Alzheimer's disease: An evolving understanding of noradrenergic involvement and the promising future of electroceutical therapies

Locus coeruleus neurons are most sensitive to chronic neuroinflammation-induced neurodegeneration

(2020) Qingshan Wang et al.   BRAIN BEHAVIOR AND IMMUNITY

Rapid and transient enhancement of thalamic information transmission induced by vagus nerve stimulation

(2020) Charles Rodenkirch et al.   Journal of Neural Engineering

Neural networks and the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation in depression

(2020) Chun-Hong Liu et al.   Journal of Neuroinflammation

β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade

(2020) Fang Zhang et al.   Science Translational Medicine

An agnostic reevaluation of the amyloid cascade hypothesis of Alzheimer's disease pathogenesis: The role of APP homeostasis

(2020) Richard J. Caselli et al.   Alzheimers & Dementia

Bilateral nucleus basalis of Meynert deep brain stimulation for dementia with Lewy bodies: A randomised clinical trial

(2020) James Gratwicke et al.   Brain Stimulation

Role of tau protein in Alzheimer's disease: The prime pathological player

(2020) Shibi Muralidar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Recent advances in tau-directed immunotherapy against Alzheimer’s disease: an overview of pre-clinical and clinical development

(2020) Pei Ying Ng et al.   METABOLIC BRAIN DISEASE

The role of the microbiota-gut-brain axis in neuropsychiatric disorders

(2020) Jaqueline S. Generoso et al.   REVISTA BRASILEIRA DE PSIQUIATRIA

The impact of the microbiota-gut-brain axis on Alzheimer’s disease pathophysiology

(2020) Tejaswini Doifode et al.   PHARMACOLOGICAL RESEARCH

A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease

(2019) Francesco Panza et al.   Nature Reviews Neurology

The Alzheimer’s Disease Clinical Spectrum

(2019) Alireza Atri   MEDICAL CLINICS OF NORTH AMERICA

The amyloid cascade and Alzheimer’s disease therapeutics: theory versus observation

(2019) Rudy J. Castellani et al.   LABORATORY INVESTIGATION

The Nucleus Basalis of Meynert and Its Role in Deep Brain Stimulation for Cognitive Disorders: A Historical Perspective

(2019) Philippos Koulousakis et al.   JOURNAL OF ALZHEIMERS DISEASE

The Gut-Brain Axis in Neurodegenerative Diseases and Relevance of the Canine Model: A Review

(2019) Yoko M. Ambrosini et al.   Frontiers in Aging Neuroscience

Microglial activation, but not tau pathology, is independently associated with amyloid positivity and memory impairment

(2019) James Zou et al.   NEUROBIOLOGY OF AGING

The Microbiota-Gut-Brain Axis

(2019) John F. Cryan et al.   PHYSIOLOGICAL REVIEWS

Mitochondria as Potential Targets in Alzheimer Disease Therapy: An Update

(2019) Giovanna Cenini et al.   Frontiers in Pharmacology

The path forward in Alzheimer's disease therapeutics: Reevaluating the amyloid cascade hypothesis

(2019) Martin Tolar et al.   Alzheimers & Dementia

Developing Effective Alzheimer’s Disease Therapies: Clinical Experience and Future Directions

(2019) David R. Elmaleh et al.   JOURNAL OF ALZHEIMERS DISEASE

Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus

(2019) Seong Su Kang et al.   JOURNAL OF CLINICAL INVESTIGATION

Advances and considerations in AD tau-targeted immunotherapy

(2019) Alice Bittar et al.   NEUROBIOLOGY OF DISEASE

Understanding the impact of sex and gender in Alzheimer's disease: A call to action

(2018) Rebecca A. Nebel et al.   Alzheimers & Dementia

The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease

(2018) Harald Hampel et al.   BRAIN

Complex noradrenergic dysfunction in Alzheimer’s disease: Low norepinephrine input is not always to blame

(2018) Mary Gannon et al.   BRAIN RESEARCH

Chronic deep brain stimulation in an Alzheimer's disease mouse model enhances memory and reduces pathological hallmarks

(2018) Amandeep Mann et al.   Brain Stimulation

Synergistic Protective Effects of Mitochondrial Division Inhibitor 1 and Mitochondria-Targeted Small Peptide SS31 in Alzheimer’s Disease

