Article
Neurosciences
Yin Jiang, Tian-Shuo Yuan, Ying-Chuan Chen, Peng Guo, Teng-Hong Lian, Yu-Ye Liu, Wei Liu, Yu-Tong Bai, Quan Zhang, Wei Zhang, Jian-Guo Zhang
Summary: NBM-DBS may improve cognitive functioning in patients with advanced AD in the short term, possibly through modulation of multi-network connectivity patterns, with the hippocampus playing an important role within these networks.
TRANSLATIONAL NEURODEGENERATION
(2022)
Article
Clinical Neurology
Dorothee Kuebler, Sophie Katharina Wellmann, Jakob Kaminski, Cornelia Skowronek, Gerd-Helge Schneider, Wolf-Julian Neumann, Kerstin Ritter, Andrea Kuehn
Summary: NBM volume can be used as a simple non-invasive predictor for cognitive outcome after DBS in Parkinson's disease, especially when combined with other clinically relevant parameters.
PARKINSONISM & RELATED DISORDERS
(2022)
Review
Neurosciences
Yu-si Chen, Kai Shu, Hui-cong Kang
Summary: Alzheimer's disease is a prevalent condition in the elderly population, with current drug therapies failing to reverse or ameliorate its progression. Deep brain stimulation (DBS), particularly targeting the nucleus basalis of Meynert (NBM), has shown promise in modulating neural network dysfunction and potentially treating AD. However, challenges such as variations in cortical blood flow and stimulation-induced neural damage need to be addressed for successful implementation of NBM-DBS.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Wei Zhang, Wei Liu, Bhavana Patel, Yingchuan Chen, Kailiang Wang, Anchao Yang, Fangang Meng, Aparna Wagle Shukla, Shanshan Cen, John Yu, Adolfo Ramirez-Zamora, Jianguo Zhang
Summary: NBM-DBS has been reported to improve cognitive function in individuals with severe AD. A study on an 80-year-old male subject showed significant improvements in MMSE and ADAS-cog assessments after 10 weeks of stimulation. Despite postoperative complications, the patient fully recovered, indicating that NBM-DBS may be a potential therapy for severe AD patients.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Milan Nemy, Martin Dyrba, Frederic Brosseron, Katharina Buerger, Peter Dechent, Laura Dobisch, Michael Ewers, Klaus Fliessbach, Wenzel Glanz, Doreen Goerss, Michael T. Heneka, Stefan Hetzer, Enise I. Incesoy, Daniel Janowitz, Ingo Kilimann, Christoph Laske, Franziska Maier, Matthias H. Munk, Robert Perneczky, Oliver Peters, Lukas Preis, Josef Priller, Boris-Stephan Rauchmann, Sandra Roeske, Nina Roy, Klaus Scheffler, Anja Schneider, Bjorn H. Schott, Annika Spottke, Eike J. Spruth, Michael Wagner, Jens Wiltfang, Renat Yakupov, Maria Eriksdotter, Eric Westman, Olga Stepankova, Lenka Vyslouzilova, Emrah Duezel, Frank Jessen, Stefan J. Teipel, Daniel Ferreira
Summary: Nemy et al. investigate cholinergic white matter projections along the Alzheimer's disease continuum, finding that alterations in these pathways are present in individuals with subjective cognitive decline. These alterations precede the more widespread changes seen in mild cognitive impairment and Alzheimer's disease dementia. The study highlights the potential of using cholinergic white matter pathways as markers for the early stages of Alzheimer's disease.
Article
Clinical Neurology
Davide Cappon, James Gratwicke, Ludvic Zrinzo, Harith Akram, Jonathan Hyam, Marwan Hariz, Patricia Limousin, Thomas Foltynie, Marjan Jahanshahi
Summary: The study evaluated the three-year effects of NBM-DBS treatment in PDD patients and found that predictive factors for treatment efficacy include baseline attention level and sleep quality. Individual patients showed slower progression in cognitive decline, which may be related to responsiveness to NBM-DBS treatment.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2022)
Article
Clinical Neurology
Franziska E. Hildesheim, Ralph H. B. Benedict, Robert Zivadinov, Michael G. Dwyer, Tom Fuchs, Dejan Jakimovski, Bianca Weinstock-Guttman, Niels Bergsland
Summary: NBM damage is associated with cognitive impairment in patients with multiple sclerosis, with diffusivity of NBM showing significant correlation with cognitive test results and ability to predict cognitive changes.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Sanskriti Sasikumar, Melanie Cohn, Irene E. Harmsen, Aaron Loh, Sang Soo Cho, Michel Saenz-Farret, Ricardo Maciel, Derrick Soh, Alexandre Boutet, Jurgen Germann, Gavin Elias, Ariana Youm, Katherine Duncan, Nathan C. Rowland, Antonio P. Strafella, Suneil K. Kalia, Andres M. Lozano, Alfonso Fasano
Summary: The study found that simultaneous GPi and NBM stimulation is safe and improves motor complications in Parkinson's disease patients, but does not improve cognition. NBM stimulation has effects on brain metabolism and functional connectivity, but does not result in lasting cognitive improvement.
