Circadian clock genes as promising therapeutic targets for autoimmune diseases

Association of PER2 gene single nucleotide polymorphisms with genetic susceptibility to systemic lupus erythematosus

(2021) Yi-Lin Dan et al.   LUPUS

Anti-neutrophil cytoplasm antibodies (ANCA) in autoimmune diseases: A matter of laboratory technique and clinical setting

(2021) Alessandro Granito et al.   AUTOIMMUNITY REVIEWS

The seasonality of Dermatomyositis associated with anti-MDA5 antibody: An argument for a respiratory viral trigger

(2021) Ségolène Toquet et al.   AUTOIMMUNITY REVIEWS

Circadian control of the secretory pathway maintains collagen homeostasis

(2020) Joan Chang et al.   NATURE CELL BIOLOGY

Circadian rhythms in the absence of the clock gene Bmal1

(2020) Sandipan Ray et al.   SCIENCE

NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis

(2020) Hui Liu et al.   Cell Death & Disease

Clinical outcome measures in multiple sclerosis: A review

(2020) Hernan Inojosa et al.   AUTOIMMUNITY REVIEWS

Autoimmune thyroid disorders and rheumatoid arthritis: A bidirectional interplay

(2020) Paola Conigliaro et al.   AUTOIMMUNITY REVIEWS

Pentraxin 3: A promising therapeutic target for autoimmune diseases

(2020) Qian Wu et al.   AUTOIMMUNITY REVIEWS

Comprehensive meta-analysis reveals an association of the HLA-DRB1*1602 allele with autoimmune diseases mediated predominantly by autoantibodies

(2020) Yan Chen et al.   AUTOIMMUNITY REVIEWS

Giant cell arteritis or polymyalgia rheumatica after influenza vaccination: A study of 12 patients and a literature review

(2020) Eric Liozon et al.   AUTOIMMUNITY REVIEWS

An Overview of the NF-kB mechanism of pathophysiology in rheumatoid arthritis, investigation of the NF-kB ligand RANKL and related nutritional interventions

(2020) Desislava (Daisy) Ilchovska et al.   AUTOIMMUNITY REVIEWS

ARNTL hypermethylation promotes tumorigenesis and inhibits cisplatin sensitivity by activating CDK5 transcription in nasopharyngeal carcinoma

(2019) Hao Peng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Circadian rhythms and the molecular clock in cardiovascular biology and disease

(2019) Sandra Crnko et al.   Nature Reviews Cardiology

Association between circadian rhythms and neurodegenerative diseases

(2019) Yue Leng et al.   LANCET NEUROLOGY

A novel RORγt inhibitor is a potential therapeutic agent for the topical treatment of psoriasis with low risk of thymic aberrations

(2019) Chihiro Imura et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

A novel comprehensive paradigm for the etiopathogenesis of multiple sclerosis: therapeutic approaches and future perspectives on its treatment

(2019) Francesco Gasperoni et al.   AMINO ACIDS

Clock Gene Disruption is an Initial Manifestation of Inflammatory Bowel Disease

(2019) Yael Weintraub et al.   Clinical Gastroenterology and Hepatology

Expressions of circadian clock genes represent disease activities of RA patients treated with biological DMARDs

(2019) Kenta Kaneshiro et al.   Modern Rheumatology

Clock gene PERIOD3 polymorphism is associated with susceptibility to Graves’ disease but not to Hashimoto’s thyroiditis

(2019) Nafiye Helvaci et al.   CHRONOBIOLOGY INTERNATIONAL

Circadian period 2: a missing beneficial factor in sickle cell disease by lowering pulmonary inflammation, iron overload, and mortality

(2019) Morayo G. Adebiyi et al.   FASEB JOURNAL

Seasonal variation in systemic lupus erythematosus and rheumatoid arthritis: An ecological study based on internet searches

