deacetylation of the RelA/p65 subunit of NF-κB
- (2017) Chutikorn Nopparat et al. JOURNAL OF PINEAL RESEARCH
- Cancerous perturbations within the ERK, PI3K/Akt, and Wnt/β-catenin signaling network constitutively activate inter-pathway positive feedback loops
- (2017) Rahul Rao Padala et al. Molecular BioSystems
- Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function
- (2017) Jun-ichi Sakamaki et al. MOLECULAR CELL
- Understanding the molecular mechanisms driving metastasis
- (2017) Joan Massagué et al. Molecular Oncology
- Microenvironmental autophagy promotes tumour growth
- (2017) Nadja S. Katheder et al. NATURE
- Molecular neurobiology of mTOR
- (2017) Katarzyna Switon et al. NEUROSCIENCE
- Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species
- (2017) J Manent et al. ONCOGENE
- Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo
- (2017) Lan Zhang et al. Chemical Science
- Overaccumulation of p53-mediated autophagy protects against betulinic acid-induced apoptotic cell death in colorectal cancer cells
- (2017) Sen Wang et al. Cell Death & Disease
- Calreticulin promotes EGF-induced EMT in pancreatic cancer cells via Integrin/EGFR-ERK/MAPK signaling pathway
- (2017) Weiwei Sheng et al. Cell Death & Disease
- MiR-23a promotes TGF-β1-induced EMT and tumor metastasis in breast cancer cells by directly targeting CDH1 and activating Wnt/β-catenin signaling
- (2017) Fei Ma et al. Oncotarget
- Human steroid sulfatase induces Wnt/β-catenin signaling and epithelial-mesenchymal transition by upregulating Twist1 and HIF-1α in human prostate and cervical cancer cells
- (2017) Sangyun Shin et al. Oncotarget
- NF-kappaB Is Involved in the Regulation of EMT Genes in Breast Cancer Cells
- (2017) Bruno R. B. Pires et al. PLoS One
- Metformin transiently inhibits colorectal cancer cell proliferation as a result of either AMPK activation or increased ROS production
- (2017) Angela Mogavero et al. Scientific Reports
- Autophagy promotes ferroptosis by degradation of ferritin
- (2016) Wen Hou et al. Autophagy
- PEBP1, a RAF kinase inhibitory protein, negatively regulates starvation-induced autophagy by direct interaction with LC3
- (2016) Hae Sook Noh et al. Autophagy
- Doxycycline inhibits the cancer stem cell phenotype and epithelial-to-mesenchymal transition in breast cancer
- (2016) Le Zhang et al. CELL CYCLE
- PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: Structural and pharmacological perspectives
- (2016) Vivek Asati et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Inactivation of p53 in pterygium influence miR-200a expression resulting in ZEB1/ZEB2 up-regulation and EMT processing
- (2016) Chueh-Wei Wu et al. EXPERIMENTAL EYE RESEARCH
- Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells
- (2016) Jessie Yanxiang Guo et al. GENES & DEVELOPMENT
- Autophagy links β-catenin and Smad signaling to promote epithelial-mesenchymal transition via upregulation of integrin linked kinase
- (2016) Min Pang et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Receptor for Activated C Kinase 1 (RACK1) Promotes Dishevelled Protein Degradation via Autophagy and Antagonizes Wnt Signaling
- (2016) Minzhang Cheng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Atg8 family LC3/GABARAP proteins are crucial for autophagosome–lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation
- (2016) Thanh Ngoc Nguyen et al. JOURNAL OF CELL BIOLOGY
- Ginkgolic Acid Inhibits Invasion and Migration and TGF-β-Induced EMT of Lung Cancer Cells Through PI3K/Akt/mTOR Inactivation
- (2016) Seung Ho Baek et al. JOURNAL OF CELLULAR PHYSIOLOGY
- ZEB1 drives epithelial-to-mesenchymal transition in lung cancer
