Sterol metabolism controls T H 17 differentiation by generating endogenous RORγ agonists

Proatherogenic Conditions Promote Autoimmune T Helper 17 Cell Responses In Vivo

(2014) Hoyong Lim et al.   IMMUNITY

Simvastatin Inhibits IL-17 Secretion by Targeting Multiple IL-17-Regulatory Cytokines and by Inhibiting the Expression of IL-17 Transcription Factor RORC in CD4+ Lymphocytes

(2014) X. Zhang et al.   JOURNAL OF IMMUNOLOGY

Pharmacologic Inhibition of ROR t Regulates Th17 Signature Gene Expression and Suppresses Cutaneous Inflammation In Vivo

(2014) J. Skepner et al.   JOURNAL OF IMMUNOLOGY

Ezetimibe decreases serum oxidized cholesterol without impairing bile acid synthesis in Japanese hypercholesterolemic patients

(2013) Satoshi Hirayama et al.   ATHEROSCLEROSIS

Th17/Treg imbalance induced by increased incidence of atherosclerosis in patients with Systemic Lupus Erythematosus (SLE)

(2013) Zhu Mengya et al.   CLINICAL RHEUMATOLOGY

A complex issue on CD4+T-cell subsets

(2013) Shuiping Jiang et al.   IMMUNOLOGICAL REVIEWS

Early signaling events that underlie fate decisions of naive CD4+T cells toward distinct T-helper cell subsets

(2013) Hidehiro Yamane et al.   IMMUNOLOGICAL REVIEWS

Dynamic regulatory network controlling TH17 cell differentiation

(2013) Nir Yosef et al.   NATURE

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

(2013) Yoko Kidani et al.   NATURE IMMUNOLOGY

Sterols and oxysterols in immune cell function

(2013) Nathanael J Spann et al.   NATURE IMMUNOLOGY

Increased Cholesterol Content in Gammadelta (γδ) T Lymphocytes Differentially Regulates Their Activation

(2013) Hsin-Yuan Cheng et al.   PLoS One

Hypercholesterolemia and Risk of Incident Psoriasis and Psoriatic Arthritis in US Women

(2013) Shaowei Wu et al.   Arthritis & Rheumatology

Identification of a Selective RORγ Ligand That Suppresses TH17 Cells and Stimulates T Regulatory Cells

(2012) Laura A. Solt et al.   ACS Chemical Biology

Cholesterol sulfate induces expression of the skin barrier protein filaggrin in normal human epidermal keratinocytes through induction of RORα

(2012) Osamu Hanyu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

(2012) Nathanael J. Spann et al.   CELL

A Validated Regulatory Network for Th17 Cell Specification

(2012) Maria Ciofani et al.   CELL

Rorγt+ innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice

(2012) Stanislav Pantelyushin et al.   JOURNAL OF CLINICAL INVESTIGATION

Therapeutic potential of targeting IL-17

(2012) Sarah A Jones et al.   NATURE IMMUNOLOGY

Metabolic checkpoints in activated T cells

(2012) Ruoning Wang et al.   NATURE IMMUNOLOGY

Ursolic Acid Suppresses Interleukin-17 (IL-17) Production by Selectively Antagonizing the Function of RORγt Protein

(2011) Tao Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation

(2011) Guoliang Cui et al.   JOURNAL OF CLINICAL INVESTIGATION

Control of TH17 cells occurs in the small intestine

(2011) Enric Esplugues et al.   NATURE

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

(2011) Jun R. Huh et al.   NATURE

Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells

(2010) Qianming Bai et al.   ATHEROSCLEROSIS

A second class of nuclear receptors for oxysterols: Regulation of RORα and RORγ activity by 24S-hydroxycholesterol (cerebrosterol)

(2010) Yongjun Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Structural Basis for Hydroxycholesterols as Natural Ligands of Orphan Nuclear Receptor RORγ

(2010) Lihua Jin et al.   MOLECULAR ENDOCRINOLOGY

Ursolic Acid Triggers Apoptosis and Bcl-2 Downregulation in MCF-7 Breast Cancer Cells

(2009) E. Kassi et al.   CANCER INVESTIGATION

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

(2009) Caroline E. Sutton et al.   IMMUNITY

Protein geranylgeranylation regulates the balance between Th17 cells and Foxp3+ regulatory T cells

(2009) S.-i. Kagami et al.   INTERNATIONAL IMMUNOLOGY

Modulation of Retinoic Acid Receptor-related Orphan Receptor α and γ Activity by 7-Oxygenated Sterol Ligands

(2009) Yongjun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATP-Binding Cassette Transporter G1 Negatively Regulates Thymocyte and Peripheral Lymphocyte Proliferation

(2009) Allison J. Armstrong et al.   JOURNAL OF IMMUNOLOGY

25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway

(2008) Yongjie Ma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

LXR Signaling Couples Sterol Metabolism to Proliferation in the Acquired Immune Response

(2008) Steven J. Bensinger et al.   CELL

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

(2008) Nicolas Manel et al.   NATURE IMMUNOLOGY

Cellular cholesterol trafficking and compartmentalization

(2008) Elina Ikonen   NATURE REVIEWS MOLECULAR CELL BIOLOGY