(2019) Hai-Feng Pan et al.   AUTOIMMUNITY REVIEWS

Retinoic acid receptor-related orphan receptor gamma-t (RORγt) inhibitors in clinical development for the treatment of autoimmune diseases: a patent review (2016-present)

(2019) Nannan Sun et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The nuclear receptor REV-ERBα modulates Th17 cell-mediated autoimmune disease

(2019) Christina Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correlation between inflammatory markers and impaired circadian clock gene expression in type 2 diabetes mellitus

(2019) Rongguo Yu et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

AhR–ROR-γt complex is a therapeutic target for MAP4K3/GLKhighIL-17Ahigh subpopulation of systemic lupus erythematosus

(2019) Huai-Chia Chuang et al.   FASEB JOURNAL

Circadian Gene Polymorphisms Associated with Breast Cancer Susceptibility

(2019) Monika Lesicka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Retinoic Acid Receptor-Related Receptor Alpha Ameliorates Autoimmune Arthritis via Inhibiting of Th17 Cells and Osteoclastogenesis

(2019) Jin-Sil Park et al.   Frontiers in Immunology

Conditional Controlled Light/Dark Cycle Influences Exercise-Induced Benefits in a Rat Model with Osteoarthritis: In Vitro and In Vivo Study

(2019) Hong et al.   Journal of Clinical Medicine

High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus

(2019) Sarah Reid et al.   ANNALS OF THE RHEUMATIC DISEASES

Circadian rhythms in innate immunity and stress responses

(2019) Matthew Baxter et al.   IMMUNOLOGY

Circadian rhythms in adaptive immunity

(2019) Polly Downton et al.   IMMUNOLOGY

Pharmacological inhibitory profile of TAK-828F, a potent and selective orally available RORγt inverse agonist

(2018) Akira Shibata et al.   BIOCHEMICAL PHARMACOLOGY

Discovery of carbazole carboxamides as novel RORγt inverse agonists

(2018) Yafei Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice

(2018) Benoit Pourcet et al.   GASTROENTEROLOGY

Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation

(2018) Marie Pariollaud et al.   JOURNAL OF CLINICAL INVESTIGATION

Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis

(2018) Polona Lavtar et al.   PLoS One

Retinoic Acid Receptor-Related Orphan Receptors: Critical Roles in Tumorigenesis

(2018) Jinshuo Fan et al.   Frontiers in Immunology

Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2

(2018) James O. Early et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Th17 cells in renal inflammation and autoimmunity

(2018) Sebastian Dolff et al.   AUTOIMMUNITY REVIEWS

Altered expression of the core circadian clock component PERIOD2 contributes to osteoarthritis-like changes in chondrocyte activity

(2018) Jing Rong et al.   CHRONOBIOLOGY INTERNATIONAL

REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis

(2018) Shuai Wang et al.   Nature Communications

REV-ERBα Regulates TH17 Cell Development and Autoimmunity

(2018) Mohammed Amir et al.   Cell Reports

Seasonality and autoimmune diseases: The contribution of the four seasons to the mosaic of autoimmunity

(2017) Abdulla Watad et al.   JOURNAL OF AUTOIMMUNITY

Oral administration of a novel RORγt antagonist attenuates psoriasis-like skin lesion of two independent mouse models through neutralization of IL-17

(2017) Mikiro Takaishi et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

The Role of IL-17 and Related Cytokines in Inflammatory Autoimmune Diseases

(2017) Taku Kuwabara et al.   MEDIATORS OF INFLAMMATION

PER2 is downregulated by the LPS-induced inflammatory response in synoviocytes in rheumatoid arthritis and is implicated in disease susceptibility

(2017) Hwayoung Lee et al.   Molecular Medicine Reports

Suprachiasmatic Nucleus and Subordinate Brain Oscillators: Clock Gene Desynchronization by Neuroinflammation

(2017) Leila Maria Guissoni Campos et al.   NEUROIMMUNOMODULATION

Circadian clock cryptochrome proteins regulate autoimmunity

(2017) Qi Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease

(2017) Caroline E. Sutton et al.   Nature Communications

PER3 VNTR polymorphism in Multiple Sclerosis: A new insight to impact of sleep disturbances in MS