(2018) P. Hemachandra Reddy et al.   JOURNAL OF ALZHEIMERS DISEASE

Deep Brain Stimulation Targeting the Fornix for Mild Alzheimer Dementia (the ADvance Trial): A Two Year Follow-up Including Results of Delayed Activation

(2018) Jeannie-Marie S. Leoutsakos et al.   JOURNAL OF ALZHEIMERS DISEASE

Deep Brain Stimulation of the Memory Circuit: Improving Cognition in Alzheimer’s Disease

(2018) Sotirios Posporelis et al.   JOURNAL OF ALZHEIMERS DISEASE

Deep Brain Stimulation of Frontal Lobe Networks to Treat Alzheimer’s Disease

(2018) Douglas W. Scharre et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau-targeting therapies for Alzheimer disease

(2018) Erin E. Congdon et al.   Nature Reviews Neurology

Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans

(2018) Panos Theofilas et al.   NEUROBIOLOGY OF AGING

Interaction between noradrenergic and cholinergic signaling in amygdala regulates anxiety- and depression-related behaviors in mice

(2018) Yann S. Mineur et al.   NEUROPSYCHOPHARMACOLOGY

Long Road to Ruin: Noradrenergic Dysfunction in Neurodegenerative Disease

(2018) David Weinshenker   TRENDS IN NEUROSCIENCES

A self-destructive nanosweeper that captures and clears amyloid β-peptides

(2018) Qiang Luo et al.   Nature Communications

Bilateral Deep Brain Stimulation of the Nucleus Basalis of Meynert for Parkinson Disease Dementia

(2018) James Gratwicke et al.   JAMA Neurology

Deep Brain Stimulation: A Potential Treatment for Dementia in Alzheimer's Disease (AD) and Parkinson's Disease Dementia (PDD)

(2018) Qing Lv et al.   Frontiers in Neuroscience

The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis

(2018) Bruno Bonaz et al.   Frontiers in Neuroscience

The neuroprotective effect of deep brain stimulation at nucleus basalis of Meynert in transgenic mice with Alzheimer's disease

(2018) Chuyi Huang et al.   Brain Stimulation

The Effects of Ramipril in Individuals at Risk for Alzheimer's Disease: Results of a Pilot Clinical Trial

(2018) Whitney Wharton et al.   JOURNAL OF ALZHEIMERS DISEASE

Investigation of Nebivolol as a Novel Therapeutic Agent for the Treatment of Alzheimer's Disease

(2018) Jun Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Influence of tau PET, amyloid PET, and hippocampal volume on cognition in Alzheimer disease

(2018) Andrew J. Aschenbrenner et al.   NEUROLOGY

The Locus Coeruleus Is a Complex and Differentiated Neuromodulatory System

(2018) Nelson K. Totah et al.   NEURON

Nucleus Basalis of Meynert Stimulation for Dementia: Theoretical and Technical Considerations

(2018) Deepak Kumbhare et al.   Frontiers in Neuroscience

The impact of Aβ and tau on prospective cognitive decline in older individuals

(2018) Reisa A. Sperling et al.   ANNALS OF NEUROLOGY

Modulation of neuroinflammation and memory dysfunction using percutaneous vagus nerve stimulation in mice

(2018) William J. Huffman et al.   Brain Stimulation

Status of Noninvasive Brain Stimulation in the Therapy of Alzheimerʼs Disease

(2018) Yi-Cong Lin et al.   CHINESE MEDICAL JOURNAL

Locus coeruleus activation enhances thalamic feature selectivity via norepinephrine regulation of intrathalamic circuit dynamics

(2018) Charles Rodenkirch et al.   NATURE NEUROSCIENCE

Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline

(2017) Stefano Tarantini et al.   EXPERIMENTAL GERONTOLOGY

Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer’s disease

(2017) Ramesh Kandimalla et al.   HUMAN MOLECULAR GENETICS

Multifactorial causal model of brain (dis)organization and therapeutic intervention: Application to Alzheimer’s disease

(2017) Yasser Iturria-Medina et al.   NEUROIMAGE

Effect of simvastatin on CSF Alzheimer disease biomarkers in cognitively normal adults

(2017) Ge Li et al.   NEUROLOGY

Neuroanatomical Characteristics Associated With Response to Deep Brain Stimulation of the Nucleus Basalis of Meynert for Alzheimer's Disease

