Altered expression of the core circadian clock component PERIOD2 contributes to osteoarthritis-like changes in chondrocyte activity

PER2 regulation of mammary gland development

(2018) Cole M. McQueen et al.   DEVELOPMENT

Emerging Players at the Intersection of Chondrocyte Loss of Maturational Arrest, Oxidative Stress, Senescence and Low-Grade Inflammation in Osteoarthritis

(2018) Manuela Minguzzi et al.   Oxidative Medicine and Cellular Longevity

Interactions between the circadian clock and TGF-β signaling pathway in zebrafish

(2018) Hadas E. Sloin et al.   PLoS One

Glucose Homeostasis: Regulation by Peripheral Circadian Clocks in Rodents and Humans

(2017) Frédéric Gachon et al.   ENDOCRINOLOGY

WNT Takes Two to Tango: Molecular Links between the Circadian Clock and the Cell Cycle in Adult Stem Cells

(2017) Toru Matsu-ura et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Dysregulated circadian rhythm pathway in human osteoarthritis: NR1D1 and BMAL1 suppression alters TGF-β signaling in chondrocytes

(2017) R. Akagi et al.   OSTEOARTHRITIS AND CARTILAGE

Site-specific phosphorylation of casein kinase 1 δ (CK1δ) regulates its activity towards the circadian regulator PER2

(2017) Gracie Wee Ling Eng et al.   PLoS One

Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress

(2017) Helmut Sies   Redox Biology

The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration

(2016) Michal Dudek et al.   ANNALS OF THE RHEUMATIC DISEASES

Decreased circadian component Bmal1 predicts tumor progression and poor prognosis in human pancreatic ductal adenocarcinoma

(2016) Wenhua Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ROS/oxidative stress signaling in osteoarthritis

(2016) Panagiotis Lepetsos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The chondrocyte-intrinsic circadian clock is disrupted in human osteoarthritis

(2016) Sarah J. B. Snelling et al.   CHRONOBIOLOGY INTERNATIONAL

A functional circadian clock is required for proper insulin secretion by human pancreatic islet cells

(2016) C. Saini et al.   DIABETES OBESITY & METABOLISM

Clock GeneBmal1Modulates Human Cartilage Gene Expression by Crosstalk With Sirt1

(2016) Wei Yang et al.   ENDOCRINOLOGY

Circadian Transcription from Beta Cell Function to Diabetes Pathophysiology

(2016) Mark Perelis et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Per2-Mediated Vascular Dysfunction Is Caused by the Upregulation of the Connective Tissue Growth Factor (CTGF)

(2016) Vaishnavi Jadhav et al.   PLoS One

The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity

(2015) Michal Dudek et al.   JOURNAL OF CLINICAL INVESTIGATION

Catabolic cytokines disrupt the circadian clock and the expression of clock-controlled genes in cartilage via an NFкB-dependent pathway

(2015) B. Guo et al.   OSTEOARTHRITIS AND CARTILAGE

IL-1beta mediates MMP secretion and IL-1beta neosynthesis via upregulation of p22phox and NOX4 activity in human articular chondrocytes

(2015) F. Rousset et al.   OSTEOARTHRITIS AND CARTILAGE

Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2

(2015) Shurei Sugita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pancreatic   cell enhancers regulate rhythmic transcription of genes controlling insulin secretion

(2015) M. Perelis et al.   SCIENCE

Circadian gene variants in cancer

(2014) Nicole M. Kettner et al.   ANNALS OF MEDICINE

Deregulated expression of circadian clock genes in gastric cancer

(2014) Ming-Luen Hu et al.   BMC GASTROENTEROLOGY

Circadian control of tissue homeostasis and adult stem cells

(2014) Peggy Janich et al.   CURRENT OPINION IN CELL BIOLOGY

Circadian clock-mediated control of stem cell division and differentiation: beyond night and day

(2014) S. A. Brown   DEVELOPMENT

CaMKII is essential for the cellular clock and coupling between morning and evening behavioral rhythms

(2014) N. Kon et al.   GENES & DEVELOPMENT

Circadian molecular clocks and cancer

(2013) Fergal C. Kelleher et al.   CANCER LETTERS

Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration

(2013) Erik S. Musiek et al.   JOURNAL OF CLINICAL INVESTIGATION

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(2013) Christos Savvidis et al.   MOLECULAR MEDICINE

A gene expression study of normal and damaged cartilage in anteromedial gonarthrosis, a phenotype of osteoarthritis

(2013) S. Snelling et al.   OSTEOARTHRITIS AND CARTILAGE

Pathogenic Role of Basic Calcium Phosphate Crystals in Destructive Arthropathies

(2013) Hang-Korng Ea et al.   PLoS One

ROS Stress Resets Circadian Clocks to Coordinate Pro-Survival Signals

(2013) Teruya Tamaru et al.   PLoS One

Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations

(2013) Jeremy Sokolove et al.   Therapeutic Advances in Musculoskeletal Disease

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Intracellular calcium oscillations in articular chondrocytes induced by basic calcium phosphate crystals lead to cartilage degradation

(2012) C. Nguyen et al.   OSTEOARTHRITIS AND CARTILAGE

The Clock GeneRev-erbα Regulates Pancreatic β-Cell Function: Modulation by Leptin and High-Fat Diet

(2011) Elaine Vieira et al.   ENDOCRINOLOGY

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

(2010) Biliana Marcheva et al.   NATURE

Calcification of articular cartilage in human osteoarthritis

(2009) M. Fuerst et al.   ARTHRITIS AND RHEUMATISM

The 4th dimension and adult stem cells: Can timing be everything?

(2009) Jeffrey M. Gimble et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The role of cell-specific circadian clocks in metabolism and disease

(2009) M. S. Bray et al.   Obesity Reviews

Wnt–β-catenin signaling in the pathogenesis of osteoarthritis

(2008) Maripat Corr   Nature clinical practice. Rheumatology