(2017) Masoud Golalipour et al.   Multiple Sclerosis and Related Disorders

Hypercholesterolemia Causes Circadian Dysfunction: A Potential Risk Factor for Cardiovascular Disease

(2017) Makoto Akashi et al.   EBioMedicine

RORγt and RORα signature genes in human Th17 cells

(2017) Glenda Castro et al.   PLoS One

Rev-erb agonist improves adverse cardiac remodeling and survival in myocardial infarction through an anti-inflammatory mechanism

(2017) Endin Nokik Stujanna et al.   PLoS One

Stimulation of nuclear receptor REV-ERBs regulates tumor necrosis factor-induced expression of proinflammatory molecules in C6 astroglial cells

(2016) Norimitsu Morioka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

The acute and temporary modulation ofPERIODgenes by hydrocortisone in healthy subjects

(2016) Türkan Yurtsever et al.   CHRONOBIOLOGY INTERNATIONAL

The chondrocyte-intrinsic circadian clock is disrupted in human osteoarthritis

(2016) Sarah J. B. Snelling et al.   CHRONOBIOLOGY INTERNATIONAL

RORγt inhibitors as potential back-ups for the phase II candidate VTP-43742 from Vitae Pharmaceuticals: patent evaluation of WO2016061160 and US20160122345

(2016) Christian Gege   EXPERT OPINION ON THERAPEUTIC PATENTS

The circadian clock regulates inflammatory arthritis

(2016) Laura E. Hand et al.   FASEB JOURNAL

Suppression of interleukin 17 contributes to the immunomodulatory effects of adipose-derived stem cells in a murine model of systemic lupus erythematosus

(2016) Xiaoliang He et al.   IMMUNOLOGIC RESEARCH

The circadian gene Arntl2 on distal mouse chromosome 6 controls thymocyte apoptosis

(2016) Basile Lebailly et al.   MAMMALIAN GENOME

Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells

(2016) David R Withers et al.   NATURE MEDICINE

Severity and Diurnal Improvement of Morning Stiffness Independently Associate with Tenosynovitis in Patients with Rheumatoid Arthritis

(2016) Yoshihisa Kobayashi et al.   PLoS One

Is the molecular clock ticking differently in bipolar disorder? Methylation analysis of the clock gene ARNTL

(2016) Susanne A. Bengesser et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Insulin Restores an Altered Corneal Epithelium Circadian Rhythm in Mice with Streptozotocin-induced Type 1 Diabetes

(2016) Fang Song et al.   Scientific Reports

Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity

(2016) Yanxia Guo et al.   Cell Reports

Shift work at young age is associated with increased risk of multiple sclerosis in a Danish population

(2016) S. Gustavsen et al.   Multiple Sclerosis and Related Disorders

Systemic Lupus Erythematosus and Deficiencies of Early Components of the Complement Classical Pathway

(2016) Ana Catarina Lunz Macedo et al.   Frontiers in Immunology

Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin

(2016) Susan H. Smith et al.   PLoS One

Pharmacologic modulation of RORγt translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis

(2016) Xiaohua Xue et al.   Scientific Reports

Suppression of atherosclerosis by synthetic REV-ERB agonist

(2015) Sadichha Sitaula et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Microglia inflammatory responses are controlled by an intrinsic circadian clock

(2015) Laura K. Fonken et al.   BRAIN BEHAVIOR AND IMMUNITY

Effect of Circadian Rhythm on Clinical and Pathophysiological Conditions and Inflammation

(2015) Takako Kizaki et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Circadian rhythm-related genes: implication in autoimmunity and type 1 diabetes

(2015) B. Lebailly et al.   DIABETES OBESITY & METABOLISM

ROR Inverse Agonist Suppresses Insulitis and Prevents Hyperglycemia in a Mouse Model of Type 1 Diabetes