MOVEMENT DISORDERS
(2022)
Article
Neuroimaging
Daniel H. Lench, Travis H. Turner, Emma Wetmore, Federico J. Rodriguez-Porcel, Gonzalo J. Revuelta
Summary: This study found that structural degeneration of the Nucleus Basalis of Meynert is associated with worsening cognitive symptoms in Parkinson's Disease patients during OFF periods, but does not affect their overall cognitive functioning in the ON-state.
BRAIN IMAGING AND BEHAVIOR
(2023)
Article
Clinical Neurology
Chen-Pei Lin, Irene Frigerio, Baayla D. C. Boon, Zihan Zhou, Annemieke J. M. Rozemuller, Femke H. Bouwman, Menno M. Schoonheim, Wilma D. J. van de Berg, Laura E. Jonkman
Summary: Cognitive deficits in Alzheimer's disease, especially memory decline, are associated with cholinergic degeneration in the basal forebrain. This study used a combination of post-mortem in situ MRI and histopathology to investigate the pathophysiology of nucleus basalis of Meynert atrophy in Alzheimer's disease. The results showed that Alzheimer's disease donors had reduced volume and altered microstructural integrity of the nucleus basalis of Meynert, which was associated with decreased cholinergic cell density and damaged cortical projections, leading to cognitive deterioration.
Article
Clinical Neurology
Nicola J. J. Ray, Prabesh Kanel, Nicolaas I. I. Bohnen
Summary: Structural imaging of the cholinergic basal forebrain may provide a biomarker for cholinergic system integrity in Parkinson's disease. This study validates the correlation between cholinergic basal forebrain morphometry and vesicular acetylcholine transporter in a large Parkinson's sample.
ANNALS OF NEUROLOGY
(2023)
Article
Neurosciences
Yawen Wang, Minye Zhan, Alard Roebroeck, Peter De Weerd, Sriranga Kashyap, Mark J. Roberts
Summary: This study examines the feasibility of using MRI to locate the nucleus basalis of Meynert (nbM) in humans, and finds that current methods of mapping nbM may have limitations, especially when dealing with high resolution MRI data. By developing a new nbM mask and utilizing high spatial resolution data, more accurate and stable volume estimates can be obtained. Direct imaging of nbM appears to be feasible, but further development is necessary for standard (f)MRI scanning to allow such imaging.
Article
Clinical Neurology
Dewen Meng, Ali-Reza Mohammadi-Nejad, Stamatios N. Sotiropoulos, Dorothee P. Auer
Summary: The use of anticholinergic medication is associated with cognitive decline and structural and functional impairment of the cholinergic nucleus basalis of Meynert. The study found that individuals on long-term anticholinergic medication have lower gray matter density and reduced functional connectivity in the nucleus basalis of Meynert, leading to cognitive impairment.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Piao Zhang, Siming Rong, Chentao He, Yan Li, Xiaohong Li, Zhenzhen Chen, Kun Nie, Limin Wang, Lijuan Wang, Yuhu Zhang
Summary: This study investigated the cholinergic basal forebrain pathology in Parkinson's disease with mild cognitive impairment (PD-MCI) and found that functional connectivity changes are frequency-specific, providing new insights into the functional alterations within the cholinergic system in cognitive impairment.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Clinical Neurology
Ying-Liang Larry Lai, Kuan Chen, Tzu-Wei Lee, Chao-Wei Tso, Hui-Hsien Lin, Li-Wei Kuo, Cheng-Yu Chen, Hua-Shan Liu
Summary: The study revealed significant differences in the associations between APOE-epsilon 4 and cholinergic structural changes among subjects with different levels of cognitive impairment, reflecting impaired brain function underlying neurocognitive degeneration in AD.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Artur Vetkas, Juergen Germann, Alexandre Boutet, Nardin Samuel, Can Sarica, Kazuaki Yamamoto, Brendan Santyr, Cletus Cheyuo, Christopher R. R. Conner, Stefan M. M. Lang, Andres M. M. Lozano, George M. M. Ibrahim, Taufik Valiante, Paul N. N. Kongkham, Suneil K. K. Kalia
Summary: This systematic review summarizes the clinical indications, outcomes, and adverse effects of insular laser interstitial thermal therapy (LITT) through a review of the literature. The results show that LITT is effective in treating both insular seizures and insular tumors. However, the lack of prospective studies highlights the need for randomized and controlled trials to evaluate the efficacy of LITT.
