Article
Environmental Sciences
Fatma Pinar Tabanli, Siddika Songuel Yalcin, Sedef Ramoglu, Sadiman Kiykac Altinbas, Anil Yirun, Aylin Balci Ozyurt, Funda Gucel, Pinar Erkekoglu, Kadriye Yurdakok
Summary: This study aimed to investigate the association between bisphenol A (BPA), 25-hydroxy vitamin D [25(OH)D], and 1 alpha,25 dihydroxy vitamin D [1,25( OH)(2)D] levels in cord blood of newborn babies. The results showed that both BPA exposure and insufficient vitamin D transfer via cord blood are common in newborns, but there is no correlation between BPA levels and vitamin D levels in cord blood.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Fatma Pinar Tabanli, Siddika Songul Yalcin, Sedef Ramoglu, Sadiman Kiykac Altinbas, Anil Yirun, Aylin Balci ozyurt, Funda Gucel, Pinar Erkekoglu, Kadriye Yurdakok
Summary: This study investigated the association between BPA, 25(OH)D, and 1,25(OH)(2)D levels in cord blood of newborn babies. The study found that both BPA exposure and insufficient vitamin D transfer via cord blood are common in newborns, but BPA levels were not correlated with vitamin D levels in cord blood.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Rheumatology
Assem M. Abo-Shanab, Shams Kholoussi, Rania Kandil, Dalia Dorgham
Summary: In juvenile onset systemic lupus erythematosus (JO-SLE) patients, levels of IFN-gamma and IL-17 were significantly higher, while 25-OH vitamin D levels were significantly lower compared to controls. There was a significant negative correlation between 25-OH vitamin D levels and SLE disease activity index (SLEDAI-2K) and IFN-gamma levels in JO-SLE patients.
Article
Surgery
Montserrat Marques-Pamies, Maria Lopez-Molina, Silvia Pellitero, Cecilia S. Santillan, Eva Martinez, Pablo Moreno, Jordi Tarasco, Maria L. Granada, Manel Puig-Domingo
Summary: The study found that after sleeve gastrectomy, there was a significant increase in f25(OH)D3 concentrations in patients with morbid obesity, while 25(OH)D levels did not change significantly. One year post-surgery, patients with a BMI <35 kg/m(2) had significantly higher concentrations of f25(OH)D3 and 25(OH)D compared to those with a BMI >35 kg/m(2).
Article
Nutrition & Dietetics
Jinhua Wu, Bule Shao, Xing Xin, Wenliang Luo, Minjia Mo, Wen Jiang, Shuting Si, Shuojia Wang, Yu Shen, Yunxian Yu
Summary: This study explored the associations of vitamin D metabolic pathway gene polymorphisms with gestational 25(OH)D levels in pregnant women, and found that the associations varied by season and VD supplements. Additionally, the Gc isoform had a significant impact on gestational 25(OH)D levels.
CLINICAL NUTRITION
(2021)
Article
Geriatrics & Gerontology
S. Karahan, F. Katkat
Summary: This study investigated the role of serum 25(OH) vitamin D level on COVID severity and related mortality in 149 COVID-19 patients, revealing that serum 25(OH) vitamin D was independently associated with mortality.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Infectious Diseases
Juraj Smaha, Martin Kuzma, Kristina Brazdilova, Samuel Nachtmann, Martin Jankovsky, Katarina Pastirova, Andrea Gazova, Peter Jackuliak, Zdenko Killinger, Jan Kyselovic, Tomas Koller, Neil Binkley, Juraj Payer
Summary: This study aimed to evaluate the mortality rate in COVID-19 patients with severe vitamin D deficiency. The results showed that patients with serum 25(OH) D levels <12 ng/ml had higher mortality, viral load, and Charlson comorbidity index. Lower 25(OH) D levels at the time of admission were independently associated with mortality, suggesting that severe vitamin D deficiency may contribute to poor outcomes.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Nutrition & Dietetics
Luis Castano, Leire Madariaga, Gema Grau, Alejandro Garcia-Castano
Summary: Vitamin D is crucial for bone mineralization in children and deficiency is common. Certain medical conditions and genetic alterations can increase the risk of vitamin D deficiency rickets. Measurement of calcifediol levels is used to assess the status of the vitamin D endocrine system. Clinical trials have demonstrated the benefits of ensuring normal 25(OH)D levels and calcium intake in preventing or treating nutritional rickets in children.
