Article
Pharmacology & Pharmacy
Yi Liu, Xiuhong Weng, Mingbo Wei, Shaoling Yu, Yumei Ding, Bo Cheng
Summary: This study investigated the expression of clock genes in pSS and found a potential therapeutic method - melatonin. The results suggest that abnormal expression of circadian genes may be associated with the pathogenesis of pSS.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hui Tian, Yanwen Jiao, Mingyue Guo, Yilin Wang, Ruiqi Wang, Cao Wang, Xiongbiao Chen, Weiming Tian
Summary: In this study, we discovered the involvement of klf7 in regulating circadian rhythm. Knocking down klf7 disrupted circadian rhythm and led to autism-like behavior. We also observed downregulation of the Clock gene and disturbance of its downstream rhythm genes in the brain of klf7 knockout mice. Melatonin, a circadian regulation drug, was able to regulate the expression of rhythm genes in klf7 knockout cells and rescue the autistic behavior of klf7 knockout mice.
CELL AND BIOSCIENCE
(2022)
Article
Biology
Vijay K. Jidigam, Onkar B. Sawant, Rebecca D. Fuller, Kenya Wilcots, Rupesh Singh, Richard A. Lang, Sujata Rao
Summary: Research has shown that clock genes are expressed in the mouse embryonic retina, and this expression requires light cues. Deletion of Bmal1 and Per2 from retinal neurons leads to retinal angiogenic defects, indicating that a dysregulated circadian clock primarily drives neovascularization.
COMMUNICATIONS BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ling Liang, Wen Min Fei, Ze Qiang Zhao, Yu Ying Hao, Chao Zhang, Yong Cui, Xin Dong Guo
Summary: The study showed that pretreatment with microneedles followed by application of calcipotriol had a better therapeutic effect on psoriasis, indicating the potential of microneedles in improving imiquimod-induced psoriasis-like dermatitis in future clinical applications.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Dermatology
Bernadetta Bilska, Aneta Zegar, Andrzej T. Slominski, Konrad Kleszczynski, Joanna Cichy, Elzbieta Pyza
Summary: The gene expression of Rarres2, Camp, and Defb1 in mouse skin was highest during high activity periods, but this rhythm was masked under constant darkness, while the gene expression of Defb3 and Defb14 showed the highest levels during sleep and were maintained under constant darkness. This indicates a correlation between specific antimicrobial peptides and different physiological states, with some being influenced by light-dark cycles and others being regulated by a circadian clock.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Shirley L. Zhang, Nicholas F. Lahens, Zhifeng Yue, Denice M. Arnold, Peter P. Pakstis, Jessica E. Schwarz, Amita Sehgal
Summary: The blood-brain barrier is critical for neural function, and this study shows that efflux of xenobiotics through the BBB follows a circadian rhythm in mice and human cells. Interestingly, limited circadian regulation of transcription was detected in brain endothelial cells, with no evident oscillations in efflux transporters. The molecular clock drives cycling of intracellular magnesium through transcriptional regulation, contributing to the rhythm in efflux.
NATURE COMMUNICATIONS
(2021)
Article
Cell & Tissue Engineering
Mengbo Yang, Lanqi Wang, Zhimin Chen, Weijie Hao, Qian You, Jianhua Lin, Jingzhi Tang, Xin Zhao, Wei-Qiang Gao, Huiming Xu
Summary: The study demonstrates that human amniotic epithelial cells (AEC-SC) can effectively ameliorate psoriasis-like skin lesions and skin inflammation, with interleukin-1 receptor antagonist (IL-1ra) playing an essential role. Therefore, topical administration of AEC-SC may provide a novel strategy for treating psoriasis-like inflammatory skin diseases.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Feng Li, Luomin Lin, Yiting He, Guanghui Sun, Dong Dong, Baojian Wu
Summary: The study found that the central clock gene Bmal1 plays a role in acne-associated inflammation. Bmal1 disruption or jet lag led to exacerbated P. acnes-induced skin inflammation, while Bmal1 restricted P. acnes-induced inflammation by regulating the NF-kappa B/NLRP3 axis. These findings enhance our understanding of the pathogenesis of acne and suggest that targeting circadian rhythms may be an effective approach for managing acne.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Immunology