- (2016) Jill E. Larsen et al. JOURNAL OF CLINICAL INVESTIGATION
- Cannabidiol Counteracts Amphetamine-Induced Neuronal and Behavioral Sensitization of the Mesolimbic Dopamine Pathway through a Novel mTOR/p70S6 Kinase Signaling Pathway
- (2016) Justine Renard et al. JOURNAL OF NEUROSCIENCE
- Autophagy Induction Results in Enhanced Anoikis Resistance in Models of Peritoneal Disease
- (2016) James L. Chen et al. MOLECULAR CANCER RESEARCH
- Resveratrol inhibits IL-6-induced ovarian cancer cell migration through epigenetic up-regulation of autophagy
- (2016) Alessandra Ferraresi et al. MOLECULAR CARCINOGENESIS
- Autophagy Regulates Chromatin Ubiquitination in DNA Damage Response through Elimination of SQSTM1/p62
- (2016) Yanan Wang et al. MOLECULAR CELL
- Epithelial-mesenchymal transition in tumor metastasis
- (2016) Kay T. Yeung et al. Molecular Oncology
- Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis
- (2016) Jun Wei et al. NATURE IMMUNOLOGY
- Cadherin-6 promotes EMT and cancer metastasis by restraining autophagy
- (2016) M Gugnoni et al. ONCOGENE
- The ATG conjugation systems are important for degradation of the inner autophagosomal membrane
- (2016) Kotaro Tsuboyama et al. SCIENCE
- The 4E-BP–eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes
- (2016) Lomon So et al. Science Signaling
- Signaling Cross Talk between TGF-β/Smad and Other Signaling Pathways
- (2016) Kunxin Luo Cold Spring Harbor Perspectives in Biology
- Autophagy and epithelial–mesenchymal transition: an intricate interplay in cancer
- (2016) Mila Gugnoni et al. Cell Death & Disease
- Inhibition of EHMT2/G9a epigenetically increases the transcription of Beclin-1 via an increase in ROS and activation of NF-κB
- (2016) Sang Eun Park et al. Oncotarget
- Autophagy negatively regulates tumor cell proliferation through phosphorylation dependent degradation of the Notch1 intracellular domain
- (2016) Ji-Seon Ahn et al. Oncotarget
- Lysophosphatidic acid stimulates epithelial to mesenchymal transition marker Slug/Snail2 in ovarian cancer cells via Gαi2, Src, and HIF1α signaling nexus
- (2016) Ji Hee Ha et al. Oncotarget
- Induction of epithelial-mesenchymal transition (EMT) by Beclin 1 knockdown via posttranscriptional upregulation of ZEB1 in thyroid cancer cells
- (2016) Si Li et al. Oncotarget
- Nesfatin-1/Nucleobindin-2 enhances cell migration, invasion, and epithelial-mesenchymal transition via LKB1/AMPK/TORC1/ZEB1 pathways in colon cancer
- (2016) Jung-Yu Kan et al. Oncotarget
- Inhibition of PI3K/Akt/mTOR signaling in PI3KR2-overexpressing colon cancer stem cells reduces tumor growth due to apoptosis
- (2016) Sugong Chen et al. Oncotarget
- p53 in the DNA-Damage-Repair Process
- (2016) Ashley B. Williams et al. Cold Spring Harbor Perspectives in Medicine
- The 4E-BP–eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes
- (2016) Lomon So et al. Science Signaling
- Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways
- (2016) Yumei Yan et al. Scientific Reports
- Ixabepilone: a new treatment option for the management of taxane-resistant metastatic breast cancer
- (2016) Rebecca Goldstein et al. Cancer Management and Research
- Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion
- (2015) Caroline Mauvezin et al. Autophagy
- p53-mediated autophagic regulation: A prospective strategy for cancer therapy
- (2015) Juanjuan Tang et al. CANCER LETTERS
- Autophagy, Metabolism, and Cancer
- (2015) E. White et al. CLINICAL CANCER RESEARCH
- Modulation of Notch Signaling as a Therapeutic Approach for Liver Cancer
- (2015) Guang Wu et al. CURRENT GENE THERAPY
- Function of human WIPI proteins in autophagosomal rejuvenation of endomembranes?