Article
Biochemistry & Molecular Biology
Martyna Fronczek, Joanna Katarzyna Strzelczyk, Krzysztof Biernacki, Silvia Salatino, Tadeusz Osadnik, Zofia Ostrowska
Summary: The study investigated the role of genetic variation in the CYP2R1 gene in vitamin D deficiency among healthy Polish individuals. Two substitutions were found in selected gene fragments, with one potentially influencing the structure and function of CYP2R1. Further functional verification is needed to confirm these findings.
Article
Pharmacology & Pharmacy
Qing Hao, Yun Qin, Wanjun Zhao, Lingyun Zhang, Han Luo
Summary: The study suggests that supplying calcitriol based on a 70% RDP cutoff may be a wise practice in thyroidectomy patients, helping to stratify high-risk patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Hye Ran Shin, Hyeon Ju Park, Sun Yung Ly
Summary: Vitamin D deficiency is prevalent among young Korean women. This study aimed to determine the optimal vitamin D intake level for maintaining adequate serum 25-hydroxyvitamin D (25[OH]D) levels in young Korean women throughout different seasons. The study identified seasonal factors influencing 25(OH)D levels, calculated the necessary vitamin D intake for sufficient levels, and analyzed the relationship between 25(OH)D and intact parathyroid hormone (iPTH) levels. The results showed that 25(OH)D levels were higher in summertime compared to wintertime, and an increase in vitamin D intake led to a corresponding increase in 25(OH)D levels. The study suggests that increasing UV irradiation time in summertime and consuming vitamin D supplements and foods throughout the year is beneficial for maintaining sufficient levels of 25(OH)D in young Korean women.
Article
Rheumatology
Lucia Novelli, Cristiana Barbati, Cristina Capuano, Serena Recalchi, Fulvia Ceccarelli, Marta Vomero, Cristiano Alessandri, Stefania Morrone, Fabrizio Conti
Summary: This study investigated the expression of KLRG1 in SLE patients compared to healthy controls on both NK and T cells, as well as its possible involvement in SLE pathogenesis. The results showed that KLRG1 expression was significantly reduced on immune cell populations in SLE patients, especially on total NK cells. In addition, KLRG1 expression on NK cells was inversely correlated with disease activity and associated with treatment with HCQ. In vitro treatment with HCQ increased KLRG1 expression on NK cells. These findings suggest a role of KLRG1 in the pathogenesis of SLE and its potential as a biomarker for this disease.
Article
Nutrition & Dietetics
Xiaoyun Shan, Xiayu Zhao, Siran Li, Pengkun Song, Qingqing Man, Zhen Liu, Yichun Hu, Lichen Yang
Summary: This study aims to analyze the associations between serum 25(OH)D levels and the risk of metabolic syndrome (MetS) and its components in non-diabetic women of childbearing age in China, considering both genetic and non-genetic factors. The findings suggest significant associations between insufficient serum 25(OH)D and components of MetS, including elevated waist circumference, triglycerides, and reduced high-density lipoprotein cholesterol. However, no independent associations were found between 25(OH)D levels and MetS, hypertension, and hyperglycemia.
Article
Immunology
Zhen Yu, Hao Cheng, Yuying Liang, Tingting Ding, Chenglan Yan, Chong Gao, Hongyan Wen
Summary: The study revealed that patients with idiopathic inflammatory myopathy (IIM) have vitamin D deficiency, which is significantly correlated with muscle enzyme levels, presence of anti-Jo-1 and anti-Mi-2 antibodies, as well as the absolute numbers of total T and Treg cells in IIM. Patients with deficient levels of vitamin D are more likely to have skin symptoms and liver involvement.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Wenting Luo, Yaping Dong, Tao Hu, Dan Liu, Xiaowei Wei, Wei Ma, Zhengwei Yuan, Qun Zhao
Summary: The study revealed that most orthopedic patients have vitamin D insufficiency, while patients with DDH are in the insufficiency range. MiR-140 was downregulated in both DDH patients' serum and rat hip joints. A combination of 25(OH)D and miR-140 showed strong performance in distinguishing DDH from controls.
Article
Rheumatology
Alessandro Giollo, Margherita Zen, Maddalena Larosa, Davide Astorri, Mariangela Salvato, Antonia Calligaro, Konstantinos Botsios, Cristina Bernardi, Gerolamo Bianchi, Andrea Doria
Summary: The failure to optimize treatment in early rheumatoid arthritis (RA) is associated with difficult-to-treat RA (D2T-RA). Treatment delay beyond 3 months and non-discontinuation of glucocorticoids after 6 months are early predictive features of D2T-RA.