(2015) Laura A. Solt et al.   ENDOCRINOLOGY

Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic Interventions

(2015) Dhavalkumar D. Patel et al.   IMMUNITY

The Circadian Clock in Skin

(2015) Maksim V. Plikus et al.   JOURNAL OF BIOLOGICAL RHYTHMS

T cells in the control of organ-specific autoimmunity

(2015) Jeffrey A. Bluestone et al.   JOURNAL OF CLINICAL INVESTIGATION

Circadian Gene Clock Regulates Psoriasis-Like Skin Inflammation in Mice

(2015) Noriko Ando et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients with psoriatic arthritis (FUTURE 2): a randomised, double-blind, placebo-controlled, phase 3 trial

(2015) Iain B McInnes et al.   LANCET

Shift work influences multiple sclerosis risk

(2015) AK Hedström et al.   Multiple Sclerosis Journal

Sterol metabolism controls T H 17 differentiation by generating endogenous RORγ agonists

(2015) Xiao Hu et al.   Nature Chemical Biology

Circadian control of innate immunity in macrophages by miR-155 targetingBmal1

(2015) Anne M. Curtis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant RORγt Inhibitors

(2015) Yonghui Wang et al.   ACS Medicinal Chemistry Letters

Association of ARNTL and PER1 genes with Parkinson's disease: a case-control study of Han Chinese

(2015) Zhuqin Gu et al.   Scientific Reports

Shift work influences multiple sclerosis risk

(2015) AK Hedström et al.   Multiple Sclerosis Journal

RORα Decreases Oxidative Stress Through the Induction of SOD2 and GPx1 Expression and Thereby Protects Against Nonalcoholic Steatohepatitis in Mice

(2014) Yong-Hyun Han et al.   ANTIOXIDANTS & REDOX SIGNALING

Clock genes in hypertension

(2014) Jacob Richards et al.   BLOOD PRESSURE MONITORING

Melatonin adjusts the expression pattern of clock genes in the suprachiasmatic nucleus and induces antidepressant-like effect in a mouse model of seasonal affective disorder

(2014) Andras David Nagy et al.   CHRONOBIOLOGY INTERNATIONAL

Linking the Circadian Rhythm GeneArntl2to Interleukin 21 Expression in Type 1 Diabetes

(2014) Basile Lebailly et al.   DIABETES

Rheumatoid arthritis and the biological clock

(2014) Angelo De Cata et al.   Expert Review of Clinical Immunology

Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms

(2014) Sheng Xiao et al.   IMMUNITY

A Crucial Role of RORγt in the Development of Spontaneous Sialadenitis-like Sjögren’s Syndrome

(2014) Mana Iizuka et al.   JOURNAL OF IMMUNOLOGY

Pharmacologic Inhibition of ROR t Regulates Th17 Signature Gene Expression and Suppresses Cutaneous Inflammation In Vivo

(2014) J. Skepner et al.   JOURNAL OF IMMUNOLOGY

Clock gene Per1 regulates the production of CCL2 and interleukin-6 through p38, JNK1 and NF-κB activation in spinal astrocytes

(2014) Tatsuhiko Sugimoto et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

REV-ERB and ROR nuclear receptors as drug targets

(2014) Douglas J. Kojetin et al.   NATURE REVIEWS DRUG DISCOVERY

Circadian clock control of endocrine factors

(2014) Karen L. Gamble et al.   Nature Reviews Endocrinology

The Nuclear Receptor REV-ERBα Regulates Fabp7 and Modulates Adult Hippocampal Neurogenesis

(2014) Anna Schnell et al.   PLoS One

Direct and Indirect Suppression of Interleukin-6 Gene Expression in Murine Macrophages by Nuclear Orphan Receptor REV-ERBα

(2014) Shogo Sato et al.   TheScientificWorldJOURNAL

Vitamin D Deficiency Is Associated with Ulcerative Colitis Disease Activity

(2013) Stacey Blanck et al.   DIGESTIVE DISEASES AND SCIENCES

Functional CLOCK gene rs1554483 G/C polymorphism is associated with susceptibility to Alzheimer's disease in the Chinese population