Zainab Taleb, Vania Carmona-Alcocer, Kyle Stokes, Marta Haireek, Huaqing Wang, Stephen M. Collins, Waliul I. Khan, Phillip Karpowicz
Summary: Circadian disruption is associated with increased risk of inflammatory bowel disease (IBD), as shown by studies on mice lacking a functional circadian clock. The severity of colitis in these mice is worsened and their recovery impaired. Inflammation, immune cell infiltration, and epithelial cell proliferation in the colon all exhibit daily rhythms, which are disrupted in mice without a functioning circadian clock. These findings highlight the importance of a functional circadian clock in the colon for inflammation and healing.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Immunology
Xiao-Lan Wang, Lianjian Li
Summary: The circadian clock plays a crucial role in regulating key physiological processes and maintaining homeostasis, with disruptions affecting immune response, brain function, and neurodegeneration. By controlling the clock mechanisms in immune and brain cells, as well as systemic inflammation, the circadian system may offer potential targets for preventing and treating inflammation and neurodegenerative diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Dermatology
Ping Xia, Lorenzo Pasquali, Chenying Gao, Ankit Srivastava, Nupur Khera, Jan Cedric Freisenhausen, Longlong Luo, Einar Rosen, Ankevan Lierop, Bernhard Homey, Andor Pivarcsi, Eniko Sonkoly
Summary: The study reveals that miR-378a plays an amplifying role in IL-17A-induced NF-kappa B signaling in psoriasis, enhancing skin inflammation through nuclear translocation and production of inflammatory mediators.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Neurosciences
Chelsea A. Vadnie, Kaitlyn A. Petersen, Lauren A. Eberhardt, Mariah A. Hildebrand, Allison J. Cerwensky, Hui Zhang, Jennifer N. Burns, Darius D. Becker-Krail, Lauren M. DePoy, Ryan W. Logan, Colleen A. McClung
Summary: Individuals with mood and anxiety disorders often experience disruptions in sleep and circadian rhythms. This study explores the potential mechanisms underlying these disturbances, focusing on the dysregulation of the suprachiasmatic nucleus (SCN) and its impact on depressive- and anxiety-like behavior in mice. The results suggest that the dampening of homecage activity rhythms, mediated by the SCN, is directly correlated with increased anxiety-like behavior.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Plant Sciences
Dain Seo, Jeonghyang Park, Jeeyoon Park, Geonhee Hwang, Pil Joon Seo, Eunkyoo Oh
Summary: Plants adapt to high temperature stress through a process called thermomorphogenesis, which is regulated by the circadian clock and involves the interaction of several proteins. The central clock component ZEITLUPE (ZTL) regulates thermoresponsive growth by modulating the activity and expression of PIF4 target genes. ZTL-mediated degradation of TOC1 and PRR5 enhances the sensitivity of hypocotyl growth to high temperatures.
PLANT CELL AND ENVIRONMENT
(2023)
Article
Immunology
Zhenguo Cai, Wuqing Wang, Yao Zhang, Yibin Zeng
Summary: This study found that curcumin has a therapeutic effect on IMQ-induced dermatitis in mice, reducing inflammation and altering gut microbiota composition to alleviate psoriatic lesions. Therefore, curcumin may be a promising candidate for the treatment of psoriasis.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Rajesh Narasimamurthy, David M. Virshup
Summary: In our modern society, the consequences of disrupting our circadian rhythms by skipping or delaying sleep are severe, leading to various disorders. The internal clock is regulated by the reversible phosphorylation of PERIOD proteins, controlled by isoforms of casein kinase 1 (CK1). Through biochemical, genetic, and structural studies, a better understanding of how the core clock is regulated has been achieved, opening new approaches for clock regulation.