Article
Rheumatology
Alain Lescoat, Doerte Huscher, Nils Schoof, Paolo Airo, Jeska De Vries-Bouwstra, Gabriela Riemekasten, Eric Hachulla, Andrea Doria, Edoardo Rosato, Nicolas Hunzelmann, Carlomaurizio Montecucco, Armando Gabrielli, Anna-Maria Hoffmann-Vold, Oliver Distler, Jennifer Ben Shimol, Maurizio Cutolo, Yannick Allanore
Summary: The prevalence and characteristics of SSc-associated interstitial lung disease (SSc-ILD) vary between geographical regions. This study aimed to explore the differences in prevalence, phenotype, treatment, and prognosis in patients with SSc-ILD from different regions in the EUSTAR database. The results showed significant variations in clinical characteristics, survival rates, and treatment approaches among different regions.
Article
Medicine, General & Internal
Eva Rakoczi, Gusztav Magocs, Sara Kovacs, Bela Nagy Jr, Gabriella Szucs, Zoltan Szekanecz
Summary: In this prospective study, the efficacy of heterologous vaccination with BNT162b2 on individuals previously administered with two doses of BBIBP-CorV vaccine was analyzed. The results showed that the total Ig levels significantly increased after BNT162b2 boosters, suggesting that BNT162b2 can successfully enhance the effects of two-dose BBIBP-CorV vaccination.
Review
Immunology
M. Gasparotto, C. Franco, E. Zanatta, A. Ghirardello, M. Zen, L. Iaccarino, B. Fabris, A. Doria, M. Gatto
Summary: Idiopathic inflammatory myopathies (IIM) have diverse molecular pathogenetic mechanisms, resulting in the partial inefficacy of current immunomodulatory drugs. Genomic and proteomic studies have revealed the role of interferon (IFN) in IIM, showing a predominant type I IFN response in dermatomyositis (DM), a type 2 IFN profile in anti-synthetase syndrome (ASyS) and inclusion body myositis (IBM), and a less robust IFN footprint in immune-mediated necrotizing myopathy (IMNM). The janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway mediates intracellular IFN signaling, which can be targeted by janus kinase inhibitors (JAKi), currently approved for other autoimmune diseases. This review summarizes the evidence of IFN role in IIM pathogenesis and the ongoing clinical trials on IFN-targeting drugs, with a focus on JAKi.
AUTOIMMUNITY REVIEWS
(2023)
Review
Medicine, Research & Experimental
Sara Bindoli, Chiara Baggio, Andrea Doria, Eugenia Bertoldo, Paolo Sfriso
Summary: Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome is a newly described autoinflammatory disease. Its diagnosis is based on somatic mutations of the UBA1 X-linked gene in hematopoietic progenitor cells. The clinical manifestations vary, ranging from autoinflammatory symptoms to underlying hematologic disorders such as myelodysplastic syndromes. The response to treatment for VEXAS is poor, but recent studies have shown that Janus kinase inhibitors (JAK-I) can be effective in managing the disease.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Chiara Franco, Anna Ghirardello, Loris Bertazza, Michela Gasparotto, Elisabetta Zanatta, Luca Iaccarino, Hadi Valadi, Andrea Doria, Mariele Gatto
Summary: This study aims to investigate the efficiency of EV isolation and characterization methods using size-exclusion chromatography (SEC) combined with ultrafiltration (UF). The results showed that the combined method is reliable for isolating intact EVs from complex fluids. This could potentially help in early disease characterization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marta Favero, Francesca Ometto, Elisa Belluzzi, Giacomo Cozzi, Laura Scagnellato, Francesca Oliviero, Pietro Ruggieri, Andrea Doria, Mariagrazia Lorenzin, Roberta Ramonda
Summary: This study aimed to evaluate the association between fetuin-A levels and radiographic sacroiliitis and syndesmophytes in early axSpA patients, and to identify potential predictors of radiographic damage. Results showed that fetuin-A levels were negatively associated with sacroiliac joint damage and may serve as a biomarker for predicting early structural damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Beatrice Moccaldi, Laura De Michieli, Marco Binda, Giulia Famoso, Roberto Depascale, Martina Perazzolo Marra, Andrea Doria, Elisabetta Zanatta
Summary: CTD-PAH is a life-threatening complication of connective tissue diseases characterized by increased pulmonary arterial pressure and resistance. Due to non-specific symptoms and lack of consensus on screening strategies, CTD-PAH is often diagnosed at an advanced stage. Non-invasive tools, particularly novel serum biomarkers, may improve early diagnosis and disease monitoring of CTD-PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Tamas Arokszallasi, Eszter Balogh, Rita Orban-Kalmandi, Mate Pasztor, Anita Arokszallasi, Edit Boglarka Nagy, Ivett Belan, Zsolt May, Tunde Csepany, Laszlo Csiba, Zsuzsa Bagoly, Laszlo Olah
Summary: A retrospective cohort study investigated the effect of acute alcohol consumption on outcomes in patients with acute ischemic stroke treated with intravenous thrombolysis (IVT). Elevated blood alcohol concentration was found to be a significant protective factor against unfavorable short-term and long-term outcomes. Patients with higher blood alcohol concentration showed lower NIHSS scores at 3 and 7 days after IVT.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Rheumatology
Federico Pettorossi, Michela Gasparotto, Anna Ghirardello, Chiara Franco, Giulio Ceolotto, Alessandra Giannella, Luca Iaccarino, Elisabetta Zanatta, Andrea Doria, Mariele Gatto
Summary: IIMs are rare autoimmune disorders characterized by muscle weakness and inflammation. MiRNAs play a role in mediating autoimmunity and inflammation and are involved in immune and nonimmune mechanisms of myofiber damage in IIMs. Further research on miRNA profiling may have an impact on the therapeutic strategies for IIMs.