(2013) Qian Chen et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Circadian clock regulates the host response to Salmonella

(2013) M. M. Bellet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNF-α modulates expression of the circadian clock genePer2in rheumatoid synovial cells

(2013) K Yoshida et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Circadian Gene Bmal1 Regulates Diurnal Oscillations of Ly6Chi Inflammatory Monocytes

(2013) K. D. Nguyen et al.   SCIENCE

TH17 Cell Differentiation Is Regulated by the Circadian Clock

(2013) X. Yu et al.   SCIENCE

The role of the circadian clock in rheumatoid arthritis

(2013) Julie E Gibbs et al.   ARTHRITIS RESEARCH & THERAPY

Pharmacologic Repression of Retinoic Acid Receptor-Related Orphan Nuclear Receptor γ Is Therapeutic in the Collagen-Induced Arthritis Experimental Model

(2013) Mi Ra Chang et al.   Arthritis & Rheumatology

Identification of a Selective RORγ Ligand That Suppresses TH17 Cells and Stimulates T Regulatory Cells

(2012) Laura A. Solt et al.   ACS Chemical Biology

Identification of SR2211: A Potent Synthetic RORγ-Selective Modulator

(2012) Naresh Kumar et al.   ACS Chemical Biology

Central and Peripheral Circadian Clocks in Mammals

(2012) Jennifer A. Mohawk et al.   Annual Review of Neuroscience

p53 Controls Autoimmune Arthritis via STAT-Mediated Regulation of the Th17 Cell/Treg Cell Balance in Mice

(2012) Jin-Sil Park et al.   ARTHRITIS AND RHEUMATISM

The RelB subunit of NFκB acts as a negative regulator of circadian gene expression

(2012) Marina M. Bellet et al.   CELL CYCLE

Lack of nitric oxide synthases increases lipoprotein immune complex deposition in the aorta and elevates plasma sphingolipid levels in lupus

(2012) Mohammed M. Al Gadban et al.   CELLULAR IMMUNOLOGY

SIRT1 and CLOCK 3111T>C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity

(2012) M Garaulet et al.   INTERNATIONAL JOURNAL OF OBESITY

Altered AKT1 and MAPK1 Gene Expression on Peripheral Blood Mononuclear Cells and Correlation with T-Helper-Transcription Factors in Systemic Lupus Erythematosus Patients

(2012) Sonia Garcia-Rodriguez et al.   MEDIATORS OF INFLAMMATION

Clocks, Metabolism, and the Epigenome

(2012) Dan Feng et al.   MOLECULAR CELL

Timing to Perfection: The Biology of Central and Peripheral Circadian Clocks

(2012) Urs Albrecht   NEURON

Core circadian protein CLOCK is a positive regulator of NF- B-mediated transcription

(2012) M. L. Spengler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines

(2012) R. Narasimamurthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Action of RORs and their ligands in (patho)physiology

(2012) Laura A. Solt et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Disruption of rhythms of molecular clocks in primary synovial fibroblasts of patients with osteoarthritis and rheumatoid arthritis, role of IL-1β/TNF

(2012) Stefanie Haas et al.   ARTHRITIS RESEARCH & THERAPY

Shift work at young age is associated with increased risk for multiple sclerosis

(2011) Anna Karin Hedström et al.   ANNALS OF NEUROLOGY

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Methotrexate Chronotherapy is Effective Against Rheumatoid Arthritis

(2011) Hideto To et al.   CHRONOBIOLOGY INTERNATIONAL

The REV-ERBs and RORs: molecular links between circadian rhythms and lipid homeostasis

(2011) Laura A Solt et al.   Future Medicinal Chemistry

Ursolic Acid Suppresses Interleukin-17 (IL-17) Production by Selectively Antagonizing the Function of RORγt Protein

