Review
Oncology
GuoYun Wang, GaiXiang Luo, MeiJing Zhao, HuiLai Miao
Summary: This article discusses the research progress on exosomes in the development of hepatocellular carcinoma, tumor microenvironment, treatment resistance, and immunosuppression. Understanding the pathogenesis and identifying early diagnostic markers are crucial for diagnosing and treating HCC.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Meijin Liu, Zhonghong Lai, Xiaoying Yuan, Qing Jin, Haibin Shen, Dingyu Rao, Defa Huang
Summary: This review explores the role of exosomes in hepatocellular carcinoma (HCC), including their involvement in cancer cell proliferation, invasion, and metastasis. Additionally, the potential applications of exosomes in HCC diagnosis and treatment are discussed, highlighting their versatility as both a diagnostic platform and drug delivery vehicle.
MOLECULAR MEDICINE
(2023)
Article
Cell Biology
Zeng-Hong Wu, Cheng Li, You-Jing Zhang, Rong Lin
Summary: This study identified atypical signature exosomes for hepatocellular carcinoma (HCC) based on analyses of exosome and online databases, providing potential biomarkers for HCC treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Shuang Li, Limin Chen
Summary: Exosomes are extracellular vesicles that play important roles in cell-to-cell communication and can be stably present in various body fluids. They have a unique double-layer saclike structure and reflect the characteristics of their host cells. Exosomes derived from hepatocellular carcinoma cells show heterogeneity in their cargo. Additionally, exosomes are capable of efficiently delivering cargoes to target cells, which significantly impact HCC progression, including tumor occurrence, development, metastasis, immune regulation, and drug resistance. Previous studies have demonstrated wide applications of exosomes in the diagnosis and treatment of HCC. This review discusses recent findings on the significant roles of exosomes in HCC, focusing on their effects and underlying mechanisms in regulating HCC progression and their potential clinical value as biomarkers and therapeutic targets.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Chenbin Liu, Han Wu, Yinqi Mao, Wei Chen, Shuying Chen
Summary: Exosomal microRNAs play a crucial role in hepatocellular carcinoma, holding significant value in the early diagnosis and treatment of this disease.
CANCER CELL INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Mengtao Xing, Xinzhi Wang, Robert A. Kiken, Ling He, Jian-Ying Zhang
Summary: Early detection and treatment of HCC are crucial for improving patient survival rates. Discovering specific biomarkers and understanding the immunological mechanisms are urgent, with the immune system playing a key role in the recognition and targeted therapy of HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Dongdong Xue, Jingzhao Han, Yifan Liu, Hongfang Tuo, Yanhui Peng
Summary: Exosomes play a crucial role in the recurrence and metastasis of HCC, serving as potential early diagnostic markers and prognostic indicators, as well as being utilized for drug delivery in cancer therapy.
CANCER BIOLOGY & THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Andrei Sorop, Diana Constantinescu, Florentina Cojocaru, Anca Dinischiotu, Dana Cucu, Simona Olimpia Dima
Summary: Hepatocellular carcinoma (HCC) is the fifth most common cancer globally and is often detected late due to its high clinical and biological heterogeneity. Small nanoparticles with an endosomal origin are valuable biomarkers or carriers for novel treatments in HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Liangyun Li, Yihui Bi, Shaoxi Diao, Xiaofeng Li, Tong Yuan, Tao Xu, Cheng Huang, Jun Li
Summary: This review article highlights the role of exosomal lncRNAs in the development of HCC, showing their crucial involvement in the growth and progression of HCC and their potential as therapeutic targets.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Leyi Liang, Ling Zhao, Ying Wang, Yan Wang
Summary: The study demonstrates that BMSC-Exos-NCTD effectively promotes cellular uptake, induces cell cycle arrest, reduces tumor cell proliferation, increases apoptosis, and shows significant in vitro and in vivo antitumor effects against HCC. Additionally, BMSC-Exos exhibit in situ homing effects on tumor sites in mice and do not show body toxicity, while also repairing damaged liver tissues and promoting cell proliferation. Overall, BMSC-Exos have great potential as drug carriers for HCC treatment in combination with anticancer drugs.