(2017) Juan Carlos Baldermann et al.   NEUROMODULATION

Entorhinal Cortical Deep Brain Stimulation Rescues Memory Deficits in Both Young and Old Mice Genetically Engineered to Model Alzheimer’s Disease

(2017) Frances Xia et al.   NEUROPSYCHOPHARMACOLOGY

Alzheimer’s disease prevention: from risk factors to early intervention

(2017) Marta Crous-Bou et al.   Alzheimers Research & Therapy

Dynamic Lateralization of Pupil Dilation Evoked by Locus Coeruleus Activation Results from Sympathetic, Not Parasympathetic, Contributions

(2017) Yang Liu et al.   Cell Reports

Tau Oligomers: Cytotoxicity, Propagation, and Mitochondrial Damage

(2017) Scott S. Shafiei et al.   Frontiers in Aging Neuroscience

Locus coeruleus cellular and molecular pathology during the progression of Alzheimer’s disease

(2017) Sarah C. Kelly et al.   Acta Neuropathologica Communications

Reconstituted high-density lipoproteins acutely reduce soluble brain Aβ levels in symptomatic APP/PS1 mice

(2016) Jérôme Robert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease

(2016) Amy R. Nelson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Locus coeruleus: From global projection system to adaptive regulation of behavior

(2016) G. Aston-Jones et al.   BRAIN RESEARCH

Deep Brain Stimulation of the Nucleus Basalis of Meynert in Alzheimer's Dementia: Potential Predictors of Cognitive Change and Results of a Long-Term Follow-Up in Eight Patients

(2016) K. Hardenacke et al.   Brain Stimulation

Reorganization of Motor Cortex by Vagus Nerve Stimulation Requires Cholinergic Innervation

(2016) Daniel R. Hulsey et al.   Brain Stimulation

The Gut-Brain Axis, Including the Microbiome, Leaky Gut and Bacterial Translocation: Mechanisms and Pathophysiological Role in Alzheimer’s Disease

(2016) Cristiano Köhler et al.   CURRENT PHARMACEUTICAL DESIGN

A Phase II Study of Fornix Deep Brain Stimulation in Mild Alzheimer’s Disease

(2016) Andres M. Lozano et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial Abnormalities and Synaptic Loss Underlie Memory Deficits Seen in Mouse Models of Obesity and Alzheimer’s Disease

(2016) Isaura V.A. Martins et al.   JOURNAL OF ALZHEIMERS DISEASE

Relationships between Pupil Diameter and Neuronal Activity in the Locus Coeruleus, Colliculi, and Cingulate Cortex

(2016) Siddhartha Joshi et al.   NEURON

Mitigating effect of chrysin loaded solid lipid nanoparticles against Amyloid β25–35 induced oxidative stress in rat hippocampal region: An efficient formulation approach for Alzheimer's disease

(2016) Aishwarya Vedagiri et al.   NEUROPEPTIDES

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

The Locus Coeruleus: Essential for Maintaining Cognitive Function and the Aging Brain

(2016) Mara Mather et al.   TRENDS IN COGNITIVE SCIENCES

Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer’s pathology

(2016) Taylor W. Schmitz et al.   Nature Communications

2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception

(2015) Michael W. Weiner et al.   Alzheimers & Dementia

Behavioral Effects of Deep Brain Stimulation of the Anterior Nucleus of Thalamus, Entorhinal Cortex and Fornix in a Rat Model of Alzheimer′s Disease

(2015) Jian-Guo Zhang et al.   CHINESE MEDICAL JOURNAL

The rationale for deep brain stimulation in Alzheimer’s disease

(2015) Zaman Mirzadeh et al.   JOURNAL OF NEURAL TRANSMISSION

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

The antidepressant mechanism of action of vagus nerve stimulation: Evidence from preclinical studies

(2015) Annelies Grimonprez et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Noradrenergic dysfunction in Alzheimer's disease

(2015) Mary Gannon et al.   Frontiers in Neuroscience

The vagus nerve alters the pulmonary dendritic cell response to injury

(2014) Debra M. Lowry et al.   JOURNAL OF SURGICAL RESEARCH

Vagal nerve stimulation modulates the dendritic cell profile in posthemorrhagic shock mesenteric lymph