(2011) Tao Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice

(2011) Sue M. Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Diurnal rhythms are altered in a mouse model of multiple sclerosis

(2011) Abigail C. Buenafe   JOURNAL OF NEUROIMMUNOLOGY

DNA Damage-Induced RORα Is Crucial for p53 Stabilization and Increased Apoptosis

(2011) Hyunkyung Kim et al.   MOLECULAR CELL

Cryptochromes mediate rhythmic repression of the glucocorticoid receptor

(2011) Katja A. Lamia et al.   NATURE

Timing of plant immune responses by a central circadian regulator

(2011) Wei Wang et al.   NATURE

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

(2011) Jun R. Huh et al.   NATURE

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

(2011) Laura A. Solt et al.   NATURE

The nuclear receptor REV-ERB  mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines

(2011) J. E. Gibbs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serum concentrations of 25-OH vitamin D in patients with systemic lupus erythematosus (SLE) are inversely related to disease activity: is it time to routinely supplement patients with SLE with vitamin D?

(2010) H. Amital et al.   ANNALS OF THE RHEUMATIC DISEASES

Suprachiasmatic Nucleus: Cell Autonomy and Network Properties

(2010) David K. Welsh et al.   Annual Review of Physiology

Downregulation of the circadian rhythm related gene Arntl2 suppresses diabetes protection in Idd6 NOD.C3H congenic mice

(2010) Chen-Xia He et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Inhibition of type 1 diabetes by upregulation of the circadian rhythm-related aryl hydrocarbon receptor nuclear translocator-like 2

(2010) Chen-Xia He et al.   IMMUNOGENETICS

Exogenous Corticosterone Induces the Expression of the Clock Protein, PERIOD2, in the Oval Nucleus of the Bed Nucleus of the Stria Terminalis and the Central Nucleus of the Amygdala of Adrenalectomized and Intact Rats

(2010) Lauren A. Segall et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Therapeutic index of methotrexate depends on circadian cycling of tumour necrosis factor-α in collagen-induced arthritic rats and mice

(2010) Hideto To et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus

(2010) Kamini Shah et al.   ARTHRITIS RESEARCH & THERAPY

DISCOVERIES OF RHYTHMS IN HUMAN BIOLOGICAL FUNCTIONS: A HISTORICAL REVIEW

(2009) Björn Lemmer   CHRONOBIOLOGY INTERNATIONAL

Seasonal variation in Escherichia coli bloodstream infection: a population-based study

(2009) M.N. Al-Hasan et al.   CLINICAL MICROBIOLOGY AND INFECTION

Interleukin-21 Is Required for the Development of Type 1 Diabetes in NOD Mice

(2009) A. P.R. Sutherland et al.   DIABETES

Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications

(2009) Nancy Nader et al.   FASEB JOURNAL

Circadian Disruption, Per3, and Human Cytokine Secretion

(2009) Jaclyn Guess et al.   INTEGRATIVE CANCER THERAPIES

Mammalian Clock Gene Cryptochrome Regulates Arthritis via Proinflammatory Cytokine TNF- 

(2009) A. Hashiramoto et al.   JOURNAL OF IMMUNOLOGY

The nuclear receptor RORα exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes

(2009) Nathalie Journiac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A circadian clock in macrophages controls inflammatory immune responses

(2009) Maren Keller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced Nitric Oxide Causes Age-Associated Impairment of Circadian Rhythmicity

(2008) Takeshige Kunieda et al.   CIRCULATION RESEARCH

Th17 Cell Differentiation: The Long and Winding Road

(2008) Mandy J. McGeachy et al.   IMMUNITY

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

(2008) Xuexian O. Yang et al.   IMMUNITY

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

(2008) Xuexian O. Yang et al.   IMMUNITY

Circadian rhythms in arthritis: Hormonal effects on the immune/inflammatory reaction

(2007) Maurizio Cutolo et al.   AUTOIMMUNITY REVIEWS