Article
Biochemistry & Molecular Biology
Mohammad A. Alfhili, Hosni A. M. Hussein, Youngyong Park, Myon Hee Lee, Shaw M. Akula
Summary: This study investigates the antitumor properties of Triclosan (TCS) in Burkitt's lymphoma (BL) cells, showing that TCS induce cell death through various mechanisms such as membrane phospholipid scrambling, compromised permeability, and activation of caspase and JNK MAPK signaling pathways. This research identifies TCS as a potential antitumor agent with insights into its molecular mechanisms of action in BL cells.
Article
Biochemistry & Molecular Biology
Shushan Guo, Zhijian Xu, Qilin Feng, Hui Zhang, Dandan Yu, Bo Li, Ke Fu, Xuejie Gao, Qikai Zhang, Hongfei Yi, Xiaosong Wu, Dongliang Song, Huabin Zhu, Haiyan Cai, Yu Peng, Weiliang Zhu, Jumei Shi
Summary: Ribonucleoside-diphosphate reductase subunit M2 (RRM2) is associated with prognosis and drug resistance in multiple myeloma. The inhibitor osalmid inhibits RRM2 translocation and regulates autophagosome synthesis and fusion with lysosomes, leading to autophagic cell death. Combination therapy with bafilomycin A1 further enhances autophagic cell death.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Cell Biology
Xi Chen, Weijie Ma, Ye Yao, Qi Zhang, Jinghua Li, Xiaoling Wu, Chengjie Mei, Xiang Jiang, Yiran Chen, Ganggang Wang, Kunlei Wang, Yingyi Liu, Yonghua Guo, Zhisu Liu, Yufeng Yuan
Summary: The study identified SDPR as a tumor suppressor in HCC by promoting apoptosis through the activation of the ASK1-JNK/p38 MAPK signaling pathways. This inhibits tumor growth and migration by enhancing cell apoptosis.
CELL DEATH & DISEASE
(2021)
Article
Pharmacology & Pharmacy
Wei Yang, Jiaqi Su, Mingjing Li, Tiantian Li, Xu Wang, Mingdong Zhao, Xuemei Hu
Summary: Myricetin inhibits the proliferation of HCC cells by downregulating MARCH1 and affecting the p38 MAPK and Stat3 signaling pathways, ultimately suppressing HCC growth. This natural flavonol also induces autophagy and cell cycle arrest in HCC cells, demonstrating its anticancer properties.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Polymer Science
Balint Viktor Lovasz, Gergely Berta, Edina Lempel, Gyorgy Setalo, Monika Vecsernyes, Jozsef Szalma
Summary: The study suggests that relevant concentrations of TEGDMA monomers leached from resin-based composite materials (RBCs) induce apoptosis in pulp cells through both caspase-dependent and caspase-independent mechanisms, possibly involving endoplasmic reticulum stress and the activation of caspase-independent apoptotic pathways.
Article
Medicine, Research & Experimental
Mahmoud Abdelnaser, Rania Alaaeldin, Mina Ezzat Attya, Moustafa Fathy
Summary: This study examined the potential hepatoprotective activity of gabapentin on cecal ligation and puncture-induced sepsis in rats. The results showed that gabapentin could alleviate liver damage, reduce inflammation, inhibit apoptosis, and regulate intracellular signaling pathways and gene expression.
Article
Parasitology
Mudassar N. N. Mughal, Christoph G. G. Grevelding, Simone Haeberlein
Summary: This study reveals that imatinib induces autophagy in Schistosoma parasites and demonstrates that co-treatment with the autophagy inhibitor bafilomycin A1 can reverse the autophagy induced by imatinib and its antischistosomal effects.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2022)
Article
Food Science & Technology
Yifeng Zhu, Heng Wang, Jianping Wang, Shunshun Han, Yao Zhang, Menggen Ma, Qing Zhu, Keying Zhang, Huadong Yin
Summary: This study investigated the effects of Zearalenone (ZEA) on chicken granulosa cells and found that ZEA inhibited cell growth by inducing apoptosis and promoting autophagy. Autophagy delayed apoptosis in ZEA-treated cells, reducing cytotoxicity. The results also showed that ZEA stimulated autophagy through PI3K-AKT-mTOR and MAPK signaling pathways in chicken granulosa cells.
Article
Biochemistry & Molecular Biology
Siyu Li, Hongmei Huang, Yan Zhang, Ling Li, Ziyu Hua
Summary: This study investigated the neuroinflammation type of A1-like astrocytes induced by unconjugated bilirubin (UCB) and its underlying regulatory mechanisms. The results showed that UCB stimulation activated A1-like astrocytes, and the inhibition of NF-Kappa B and caspase-1 alleviated A1-like astrocytes and exerted anti-inflammatory protective effects.
NEUROCHEMICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Donglin Yang, Liujun He, Shuiqing Ma, Shiqiang Li, Yajun Zhang, Chunsheng Hu, Jiuhong Huang, Zhigang Xu, Dianyong Tang, Zhongzhu Chen
Summary: Compound 6d, a spiroindoline compound, inhibits CRC growth by acting as an inhibitor of Bcl-2 and inducing caspase 3-mediated intrinsic apoptosis. Caspase 3 activation by compound 6d directly cleaves HDAC6, with cleavage occurring at D1088 in the DMAD-S motif. Compound 6d-induced apoptosis promotes autophagy initiation by disrupting the interaction between Bcl-2 and Beclin 1, resulting in the accumulation of ubiquitinated proteins and reduction of autophagic flux.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Huikyong Lee, Jae-Young Koh
Summary: The study revealed that cAMP can reverse lysosomal acidification defects through the activation of protein kinase A, and increase autophagy flux. Moreover, in the presence of v-ATPase inhibition, H+/K+-ATPase may act as an alternative route for lysosomal acidification.
Article
Cell Biology
Ling Liu, Yihao Xing, Mengyao Cao, Jinglei Xu, Jingjing Chen
Summary: JS-K induces apoptosis in hepatocellular carcinoma cells by activating JNK and p38 MAPK and inhibiting the Raf/MEK/ERK signaling pathway.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Young-Eun Cho, Yong-Jun Kim, Sun Lee, Jae-Hoon Park
Summary: In this study, a novel nucleolar-cytoplasmic axis involving nucleolar protein NOP53 was identified to regulate the cytoplasmic autophagy process through ZKSCAN3-dependent and -independent pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Nhat-Tu Le
Summary: ERK5, a member of the MAPK family, has distinct activation mechanisms and catalytic-independent functions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Guangya Xu, Xueling Yan, Zhongjia Hu, Lulu Zheng, Ke Ding, Yamei Zhang, Yi Qing, Tao Liu, Lijia Cheng, Zheng Shi
Summary: Glucocappasalin (GCP) from Descurainia sophia seeds shows potential antitumor activity in HeLa cervical carcinoma cells. GCP induces cell cycle G2/M-phase arrest, apoptosis, and autophagy by acting on the PI3K/AKT/mTOR signaling pathways, making it a promising agent for cervical cancer eradication.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Lili Lu, Li Ma, Xianbin Zhang, Christina Susanne Mullins, Michael Linnebacher
Summary: The study revealed a significant decrease in death from the original diagnosis among CRC patients over time, along with an increase in non-cancer death causes. The most common non-cancer death cause for elderly patients was heart disease, while younger CRC patients tended to die from accidents and adverse effects. The findings also showed changes in specific causes of non-cancer deaths over follow-up time and patient age, suggesting the importance of modifying preventive measures and clinical management for CRC patients.
Article
Oncology
Yuru Shang, Xianbin Zhang, Lili Lu, Ke Jiang, Mathias Krohn, Stephanie Matschos, Christina Susanne Mullins, Brigitte Vollmar, Dietmar Zechner, Peng Gong, Michael Linnebacher
Summary: Pharmaceutical-grade human IgG was found to influence the viability of colorectal cancer cell lines and impair the anti-tumoral effects of oxaliplatin. Cancer cells express IgG receptors and accumulate human IgG intracellularly.
BRITISH JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Jianhua Qu, Biao Zheng, Kenoki Ohuchida, Haimin Feng, Stephen Jun Fei Chong, Xianbin Zhang, Rui Liang, Zhong Liu, Kengo Shirahane, Kazuhiro Mizumoto, Peng Gong, Masafumi Nakamura
Summary: This study found that PIK3CB is involved in PAAD metastasis and may serve as a potential therapeutic target for PAAD treatment. PIK3CB depletion significantly reduced PAAD metastasis potential by suppressing cell adhesion to collagen I in PAAD cells.
JOURNAL OF ADVANCED RESEARCH
(2021)
Review
Medicine, Research & Experimental
Tingting Sun, Liming Tian, Yunyun Guo, Yu Zheng, Linglong Ouyang, Xianbin Zhang, Yingrong Lai, Guofen Yang
Summary: This case report highlights the clinical characteristics and treatment outcome of a patient with anaplastic carcinoma in an ovarian tumor (ACOT). Surgical resection followed by chemotherapy with paclitaxel and carboplatin led to a favorable prognosis in the patient with FIGO stage IIIa ACOT. Surveillance, epidemiology, and end result database analysis showed similar benefits of surgery and chemotherapy in patients with ACOT.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Jing-Qiang Huang, He-Feng Li, Jing Zhu, Jun-Wei Song, Xian-Bin Zhang, Peng Gong, Qiu-Yu Liu, Chun-Hui Zhou, Liang Wang, Li-Yun Gong
Summary: SRPK1 is overexpressed in colon cancer and correlated with clinical stage and TNM classifications. High levels of SRPK1 are associated with poor prognosis. Mechanistically, SRPK1 enhances the anti-apoptosis ability of colon cancer cells under oxaliplatin treatment by promoting NF-κB pathway activation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, General & Internal
Yan Xia, Ye Li, Peng Gong, Huifeng Jiang, Xianbin Zhang
Summary: This case report describes a histiocyte-rich rhabdomyoblastic tumor with unique pathologic characteristics that do not fit into traditional classifications of skeletal muscle tumors. Despite minor atypia, the tumor exhibited an indolent clinical course, challenging the accurate classification of benign or malignant. Next-generation sequencing revealed mutations in key genes potentially influencing the development of this tumor, suggesting the need for its inclusion in the WHO Classification of Soft Tissue Tumors.
