期刊
CRITICAL REVIEWS IN IMMUNOLOGY
卷 35, 期 4, 页码 261-275出版社
BEGELL HOUSE INC
DOI: 10.1615/CritRevImmunol.2015014925
关键词
Circadian rhythm; Clock gene; Inflammation; Immune responses; Macrophages
类别
资金
- Japanese Ministry of Education, Culture Sports, Science and Technology
- Nakatomi Foundation
- Grants-in-Aid for Scientific Research [26350819, 15K01627, 15K08050, 26282186, 15K01626] Funding Source: KAKEN
Circadian rhythms have long been known to regulate numerous physiological processes that vary across the diurnal cycle. The circadian clock system also controls various parameters of the immune system and its biological defense functions, allowing an organism to anticipate daily changes in activity and feeding and the associated risk of infection. Inflammation is an immune response triggered in living organisms in response to external stimuli. The risk of sepsis, an excessive inflammatory response, has been shown to have a diurnal variation. On the other hand, inflammatory responses are emerging to be induced by endogenous factors. Recent studies have suggested that chronic inflammation causes chronic diseases including rheumatoid arthritis, allergies, and aging-related diseases and that proteins encoded by clock genes affect the development of such chronic inflammatory diseases or increase the severity of their symptoms. Therefore, detailed understanding of circadian rhythm effects on inflammatory responses is expected to lead to new strategies for prevention or treatment of inflammatory diseases.
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