- (2015) Amelie Johanna Müller et al. FEBS LETTERS
- The Notch pathway in colorectal cancer
- (2015) Kaitlyn E. Vinson et al. INTERNATIONAL JOURNAL OF CANCER
- The Wnt Signaling Antagonist Dapper1 Accelerates Dishevelled2 Degradation via Promoting Its Ubiquitination and Aggregate-induced Autophagy
- (2015) Benyu Ma et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The role for autophagy in cancer
- (2015) Eileen White JOURNAL OF CLINICAL INVESTIGATION
- Treatment of relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma with everolimus (RAD001) and alemtuzumab: a Phase I/II study
- (2015) Clive S. Zent et al. LEUKEMIA & LYMPHOMA
- Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates
- (2015) Daniel F. Egan et al. MOLECULAR CELL
- Autophagy induction impairs migration and invasion by reversing EMT in glioblastoma cells
- (2015) Myriam Catalano et al. Molecular Oncology
- Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
- (2015) Xiaofeng Zheng et al. NATURE
- Autophagy mediates degradation of nuclear lamina
- (2015) Zhixun Dou et al. NATURE
- Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism
- (2015) Rushika M. Perera et al. NATURE
- STAT3 integrates cooperative Ras and TGF-β signals that induce Snail expression
- (2015) M Saitoh et al. ONCOGENE
- Evaluation of the effects of a plasma activated medium on cancer cells
- (2015) S. Mohades et al. PHYSICS OF PLASMAS
- MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells
- (2015) Diego Ploper et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- GSK-3β controls autophagy by modulating LKB1-AMPK pathway in prostate cancer cells
- (2015) Aijing Sun et al. PROSTATE
- Autophagy Sustains Hematopoiesis Through Targeting Notch
- (2015) Yan Cao et al. STEM CELLS AND DEVELOPMENT
- Metformin inhibits thyroid cancer cell growth, migration, and EMT through the mTOR pathway
- (2015) Baiyu Han et al. TUMOR BIOLOGY
- Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation
- (2015) G Grassi et al. Cell Death & Disease
- A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transition
- (2015) Wenting Xu et al. Cell Adhesion & Migration
- Addition of rapamycin and hydroxychloroquine to metronomic chemotherapy as a second line treatment results in high salvage rates for refractory metastatic solid tumors: a pilot safety and effectiveness analysis in a small patient cohort
- (2015) Kwan-Hwa Chi et al. Oncotarget
- Inhibition of autophagy promotes metastasis and glycolysis by inducing ROS in gastric cancer cells
- (2015) Wenjie Qin et al. Oncotarget
- Intact LKB1 activity is required for survival of dormant ovarian cancer spheroids
- (2015) Teresa Peart et al. Oncotarget
- Macroautophagy in Endogenous Processing of Self- and Pathogen-Derived Antigens for MHC Class II Presentation
- (2015) Fernanda V. Duraes et al. Frontiers in Immunology
- Metformin Inhibits Growth of Human Glioblastoma Cells and Enhances Therapeutic Response
- (2015) Julie Sesen et al. PLoS One
- ROS-induced epithelial-mesenchymal transition in mammary epithelial cells is mediated by NF-κB-dependent activation of Snail
- (2015) Magdalena A. Cichon et al. Oncotarget
- Role of aberrant PI3K pathway activation in gallbladder tumorigenesis
- (2015) Andrea Lunardi et al. Oncotarget
- Chloroquine potentiates the anti-cancer effect of lidamycin on non-small cell lung cancer cells in vitro
- (2014) Fang Liu et al. ACTA PHARMACOLOGICA SINICA
- Phase I clinical trial and pharmacodynamic evaluation of combination hydroxychloroquine and doxorubicin treatment in pet dogs treated for spontaneously occurring lymphoma
- (2014) Rebecca A Barnard et al. Autophagy
- Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity
- (2014) Michelle Cicchini et al. Autophagy
- Inhibition of autophagy attenuates pancreatic cancer growth independent ofTP53/TRP53status
- (2014) Annan Yang et al. Autophagy
- Combined autophagy and HDAC inhibition