FRONTIERS IN NEUROLOGY
(2023)
Letter
Clinical Neurology
Arjun Balachandar, Alexandre Boutet, Artur Vetkas, Jurgen Germann, Ian Y. M. Chan, David Mikulis, Renato P. Munhoz, Alfonso Fasano, Suneil K. Kalia, Andres M. Lozano
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Neurosciences
Diellor Basha, Suneil K. K. Kalia, Mojgan Hodaie, Adriana L. Lopez L. Rios, Andres M. M. Lozano, William D. D. Hutchison
Summary: This study investigates the role of beta oscillations in the basal ganglia and cerebellar regions in visuomotor coordination. The recordings during the visuomotor task showed a decrease in beta oscillations and an increase in firing rates. These findings suggest that beta oscillations are modulated by novel visuomotor tasks and facilitate information transmission to the thalamocortical circuit.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Vibhor Krishna, Paul S. Fishman, Howard M. Eisenberg, Michael Kaplitt, Gordon Baltuch, Jin Woo Chang, Wei-Chieh Chang, Raul Martinez Fernandez, Marta del Alamo, Casey H. Halpern, Pejman Ghanouni, Roberto Eleopra, Rees Cosgrove, Jorge Guridi, Ryder Gwinn, Pravin Khemani, Andres M. Lozano, Nathan McDannold, Alfonso Fasano, Marius Constantinescu, Ilana Schlesinger, Arif Dalvi, W. Jeff Elias
Summary: Unilateral pallidal ultrasound ablation can alleviate motor symptoms in patients with Parkinson's disease, but it is associated with adverse events. Larger and longer trials are needed to determine the efficacy and safety of this technique.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Letter
Clinical Neurology
Jinyoung Youn, Carolina Gorodetsky, Andres M. Lozano, Anthony E. Lang, Alfonso Fasano
Summary: Despite no previous reports on parkinsonism in Poland syndrome (PS) and the lack of studies on treatment response, we present a case of ipsilateral parkinsonism in PS, resembling hemiatrophy-hemiparkinsonism, with a positive response to levodopa and subthalamic deep brain stimulation.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Stefan Lang, Artur Vetkas, Christopher Conner, Lorraine V. Kalia, Andres M. Lozano, Suneil K. Kalia
Summary: This study identified features at early diagnosis that can predict the need for deep brain stimulation surgery in newly diagnosed Parkinson's disease patients. The results from the logistic regression and linear mixed effect models suggest that these features can be used for early identification and surgical decision-making.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Jurgen Germann, Brendan Santyr, Alexandre Boutet, Can Sarica, Clement T. Chow, Gavin J. B. Elias, Artur Vetkas, Andrew Yang, Mojgan Hodaie, Alfonso Fasano, Suneil K. Kalia, Michael L. Schwartz, Andres M. Lozano
Summary: Comparing the efficacy maps of DBS and MRgFUS suggests a potential alternative location for lesioning, more antero-superiorly. This may reduce complications, without sacrificing efficacy, and individualise targeting.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Brendan Santyr, Aaron Loh, Artur Vetkas, Dave Gwun, Wilson K. W. Fung, Shakeel Qazi, Jurgen Germann, Alexandre Boutet, Can Sarica, Andrew Yang, Gavin Elias, Suneil K. Kalia, Alfonso Fasano, Andres M. Lozano
Summary: We report a case of a cervical dystonia patient who lost the ability to swim and dance during active stimulation of the globus pallidus internus. Using unique functional and structural imaging analysis, we investigated the anatomical underpinning of this phenomenon. The results showed significant stimulation-evoked responses during fMRI.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Daniel G. Di Luca, Carolina Ramirez-Gomez, Jurgen Germann, Brendan Santyr, Alexandre Boutet, Luka Milosevic, Anthony E. Lang, Suneil K. Kalia, Andres M. Lozano, Alfonso Fasano
Summary: This study aimed to evaluate the safety and efficacy of deep brain stimulation on the globus pallidus pars interna and externa in MSA-P patients. The surgery did not result in major complications, but did not provide significant clinical benefit as measured by MDS-UPDRS III.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Nardin Samuel, Mandy Yi Rong Ding, Can Sarica, Ghazaleh Darmani, Irene E. Harmsen, Talyta Grippe, Xingyu Chen, Andrew Yang, Negar Nasrkhani, Ke Zeng, Robert Chen, Andres M. Lozano
Summary: Low-intensity transcranial focused ultrasound (TUS) can increase motor cortex excitability in patients with Parkinson's disease and is a feasible non-invasive neuromodulation strategy.