(2014) Koji Morishita et al.   Journal of Trauma and Acute Care Surgery

Deep brain stimulation of the nucleus basalis of Meynert in Alzheimer’s dementia

(2014) J Kuhn et al.   MOLECULAR PSYCHIATRY

Monoamine Oxidase Inhibitory Constituents of Propolis: Kinetics and Mechanism of Inhibition of Recombinant Human MAO-A and MAO-B

(2014) Narayan Chaurasiya et al.   MOLECULES

Norepinephrine deficiency in Parkinson's disease: The case for noradrenergic enhancement

(2014) Alberto J. Espay et al.   MOVEMENT DISORDERS

Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase

(2014) Javier Sanchez-Padilla et al.   NATURE NEUROSCIENCE

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

α1-Adrenergic receptor subtypes in the central nervous system: insights from genetically engineered mouse models

(2014) Irena Nalepa et al.   Pharmacological Reports

α2Aadrenergic receptor promotes amyloidogenesis through disrupting APP-SorLA interaction

(2014) Yunjia Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical epidemiology of Alzheimer’s disease: assessing sex and gender differences

(2014) Michelle Mielke et al.   Clinical Epidemiology

The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives

(2013) Russell H. Swerdlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Effect of methylphenidate on attention in apathetic AD patients in a randomized, placebo-controlled trial

(2013) Krista L. Lanctôt et al.   INTERNATIONAL PSYCHOGERIATRICS

β2Adrenergic Receptor, Protein Kinase A (PKA) and c-Jun N-terminal Kinase (JNK) Signaling Pathways Mediate Tau Pathology in Alzheimer Disease Models

(2013) Dayong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholinergic circuitry of the human nucleus basalis and its fate in Alzheimer's disease

(2013) M.-Marsel Mesulam   JOURNAL OF COMPARATIVE NEUROLOGY

Noradrenergic modulation of cognition: Therapeutic implications

(2013) Samuel R Chamberlain et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Uptake of environmental toxicants by the locus ceruleus: A potential trigger for neurodegenerative, demyelinating and psychiatric disorders

(2013) Roger Pamphlett   MEDICAL HYPOTHESES

Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease

(2013) Usman A Khan et al.   NATURE NEUROSCIENCE

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

(2013) L. E. Hebert et al.   NEUROLOGY

Environmental Novelty Activates β2-Adrenergic Signaling to Prevent the Impairment of Hippocampal LTP by Aβ Oligomers

(2013) Shaomin Li et al.   NEURON

Differential effectiveness of tianeptine, clonidine and amitriptyline in blocking traumatic memory expression, anxiety and hypertension in an animal model of PTSD

(2013) Phillip R. Zoladz et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Propagation of tau pathology in Alzheimer’s disease: identification of novel therapeutic targets

(2013) Amy M Pooler et al.   Alzheimers Research & Therapy

Targeting norepinephrine in mild cognitive impairment and Alzheimer's disease

(2013) Termpanit Chalermpalanupap et al.   Alzheimers Research & Therapy

Clinical, imaging, and pathological heterogeneity of the Alzheimer's disease syndrome

(2013) Benjamin Lam et al.   Alzheimers Research & Therapy

Neurovascular Dysfunction and Faulty Amyloid  -Peptide Clearance in Alzheimer Disease

(2013) A. P. Sagare et al.   Cold Spring Harbor Perspectives in Medicine

Epidemiology of Alzheimer Disease

(2013) R. Mayeux et al.   Cold Spring Harbor Perspectives in Medicine

Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions

(2013) Geert Jan Biessels et al.   Lancet Diabetes & Endocrinology

Gender, sex steroid hormones, and Alzheimer's disease

(2012) Rebekah S. Vest et al.   HORMONES AND BEHAVIOR

Pathophysiology of the Neurovascular Unit: Disease Cause or Consequence?