- (2014) Devalingam Mahalingam et al. Autophagy
- A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme
- (2014) Myrna R Rosenfeld et al. Autophagy
- Tumor Vessel Normalization by Chloroquine Independent of Autophagy
- (2014) Hannelore Maes et al. CANCER CELL
- Autophagy eliminates cytoplasmic β-catenin and NICD to promote the cardiac differentiation of P19CL6 cells
- (2014) Zhuqing Jia et al. CELLULAR SIGNALLING
- Chloroquine Inhibits Autophagy to Potentiate Antiestrogen Responsiveness in ER+ Breast Cancer
- (2014) K. L. Cook et al. CLINICAL CANCER RESEARCH
- The Role of Snail in EMT and Tumorigenesis
- (2014) Yifan Wang et al. CURRENT CANCER DRUG TARGETS
- Tumor-Associated Macrophages: From Mechanisms to Therapy
- (2014) Roy Noy et al. IMMUNITY
- Current clinical regulation of PI3K/PTEN/Akt/mTOR signalling in treatment of human cancer
- (2014) Hui Jun Lim et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Inhibition of mTOR pathway attenuates migration and invasion of gallbladder cancer via EMT inhibition
- (2014) Huajie Zong et al. MOLECULAR BIOLOGY REPORTS
- Mutational Landscape of the Essential Autophagy Gene BECN1 in Human Cancers
- (2014) Saurabh V. Laddha et al. MOLECULAR CANCER RESEARCH
- AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation
- (2014) Valentina Cianfanelli et al. NATURE CELL BIOLOGY
- Autophagy is essential for effector CD8+ T cell survival and memory formation
- (2014) Xiaojin Xu et al. NATURE IMMUNOLOGY
- Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy
- (2014) Encouse B. Golden et al. Neurosurgical Focus
- Resveratrol Triggers Protective Autophagy Through the Ceramide/Akt/mTOR Pathway in Melanoma B16 Cells
- (2014) Meng Wang et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
- Autophagy regulates tissue overgrowth in a context-dependent manner
- (2014) E Pérez et al. ONCOGENE
- FOXM1 Regulated by ERK Pathway MediatesTGF-β1-Induced EMT in NSCLC
- (2014) Fei-Fei Kong et al. ONCOLOGY RESEARCH
- Regulation of cell proliferation and migration by p62 through stabilization of Twist1
- (2014) L. Qiang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mutation analysis of key genes in RAS/RAF and PI3K/PTEN pathways in Chinese patients with hepatocellular carcinoma
- (2014) WENMIN HOU et al. Oncology Letters
- Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut
- (2014) Maia Chanrion et al. Nature Communications
- A dual role for autophagy in a murine model of lung cancer
- (2014) Shuan Rao et al. Nature Communications
- Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations
- (2014) A. Yang et al. Cancer Discovery
- Autophagy is a critical regulator of memory CD8+ T cell formation
- (2014) Daniel J Puleston et al. eLife
- An Overview of Autophagy: Morphology, Mechanism, and Regulation
- (2013) Katherine R. Parzych et al. ANTIOXIDANTS & REDOX SIGNALING
- TRAF6 mediates ubiquitination of KIF23/MKLP1 and is required for midbody ring degradation by selective autophagy
- (2013) Pauline Isakson et al. Autophagy
- Autophagic degradation of GZMB/granzyme B
- (2013) Elodie Viry et al. Autophagy
- Q6, a novel hypoxia-targeted drug, regulates hypoxia-inducible factor signaling via an autophagy-dependent mechanism in hepatocellular carcinoma
- (2013) Xiao-Wen Liu et al. Autophagy
- Crosstalk between apoptosis, necrosis and autophagy
- (2013) Vassiliki Nikoletopoulou et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Neferine, an alkaloid from lotus seed embryo, inhibits human lung cancer cell growth by MAPK activation and cell cycle arrest
- (2013) Paramasivan Poornima et al. BIOFACTORS
- Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability
- (2013) A. Belaid et al. CANCER RESEARCH
- The Notch signaling pathway as a mediator of tumor survival
- (2013) K. M. Capaccione et al. CARCINOGENESIS
- Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial–mesenchymal transition
- (2013) Jun Li et al. CARCINOGENESIS