MOVEMENT DISORDERS
(2023)
Article
Computer Science, Artificial Intelligence
Nebras M. Warsi, Simeon M. Wong, Juergen Germann, Alexandre Boutet, Olivia N. Arski, Ryan Anderson, Lauren Erdman, Han Yan, Hrishikesh Suresh, Flavia Venetucci Gouveia, Aaron Loh, Gavin J. B. Elias, Elizabeth Kerr, Mary Lou Smith, Ayako Ochi, Hiroshi Otsubo, Roy Sharma, Puneet Jain, Elizabeth Donner, Andres M. Lozano, O. Carter Snead, George M. Ibrahim
Summary: Deep learning is applied to decode neural features and accurately predict task performance in children with epilepsy. The dorsal default mode network plays a crucial role in attention shift. Despite inter subject variability in electrode implantations, consistent functional network results are obtained.
Article
Health Care Sciences & Services
Can Sarica, Christopher R. Conner, Kazuaki Yamamoto, Andrew Yang, Juergen Germann, Melissa M. Lannon, Nardin Samuel, Michael Colditz, Brendan Santyr, Clement T. Chow, Christian Iorio-Morin, David H. Aguirre-Padilla, Stefan Thomas Lang, Artur Vetkas, Cletus Cheyuo, Aaron Loh, Ghazaleh Darmani, Oliver Flouty, Vanessa Milano, Michelle Paff, Mojgan Hodaie, Suneil K. Kalia, Renato P. Munhoz, Alfonso Fasano, Andres M. Lozanoa
Summary: This study analyzed the utilization of DBS procedures in the United States and compared patients with different indications. The study found demographic and socioeconomic disparities in DBS use.
LANCET REGIONAL HEALTH-AMERICAS
(2023)
Article
Oncology
Nardin Samuel, Irene E. Harmsen, Mandy Yi Rong Ding, Can Sarica, Artur Vetkas, Christine Wong, Vanessa Lawton, Andrew Yang, Nathan C. Rowland, Suneil K. Kalia, Taufik Valiante, Richard Wennberg, Gelareh Zadeh, Paul Kongkham, Aristotelis Kalyvas, Andres M. Lozano
Summary: This study used magnetoencephalography to investigate the neurophysiologic and functional connectivity changes following glioma surgery. The findings showed distinct alterations in spectral power following tumor resection, with frequency band changes unique to each patient. Recovery of regional functional connectivity was observed in the post-operative setting, with comparable changes in low to mid gamma-associated functional connectivity noted in four patients. These findings provide a framework for future studies to examine other network changes in glioma patients and correlate neurophysiologic changes with individual patients' clinical outcomes.
NEURO-ONCOLOGY ADVANCES
(2023)
Review
Neurosciences
Can Sarica, Ajmal Zemmar, Omid Yousefi, Andrew C. Yang, Ayse Uzuner, Zhiyuan Sheng, Brendan Santyr, Nardin Samuel, Michael Colditz, Artur Vetkas, Jurgen Germann, Cletus Cheyuo, Mohammadmahdi Sabahi, Raja Jani, Ghazaleh Darmani, Kazuaki Yamamoto, David H. Aguirre-Padilla, Joseph Neimat, Suneil K. Kalia, Robert Chen, Alfonso Fasano, Andres M. Lozano
Summary: This systematic review and meta-analysis evaluated the safety and effectiveness of spinal cord stimulation (SCS) as a potential therapeutic option for managing refractory symptoms in patients with Parkinson's disease (PD). The analysis suggests that SCS may provide significant motor and pain benefits for PD patients, but caution should be exercised when interpreting the results due to potential limitations.
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
(2023)
Article
Computer Science, Artificial Intelligence
Simon Oxenford, Ana Sofia Rios, Barbara Hollunder, Clemens Neudorfer, Alexandre Boutet, Gavin J. B. Elias, Jurgen Germann, Aaron Loh, Wissam Deeb, Bryan Salvato, Leonardo Almeida, Kelly D. Foote, Robert Amaral, Paul B. Rosenberg, David F. Tang-Wai, David A. Wolk, Anna D. Burke, Marwan N. Sabbagh, Stephen Salloway, M. Mallar Chakravarty, Gwenn S. Smith, Constantine G. Lyketsos, Michael S. Okun, William S., Zoltan Mari, Francisco A. Ponce, Andres Lozano, Wolf-Julian Neumann, Bassam Al-Fatly, Andreas Horn
Summary: Spatial normalization is a method to map subject brain images to an average template brain, allowing comparison of brain imaging results. We introduce a novel tool called WarpDrive, which enables manual refinements of image alignment after automated registration. The tool improves accuracy of data representation and aids in understanding patient outcomes.
MEDICAL IMAGE ANALYSIS
(2024)