MOLECULAR PHARMACEUTICS
(2021)
Review
Immunology
Sihang Yu, Lei Zhou, Jiaying Fu, Long Xu, Buhan Liu, Yuanxin Zhao, Jian Wang, Xiaoyu Yan, Jing Su
Summary: There is increasing evidence showing the crucial role of the immune microenvironment, particularly the polarization state and function of macrophages, in the development of hepatocellular carcinoma. Tumor-derived exosomes in hepatocellular carcinoma act as information carriers and regulate the physiological state of cells in the microenvironment, thus controlling cancer progression. This review focuses on the role of exosome content in disease outcomes at different stages of hepatitis B virus/hepatitis C virus-induced hepatocellular carcinoma, and explores the mechanism by which macrophages contribute to hepatocellular carcinoma formation and the regulation of macrophage functions by the heterogeneity of exosome loading. The application prospects of exosome-based targeted drug delivery in immunotherapy research on hepatocellular carcinoma are also summarized.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Man Yao, Shufang Liang, Binbin Cheng
Summary: Hepatocellular carcinoma (HCC) is typically associated with chronic liver inflammation and cirrhosis. Exosomes, nanometer-sized membrane vesicles, play a crucial role in the initiation and progression of HCC. They mediate cell-cell communication and regulate the tumor microenvironment by carrying proteins, DNAs, and various forms of RNA. Studies have shown that exosomes are involved in the communication between HCC cells and stromal cells, and they influence tumor proliferation, metastasis, immune evasion, and immunotherapy. Furthermore, exosomes can be utilized for the diagnosis and treatment of HCC, serving as biomarkers for early detection and drug delivery vehicles. Chinese herbal medicine, commonly used in HCC prevention and treatment in China, may regulate the release of exosomes and exosomes-mediated intercellular communication. This review summarizes the role of exosomes in HCC initiation, progression, and treatment, as well as the potential value of Traditional Chinese medicine in exosomes-mediated biological behaviors of HCC.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mehrdad Hashemi, Eisa Sabouni, Parham Rahmanian, Maliheh Entezari, Mahsa Mojtabavi, Behnaz Raei, Mohammad Arad Zandieh, Mitra Behroozaghdam, Sepideh Mirzaei, Kiavash Hushmandi, Noushin Nabavi, Shokooh Salimimoghadam, Jun Ren, Mohsen Rashidi, Rasoul Raesi, Afshin Taheriazam, Athanasios Alexiou, Marios Papadakis, Shing Cheng Tan
Summary: Hepatocellular carcinoma (HCC) is a common form of liver cancer and poses a great challenge to human life. Targeting the molecular signaling pathways through STAT3 may provide new and effective therapies for HCC. This review discusses the expression and phosphorylation status of STAT3 in HCC, highlighting its role as an oncogenic factor that prevents apoptosis and promotes cancer progression.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Biotechnology & Applied Microbiology
Zhijun Liu, Yuyu You, Qiyi Chen, Guobang Li, Wenfeng Pan, Qing Yang, Jiajun Dong, Yi Wu, Jin-Xin Bei, Chaoyun Pan, Fuming Li, Bo Li
Summary: Hepatocellular carcinoma (HCC) is characterized by metabolic and immune remodeling in the tumor microenvironment. Liver-specific deletion of fructose-1, 6-bisphosphatase 1 (FBP1) promotes liver tumorigenesis, partly due to the suppression of natural killer (NK) cells. Mechanistically, FBP1 attenuation in hepatocytes inhibits PKLR expression and reduces the activity of NK cells by transferring PKLR-attenuated extracellular vesicles (EVs) from hepatocytes.
Review
Biochemistry & Molecular Biology
Wan-Ting Wang, Wei-Lin Jin, Xun Li
Summary: Hepatocellular carcinoma (HCC), one of the most common tumors worldwide, poses a significant threat to cancer patients' lives. The early diagnosis of HCC is hindered by various problems that need urgent solutions. The tumor microecosystem is a complex network comprising different microenvironments and intercellular communication plays a crucial role in mediating the crosstalk between cells and components within the HCC microecosystem. Understanding and targeting intercellular communication can lead to improved clinical diagnosis and treatment for HCC.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