- Autophagy-Mediated Tumor Promotion
- (2013) Jessie Yanxiang Guo et al. CELL
- The machinery of macroautophagy
- (2013) Yuchen Feng et al. CELL RESEARCH
- Phase I Study of Panobinostat plus Everolimus in Patients with Relapsed or Refractory Lymphoma
- (2013) Y. Oki et al. CLINICAL CANCER RESEARCH
- Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses
- (2013) D. Kenzelmann Broz et al. GENES & DEVELOPMENT
- TIM-4 Glycoprotein-Mediated Degradation of Dying Tumor Cells by Autophagy Leads to Reduced Antigen Presentation and Increased Immune Tolerance
- (2013) Muhammad Baghdadi et al. IMMUNITY
- The role of membrane-trafficking small GTPases in the regulation of autophagy
- (2013) C. F. Bento et al. JOURNAL OF CELL SCIENCE
- p53 status determines the role of autophagy in pancreatic tumour development
- (2013) Mathias T. Rosenfeldt et al. NATURE
- Autophagosomes form at ER–mitochondria contact sites
- (2013) Maho Hamasaki et al. NATURE
- Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1
- (2013) Jacob M. Gump et al. NATURE CELL BIOLOGY
- ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
- (2013) Ryan C. Russell et al. NATURE CELL BIOLOGY
- The autophagosome: origins unknown, biogenesis complex
- (2013) Christopher A. Lamb et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment
- (2013) X Sui et al. Cell Death & Disease
- Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors
- (2013) A. M. Strohecker et al. Cancer Discovery
- Autophagy induced by p53-reactivating molecules protects pancreatic cancer cells from apoptosis
- (2012) Claudia Fiorini et al. APOPTOSIS
- Low expression of Beclin 1, associated with high Bcl-xL, predicts a malignant phenotype and poor prognosis of gastric cancer
- (2012) Wei-Hua Zhou et al. Autophagy
- The roles of BECN1 and autophagy in cancer are context dependent
- (2012) Chang Gong et al. Autophagy
- A novel method for autophagy detection in primary cells
- (2012) Kanchan Phadwal et al. Autophagy
- Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy
- (2012) Paola Maycotte et al. Autophagy
- The lack of autophagy triggers precocious activation of Notch signaling during Drosophila oogenesis
- (2012) Julia MI Barth et al. BMC DEVELOPMENTAL BIOLOGY
- Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
- (2012) Douglas Hanahan et al. CANCER CELL
- Phase I study of bevacizumab, everolimus, and panobinostat (LBH-589) in advanced solid tumors
- (2012) John H. Strickler et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- DEDD Interacts with PI3KC3 to Activate Autophagy and Attenuate Epithelial-Mesenchymal Transition in Human Breast Cancer
- (2012) Q. Lv et al. CANCER RESEARCH
- Tumor Microenvironment Complexity: Emerging Roles in Cancer Therapy
- (2012) M. A. Swartz et al. CANCER RESEARCH
- The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes
- (2012) Eisuke Itakura et al. CELL
- Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- (2012) Scott J. Dixon et al. CELL
- Wnt/β-Catenin Signaling and Disease
- (2012) Hans Clevers et al. CELL
- Metabolic remodeling of the tumor microenvironment: Migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth
- (2012) Valentina Carito et al. CELL CYCLE
- Knockdown of β-catenin controls both apoptotic and autophagic cell death through LKB1/AMPK signaling in head and neck squamous cell carcinoma cell lines
- (2012) Hyo Won Chang et al. CELLULAR SIGNALLING
- TGF-β signaling and epithelial–mesenchymal transition in cancer progression
- (2012) Yoko Katsuno et al. CURRENT OPINION IN ONCOLOGY
- The translational landscape of mTOR signalling steers cancer initiation and metastasis
- (2012) Andrew C. Hsieh et al. NATURE
- Beclin 1 and autophagy are required for the tumorigenicity of breast cancer stem-like/progenitor cells
- (2012) C Gong et al. ONCOGENE
- Mutant p53 gain-of-function induces epithelial–mesenchymal transition through modulation of the miR-130b–ZEB1 axis