Letter
Dermatology
Rui Aoki, Tatsuyoshi Kawamura, Fumi Goshima, Youichi Ogawa, Susumu Nakae, Kohji Moriishi, Atsuhito Nakao, Shinji Shimada
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2016)
Letter
Dermatology
Youichi Ogawa, Manao Kinoshita, Nao Mizumura, Shiho Miyazaki, Rui Aoki, Akira Momosawa, Shinji Shimada, Taiho Kambe, Tatsuyoshi Kawamura
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2018)
Review
Dermatology
Tatsuyoshi Kawamura, Youichi Ogawa, Rui Aoki, Shinji Shimada
JOURNAL OF DERMATOLOGICAL SCIENCE
(2014)
Letter
Dermatology
Youichi Ogawa, Tatsuyoshi Kawamura, Takamitsu Matsuzawa, Rui Aoki, Shinji Shimada
JOURNAL OF DERMATOLOGICAL SCIENCE
(2014)
Letter
Dermatology
Takamitsu Matsuzawa, Tatsuyoshi Kawamura, Youichi Ogawa, Masaaki Takahashi, Rui Aoki, Kohji Moriishi, Yoshio Koyanagi, Hiroyuki Gatanaga, Andrew Blauvelt, Shinji Shimada
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2013)
Article
Dermatology
R. Aoki, B. M. Clanner-Engelshofen, S. Charnowski, T. Ruzicka, M. Reinholz
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2019)
Article
Biochemical Research Methods
Isin S. Bagci, Rui Aoki, Sebastian Krammer, Thomas Ruzicka, Miklos Sardy, Daniela Hartmann
JOURNAL OF BIOPHOTONICS
(2019)
Article
Dermatology
I. S. Bagci, R. Aoki, S. Krammer, T. Ruzicka, M. Sardy, L. E. French, D. Hartmann
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2019)
Article
Biochemical Research Methods
Isin Sinem Bagci, Rui Aoki, Sebastian Krammer, Gabriela Vladimirova, Thomas Ruzicka, Miklos Sardy, Lars E. French, Daniela Hartmann
JOURNAL OF BIOPHOTONICS
(2020)
Article
Dermatology
Isin Sinem Bagci, Rui Aoki, Gabriela Vladimirova, Ecem Ergun, Thomas Ruzicka, Miklos Sardy, Lars E. French, Daniela Hartmann
Summary: Ex vivo confocal laser scanning microscopy shows potential in identifying histopathological features and immunofluorescence in cutaneous lupus erythematosus, with a high level of agreement with conventional histopathology.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Biochemical Research Methods
Isin Sinem Bagci, Rui Aoki, Gabriela Vladimirova, Miklos Sardy, Thomas Ruzicka, Lars E. French, Daniela Hartmann
Summary: Ex vivo confocal laser scanning microscopy showed potential in histomorphological and direct immunofluorescence examination of pemphigus vulgaris. In PV patients, intraepidermal blisters were detected in 80% and acantholytic cells in 60%, with a sensitivity of 90% for detecting intraepidermal fluorescence with IgG and C3. The specificity for IgG and C3 staining was 70% and 90% respectively.
JOURNAL OF BIOPHOTONICS
(2021)
Review
Dermatology
Tobias Nellessen, Rui Aoki, Claudia Kammerbauer, Benjamin M. Clanner-Engelshofen, Lars E. French, Markus Reinholz
Summary: This study demonstrates that alpha-HPV positivity is very rare in common non-genital SK. The rare alpha-HPV-positive SK lesions histologically belonged to the acanthotic type, implying a potential impact of HPV infection on epidermal hyperproliferation. Although a possible association cannot be excluded, our findings suggest that alpha-HPV is not a major causative factor for non-genital SK.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Dermatology
Ecem Zeliha Ergun, Rui Aoki, Orsolya N. Horvath, Daniela Hartmann, Takashi K. Satoh, Laura Calabrese, Ayse Esra Koku Aksu, Mehmet Salih Gurel, Vildan Manav, Michael J. Flaig, Miklos Sardy, Thomas Ruzicka, Lars E. French, Isin Sinem Bagci
Summary: A study comparing patients with bullous pemphigoid (BP) and pemphigus vulgaris (PV) found that the expression levels of the pruritogenic cytokine IL-31 and its receptor IL-31RA were significantly higher in BP lesions compared to PV lesions. This suggests a possible contribution of the IL-31/IL-31RA pathway to the difference in pruritus between BP and PV.
EXPERIMENTAL DERMATOLOGY
(2023)
Review
Dermatology
Takashi K. Satoh, Matthias Munoz Neulinger, Pia-Charlotte Stadler, Rui Aoki, Lars E. French
Summary: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, but they can also lead to immune-related adverse events (irAEs), including severe cutaneous reactions such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). This study analyzed 95 cases of ICI-induced SJS/TEN and found that PD-1 inhibitors were most commonly associated with these reactions. SJS/TEN typically occurred within the first 4 weeks of treatment, and corticosteroid monotherapy was the most frequently chosen treatment approach. The overall mortality rate of ICI-induced SJS/TEN was high.
JOURNAL OF DERMATOLOGY
(2023)