(2012) Danica B Stanimirovic et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Sex and Gender Differences in Alzheimer's Disease: Recommendations for Future Research

(2012) Christine L. Carter et al.   JOURNAL OF WOMENS HEALTH

Amyloid precursor protein (APP) regulates synaptic structure and function

(2012) Sheue-Houy Tyan et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Role of mitochondrial homeostasis and dynamics in Alzheimer's disease

(2012) J. Eva Selfridge et al.   NEUROBIOLOGY OF DISEASE

In Vivo Spreading of Tau Pathology

(2012) Claudio Soto   NEURON

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Orienting and Reorienting: The Locus Coeruleus Mediates Cognition through Arousal

(2012) Susan J. Sara et al.   NEURON

Preclinical Evaluation of Reconsolidation Blockade by Clonidine as a Potential Novel Treatment for Posttraumatic Stress Disorder

(2012) Karine Gamache et al.   NEUROPSYCHOPHARMACOLOGY

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alzheimer’s pathogenesis: is there neuron-to-neuron propagation?

(2011) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Marilyn S. Albert et al.   Alzheimers & Dementia

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Atrophy of the Cholinergic Basal Forebrain Over the Adult Age Range and in Early Stages of Alzheimer's Disease

(2011) Michel Grothe et al.   BIOLOGICAL PSYCHIATRY

Potential contribution of oxidative stress and inflammation to anxiety and hypertension

(2011) Samina Salim et al.   BRAIN RESEARCH

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The Mitochondria-Targeted Antioxidant MitoQ Prevents Loss of Spatial Memory Retention and Early Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease

(2011) M. J. McManus et al.   JOURNAL OF NEUROSCIENCE

Long-Term  1A-Adrenergic Receptor Stimulation Improves Synaptic Plasticity, Cognitive Function, Mood, and Longevity

(2011) V. A. Doze et al.   MOLECULAR PHARMACOLOGY

Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies

(2011) K. J. Anstey et al.   Obesity Reviews

Morris water maze performance deficit produced by intermittent swim stress is partially mediated by norepinephrine

(2011) Timothy A. Warner et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Use of Psychostimulants in Patients with Dementia

(2010) Christian R Dolder et al.   ANNALS OF PHARMACOTHERAPY

Blocking β2-adrenergic receptor attenuates acute stress-induced amyloid β peptides production

(2010) Nan-Nan Yu et al.   BRAIN RESEARCH

The Role of Tau in Alzheimer's Disease and Related Disorders

(2010) Rodrigo Medeiros et al.   CNS Neuroscience & Therapeutics

Rosiglitazone Monotherapy in Mild-to-Moderate Alzheimer’s Disease: Results from a Randomized, Double-Blind, Placebo-Controlled Phase III Study

(2010) Michael Gold et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Regulation of MCP-1 production in brain by stress and noradrenaline-modulating drugs

(2010) Jose L. M. Madrigal et al.   JOURNAL OF NEUROCHEMISTRY

Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice

(2010) Mikko Käenmäki et al.   JOURNAL OF NEUROCHEMISTRY

The norepinephrine transporter (NET) radioligand (S,S)-[18F]FMeNER-D2 shows significant decreases in NET density in the human brain in Alzheimer's disease: A post-mortem autoradiographic study

(2010) Balázs Gulyás et al.   NEUROCHEMISTRY INTERNATIONAL

Induced LC degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits

(2010) Daniel Jardanhazi-Kurutz et al.   NEUROCHEMISTRY INTERNATIONAL

Distinct adrenergic system changes and neuroinflammation in response to induced locus ceruleus degeneration in APP/PS1 transgenic mice

(2010) D. Jardanhazi-Kurutz et al.   NEUROSCIENCE

Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

(2010) M. T. Heneka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Locus Coeruleus Activation Facilitates Memory Encoding and Induces Hippocampal LTD that Depends on  -Adrenergic Receptor Activation

(2009) N. Lemon et al.   CEREBRAL CORTEX

Chronic vagus nerve stimulation induces neuronal plasticity in the rat hippocampus

(2009) Francesca Biggio et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

The locus coeruleus and noradrenergic modulation of cognition

(2009) Susan J. Sara   NATURE REVIEWS NEUROSCIENCE

Gender effect on the accumulation of hyperphosphorylated tau in the brain of locus-ceruleus-injured APP-transgenic mouse

(2009) Naoto Oikawa et al.   NEUROSCIENCE LETTERS

Functional Consequences of Locus Coeruleus Degeneration in Alzheimers Disease

(2008) David Weinshenker   Current Alzheimer Research

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

Memory loss caused by β-amyloid protein is rescued by a β3-adrenoceptor agonist

(2008) Marie E. Gibbs et al.   NEUROBIOLOGY OF AGING