CURRENT OPINION IN RHEUMATOLOGY
(2023)
Article
Rheumatology
Margherita Zen, Marta Tonello, Maria Favaro, Teresa Del Ross, Antonia Calligaro, Alessandro Giollo, Filippo Vesentini, Ilenia Anna Gennaio, Federico Arru, Amelia Ruffatti, Andrea Doria
Summary: This study aimed to assess complement activation and its association with clinical variables in aPL-positive patients with a favorable disease course. The results showed that complement activation persists in the quiescent phase of the disease in patients with catastrophic APS, re-thrombosis, and aPL carriers. This finding suggests a possible mechanism for aPL-induced thrombosis.
Article
Rheumatology
Liliana Saraiva, Rita N. Cunha, Diogo Jesus, Mariele Gatto, Margherita Zen, Luca Iaccarino, Jose A. P. da Silva, Andrea Doria, Luis Sousa Ines
Summary: The study aims to assess the criterion validity of the SLE disease activity score (SLE-DAS) flare tool and compare its performance in identifying flares against other instruments. The results show that the SLE-DAS accurately identifies and categorizes mild or moderate/severe flares, which has practical significance for physicians' treatment decisions in the clinical practice setting.
Article
Rheumatology
Augusta Ortolan, Mariagrazia Lorenzin, Giacomo Cozzi, Laura Scagnellato, Marta Favero, Giovanni Striani, Stefania Vio, Vanna Scapin, Giorgio De Conti, Andrea Doria, Roberta Ramonda
Summary: The study aims to describe the frequency of minimal disease activity (MDA) in real-life psoriatic arthritis (PsA) patients, explore predictors of MDA longitudinally, and examine the frequency and predictors of low disease activity (LDA) in patients with axial involvement (axPsA). PsA patients receiving stable biological/targeted-synthetic Disease-Modifying Anti-Rheumatic Drugs (bDMARDs/tDMARDs) were evaluated for disease activity indices, including MDA and ankylosing spondylitis disease activity score-LDA (ASDAS-LDA), at baseline and every 6 months. The results showed that 52-61% of patients achieved MDA and 17-24% achieved ASDAS-LDA. AxPsA, fibromyalgia, osteoarthritis, and BMI ≥35 were less frequently observed in patients with sustained MDA. Age, bDMARDs/tDMARDs duration, axPsA, fibromyalgia, osteoarthritis, and BMI ≥35 were significantly and independently associated with MDA. Age, fibromyalgia, and osteoarthritis were also independently associated with ASDAS-LDA.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Immunology
Giovanni Striani, Ariela Hoxha, Mariagrazia Lorenzin, Giacomo Cozzi, Laura Scagnellato, Tatiana Vangelista, Francesca Frizzera, Pierino De Sandre, Paolo Simioni, Andrea Doria, Roberta Ramonda
Summary: This study investigated the effects of SARS-CoV-2 infection and vaccination in patients with inflammatory arthritis (IA). It found that IA patients who contracted SARS-CoV-2 infection had a higher rate of arthritis flare, and IA patients may also experience flare-ups after SARS-CoV-2 vaccination, although not statistically significant.
FRONTIERS IN IMMUNOLOGY
(2023)
Meeting Abstract
Rheumatology
Katalin Szabo, Levente Bodoki, Melinda Nagy-Vincze, Tibor Beldi, Anett Vincze, Erika Zilahi, Jozsef Varga, Gabriella Szucs, Katalin Danko, Zoltan Griger
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)