- (2012) P Dong et al. ONCOGENE
- Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency
- (2012) Q. McAfee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Role of Atg Proteins in Autophagosome Formation
- (2011) Noboru Mizushima et al. Annual Review of Cell and Developmental Biology
- AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets
- (2011) Ken Inoki et al. Annual Review of Pharmacology and Toxicology
- Quercetin induces protective autophagy in gastric cancer cells: Involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling
- (2011) Kui Wang et al. Autophagy
- Role of Autophagy in Cancer Prevention
- (2011) Hsin-Yi Chen et al. Cancer Prevention Research
- GABARAPL1 Negatively Regulates Wnt/β-catenin Signaling by Mediating Dvl2 Degradation through the Autophagy Pathway
- (2011) Yanquan Zhang et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Pancreatic cancers require autophagy for tumor growth
- (2011) S. Yang et al. GENES & DEVELOPMENT
- Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
- (2011) J. Y. Guo et al. GENES & DEVELOPMENT
- Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways
- (2011) Michela Palmieri et al. HUMAN MOLECULAR GENETICS
- p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2
- (2011) Taewan Kim et al. JOURNAL OF EXPERIMENTAL MEDICINE
- A Role for Autophagic Protein Beclin 1 Early in Lymphocyte Development
- (2011) I. Arsov et al. JOURNAL OF IMMUNOLOGY
- Arsenic trioxide induces autophagy and apoptosis in human glioma cells in vitro and in vivo through downregulation of survivin
- (2011) Hui-Wen Chiu et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks
- (2011) S. Alers et al. MOLECULAR AND CELLULAR BIOLOGY
- Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity
- (2011) Tse-Chun Kuo et al. NATURE CELL BIOLOGY
- p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs
- (2011) Chun-Ju Chang et al. NATURE CELL BIOLOGY
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- (2011) Joungmok Kim et al. NATURE CELL BIOLOGY
- Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice
- (2011) M. Michaud et al. SCIENCE
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- (2011) C. Settembre et al. SCIENCE
- Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging
- (2011) D. R. Green et al. SCIENCE
- A Perspective on Cancer Cell Metastasis
- (2011) C. L. Chaffer et al. SCIENCE
- Atg8: an autophagy-related ubiquitin-like protein family
- (2011) Tomer Shpilka et al. GENOME BIOLOGY
- The Tor and cAMP-dependent protein kinase signaling pathways coordinately control autophagy inSaccharomyces cerevisiae
- (2010) Joseph S. Stephan et al. Autophagy
- Regulation of autophagy by transforming growth factor-β (TGF-β) signaling
- (2010) Hiroshi I. Suzuki et al. Autophagy
- Genetic and epigenetic silencing of the beclin 1gene in sporadic breast tumors
- (2010) Zidong Li et al. BMC CANCER
- Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells
- (2010) Kazuhito Sasaki et al. BMC CANCER
- NF-κB promotes epithelial–mesenchymal transition, migration and invasion of pancreatic carcinoma cells
- (2010) Harald J. Maier et al. CANCER LETTERS
- Quantitative In vivo Imaging of the Effects of Inhibiting Integrin Signaling via Src and FAK on Cancer Cell Movement: Effects on E-cadherin Dynamics
- (2010) M. Canel et al. CANCER RESEARCH
- Autophagic Survival in Resistance to Histone Deacetylase Inhibitors: Novel Strategies to Treat Malignant Peripheral Nerve Sheath Tumors
- (2010) G. Lopez et al. CANCER RESEARCH
- Dishevelled-DEP domain interacting protein (DDIP) inhibits Wnt signaling by promoting TCF4 degradation and disrupting the TCF4/β-catenin complex
- (2010) Haiwei Zhang et al. CELLULAR SIGNALLING
- Autophagy regulation by p53
- (2010) Maria Chiara Maiuri et al. CURRENT OPINION IN CELL BIOLOGY
- Regulation of autophagy by phosphatidylinositol 3-phosphate
- (2010) Chloe Burman et al. FEBS LETTERS