Article
Oncology
Wenhao Wu, Shun Zeng, Xianbin Zhang, Peng Liu, Tong Qiu, Shulin Li, Peng Gong
Summary: The presence of tumor deposits (TDs) in colorectal cancer is associated with an increased risk of distant metastasis. Patients with TDs positive have a similar prognosis as stage IV patients, suggesting that these patients should be classified as stage IV.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Cell Biology
Eilis Russell, Melissa J. Conroy, Martin P. Barr
Summary: Lung cancer, with NSCLC as the majority, is the leading cause of cancer-related deaths worldwide. Early lung cancer often presents with no symptoms, leading to late-stage diagnosis. Despite current treatments, many patients experience tumor relapse or develop therapeutic resistance, highlighting the need for more effective therapies.
Article
Biochemistry & Molecular Biology
Zihan Zhou, Peifeng Li, Xianbin Zhang, Juan Xu, Jin Xu, Shui Yu, Dongqing Wang, Wei Dong, Xiujuan Cao, Hongjiang Yan, Mingping Sun, Xiuping Ding, Jun Xing, Peng Zhang, Limin Zhai, Tingyong Fan, Shiyu Tian, Xinhua Yang, Man Hu
Summary: A comprehensive mutational landscape of nasopharyngeal carcinoma tumors was drawn in this study, identifying the top 20 most frequently mutated genes and predictors such as N stage, tumor mutational burden (TMB), PIK3CA, and SF3B1. A novel four predictor-based prognostic model was established, showing superior predictive capacity compared to the TNM stage model. Patients with tumors harboring PI3K/AKT or RAS pathway mutations were found to have worse distant metastasis-free survival than those with wild-type counterparts.
MOLECULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Simone Kumstel, Tim Schreiber, Lea Goldstein, Jan Stenzel, Tobias Lindner, Markus Joksch, Xianbin Zhang, Edgar Heinz Uwe Wendt, Maria Schoenrogge, Bernd Krause, Brigitte Vollmar, Dietmar Zechner
Summary: Pancreatic cancer has a high mortality rate and current therapeutic approaches are not effective. This study found that inhibiting different metabolic pathways in combination significantly suppressed pancreatic cancer cell growth and induced cell death in vitro. However, in vivo experiments suggest that higher dosage or alternative drugs targeting these pathways may be more promising.
Article
Immunology
Xianbin Zhang, Li Li, Peng Liu, Yu Tian, Peng Gong
Summary: This study aimed to evaluate the role of transcription factors (TFs) in pancreatic adenocarcinoma (PAAD) and develop a TF-based prognostic signature. The results showed that certain TFs were abnormally expressed in PAAD tissues and were associated with transcriptional misregulation in cancer. By conducting multivariate analysis, the researchers identified two TFs as prognostic factors and developed a risk score model for predicting patient survival. Additionally, high risk scores were associated with advanced tumor stage and immune infiltrates.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Oncology
Swati Misri, Kirti Kaul, Sanjay Mishra, Manish Charan, Ajeet Kumar Verma, Martin P. Barr, Dinesh K. Ahirwar, Ramesh K. Ganju
Summary: This study demonstrates that cannabidiol (CBD) inhibits the growth and metastasis of drug-resistant non-small cell lung cancer cells (NSCLC) and induces apoptosis of cisplatin-resistant cells. It acts through the TRPV2 receptor and modulates oxidative stress pathways. CBD could be a promising therapeutic strategy for cisplatin-resistant NSCLC.
Article
Oncology
Xin Dong, Xianbin Zhang, Peng Liu, Yu Tian, Li Li, Peng Gong
Summary: LSR binds to YAP1 via the PPPY motif, increasing the phosphorylation of YAP1 and impairing the growth of HCC. Targeting LSR might be a promising therapeutic strategy for HCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Martin P. Barr, Anne-Marie Baird, Sophia Halliday, Petra Martin, Emma H. Allott, James Phelan, Greg Korpanty, Linda Coate, Cathal O'Brien, Steven G. Gray, Jane S. Y. Sui, Brian Hayes, Sinead Cuffe, Stephen P. Finn
Summary: Liquid biopsy has the potential to improve patient care in the diagnostic and therapeutic setting in non-small cell lung cancer (NSCLC). It can be used to monitor EGFR mutations and inflammatory markers as prognostic indicators in NSCLC.
Article
Oncology
Xianbin Zhang, Lili Lu, Jun Liu, Weihan Liu, Li Li, Yushan Wei, Jinhu Fan, Li Ma, Peng Gong
Summary: A predictive nomogram was developed and validated to accurately identify the risk of distant organ metastasis in pancreatic neuroendocrine tumor (pNET) patients. The nomogram showed good accuracy in predicting metastasis in training, internal validation, and external validation cohorts. These results are important for clinicians to identify pNET patients with distant organ metastasis and develop personalized treatment strategies.
CLINICAL MEDICINE INSIGHTS-ONCOLOGY
(2022)