- Kinetics Comparisons of Mammalian Atg4 Homologues Indicate Selective Preferences toward Diverse Atg8 Substrates
- (2010) Min Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of the autophagy protein LC3 by phosphorylation
- (2010) Salvatore J. Cherra et al. JOURNAL OF CELL BIOLOGY
- Combinational Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor Proteins VAMP8 and Vti1b Mediate Fusion of Antimicrobial and Canonical Autophagosomes with Lysosomes
- (2010) Nobumichi Furuta et al. MOLECULAR BIOLOGY OF THE CELL
- cAMP-Dependent Activation of Mammalian Target of Rapamycin (mTOR) in Thyroid Cells. Implication in Mitogenesis and Activation of CDK4
- (2010) Sara Blancquaert et al. MOLECULAR ENDOCRINOLOGY
- Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation
- (2010) Chan Gao et al. NATURE CELL BIOLOGY
- Targeting cancer stem cells by inhibiting Wnt, Notch and Hedgehog pathways
- (2010) Naoko Takebe et al. Nature Reviews Clinical Oncology
- mTOR: from growth signal integration to cancer, diabetes and ageing
- (2010) Roberto Zoncu et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Transforming growth factor-β-induced epithelial–mesenchymal transition facilitates epidermal growth factor-dependent breast cancer progression
- (2010) M K Wendt et al. ONCOGENE
- Regulation Mechanisms and Signaling Pathways of Autophagy
- (2009) Congcong He et al. Annual Review of Genetics
- TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways
- (2009) Claudio Marcelo Fader et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion
- (2009) Yadi Wu et al. CANCER CELL
- Autophagy Suppresses Tumorigenesis through Elimination of p62
- (2009) Robin Mathew et al. CELL
- The Double-Edged Sword of Autophagy Modulation in Cancer
- (2009) E. White et al. CLINICAL CANCER RESEARCH
- TOR-dependent control of autophagy: biting the hand that feeds
- (2009) Thomas P Neufeld CURRENT OPINION IN CELL BIOLOGY
- Mammalian autophagy: core molecular machinery and signaling regulation
- (2009) Zhifen Yang et al. CURRENT OPINION IN CELL BIOLOGY
- PKA phosphorylates and inactivates AMPKα to promote efficient lipolysis
- (2009) Nabil Djouder et al. EMBO JOURNAL
- Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: Association with MMP-9
- (2009) Jing-song Chen et al. HEPATOLOGY RESEARCH
- Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy
- (2009) Nao Hosokawa et al. MOLECULAR BIOLOGY OF THE CELL
- ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery
- (2009) Chang Hwa Jung et al. MOLECULAR BIOLOGY OF THE CELL
- The autophagy effector Beclin 1: a novel BH3-only protein
- (2009) S Sinha et al. ONCOGENE
- Transforming growth factor-β signaling in epithelial-mesenchymal transition and progression of cancer
- (2009) Kohei MIYAZONO PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
- The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy
- (2009) J. S. Stephan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
- (2008) Sendurai A. Mani et al. CELL
- Stat3 Is Involved in Angiotensin II-Induced Expression of MMP2 in Gastric Cancer Cells
- (2008) Wei Huang et al. DIGESTIVE DISEASES AND SCIENCES
- The Atg18-Atg2 Complex Is Recruited to Autophagic Membranes via Phosphatidylinositol 3-Phosphate and Exerts an Essential Function
- (2008) Keisuke Obara et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells
- (2008) Taichi Hara et al. JOURNAL OF CELL BIOLOGY
- AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
- (2008) Dana M. Gwinn et al. MOLECULAR CELL
- Autophagy fights disease through cellular self-digestion
- (2008) Noboru Mizushima et al. NATURE
- p53: The Janus of autophagy?
- (2008) Beth Levine et al. NATURE CELL BIOLOGY
- Regulation of autophagy by cytoplasmic p53
- (2008) Ezgi Tasdemir et al. NATURE CELL BIOLOGY
- Sorafenib in Advanced Hepatocellular Carcinoma
- (2008) Josep M. Llovet et al. NEW ENGLAND JOURNAL OF MEDICINE
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